Details for: CSE1L

Gene ID: 1434

Symbol: CSE1L

Ensembl ID: ENSG00000124207

Description: chromosome segregation 1 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 162.8465
    Cell Significance Index: -25.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 120.9967
    Cell Significance Index: -30.6900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.6407
    Cell Significance Index: -31.1600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.3072
    Cell Significance Index: -34.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.3526
    Cell Significance Index: -28.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.7200
    Cell Significance Index: -28.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.1485
    Cell Significance Index: -32.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9902
    Cell Significance Index: -32.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3704
    Cell Significance Index: -33.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0763
    Cell Significance Index: -11.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.8865
    Cell Significance Index: 549.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0182
    Cell Significance Index: 53.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9565
    Cell Significance Index: 318.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9074
    Cell Significance Index: 378.5300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.7608
    Cell Significance Index: 13.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7019
    Cell Significance Index: 27.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2850
    Cell Significance Index: 35.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1122
    Cell Significance Index: 1004.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9751
    Cell Significance Index: 58.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9627
    Cell Significance Index: 193.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8854
    Cell Significance Index: 12.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8590
    Cell Significance Index: 48.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5271
    Cell Significance Index: 64.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5235
    Cell Significance Index: 94.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4900
    Cell Significance Index: 175.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4568
    Cell Significance Index: 249.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4295
    Cell Significance Index: 29.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4170
    Cell Significance Index: 11.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3540
    Cell Significance Index: 12.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3513
    Cell Significance Index: 21.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3444
    Cell Significance Index: 17.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3270
    Cell Significance Index: 226.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3018
    Cell Significance Index: 133.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2822
    Cell Significance Index: 38.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2766
    Cell Significance Index: 14.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2415
    Cell Significance Index: 28.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2316
    Cell Significance Index: 5.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2016
    Cell Significance Index: 9.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1980
    Cell Significance Index: 5.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1953
    Cell Significance Index: 13.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1886
    Cell Significance Index: 2.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1682
    Cell Significance Index: 7.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1436
    Cell Significance Index: 18.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1431
    Cell Significance Index: 24.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1381
    Cell Significance Index: 13.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1274
    Cell Significance Index: 2.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0952
    Cell Significance Index: 12.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0774
    Cell Significance Index: 2.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0715
    Cell Significance Index: 3.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0693
    Cell Significance Index: 5.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0682
    Cell Significance Index: 92.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0634
    Cell Significance Index: 97.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0521
    Cell Significance Index: 1.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0506
    Cell Significance Index: 95.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0376
    Cell Significance Index: 69.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0152
    Cell Significance Index: 0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0107
    Cell Significance Index: 6.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0087
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0112
    Cell Significance Index: -7.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0217
    Cell Significance Index: -1.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0253
    Cell Significance Index: -0.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0257
    Cell Significance Index: -19.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0263
    Cell Significance Index: -0.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0265
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0351
    Cell Significance Index: -19.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0373
    Cell Significance Index: -5.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0612
    Cell Significance Index: -1.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0729
    Cell Significance Index: -1.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0754
    Cell Significance Index: -5.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0758
    Cell Significance Index: -7.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0814
    Cell Significance Index: -17.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0872
    Cell Significance Index: -1.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0889
    Cell Significance Index: -5.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0952
    Cell Significance Index: -27.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1093
    Cell Significance Index: -12.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1109
    Cell Significance Index: -2.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1314
    Cell Significance Index: -8.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1316
    Cell Significance Index: -5.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1347
    Cell Significance Index: -3.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1473
    Cell Significance Index: -0.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1634
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1804
    Cell Significance Index: -20.6700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2021
    Cell Significance Index: -23.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2044
    Cell Significance Index: -7.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2791
    Cell Significance Index: -29.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2988
    Cell Significance Index: -15.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3347
    Cell Significance Index: -8.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3370
    Cell Significance Index: -26.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3446
    Cell Significance Index: -21.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3535
    Cell Significance Index: -6.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3907
    Cell Significance Index: -11.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4059
    Cell Significance Index: -3.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4530
    Cell Significance Index: -5.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4899
    Cell Significance Index: -13.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5715
    Cell Significance Index: -12.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5799
    Cell Significance Index: -18.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5986
    Cell Significance Index: -13.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6236
    Cell Significance Index: -19.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein Expression**: The CSE1L gene encodes for the protein Exportin-2 (XPO2_HUMAN), which plays a crucial role in nuclear export and protein transport. This protein is characterized by its ability to bind with high affinity to nuclear export signal receptors, facilitating the export of proteins from the nucleus to the cytoplasm. 2. **Cellular Localization**: The protein is predominantly localized to the cytoplasm and nucleus, where it interacts with various cellular components, including the nuclear envelope and the nucleoplasm. 3. **Significant Expressions**: CSE1L is significantly expressed in oogonial cells, erythroid progenitor cells, secondary lens fibers, proerythroblast, oocytes, male germ cells, placental villous trophoblasts, primordial germ cells, L6b glutamatergic cortical neurons, and migratory enteric neural crest cells, highlighting its widespread importance in cellular development and function. **Pathways and Functions:** 1. **Nuclear Export**: The CSE1L gene plays a pivotal role in nuclear export, facilitating the transport of proteins from the nucleus to the cytoplasm. This process is critical for various cellular functions, including gene regulation, protein degradation, and cell cycle progression. 2. **Protein Binding**: XPO2_HUMAN binds to nuclear export signal receptors, interacting with a wide range of cellular proteins, including transcription factors, signaling molecules, and structural proteins. 3. **Cellular Regulation**: The CSE1L gene is involved in regulating various cellular processes, including cell cycle progression, apoptosis, and differentiation, highlighting its importance in maintaining cellular homeostasis. 4. **Regulation of Gene Expression**: The nuclear export function of XPO2_HUMAN regulates gene expression by controlling the export of transcription factors and other regulatory proteins, thereby influencing the expression of target genes. **Clinical Significance:** 1. **Cancer Association**: The CSE1L gene has been implicated in various cancers, including breast, lung, and colon cancer, where its dysregulation can contribute to tumorigenesis and metastasis. 2. **Neurological Disorders**: XPO2_HUMAN has been linked to neurological disorders, such as Alzheimer's disease, where its dysfunction can contribute to protein aggregation and neuronal degeneration. 3. **Immunological Disorders**: The CSE1L gene has been associated with immunological disorders, including autoimmune diseases, where its dysregulation can contribute to immune system dysfunction. 4. **Developmental Abnormalities**: The CSE1L gene plays a critical role in developmental processes, and its dysregulation can lead to developmental abnormalities, including birth defects and congenital disorders. In conclusion, the CSE1L gene, with its unique characteristics and functions, has far-reaching implications in various cellular processes, including nuclear export, protein binding, and regulation of gene expression. Its dysregulation has been linked to various diseases, highlighting the importance of further research into this enigmatic gene.

Genular Protein ID: 836484772

Symbol: XPO2_HUMAN

Name: Exportin-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7479798

Title: Cloning and characterization of a cellular apoptosis susceptibility gene, the human homologue to the yeast chromosome segregation gene CSE1.

PubMed ID: 7479798

DOI: 10.1073/pnas.92.22.10427

PubMed ID: 10331944

Title: Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene.

PubMed ID: 10331944

DOI: 10.1006/geno.1998.5700

PubMed ID: 11703094

Title: IRF-1-mediated CAS expression enhances interferon-gamma-induced apoptosis of HT-29 colon adenocarcinoma cells.

PubMed ID: 11703094

DOI: 10.1006/mcbr.2001.0303

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9323134

Title: Export of importin-alpha from the nucleus is mediated by a specific nuclear transport factor.

PubMed ID: 9323134

DOI: 10.1016/s0092-8674(00)80372-4

PubMed ID: 9786944

Title: Determination of the functional domain organization of the importin alpha nuclear import factor.

PubMed ID: 9786944

DOI: 10.1083/jcb.143.2.309

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20933420

Title: Cse1l is a negative regulator of CFTR-dependent fluid secretion.

PubMed ID: 20933420

DOI: 10.1016/j.cub.2010.09.012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 971
  • Mass: 110417
  • Checksum: 08E837AB5008EBFD
  • Sequence:
  • MELSDANLQT LTEYLKKTLD PDPAIRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIKV 
    CASVTFKNYI KRNWRIVEDE PNKICEADRV AIKANIVHLM LSSPEQIQKQ LSDAISIIGR 
    EDFPQKWPDL LTEMVNRFQS GDFHVINGVL RTAHSLFKRY RHEFKSNELW TEIKLVLDAF 
    ALPLTNLFKA TIELCSTHAN DASALRILFS SLILISKLFY SLNFQDLPEF FEDNMETWMN 
    NFHTLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQRYL PRFVTAIWNL 
    LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDQNTL TSICEKVIVP NMEFRAADEE 
    AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTGIFSGYVN SMLQEYAKNP 
    SVNWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLTEF FVNHILPDLK SANVNEFPVL 
    KADGIKYIMI FRNQVPKEHL LVSIPLLINH LQAESIVVHT YAAHALERLF TMRGPNNATL 
    FTAAEIAPFV EILLTNLFKA LTLPGSSENE YIMKAIMRSF SLLQEAIIPY IPTLITQLTQ 
    KLLAVSKNPS KPHFNHYMFE AICLSIRITC KANPAAVVNF EEALFLVFTE ILQNDVQEFI 
    PYVFQVMSLL LETHKNDIPS SYMALFPHLL QPVLWERTGN IPALVRLLQA FLERGSNTIA 
    SAAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESVDQYRKQI FILLFQRLQN 
    SKTTKFIKSF LVFINLYCIK YGALALQEIF DGIQPKMFGM VLEKIIIPEI QKVSGNVEKK 
    ICAVGITKLL TECPPMMDTE YTKLWTPLLQ SLIGLFELPE DDTIPDEEHF IDIEDTPGYQ 
    TAFSQLAFAG KKEHDPVGQM VNNPKIHLAQ SLHKLSTACP GRVPSMVSTS LNAEALQYLQ 
    GYLQAASVTL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.