Genular: Defining Cellular Identity and Function

Details for: Fzd5

Gene ID: 14367

Symbol: Fzd5

Ensembl ID: ENSMUSG00000045005

Description: frizzled class receptor 5

Associated with

Asymmetric localization of pcp proteins
(R-MMU-4608870)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Ca2+ pathway
(R-MMU-4086398)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Pcp/ce pathway
(R-MMU-4086400)
Regulation of fzd by ubiquitination
(R-MMU-4641263)
Signaling by wnt
(R-MMU-195721)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Wnt5a-dependent internalization of fzd2, fzd5 and ror2
(R-MMU-5140745)
Amyloid-beta binding
(GO:0001540)
Angiogenesis
(GO:0001525)
Anterior/posterior axis specification, embryo
(GO:0008595)
Apoptotic process involved in morphogenesis
(GO:0060561)
Bicellular tight junction
(GO:0005923)
Branching involved in labyrinthine layer morphogenesis
(GO:0060670)
Canonical wnt signaling pathway
(GO:0060070)
Cell differentiation
(GO:0030154)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to molecule of bacterial origin
(GO:0071219)
Chorionic trophoblast cell differentiation
(GO:0060718)
Early endosome
(GO:0005769)
Embryonic axis specification
(GO:0000578)
Embryonic camera-type eye development
(GO:0031076)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Glandular epithelial cell maturation
(GO:0002071)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Intestinal epithelial cell maturation
(GO:0060574)
Labyrinthine layer blood vessel development
(GO:0060716)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of cell population proliferation
(GO:0008285)
Non-canonical wnt signaling pathway
(GO:0035567)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of t cell cytokine production
(GO:0002726)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type ii interferon production
(GO:0032729)
Post-embryonic camera-type eye development
(GO:0031077)
Presynapse assembly
(GO:0099054)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of bicellular tight junction assembly
(GO:2000810)
Regulation of chorionic trophoblast cell proliferation
(GO:1901382)
Signal transduction
(GO:0007165)
Spemann organizer formation
(GO:0060061)
Synapse
(GO:0045202)
Syncytiotrophoblast cell differentiation involved in labyrinthine layer development
(GO:0060715)
T cell differentiation in thymus
(GO:0033077)
Transmembrane signaling receptor activity
(GO:0004888)
Ubiquitin protein ligase binding
(GO:0031625)
Vasculature development
(GO:0001944)
Wnt-protein binding
(GO:0017147)
Wnt receptor activity
(GO:0042813)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Frizzled-5
Q3UEG1_MOUSE

Genular Protein ID: 2102497064

Symbol: FZD5_MOUSE

Name: Frizzled-5

UniProtKB Accession Codes:

Q9EQD0 G5E8F0 O08975 Q8BMR2 Q8CHK9

Database IDs:

Citations:

PubMed ID: 11092808

Title: Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.

PubMed ID: 11092808

DOI: 10.1242/dev.128.1.25

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8626800

Title: A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.

PubMed ID: 8626800

DOI: 10.1074/jbc.271.8.4468

PubMed ID: 11520064

Title: Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.

PubMed ID: 11520064

DOI: 10.1006/bbrc.2001.5430

PubMed ID: 18230341

Title: Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP.

PubMed ID: 18230341

DOI: 10.1016/j.bbrc.2008.01.088

PubMed ID: 20530549

Title: Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis.

PubMed ID: 20530549

DOI: 10.1242/dev.046722

Sequence Information:

Length: 585
Mass: 64138
Checksum: 5FC03620AF087733
Sequence:

MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH MPNQFNHDTQ 
DEAGLEVHQF WPLVEIHCSP DLRFFLCSMY TPICLPDYHK PLPPCRSVCE RAKAGCSPLM 
RQYGFAWPER MSCDRLPVLG GDAEVLCMDY NRSEATTASP KSFPAKPTLP GPPGAPSSGG 
ECPSGGPSVC TCREPFVPIL KESHPLYNKV RTGQVPNCAV PCYQPSFSPD ERTFATFWIG 
LWSVLCFIST STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR 
EHSHIHYETT GPALCTVVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN EAIAGYAQYF 
HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL RGFVLGPLVL YLLVGTLFLL 
AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI GIFTLLYTVP ASIVVACYLY EQHYRESWEA 
ALTCACPGPD AGQPRAKPEY WVLMLKYFMC LVVGITSGVW IWSGKTLESW RRFTSRCCCS 
SRRGHKSGGA MAAGDYAEAS AALTGRTGPP GPTAAYHKQV SLSHV

Genular Protein ID: 2871060041

Symbol: Q3UEG1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UEG1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 141
Mass: 16097
Checksum: EA76BFCD7E95DF26
Sequence:

MPQGLSGKKR SSHWECKQSE GVHICKILCP RSLESELEFQ WLPQDLVHLD AGLCEGLIPM 
PFSFREPQHT HWLCTTSVFQ MRFFSYHLAL LPCLAWSSQN LLLPPHPPPL SLLCIVRVVP 
LSQRKSRIGH TVYLKVVGWS G

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fzd5

Associated with

Other Information

Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. PubMed ID: 11092808

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. PubMed ID: 8626800

Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. PubMed ID: 11520064

Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP. PubMed ID: 18230341

Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. PubMed ID: 20530549

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073