Details for: CSF1R
Associated with
Other Information
Genular Protein ID: 2106677415
Symbol: CSF1R_HUMAN
Name: Macrophage colony-stimulating factor 1 receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2524025
Title: Nucleotide sequence and structural organization of the human FMS proto-oncogene.
PubMed ID: 2524025
PubMed ID: 2421165
Title: Structural alteration of viral homologue of receptor proto-oncogene fms at carboxyl terminus.
PubMed ID: 2421165
DOI: 10.1038/320277a0
PubMed ID: 9027509
Title: Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes.
PubMed ID: 9027509
PubMed ID: 18593464
Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
PubMed ID: 18593464
DOI: 10.1186/ar2447
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2524648
Title: Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.
PubMed ID: 2524648
PubMed ID: 3525854
Title: The amino-terminal domain of the v-fms oncogene product includes a functional signal peptide that directs synthesis of a transforming glycoprotein in the absence of feline leukemia virus gag sequences.
PubMed ID: 3525854
PubMed ID: 4028159
Title: Expression of the human c-fms proto-oncogene in hematopoietic cells and its deletion in the 5q- syndrome.
PubMed ID: 4028159
PubMed ID: 3532121
Title: 'Replacement' of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential.
PubMed ID: 3532121
PubMed ID: 7683918
Title: Expression of human colony-stimulating factor-1 (CSF-1) receptor in murine pluripotent hematopoietic NFS-60 cells induces long-term proliferation in response to CSF-1 without loss of erythroid differentiation potential.
PubMed ID: 7683918
PubMed ID: 7681396
Title: Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.
PubMed ID: 7681396
PubMed ID: 7845678
Title: Transcriptional regulation of the c-fms (CSF-1R) proto-oncogene in human breast carcinoma cells by glucocorticoids.
PubMed ID: 7845678
PubMed ID: 10340379
Title: Cell specific transformation by c-fms activating loop mutations is attributable to constitutive receptor degradation.
PubMed ID: 10340379
PubMed ID: 12882960
Title: The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.
PubMed ID: 12882960
PubMed ID: 15117969
Title: Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture.
PubMed ID: 15117969
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16648572
Title: Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors.
PubMed ID: 16648572
PubMed ID: 17121910
Title: A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.
PubMed ID: 17121910
PubMed ID: 16170366
Title: FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.
PubMed ID: 16170366
PubMed ID: 18467591
Title: Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.
PubMed ID: 18467591
PubMed ID: 18814279
Title: Imatinib mesylate suppresses bone metastases of breast cancer by inhibiting osteoclasts through the blockade of c-Fms signals.
PubMed ID: 18814279
DOI: 10.1002/ijc.23903
PubMed ID: 19934330
Title: Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.
PubMed ID: 19934330
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20156689
Title: Colony stimulating factor-1 receptor as a target for small molecule inhibitors.
PubMed ID: 20156689
PubMed ID: 20489731
Title: IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.
PubMed ID: 20489731
DOI: 10.1038/cdd.2010.60
PubMed ID: 20829061
Title: Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.
PubMed ID: 20829061
PubMed ID: 20504948
Title: Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.
PubMed ID: 20504948
DOI: 10.1189/jlb.1209822
PubMed ID: 15519852
Title: CSF-1 regulation of the wandering macrophage: complexity in action.
PubMed ID: 15519852
PubMed ID: 16337366
Title: Colony-stimulating factor-1 in immunity and inflammation.
PubMed ID: 16337366
PubMed ID: 18687298
Title: Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies.
PubMed ID: 18687298
PubMed ID: 19132917
Title: Blood monocytes: development, heterogeneity, and relationship with dendritic cells.
PubMed ID: 19132917
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 17132624
Title: Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.
PubMed ID: 17132624
PubMed ID: 17292918
Title: The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain.
PubMed ID: 17292918
PubMed ID: 18342505
Title: Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.
PubMed ID: 18342505
PubMed ID: 19193011
Title: Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors.
PubMed ID: 19193011
DOI: 10.1021/jm801406h
PubMed ID: 20137931
Title: Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
PubMed ID: 20137931
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 22197934
Title: Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.
PubMed ID: 22197934
DOI: 10.1038/ng.1027
PubMed ID: 23408870
Title: CSF1R mutations link POLD and HDLS as a single disease entity.
PubMed ID: 23408870
PubMed ID: 24532199
Title: Hereditary diffuse leukoencephalopathy with axonal spheroids: three patients with stroke-like presentation carrying new mutations in the CSF1R gene.
PubMed ID: 24532199
PubMed ID: 24336230
Title: Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS.
PubMed ID: 24336230
PubMed ID: 30982609
Title: Bi-allelic CSF1R Mutations Cause Skeletal Dysplasia of Dysosteosclerosis-Pyle Disease Spectrum and Degenerative Encephalopathy with Brain Malformation.
PubMed ID: 30982609
PubMed ID: 30982608
Title: Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia.
PubMed ID: 30982608
Sequence Information:
- Length: 972
- Mass: 107984
- Checksum: A8D99BE237573FE8
- Sequence:
MGPGVLLLLL VATAWHGQGI PVIEPSVPEL VVKPGATVTL RCVGNGSVEW DGPPSPHWTL YSDGSSSILS TNNATFQNTG TYRCTEPGDP LGGSAAIHLY VKDPARPWNV LAQEVVVFED QDALLPCLLT DPVLEAGVSL VRVRGRPLMR HTNYSFSPWH GFTIHRAKFI QSQDYQCSAL MGGRKVMSIS IRLKVQKVIP GPPALTLVPA ELVRIRGEAA QIVCSASSVD VNFDVFLQHN NTKLAIPQQS DFHNNRYQKV LTLNLDQVDF QHAGNYSCVA SNVQGKHSTS MFFRVVESAY LNLSSEQNLI QEVTVGEGLN LKVMVEAYPG LQGFNWTYLG PFSDHQPEPK LANATTKDTY RHTFTLSLPR LKPSEAGRYS FLARNPGGWR ALTFELTLRY PPEVSVIWTF INGSGTLLCA ASGYPQPNVT WLQCSGHTDR CDEAQVLQVW DDPYPEVLSQ EPFHKVTVQS LLTVETLEHN QTYECRAHNS VGSGSWAFIP ISAGAHTHPP DEFLFTPVVV ACMSIMALLL LLLLLLLYKY KQKPKYQVRW KIIESYEGNS YTFIDPTQLP YNEKWEFPRN NLQFGKTLGA GAFGKVVEAT AFGLGKEDAV LKVAVKMLKS TAHADEKEAL MSELKIMSHL GQHENIVNLL GACTHGGPVL VITEYCCYGD LLNFLRRKAE AMLGPSLSPG QDPEGGVDYK NIHLEKKYVR RDSGFSSQGV DTYVEMRPVS TSSNDSFSEQ DLDKEDGRPL ELRDLLHFSS QVAQGMAFLA SKNCIHRDVA ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK WMAPESIFDC VYTVQSDVWS YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF APKNIYSIMQ ACWALEPTHR PTFQQICSFL QEQAQEDRRE RDYTNLPSSS RSGGSGSSSS ELEEESSSEH LTCCEQGDIA QPLLQPNNYQ FC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.