Details for: CSF1R

Gene ID: 1436

Symbol: CSF1R

Ensembl ID: ENSG00000182578

Description: colony stimulating factor 1 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 88.7202
    Cell Significance Index: -13.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.9591
    Cell Significance Index: -13.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.0085
    Cell Significance Index: -16.6600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 40.8547
    Cell Significance Index: -16.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.8875
    Cell Significance Index: -18.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2007
    Cell Significance Index: -13.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 6.1248
    Cell Significance Index: 94.7600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4275
    Cell Significance Index: -9.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.7492
    Cell Significance Index: 32.3300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.1938
    Cell Significance Index: 7.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0565
    Cell Significance Index: 28.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0378
    Cell Significance Index: 63.6300
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.7847
    Cell Significance Index: 8.5700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3605
    Cell Significance Index: 2.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3574
    Cell Significance Index: 75.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3373
    Cell Significance Index: 64.1900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2876
    Cell Significance Index: 2.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1904
    Cell Significance Index: 18.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1812
    Cell Significance Index: 163.6500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1247
    Cell Significance Index: 1.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0914
    Cell Significance Index: 14.8700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.0649
    Cell Significance Index: 0.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0519
    Cell Significance Index: 7.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0493
    Cell Significance Index: 30.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0083
    Cell Significance Index: 1.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0012
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0030
    Cell Significance Index: -1.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0073
    Cell Significance Index: -0.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0080
    Cell Significance Index: -5.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0147
    Cell Significance Index: -27.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0158
    Cell Significance Index: -24.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0181
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0198
    Cell Significance Index: -26.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0212
    Cell Significance Index: -0.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0216
    Cell Significance Index: -13.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0229
    Cell Significance Index: -8.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0242
    Cell Significance Index: -17.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0273
    Cell Significance Index: -14.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0324
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0336
    Cell Significance Index: -5.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0370
    Cell Significance Index: -7.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0395
    Cell Significance Index: -17.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0408
    Cell Significance Index: -11.7500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0425
    Cell Significance Index: -0.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0436
    Cell Significance Index: -2.8200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0554
    Cell Significance Index: -0.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0600
    Cell Significance Index: -10.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0610
    Cell Significance Index: -2.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0800
    Cell Significance Index: -5.5300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0935
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1024
    Cell Significance Index: -11.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1047
    Cell Significance Index: -14.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1114
    Cell Significance Index: -2.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1199
    Cell Significance Index: -14.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1269
    Cell Significance Index: -7.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1298
    Cell Significance Index: -13.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1302
    Cell Significance Index: -15.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1330
    Cell Significance Index: -17.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1450
    Cell Significance Index: -16.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1515
    Cell Significance Index: -2.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1553
    Cell Significance Index: -18.3100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1626
    Cell Significance Index: -1.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1681
    Cell Significance Index: -12.9000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1738
    Cell Significance Index: -2.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1819
    Cell Significance Index: -23.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1877
    Cell Significance Index: -8.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1962
    Cell Significance Index: -1.6000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2033
    Cell Significance Index: -2.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2034
    Cell Significance Index: -4.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2048
    Cell Significance Index: -6.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2133
    Cell Significance Index: -14.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2276
    Cell Significance Index: -16.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2306
    Cell Significance Index: -11.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2327
    Cell Significance Index: -10.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2396
    Cell Significance Index: -14.7300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2585
    Cell Significance Index: -4.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2666
    Cell Significance Index: -16.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2668
    Cell Significance Index: -14.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2721
    Cell Significance Index: -4.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3061
    Cell Significance Index: -6.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3158
    Cell Significance Index: -13.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3177
    Cell Significance Index: -16.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3391
    Cell Significance Index: -15.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3451
    Cell Significance Index: -12.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3657
    Cell Significance Index: -13.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3893
    Cell Significance Index: -10.8800
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3945
    Cell Significance Index: -3.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4229
    Cell Significance Index: -13.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4235
    Cell Significance Index: -8.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4264
    Cell Significance Index: -10.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4314
    Cell Significance Index: -13.7400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4442
    Cell Significance Index: -10.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4486
    Cell Significance Index: -12.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4966
    Cell Significance Index: -18.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5074
    Cell Significance Index: -14.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CSF1R gene exhibits several key characteristics that make it an essential component of the immune system. These include: 1. **Transmembrane protein tyrosine kinase**: The CSF1R gene encodes for a transmembrane protein tyrosine kinase, a type of receptor that is involved in signaling pathways that regulate cell growth, differentiation, and survival. 2. **Specific ligand binding**: The CSF1R gene specifically binds to its ligand, macrophage colony-stimulating factor (M-CSF), which is essential for the development and function of macrophages. 3. **Signaling pathways**: The CSF1R gene is involved in various signaling pathways that regulate macrophage function, including the JAK/STAT, PI3K/AKT, and MAPK/ERK pathways. 4. **Cellular expression**: The CSF1R gene is significantly expressed in various cell types, including macrophages, monocytes, and other immune cells. **Pathways and Functions** The CSF1R gene plays a critical role in the development, maturation, and function of macrophages through various signaling pathways. These pathways include: 1. **Macrophage colony-stimulating factor signaling pathway**: The CSF1R gene is involved in the signaling pathway that regulates the development and function of macrophages in response to M-CSF. 2. **Cytokine-mediated signaling pathway**: The CSF1R gene is also involved in the signaling pathway that regulates the function of macrophages in response to various cytokines, including IL-1β, TNF-α, and IL-10. 3. **Cell surface signaling**: The CSF1R gene is involved in cell surface signaling that regulates macrophage function, including the regulation of cell migration, chemotaxis, and phagocytosis. 4. **Intracellular signaling**: The CSF1R gene is also involved in intracellular signaling that regulates macrophage function, including the regulation of gene expression and protein synthesis. **Clinical Significance** The CSF1R gene has significant implications for human health, particularly in the context of immune-related disorders. Some of the clinical significance of the CSF1R gene includes: 1. **Inflammatory disorders**: The CSF1R gene is involved in the regulation of inflammatory responses, making it a potential target for the treatment of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: The CSF1R gene is also involved in the regulation of cancer progression, making it a potential target for the treatment of various types of cancer, including breast cancer and leukemia. 3. **Neurological disorders**: The CSF1R gene is involved in the regulation of neurological disorders, such as Alzheimer's disease and Parkinson's disease, making it a potential target for the treatment of these conditions. In conclusion, the CSF1R gene is a crucial component of the immune system that plays a pivotal role in the development, function, and regulation of macrophages. Its involvement in various signaling pathways and its significant expression in various cell types make it an essential target for the treatment of immune-related disorders. Further research is needed to fully understand the implications of the CSF1R gene for human health and to develop effective therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 2106677415

Symbol: CSF1R_HUMAN

Name: Macrophage colony-stimulating factor 1 receptor

UniProtKB Accession Codes:

P07333 B5A955 D3DQG2 Q6LDW5 Q6LDY4 Q86VW7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 2 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 2 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 55 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 15 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PIRSF 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2524025

Title: Nucleotide sequence and structural organization of the human FMS proto-oncogene.

PubMed ID: 2524025

PubMed ID: 2421165

Title: Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus.

PubMed ID: 2421165

DOI: 10.1038/320277a0

PubMed ID: 9027509

Title: Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes.

PubMed ID: 9027509

DOI: 10.1006/geno.1996.4482

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2524648

Title: Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.

PubMed ID: 2524648

DOI: 10.1128/mcb.9.3.1336-1341.1989

PubMed ID: 3525854

Title: The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences.

PubMed ID: 3525854

DOI: 10.1128/jvi.59.2.224-233.1986

PubMed ID: 4028159

Title: Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome.

PubMed ID: 4028159

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PubMed ID: 3532121

Title: 'Replacement' of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential.

PubMed ID: 3532121

DOI: 10.1073/pnas.83.20.7800

PubMed ID: 7683918

Title: Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential.

PubMed ID: 7683918

PubMed ID: 7681396

Title: Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

PubMed ID: 7681396

DOI: 10.1002/j.1460-2075.1993.tb05735.x

PubMed ID: 7845678

Title: Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids.

PubMed ID: 7845678

PubMed ID: 10340379

Title: Cell specific transformation by c-fms activating loop mutations is attributable to constitutive receptor degradation.

PubMed ID: 10340379

DOI: 10.1038/sj.onc.1202646

PubMed ID: 12882960

Title: The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.

PubMed ID: 12882960

DOI: 10.1074/jbc.m305021200

PubMed ID: 15117969

Title: Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture.

PubMed ID: 15117969

DOI: 10.1083/jcb.200309102

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16648572

Title: Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors.

PubMed ID: 16648572

DOI: 10.1158/1535-7163.mct-05-0359

PubMed ID: 17121910

Title: A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.

PubMed ID: 17121910

DOI: 10.1158/1535-7163.mct-05-0313

PubMed ID: 16170366

Title: FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.

PubMed ID: 16170366

DOI: 10.1038/sj.onc.1209007

PubMed ID: 18467591

Title: Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.

PubMed ID: 18467591

DOI: 10.1126/science.1154370

PubMed ID: 18814279

Title: Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals.

PubMed ID: 18814279

DOI: 10.1002/ijc.23903

PubMed ID: 19934330

Title: Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.

PubMed ID: 19934330

DOI: 10.1158/0008-5472.can-09-1868

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20156689

Title: Colony stimulating factor-1 receptor as a target for small molecule inhibitors.

PubMed ID: 20156689

DOI: 10.1016/j.bmc.2010.01.056

PubMed ID: 20489731

Title: IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.

PubMed ID: 20489731

DOI: 10.1038/cdd.2010.60

PubMed ID: 20829061

Title: Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.

PubMed ID: 20829061

DOI: 10.1016/j.cyto.2010.08.005

PubMed ID: 20504948

Title: Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.

PubMed ID: 20504948

DOI: 10.1189/jlb.1209822

PubMed ID: 15519852

Title: CSF-1 regulation of the wandering macrophage: complexity in action.

PubMed ID: 15519852

DOI: 10.1016/j.tcb.2004.09.016

PubMed ID: 16337366

Title: Colony-stimulating factor-1 in immunity and inflammation.

PubMed ID: 16337366

DOI: 10.1016/j.coi.2005.11.006

PubMed ID: 18687298

Title: Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies.

PubMed ID: 18687298

DOI: 10.1016/j.intimp.2008.04.016

PubMed ID: 19132917

Title: Blood monocytes: development, heterogeneity, and relationship with dendritic cells.

PubMed ID: 19132917

DOI: 10.1146/annurev.immunol.021908.132557

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17132624

Title: Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.

PubMed ID: 17132624

DOI: 10.1074/jbc.m608183200

PubMed ID: 17292918

Title: The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain.

PubMed ID: 17292918

DOI: 10.1016/j.jmb.2007.01.036

PubMed ID: 18342505

Title: Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.

PubMed ID: 18342505

DOI: 10.1016/j.bmcl.2008.02.070

PubMed ID: 19193011

Title: Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.

PubMed ID: 19193011

DOI: 10.1021/jm801406h

PubMed ID: 20137931

Title: Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.

PubMed ID: 20137931

DOI: 10.1016/j.bmcl.2010.01.078

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 22197934

Title: Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.

PubMed ID: 22197934

DOI: 10.1038/ng.1027

PubMed ID: 23408870

Title: CSF1R mutations link POLD and HDLS as a single disease entity.

PubMed ID: 23408870

DOI: 10.1212/wnl.0b013e31828726a7

PubMed ID: 24532199

Title: Hereditary diffuse leukoencephalopathy with axonal spheroids: three patients with stroke-like presentation carrying new mutations in the CSF1R gene.

PubMed ID: 24532199

DOI: 10.1007/s00415-014-7257-3

PubMed ID: 24336230

Title: Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS.

PubMed ID: 24336230

DOI: 10.1212/wnl.0000000000000046

PubMed ID: 30982609

Title: Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation.

PubMed ID: 30982609

DOI: 10.1016/j.ajhg.2019.03.004

PubMed ID: 30982608

Title: Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia.

PubMed ID: 30982608

DOI: 10.1016/j.ajhg.2019.03.010

Sequence Information:

  • Length: 972
  • Mass: 107984
  • Checksum: A8D99BE237573FE8
  • Sequence:
    • MGPGVLLLLL VATAWHGQGI PVIEPSVPEL VVKPGATVTL RCVGNGSVEW DGPPSPHWTL 
YSDGSSSILS TNNATFQNTG TYRCTEPGDP LGGSAAIHLY VKDPARPWNV LAQEVVVFED 
QDALLPCLLT DPVLEAGVSL VRVRGRPLMR HTNYSFSPWH GFTIHRAKFI QSQDYQCSAL 
MGGRKVMSIS IRLKVQKVIP GPPALTLVPA ELVRIRGEAA QIVCSASSVD VNFDVFLQHN 
NTKLAIPQQS DFHNNRYQKV LTLNLDQVDF QHAGNYSCVA SNVQGKHSTS MFFRVVESAY 
LNLSSEQNLI QEVTVGEGLN LKVMVEAYPG LQGFNWTYLG PFSDHQPEPK LANATTKDTY 
RHTFTLSLPR LKPSEAGRYS FLARNPGGWR ALTFELTLRY PPEVSVIWTF INGSGTLLCA 
ASGYPQPNVT WLQCSGHTDR CDEAQVLQVW DDPYPEVLSQ EPFHKVTVQS LLTVETLEHN 
QTYECRAHNS VGSGSWAFIP ISAGAHTHPP DEFLFTPVVV ACMSIMALLL LLLLLLLYKY 
KQKPKYQVRW KIIESYEGNS YTFIDPTQLP YNEKWEFPRN NLQFGKTLGA GAFGKVVEAT 
AFGLGKEDAV LKVAVKMLKS TAHADEKEAL MSELKIMSHL GQHENIVNLL GACTHGGPVL 
VITEYCCYGD LLNFLRRKAE AMLGPSLSPG QDPEGGVDYK NIHLEKKYVR RDSGFSSQGV 
DTYVEMRPVS TSSNDSFSEQ DLDKEDGRPL ELRDLLHFSS QVAQGMAFLA SKNCIHRDVA 
ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK WMAPESIFDC VYTVQSDVWS 
YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF APKNIYSIMQ ACWALEPTHR 
PTFQQICSFL QEQAQEDRRE RDYTNLPSSS RSGGSGSSSS ELEEESSSEH LTCCEQGDIA 
QPLLQPNNYQ FC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.