CSF1 | ENSG00000184371 | NCBI 1435

Details for: CSF1

Gene ID: 1435

Symbol: CSF1

Ensembl ID: ENSG00000184371

Description: colony stimulating factor 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-10 signaling
(R-HSA-6783783)
Metabolism of proteins
(R-HSA-392499)
Other interleukin signaling
(R-HSA-449836)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by interleukins
(R-HSA-449147)
Branching involved in mammary gland duct morphogenesis
(GO:0060444)
Csf1-csf1r complex
(GO:1990682)
Cytokine activity
(GO:0005125)
Developmental process involved in reproduction
(GO:0003006)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Homeostasis of number of cells within a tissue
(GO:0048873)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Macrophage colony-stimulating factor receptor binding
(GO:0005157)
Macrophage colony-stimulating factor signaling pathway
(GO:0038145)
Macrophage differentiation
(GO:0030225)
Macrophage homeostasis
(GO:0061519)
Mammary duct terminal end bud growth
(GO:0060763)
Mammary gland fat development
(GO:0060611)
Membrane
(GO:0016020)
Microglial cell proliferation
(GO:0061518)
Monocyte activation
(GO:0042117)
Monocyte differentiation
(GO:0030224)
Monocyte homeostasis
(GO:0035702)
Myeloid leukocyte migration
(GO:0097529)
Neutrophil homeostasis
(GO:0001780)
Nuclear body
(GO:0016604)
Osteoclast differentiation
(GO:0030316)
Osteoclast proliferation
(GO:0002158)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of macrophage colony-stimulating factor signaling pathway
(GO:1902228)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of macrophage migration
(GO:1905523)
Positive regulation of microglial cell migration
(GO:1904141)
Positive regulation of monocyte differentiation
(GO:0045657)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of odontogenesis of dentin-containing tooth
(GO:0042488)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of ras protein signal transduction
(GO:0046579)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Ras protein signal transduction
(GO:0007265)
Regulation of macrophage derived foam cell differentiation
(GO:0010743)
Regulation of ossification
(GO:0030278)
Response to ischemia
(GO:0002931)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Macrophage colony-stimulating factor 1

Genular Protein ID: 358682337

Symbol: CSF1_HUMAN

Name: Macrophage colony-stimulating factor 1

UniProtKB Accession Codes:

P09603 A8K6J5 Q13130 Q14086 Q14806 Q5VVF3 Q5VVF4 Q9UQR8

Database IDs:

Citations:

PubMed ID: 2996129

Title: Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1).

PubMed ID: 2996129

DOI: 10.1126/science.2996129

PubMed ID: 3493529

Title: Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.

PubMed ID: 3493529

DOI: 10.1126/science.3493529

PubMed ID: 2460758

Title: Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene.

PubMed ID: 2460758

DOI: 10.1016/0161-5890(88)90112-5

PubMed ID: 2660794

Title: Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF.

PubMed ID: 2660794

DOI: 10.1016/0006-291x(89)92683-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3500041

Title: Human CSF-1: gene structure and alternative splicing of mRNA precursors.

PubMed ID: 3500041

DOI: 10.1002/j.1460-2075.1987.tb02561.x

PubMed ID: 1791839

Title: Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1.

PubMed ID: 1791839

DOI: 10.1210/mend-5-12-1931

PubMed ID: 8262907

Title: The structure of recombinant human carboxy-terminal-truncated macrophage colony-stimulating factor derived from mammalian cells.

PubMed ID: 8262907

DOI: 10.1093/oxfordjournals.jbchem.a124163

PubMed ID: 3498652

Title: Macrophage colony-stimulating factor purified from normal human urine. Amino-terminal sequence and amino acid composition.

PubMed ID: 3498652

DOI: 10.1016/0014-5793(87)80398-8

PubMed ID: 8051056

Title: Structural analysis of proteoglycan macrophage colony-stimulating factor.

PubMed ID: 8051056

DOI: 10.1016/s0021-9258(17)32085-9

PubMed ID: 3259875

Title: Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis.

PubMed ID: 3259875

DOI: 10.1016/s0006-291x(88)80441-8

PubMed ID: 3039346

Title: Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes.

PubMed ID: 3039346

DOI: 10.1128/mcb.7.7.2378-2387.1987

PubMed ID: 3264877

Title: Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs.

PubMed ID: 3264877

DOI: 10.1128/mcb.8.11.5026-5034.1988

PubMed ID: 1531650

Title: Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species.

PubMed ID: 1531650

DOI: 10.1016/s0021-9258(18)42841-4

PubMed ID: 8422357

Title: Assignment of the inter- and intramolecular disulfide linkages in recombinant human macrophage colony stimulating factor using fast atom bombardment mass spectrometry.

PubMed ID: 8422357

DOI: 10.1021/bi00053a012

PubMed ID: 15519852

Title: CSF-1 regulation of the wandering macrophage: complexity in action.

PubMed ID: 15519852

DOI: 10.1016/j.tcb.2004.09.016

PubMed ID: 16337366

Title: Colony-stimulating factor-1 in immunity and inflammation.

PubMed ID: 16337366

DOI: 10.1016/j.coi.2005.11.006

PubMed ID: 18687298

Title: Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies.

PubMed ID: 18687298

DOI: 10.1016/j.intimp.2008.04.016

PubMed ID: 19934330

Title: Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.

PubMed ID: 19934330

DOI: 10.1158/0008-5472.can-09-1868

PubMed ID: 20829061

Title: Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.

PubMed ID: 20829061

DOI: 10.1016/j.cyto.2010.08.005

PubMed ID: 20504948

Title: Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.

PubMed ID: 20504948

DOI: 10.1189/jlb.1209822

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 1455231

Title: Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor.

PubMed ID: 1455231

DOI: 10.1126/science.1455231

Sequence Information:

Length: 554
Mass: 60179
Checksum: 656B0894F9255AED
Sequence:

MTAPGAAGRC PPTTWLGSLL LLVCLLASRS ITEEVSEYCS HMIGSGHLQS LQRLIDSQME 
TSCQITFEFV DQEQLKDPVC YLKKAFLLVQ DIMEDTMRFR DNTPNAIAIV QLQELSLRLK 
SCFTKDYEEH DKACVRTFYE TPLQLLEKVK NVFNETKNLL DKDWNIFSKN CNNSFAECSS 
QDVVTKPDCN CLYPKAIPSS DPASVSPHQP LAPSMAPVAG LTWEDSEGTE GSSLLPGEQP 
LHTVDPGSAK QRPPRSTCQS FEPPETPVVK DSTIGGSPQP RPSVGAFNPG MEDILDSAMG 
TNWVPEEASG EASEIPVPQG TELSPSRPGG GSMQTEPARP SNFLSASSPL PASAKGQQPA 
DVTGTALPRV GPVRPTGQDW NHTPQKTDHP SALLRDPPEP GSPRISSLRP QGLSNPSTLS 
AQPQLSRSHS SGSVLPLGEL EGRRSTRDRR SPAEPEGGPA SEGAARPLPR FNSVPLTDTG 
HERQSEGSFS PQLQESVFHL LVPSVILVLL AVGGLLFYRW RRRSHQEPQR ADSPLEQPEG 
SPLTQDDRQV ELPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CSF1

Associated with

Other Information

Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1). PubMed ID: 2996129

Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein. PubMed ID: 3493529

Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene. PubMed ID: 2460758

Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF. PubMed ID: 2660794

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human CSF-1: gene structure and alternative splicing of mRNA precursors. PubMed ID: 3500041

Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1. PubMed ID: 1791839

The structure of recombinant human carboxy-terminal-truncated macrophage colony-stimulating factor derived from mammalian cells. PubMed ID: 8262907

Macrophage colony-stimulating factor purified from normal human urine. Amino-terminal sequence and amino acid composition. PubMed ID: 3498652

Structural analysis of proteoglycan macrophage colony-stimulating factor. PubMed ID: 8051056

Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis. PubMed ID: 3259875

Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes. PubMed ID: 3039346

Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs. PubMed ID: 3264877

Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species. PubMed ID: 1531650

Assignment of the inter- and intramolecular disulfide linkages in recombinant human macrophage colony stimulating factor using fast atom bombardment mass spectrometry. PubMed ID: 8422357

CSF-1 regulation of the wandering macrophage: complexity in action. PubMed ID: 15519852

Colony-stimulating factor-1 in immunity and inflammation. PubMed ID: 16337366

Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies. PubMed ID: 18687298

Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor. PubMed ID: 19934330

Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood. PubMed ID: 20829061

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. PubMed ID: 20504948

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. PubMed ID: 22171320

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. PubMed ID: 1455231