Details for: MAPK14

Gene ID: 1432

Symbol: MAPK14

Ensembl ID: ENSG00000112062

Description: mitogen-activated protein kinase 14

Associated with

Other Information

Genular Protein ID: 3678437772

Symbol: MK14_HUMAN

Name: Cytokine suppressive anti-inflammatory drug-binding protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7997261

Title: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.

PubMed ID: 7997261

DOI: 10.1038/372739a0

PubMed ID: 7696354

Title: Molecular cloning of human p38 MAP kinase.

PubMed ID: 7696354

DOI: 10.1016/0167-4889(95)00002-a

PubMed ID: 7479834

Title: Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.

PubMed ID: 7479834

DOI: 10.1073/pnas.92.23.10531

PubMed ID: 10727080

Title: Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4.

PubMed ID: 10727080

DOI: 10.3109/10425179909033952

PubMed ID: 11866441

Title: Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.

PubMed ID: 11866441

DOI: 10.1006/bbrc.2002.6529

PubMed ID: 19906316

Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.

PubMed ID: 19906316

DOI: 10.1186/1471-2164-10-518

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 7923354

Title: Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

PubMed ID: 7923354

DOI: 10.1016/0092-8674(94)90278-x

PubMed ID: 7535770

Title: Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.

PubMed ID: 7535770

DOI: 10.1074/jbc.270.13.7420

PubMed ID: 7493921

Title: Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast.

PubMed ID: 7493921

DOI: 10.1074/jbc.270.49.29043

PubMed ID: 8622669

Title: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.

PubMed ID: 8622669

DOI: 10.1128/mcb.16.3.1247

PubMed ID: 9687510

Title: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

PubMed ID: 9687510

DOI: 10.1093/emboj/17.15.4426

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 9792677

Title: RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).

PubMed ID: 9792677

DOI: 10.1074/jbc.273.45.29661

PubMed ID: 10391943

Title: Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.

PubMed ID: 10391943

DOI: 10.1074/jbc.274.28.19949

PubMed ID: 9858528

Title: Regulation of the MEF2 family of transcription factors by p38.

PubMed ID: 9858528

DOI: 10.1128/mcb.19.1.21

PubMed ID: 10330143

Title: Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.

PubMed ID: 10330143

DOI: 10.1128/mcb.19.6.4028

PubMed ID: 10943842

Title: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.

PubMed ID: 10943842

DOI: 10.1016/s0092-8674(00)00027-1

PubMed ID: 10838079

Title: Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2.

PubMed ID: 10838079

DOI: 10.1016/s0014-5793(00)01598-2

PubMed ID: 10747897

Title: Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.

PubMed ID: 10747897

DOI: 10.1074/jbc.m000312200

PubMed ID: 11010976

Title: Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength.

PubMed ID: 11010976

DOI: 10.1074/jbc.m007835200

PubMed ID: 11278799

Title: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1.

PubMed ID: 11278799

DOI: 10.1074/jbc.m010966200

PubMed ID: 11359773

Title: A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.

PubMed ID: 11359773

DOI: 10.1074/jbc.m101981200

PubMed ID: 11154262

Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.

PubMed ID: 11154262

DOI: 10.1128/mcb.21.3.743-754.2001

PubMed ID: 11333986

Title: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.

PubMed ID: 11333986

DOI: 10.1038/35075107

PubMed ID: 11847341

Title: MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.

PubMed ID: 11847341

DOI: 10.1126/science.1067289

PubMed ID: 15284239

Title: Active mutants of the human p38alpha mitogen-activated protein kinase.

PubMed ID: 15284239

DOI: 10.1074/jbc.m404595200

PubMed ID: 15905572

Title: Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils.

PubMed ID: 15905572

DOI: 10.4049/jimmunol.174.11.7257

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 15735648

Title: Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.

PubMed ID: 15735648

DOI: 10.1038/ni1177

PubMed ID: 15735649

Title: The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.

PubMed ID: 15735649

DOI: 10.1038/ni1176

PubMed ID: 16751104

Title: p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.

PubMed ID: 16751104

DOI: 10.1016/j.cell.2006.03.048

PubMed ID: 16932740

Title: p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy.

PubMed ID: 16932740

DOI: 10.1038/sj.emboj.7601297

PubMed ID: 17003045

Title: Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.

PubMed ID: 17003045

DOI: 10.1074/jbc.m606568200

PubMed ID: 16352664

Title: Nuclear protein NP60 regulates p38 MAPK activity.

PubMed ID: 16352664

DOI: 10.1242/jcs.02699

PubMed ID: 17724032

Title: p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.

PubMed ID: 17724032

DOI: 10.1074/jbc.m703857200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19893488

Title: Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP.

PubMed ID: 19893488

DOI: 10.1038/emboj.2009.321

PubMed ID: 20932473

Title: DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

PubMed ID: 20932473

DOI: 10.1016/j.molcel.2010.09.018

PubMed ID: 20188673

Title: Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.

PubMed ID: 20188673

DOI: 10.1016/j.molcel.2010.01.034

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21224381

Title: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation.

PubMed ID: 21224381

DOI: 10.1074/jbc.m110.185645

PubMed ID: 21586573

Title: The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-gamma production through the p38 mitogen-activated protein kinase pathway.

PubMed ID: 21586573

DOI: 10.1074/jbc.m111.234062

PubMed ID: 21444723

Title: Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.

PubMed ID: 21444723

DOI: 10.1128/mcb.01205-10

PubMed ID: 21283629

Title: LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).

PubMed ID: 21283629

DOI: 10.1371/journal.pone.0016427

PubMed ID: 12452429

Title: In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.

PubMed ID: 12452429

DOI: 10.1515/bc.2002.173

PubMed ID: 20626350

Title: Mechanisms and functions of p38 MAPK signalling.

PubMed ID: 20626350

DOI: 10.1042/bj20100323

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30878395

Title: MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction.

PubMed ID: 30878395

DOI: 10.1016/j.yjmcc.2019.03.005

PubMed ID: 35857590

Title: ZAKalpha-driven ribotoxic stress response activates the human NLRP1 inflammasome.

PubMed ID: 35857590

DOI: 10.1126/science.abl6324

PubMed ID: 8910361

Title: Crystal structure of p38 mitogen-activated protein kinase.

PubMed ID: 8910361

DOI: 10.1074/jbc.271.44.27696

PubMed ID: 9095200

Title: A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket.

PubMed ID: 9095200

DOI: 10.1038/nsb0497-311

PubMed ID: 9753691

Title: Structural basis of inhibitor selectivity in MAP kinases.

PubMed ID: 9753691

DOI: 10.1016/s0969-2126(98)00113-0

PubMed ID: 10633045

Title: Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.

PubMed ID: 10633045

DOI: 10.1021/jm990401t

PubMed ID: 11896401

Title: Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.

PubMed ID: 11896401

DOI: 10.1038/nsb770

PubMed ID: 12482439

Title: Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.

PubMed ID: 12482439

DOI: 10.1016/s0960-894x(02)00752-7

PubMed ID: 14561090

Title: Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.

PubMed ID: 14561090

DOI: 10.1021/jm0301787

PubMed ID: 12897767

Title: Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.

PubMed ID: 12897767

DOI: 10.1038/nsb949

PubMed ID: 14726206

Title: Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.

PubMed ID: 14726206

DOI: 10.1016/j.bbapap.2003.09.009

PubMed ID: 16342939

Title: Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.

PubMed ID: 16342939

DOI: 10.1021/bi051714v

PubMed ID: 15837335

Title: Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.

PubMed ID: 15837335

DOI: 10.1016/j.bmcl.2005.02.010

PubMed ID: 16169718

Title: Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes.

PubMed ID: 16169718

DOI: 10.1016/j.bmcl.2005.08.038

PubMed ID: 15658854

Title: Fragment-based lead discovery using X-ray crystallography.

PubMed ID: 15658854

DOI: 10.1021/jm0495778

PubMed ID: 17255097

Title: Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.

PubMed ID: 17255097

DOI: 10.1074/jbc.m611165200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 360
  • Mass: 41293
  • Checksum: 286C81D0487618B3
  • Sequence:
  • MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 
    SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 
    KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 
    GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG 
    TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 
    QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES

Genular Protein ID: 982629323

Symbol: L7RSM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 360
  • Mass: 41493
  • Checksum: 062EBC3E56683D14
  • Sequence:
  • MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ 
    SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ 
    KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT 
    GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG 
    TPPAYLINRM PSHEARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA 
    QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES

Genular Protein ID: 465631473

Symbol: B4E0K5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 283
  • Mass: 32357
  • Checksum: C840DAA6DF8E68B2
  • Sequence:
  • MKHENVIGLL DVFTPARSLE EFNDVYLVTH LMGADLNNIV KCQKLTDDHV QFLIYQILRG 
    LKYIHSADII HRDLKPSNLA VNEDCELKIL DFGLARHTDD EMTGYVATRW YRAPEIMLNW 
    MHYNQTVDIW SVGCIMAELL TGRTLFPGTD HIDQLKLILR LVGTPGAELL KKISSESARN 
    YIQSLTQMPK MNFANVFIGA NPLAVDLLEK MLVLDSDKRI TAAQALAHAY FAQYHDPDDE 
    PVADPYDQSF ESRDLLIDEW KSLTYDEVIS FVPPPLDQEE MES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.