Details for: CSE1L

Gene ID: 1434

Symbol: CSE1L

Ensembl ID: ENSG00000124207

Description: chromosome segregation 1 like

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.06
    Marker Score: 2967
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.81
    Marker Score: 1892
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.57
    Marker Score: 920
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.49
    Marker Score: 1011
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.46
    Marker Score: 361
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.43
    Marker Score: 411.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.39
    Marker Score: 5450.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.36
    Marker Score: 1710
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.32
    Marker Score: 11312
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.26
    Marker Score: 1185
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.23
    Marker Score: 611
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.21
    Marker Score: 18044
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 73124
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.19
    Marker Score: 4913
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.17
    Marker Score: 2443
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.17
    Marker Score: 1249
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42728
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.16
    Marker Score: 1222
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.15
    Marker Score: 10900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.14
    Marker Score: 1944
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.13
    Marker Score: 1219
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.12
    Marker Score: 1732
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.1
    Marker Score: 949
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.1
    Marker Score: 10327.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.1
    Marker Score: 4470
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.07
    Marker Score: 1135
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.07
    Marker Score: 1207
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.06
    Marker Score: 40217
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.06
    Marker Score: 1281
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.03
    Marker Score: 2804
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.03
    Marker Score: 10595.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.02
    Marker Score: 413
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.02
    Marker Score: 323
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.01
    Marker Score: 756
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1
    Marker Score: 3858
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71684
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1
    Marker Score: 7638
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47909
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30388
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.98
    Marker Score: 2666
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.97
    Marker Score: 19233
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.96
    Marker Score: 1237
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.95
    Marker Score: 8184.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.95
    Marker Score: 3659
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.93
    Marker Score: 963
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.91
    Marker Score: 1004
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.91
    Marker Score: 915
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5174
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2695
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13850
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.88
    Marker Score: 1172.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.88
    Marker Score: 2062
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.87
    Marker Score: 305
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.87
    Marker Score: 2072
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.85
    Marker Score: 3557
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.85
    Marker Score: 357
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.85
    Marker Score: 531
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.84
    Marker Score: 529
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1365
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.84
    Marker Score: 1231
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.82
    Marker Score: 1100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.81
    Marker Score: 3007
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.81
    Marker Score: 1841
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.8
    Marker Score: 450
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8
    Marker Score: 5218.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8
    Marker Score: 27625
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.79
    Marker Score: 530
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.79
    Marker Score: 541
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.79
    Marker Score: 953.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.78
    Marker Score: 456
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.78
    Marker Score: 1961
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.77
    Marker Score: 379
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.76
    Marker Score: 634
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.76
    Marker Score: 1666
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.76
    Marker Score: 7627
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.75
    Marker Score: 3159
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.75
    Marker Score: 847
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.75
    Marker Score: 242
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.75
    Marker Score: 176
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.75
    Marker Score: 1765
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.75
    Marker Score: 25248
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 806
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.74
    Marker Score: 659
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.74
    Marker Score: 201
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.73
    Marker Score: 402
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 375.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.73
    Marker Score: 12872.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.72
    Marker Score: 1112.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.72
    Marker Score: 4280
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.72
    Marker Score: 1710.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.72
    Marker Score: 823
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.71
    Marker Score: 189
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 471

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Other Information

**Key characteristics:** * CSE1L is a protein that is involved in the cytoplasmic-nuclear trafficking of proteins. * It is a member of the Exportin family of proteins, which are responsible for the transport of proteins between the nucleus and the cytoplasm. * CSE1L is expressed in a variety of cell types, including oogonial cells, erythroid progenitor cells, secondary lens fiber cells, proerythroblast cells, oocyte, male germ cell, placental villous trophoblast, primordial germ cell, and L6b glutamatergic cortical neuron. * It is a highly conserved protein, with a sequence that is similar to proteins from other members of the Exportin family. **Pathways and functions:** * CSE1L is involved in the transport of proteins from the nucleus to the cytoplasm. * It is thought to play a role in the regulation of protein synthesis and secretion. * It is also involved in the control of cell cycle progression and differentiation. **Clinical significance:** * Mutations in the CSE1L gene have been linked to a number of human diseases, including cancer and developmental disorders. * These diseases are often caused by mutations in genes that are involved in the transport of proteins between the nucleus and the cytoplasm. * Targeting CSE1L has been explored as a therapeutic strategy for these diseases.

Genular Protein ID: 836484772

Symbol: XPO2_HUMAN

Name: Exportin-2

UniProtKB Accession Codes:

P55060 A3RLL6 B2R5T4 E1P5Y0 F8W904 O75432 Q32M40 Q9H5B7 Q9NTS0 Q9UP98 Q9UP99 Q9UPA0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7479798

Title: Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.

PubMed ID: 7479798

DOI: 10.1073/pnas.92.22.10427

PubMed ID: 10331944

Title: Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene.

PubMed ID: 10331944

DOI: 10.1006/geno.1998.5700

PubMed ID: 11703094

Title: IRF-1-mediated CAS expression enhances interferon-gamma-induced apoptosis of HT-29 colon adenocarcinoma cells.

PubMed ID: 11703094

DOI: 10.1006/mcbr.2001.0303

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9323134

Title: Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor.

PubMed ID: 9323134

DOI: 10.1016/s0092-8674(00)80372-4

PubMed ID: 9786944

Title: Determination of the functional domain organization of the importin alpha nuclear import factor.

PubMed ID: 9786944

DOI: 10.1083/jcb.143.2.309

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20933420

Title: Cse1l is a negative regulator of CFTR-dependent fluid secretion.

PubMed ID: 20933420

DOI: 10.1016/j.cub.2010.09.012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 971
  • Mass: 110417
  • Checksum: 08E837AB5008EBFD
  • Sequence:
    • MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIKV 
CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM LSSPEQIQKQ LSDAISIIGR 
EDFPQKWPDL LTEMVNRFQS GDFHVINGVL RTAHSLFKRY RHEFKSNELW TEIKLVLDAF 
ALPLTNLFKA TIELCSTHAN DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN 
NFHTLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL 
LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP NMEFRAADEE 
AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTGIFSGYVN SMLQEYAKNP 
SVNWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLTEF FVNHILPDLK SANVNEFPVL 
KADGIKYIMI FRNQVPKEHL LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL 
FTAAEIAPFV EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ 
KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE ILQNDVQEFI 
PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN IPALVRLLQA FLERGSNTIA 
SAAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESVDQYRKQI FILLFQRLQN 
SKTTKFIKSF LVFINLYCIK YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK 
ICAVGITKLL TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ 
TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS LNAEALQYLQ 
GYLQAASVTL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.