Details for: MAPK14
Associated with
Other Information
Genular Protein ID: 3678437772
Symbol: MK14_HUMAN
Name: Cytokine suppressive anti-inflammatory drug-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7997261
Title: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.
PubMed ID: 7997261
DOI: 10.1038/372739a0
PubMed ID: 7696354
Title: Molecular cloning of human p38 MAP kinase.
PubMed ID: 7696354
PubMed ID: 7479834
Title: Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.
PubMed ID: 7479834
PubMed ID: 10727080
Title: Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4.
PubMed ID: 10727080
PubMed ID: 11866441
Title: Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.
PubMed ID: 11866441
PubMed ID: 19906316
Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.
PubMed ID: 19906316
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 7923354
Title: Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.
PubMed ID: 7923354
PubMed ID: 7535770
Title: Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine.
PubMed ID: 7535770
PubMed ID: 7493921
Title: Human mitogen-activated protein kinase CSBP1, but not CSBP2, complements a hog1 deletion in yeast.
PubMed ID: 7493921
PubMed ID: 8622669
Title: MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
PubMed ID: 8622669
PubMed ID: 9687510
Title: Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.
PubMed ID: 9687510
PubMed ID: 9430721
Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.
PubMed ID: 9430721
PubMed ID: 9792677
Title: RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK).
PubMed ID: 9792677
PubMed ID: 10391943
Title: Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5.
PubMed ID: 10391943
PubMed ID: 9858528
Title: Regulation of the MEF2 family of transcription factors by p38.
PubMed ID: 9858528
DOI: 10.1128/mcb.19.1.21
PubMed ID: 10330143
Title: Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.
PubMed ID: 10330143
PubMed ID: 10943842
Title: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.
PubMed ID: 10943842
PubMed ID: 10838079
Title: Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2.
PubMed ID: 10838079
PubMed ID: 10747897
Title: Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase.
PubMed ID: 10747897
PubMed ID: 11010976
Title: Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength.
PubMed ID: 11010976
PubMed ID: 11278799
Title: Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1.
PubMed ID: 11278799
PubMed ID: 11359773
Title: A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs.
PubMed ID: 11359773
PubMed ID: 11154262
Title: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.
PubMed ID: 11154262
PubMed ID: 11333986
Title: Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase.
PubMed ID: 11333986
DOI: 10.1038/35075107
PubMed ID: 11847341
Title: MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha.
PubMed ID: 11847341
PubMed ID: 15284239
Title: Active mutants of the human p38alpha mitogen-activated protein kinase.
PubMed ID: 15284239
PubMed ID: 15905572
Title: Myeloid-related protein-14 is a p38 MAPK substrate in human neutrophils.
PubMed ID: 15905572
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 15735648
Title: Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
PubMed ID: 15735648
DOI: 10.1038/ni1177
PubMed ID: 15735649
Title: The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
PubMed ID: 15735649
DOI: 10.1038/ni1176
PubMed ID: 16751104
Title: p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.
PubMed ID: 16751104
PubMed ID: 16932740
Title: p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy.
PubMed ID: 16932740
PubMed ID: 17003045
Title: Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.
PubMed ID: 17003045
PubMed ID: 16352664
PubMed ID: 17724032
Title: p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.
PubMed ID: 17724032
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19893488
Title: Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP.
PubMed ID: 19893488
PubMed ID: 20932473
Title: DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.
PubMed ID: 20932473
PubMed ID: 20188673
Title: Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.
PubMed ID: 20188673
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21224381
Title: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation.
PubMed ID: 21224381
PubMed ID: 21586573
Title: The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-gamma production through the p38 mitogen-activated protein kinase pathway.
PubMed ID: 21586573
PubMed ID: 21444723
Title: Acetylation of a conserved lysine residue in the ATP binding pocket of p38 augments its kinase activity during hypertrophy of cardiomyocytes.
PubMed ID: 21444723
DOI: 10.1128/mcb.01205-10
PubMed ID: 21283629
Title: LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
PubMed ID: 21283629
PubMed ID: 12452429
Title: In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.
PubMed ID: 12452429
DOI: 10.1515/bc.2002.173
PubMed ID: 20626350
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 30878395
Title: MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction.
PubMed ID: 30878395
PubMed ID: 35857590
Title: ZAKalpha-driven ribotoxic stress response activates the human NLRP1 inflammasome.
PubMed ID: 35857590
PubMed ID: 8910361
Title: Crystal structure of p38 mitogen-activated protein kinase.
PubMed ID: 8910361
PubMed ID: 9095200
Title: A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket.
PubMed ID: 9095200
DOI: 10.1038/nsb0497-311
PubMed ID: 9753691
Title: Structural basis of inhibitor selectivity in MAP kinases.
PubMed ID: 9753691
PubMed ID: 10633045
Title: Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.
PubMed ID: 10633045
DOI: 10.1021/jm990401t
PubMed ID: 11896401
Title: Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.
PubMed ID: 11896401
DOI: 10.1038/nsb770
PubMed ID: 12482439
Title: Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
PubMed ID: 12482439
PubMed ID: 14561090
Title: Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.
PubMed ID: 14561090
DOI: 10.1021/jm0301787
PubMed ID: 12897767
Title: Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.
PubMed ID: 12897767
DOI: 10.1038/nsb949
PubMed ID: 14726206
Title: Lattice stabilization and enhanced diffraction in human p38 alpha crystals by protein engineering.
PubMed ID: 14726206
PubMed ID: 16342939
Title: Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.
PubMed ID: 16342939
DOI: 10.1021/bi051714v
PubMed ID: 15837335
Title: Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
PubMed ID: 15837335
PubMed ID: 16169718
Title: Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes.
PubMed ID: 16169718
PubMed ID: 15658854
Title: Fragment-based lead discovery using X-ray crystallography.
PubMed ID: 15658854
DOI: 10.1021/jm0495778
PubMed ID: 17255097
Title: Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer.
PubMed ID: 17255097
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 360
- Mass: 41293
- Checksum: 286C81D0487618B3
- Sequence:
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES
Genular Protein ID: 982629323
Symbol: L7RSM2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 360
- Mass: 41493
- Checksum: 062EBC3E56683D14
- Sequence:
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHIN QLQQIMRLTG TPPAYLINRM PSHEARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES
Genular Protein ID: 465631473
Symbol: B4E0K5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18088087
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 283
- Mass: 32357
- Checksum: C840DAA6DF8E68B2
- Sequence:
MKHENVIGLL DVFTPARSLE EFNDVYLVTH LMGADLNNIV KCQKLTDDHV QFLIYQILRG LKYIHSADII HRDLKPSNLA VNEDCELKIL DFGLARHTDD EMTGYVATRW YRAPEIMLNW MHYNQTVDIW SVGCIMAELL TGRTLFPGTD HIDQLKLILR LVGTPGAELL KKISSESARN YIQSLTQMPK MNFANVFIGA NPLAVDLLEK MLVLDSDKRI TAAQALAHAY FAQYHDPDDE PVADPYDQSF ESRDLLIDEW KSLTYDEVIS FVPPPLDQEE MES
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.