Details for: MAPK14

Gene ID: 1432

Symbol: MAPK14

Ensembl ID: ENSG00000112062

Description: mitogen-activated protein kinase 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 273.8110
    Cell Significance Index: -42.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 161.2697
    Cell Significance Index: -40.9100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.0966
    Cell Significance Index: -47.7300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.6967
    Cell Significance Index: -39.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.3859
    Cell Significance Index: -44.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 71.0111
    Cell Significance Index: -47.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.6447
    Cell Significance Index: -39.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.8789
    Cell Significance Index: -45.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4977
    Cell Significance Index: -44.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.8436
    Cell Significance Index: -42.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.8676
    Cell Significance Index: -46.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1373
    Cell Significance Index: -24.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.1244
    Cell Significance Index: 83.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3406
    Cell Significance Index: 464.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2814
    Cell Significance Index: 457.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1515
    Cell Significance Index: 250.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5939
    Cell Significance Index: 157.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3704
    Cell Significance Index: 491.5300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1830
    Cell Significance Index: 18.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1031
    Cell Significance Index: 21.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0709
    Cell Significance Index: 47.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0413
    Cell Significance Index: 29.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0192
    Cell Significance Index: 38.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9579
    Cell Significance Index: 662.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8986
    Cell Significance Index: 60.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8325
    Cell Significance Index: 51.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8217
    Cell Significance Index: 63.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8130
    Cell Significance Index: 48.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7992
    Cell Significance Index: 129.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7241
    Cell Significance Index: 40.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5948
    Cell Significance Index: 10.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5521
    Cell Significance Index: 13.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5379
    Cell Significance Index: 15.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4159
    Cell Significance Index: 28.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3884
    Cell Significance Index: 11.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3731
    Cell Significance Index: 67.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3132
    Cell Significance Index: 38.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2862
    Cell Significance Index: 156.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2270
    Cell Significance Index: 31.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2024
    Cell Significance Index: 381.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1749
    Cell Significance Index: 33.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1648
    Cell Significance Index: 7.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1382
    Cell Significance Index: 61.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1357
    Cell Significance Index: 2.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1255
    Cell Significance Index: 2.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1039
    Cell Significance Index: 5.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0961
    Cell Significance Index: 43.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0904
    Cell Significance Index: 57.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0627
    Cell Significance Index: 56.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0573
    Cell Significance Index: 3.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0253
    Cell Significance Index: 46.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0156
    Cell Significance Index: 0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0117
    Cell Significance Index: 18.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0117
    Cell Significance Index: -15.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0138
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0229
    Cell Significance Index: -16.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0289
    Cell Significance Index: -4.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0375
    Cell Significance Index: -23.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0402
    Cell Significance Index: -29.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0456
    Cell Significance Index: -25.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0499
    Cell Significance Index: -37.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0567
    Cell Significance Index: -7.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0888
    Cell Significance Index: -4.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0980
    Cell Significance Index: -11.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0989
    Cell Significance Index: -3.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1402
    Cell Significance Index: -40.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1503
    Cell Significance Index: -31.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1768
    Cell Significance Index: -18.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2097
    Cell Significance Index: -5.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2133
    Cell Significance Index: -11.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2213
    Cell Significance Index: -10.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2521
    Cell Significance Index: -5.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2648
    Cell Significance Index: -34.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2739
    Cell Significance Index: -19.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2747
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3099
    Cell Significance Index: -35.5000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3556
    Cell Significance Index: -8.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3714
    Cell Significance Index: -38.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3767
    Cell Significance Index: -5.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3828
    Cell Significance Index: -43.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3942
    Cell Significance Index: -8.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4117
    Cell Significance Index: -25.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4640
    Cell Significance Index: -7.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4679
    Cell Significance Index: -34.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4777
    Cell Significance Index: -12.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4877
    Cell Significance Index: -10.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5027
    Cell Significance Index: -7.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5101
    Cell Significance Index: -26.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5152
    Cell Significance Index: -40.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5263
    Cell Significance Index: -13.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5582
    Cell Significance Index: -34.2200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5809
    Cell Significance Index: -7.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6529
    Cell Significance Index: -20.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6595
    Cell Significance Index: -13.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6745
    Cell Significance Index: -17.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6752
    Cell Significance Index: -14.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6817
    Cell Significance Index: -22.3200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6950
    Cell Significance Index: -9.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7353
    Cell Significance Index: -25.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7471
    Cell Significance Index: -11.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAPK14 is a serine/threonine kinase that is activated by a variety of stimuli, including stress, cytokines, and growth factors. The gene is characterized by its ability to regulate a wide range of cellular processes, including: * Inflammation: MAPK14 is involved in the regulation of inflammatory responses, including the modulation of cytokine signaling and the regulation of immune responses. * Cell growth and differentiation: MAPK14 is involved in the regulation of cell growth and differentiation, including the regulation of cell cycle progression and the modulation of gene expression. * Apoptosis and autophagy: MAPK14 is involved in the regulation of apoptosis and autophagy, including the regulation of pro-apoptotic and anti-apoptotic signaling pathways. * Senescence: MAPK14 is involved in the regulation of cellular senescence, including the regulation of telomere length and the modulation of gene expression. **Pathways and Functions** MAPK14 is involved in a wide range of signaling pathways, including: * Toll-like receptor (TLR) signaling: MAPK14 is activated by TLRs, which recognize pathogen-associated molecular patterns (PAMPs) and activate immune responses. * Cytokine signaling: MAPK14 is activated by cytokines, which are small proteins that regulate immune responses. * Stress signaling: MAPK14 is activated by stress, including heat shock, oxidative stress, and endoplasmic reticulum stress. * Growth factor signaling: MAPK14 is activated by growth factors, which regulate cell growth and differentiation. * Apoptosis and autophagy signaling: MAPK14 is involved in the regulation of apoptosis and autophagy, including the regulation of pro-apoptotic and anti-apoptotic signaling pathways. **Clinical Significance** MAPK14 is involved in various diseases, including: * Inflammatory disorders: MAPK14 is involved in the regulation of inflammatory responses, and dysregulation of MAPK14 has been implicated in various inflammatory disorders, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. * Cancer: MAPK14 is involved in the regulation of cell growth and differentiation, and dysregulation of MAPK14 has been implicated in various types of cancer, including breast cancer, lung cancer, and colon cancer. * Neurodegenerative disorders: MAPK14 is involved in the regulation of cellular stress responses, and dysregulation of MAPK14 has been implicated in various neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. * Infectious diseases: MAPK14 is involved in the regulation of immune responses, and dysregulation of MAPK14 has been implicated in various infectious diseases, including HIV, tuberculosis, and malaria. In conclusion, MAPK14 is a critical regulator of various cellular processes, including signal transduction, inflammation, cell growth, and differentiation. The gene is involved in a wide range of signaling pathways, including TLR signaling, cytokine signaling, stress signaling, growth factor signaling, apoptosis, and autophagy signaling. Dysregulation of MAPK14 has been implicated in various diseases, including inflammatory disorders, cancer, neurodegenerative disorders, and infectious diseases. Further research is needed to fully understand the role of MAPK14 in human health and disease.

Genular Protein ID: 3678437772

Symbol: MK14_HUMAN

Name: Cytokine suppressive anti-inflammatory drug-binding protein

UniProtKB Accession Codes:

Q16539 A6ZJ92 A8K6P4 B0LPH0 B5TY32 O60776 Q13083 Q14084 Q8TDX0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 11 CPTC 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 57 DrugCentral 1 EC 2 ELM 1 EMBL 15 EMDB 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 85 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 17 RefSeq 4 Rhea 8 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7997261

Title: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.

PubMed ID: 7997261

DOI: 10.1038/372739a0

PubMed ID: 7696354

Title: Molecular cloning of human p38 MAP kinase.

PubMed ID: 7696354

DOI: 10.1016/0167-4889(95)00002-a

PubMed ID: 7479834

Title: Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.

PubMed ID: 7479834

DOI: 10.1073/pnas.92.23.10531

PubMed ID: 10727080

Title: Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4.

PubMed ID: 10727080

DOI: 10.3109/10425179909033952

PubMed ID: 11866441

Title: Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.

PubMed ID: 11866441

DOI: 10.1006/bbrc.2002.6529

PubMed ID: 19906316

Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.

PubMed ID: 19906316

DOI: 10.1186/1471-2164-10-518

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7923354

Title: Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

PubMed ID: 7923354

DOI: 10.1016/0092-8674(94)90278-x

PubMed ID: 7535770

Title: Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.

PubMed ID: 7535770

DOI: 10.1074/jbc.270.13.7420

PubMed ID: 7493921

Title: Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast.

PubMed ID: 7493921

DOI: 10.1074/jbc.270.49.29043

PubMed ID: 8622669

Title: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

PubMed ID: 8622669

DOI: 10.1128/mcb.16.3.1247

PubMed ID: 9687510

Title: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

PubMed ID: 9687510

DOI: 10.1093/emboj/17.15.4426

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 9792677

Title: RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).

PubMed ID: 9792677

DOI: 10.1074/jbc.273.45.29661

PubMed ID: 10391943

Title: Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.

PubMed ID: 10391943

DOI: 10.1074/jbc.274.28.19949

PubMed ID: 9858528

Title: Regulation of the MEF2 family of transcription factors by p38.

PubMed ID: 9858528

DOI: 10.1128/mcb.19.1.21

PubMed ID: 10330143

Title: Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.

PubMed ID: 10330143

DOI: 10.1128/mcb.19.6.4028

PubMed ID: 10943842

Title: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.

PubMed ID: 10943842

DOI: 10.1016/s0092-8674(00)00027-1

PubMed ID: 10838079

Title: Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2.

PubMed ID: 10838079

DOI: 10.1016/s0014-5793(00)01598-2

PubMed ID: 10747897

Title: Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.

PubMed ID: 10747897

DOI: 10.1074/jbc.m000312200

PubMed ID: 11010976

Title: Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength.

PubMed ID: 11010976

DOI: 10.1074/jbc.m007835200

PubMed ID: 11278799

Title: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1.

PubMed ID: 11278799

DOI: 10.1074/jbc.m010966200

PubMed ID: 11359773

Title: A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.

PubMed ID: 11359773

DOI: 10.1074/jbc.m101981200

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 11333986

Title: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.

PubMed ID: 11333986

DOI: 10.1038/35075107

PubMed ID: 11847341

Title: MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

PubMed ID: 11847341

DOI: 10.1126/science.1067289

PubMed ID: 15284239

Title: Active mutants of the human p38alpha mitogen-activated protein kinase.

PubMed ID: 15284239

DOI: 10.1074/jbc.m404595200

PubMed ID: 15905572

Title: Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils.

PubMed ID: 15905572

DOI: 10.4049/jimmunol.174.11.7257

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15735648

Title: Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.

PubMed ID: 15735648

DOI: 10.1038/ni1177

PubMed ID: 15735649

Title: The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.

PubMed ID: 15735649

DOI: 10.1038/ni1176

PubMed ID: 16751104

Title: p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.

PubMed ID: 16751104

DOI: 10.1016/j.cell.2006.03.048

PubMed ID: 16932740

Title: p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy.

PubMed ID: 16932740

DOI: 10.1038/sj.emboj.7601297

PubMed ID: 17003045

Title: Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.

PubMed ID: 17003045

DOI: 10.1074/jbc.m606568200

PubMed ID: 16352664

Title: Nuclear protein NP60 regulates p38 MAPK activity.

PubMed ID: 16352664

DOI: 10.1242/jcs.02699

PubMed ID: 17724032

Title: p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.

PubMed ID: 17724032

DOI: 10.1074/jbc.m703857200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19893488

Title: Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP.

PubMed ID: 19893488

DOI: 10.1038/emboj.2009.321

PubMed ID: 20932473

Title: DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

PubMed ID: 20932473

DOI: 10.1016/j.molcel.2010.09.018

PubMed ID: 20188673

Title: Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.

PubMed ID: 20188673

DOI: 10.1016/j.molcel.2010.01.034

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21224381

Title: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation.

PubMed ID: 21224381

DOI: 10.1074/jbc.m110.185645

PubMed ID: 21586573

Title: The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-gamma production through the p38 mitogen-activated protein kinase pathway.

PubMed ID: 21586573

DOI: 10.1074/jbc.m111.234062

PubMed ID: 21444723

Title: Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.

PubMed ID: 21444723

DOI: 10.1128/mcb.01205-10

PubMed ID: 21283629

Title: LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).

PubMed ID: 21283629

DOI: 10.1371/journal.pone.0016427

PubMed ID: 12452429

Title: In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.

PubMed ID: 12452429

DOI: 10.1515/bc.2002.173

PubMed ID: 20626350

Title: Mechanisms and functions of p38 MAPK signalling.

PubMed ID: 20626350

DOI: 10.1042/bj20100323

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30878395

Title: MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction.

PubMed ID: 30878395

DOI: 10.1016/j.yjmcc.2019.03.005

PubMed ID: 35857590

Title: ZAKalpha-driven ribotoxic stress response activates the human NLRP1 inflammasome.

PubMed ID: 35857590

DOI: 10.1126/science.abl6324

PubMed ID: 8910361

Title: Crystal structure of p38 mitogen-activated protein kinase.

PubMed ID: 8910361

DOI: 10.1074/jbc.271.44.27696

PubMed ID: 9095200

Title: A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket.

PubMed ID: 9095200

DOI: 10.1038/nsb0497-311

PubMed ID: 9753691

Title: Structural basis of inhibitor selectivity in MAP kinases.

PubMed ID: 9753691

DOI: 10.1016/s0969-2126(98)00113-0

PubMed ID: 10633045

Title: Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.

PubMed ID: 10633045

DOI: 10.1021/jm990401t

PubMed ID: 11896401

Title: Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.

PubMed ID: 11896401

DOI: 10.1038/nsb770

PubMed ID: 12482439

Title: Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.

PubMed ID: 12482439

DOI: 10.1016/s0960-894x(02)00752-7

PubMed ID: 14561090

Title: Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.

PubMed ID: 14561090

DOI: 10.1021/jm0301787

PubMed ID: 12897767

Title: Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.

PubMed ID: 12897767

DOI: 10.1038/nsb949

PubMed ID: 14726206

Title: Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.

PubMed ID: 14726206

DOI: 10.1016/j.bbapap.2003.09.009

PubMed ID: 16342939

Title: Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.

PubMed ID: 16342939

DOI: 10.1021/bi051714v

PubMed ID: 15837335

Title: Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.

PubMed ID: 15837335

DOI: 10.1016/j.bmcl.2005.02.010

PubMed ID: 16169718

Title: Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes.

PubMed ID: 16169718

DOI: 10.1016/j.bmcl.2005.08.038

PubMed ID: 15658854

Title: Fragment-based lead discovery using X-ray crystallography.

PubMed ID: 15658854

DOI: 10.1021/jm0495778

PubMed ID: 17255097

Title: Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.

PubMed ID: 17255097

DOI: 10.1074/jbc.m611165200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 360
  • Mass: 41293
  • Checksum: 286C81D0487618B3
  • Sequence:
    • MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 
SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 
KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG 
TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES

Genular Protein ID: 465631473

Symbol: B4E0K5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0K5

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 283
  • Mass: 32357
  • Checksum: C840DAA6DF8E68B2
  • Sequence:
    • MKHENVIGLL DVFTPARSLE EFNDVYLVTH LMGADLNNIV KCQKLTDDHV QFLIYQILRG 
LKYIHSADII HRDLKPSNLA VNEDCELKIL DFGLARHTDD EMTGYVATRW YRAPEIMLNW 
MHYNQTVDIW SVGCIMAELL TGRTLFPGTD HIDQLKLILR LVGTPGAELL KKISSESARN 
YIQSLTQMPK MNFANVFIGA NPLAVDLLEK MLVLDSDKRI TAAQALAHAY FAQYHDPDDE 
PVADPYDQSF ESRDLLIDEW KSLTYDEVIS FVPPPLDQEE MES

Genular Protein ID: 982629323

Symbol: L7RSM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

L7RSM2

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 360
  • Mass: 41493
  • Checksum: 062EBC3E56683D14
  • Sequence:
    • MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 
SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 
KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG 
TPPAYLINRM PSHEARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.