Genular: Defining Cellular Identity and Function

Details for: Fzd6

Gene ID: 14368

Symbol: Fzd6

Ensembl ID: ENSMUSG00000022297

Description: frizzled class receptor 6

Associated with

Beta-catenin independent wnt signaling
(R-MMU-3858494)
Ca2+ pathway
(R-MMU-4086398)
Pcp/ce pathway
(R-MMU-4086400)
Regulation of fzd by ubiquitination
(R-MMU-4641263)
Signaling by wnt
(R-MMU-195721)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Apicolateral plasma membrane
(GO:0016327)
Canonical wnt signaling pathway
(GO:0060070)
Cell proliferation in midbrain
(GO:0033278)
Cell surface receptor signaling pathway
(GO:0007166)
Cytoplasmic vesicle
(GO:0031410)
Embryonic nail plate morphogenesis
(GO:0035880)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Establishment of body hair planar orientation
(GO:0048105)
Establishment of planar polarity
(GO:0001736)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Hair follicle development
(GO:0001942)
Inner ear morphogenesis
(GO:0042472)
Membrane
(GO:0016020)
Midbrain development
(GO:0030901)
Multicellular organism development
(GO:0007275)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Nervous system development
(GO:0007399)
Neural tube closure
(GO:0001843)
Non-canonical wnt signaling pathway
(GO:0035567)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
Transmembrane signaling receptor activity
(GO:0004888)
Ubiquitin protein ligase binding
(GO:0031625)
Wnt-protein binding
(GO:0017147)
Wnt receptor activity
(GO:0042813)
Wnt signaling pathway
(GO:0016055)
Wnt signaling pathway, planar cell polarity pathway
(GO:0060071)

Other Information

Proteins

Frizzled-6
Q3UTZ0_MOUSE

Genular Protein ID: 171298351

Symbol: FZD6_MOUSE

Name: Frizzled-6

UniProtKB Accession Codes:

Q61089

Database IDs:

Citations:

PubMed ID: 8626800

Title: A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.

PubMed ID: 8626800

DOI: 10.1074/jbc.271.8.4468

PubMed ID: 10395542

Title: Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner.

PubMed ID: 10395542

DOI: 10.1016/s0960-9822(99)80310-8

PubMed ID: 10097073

Title: Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.

PubMed ID: 10097073

DOI: 10.1073/pnas.96.7.3546

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21665003

Title: Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.

PubMed ID: 21665003

DOI: 10.1016/j.ajhg.2011.05.013

PubMed ID: 16495441

Title: The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells.

PubMed ID: 16495441

DOI: 10.1523/jneurosci.4698-05.2005

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

Sequence Information:

Length: 709
Mass: 79082
Checksum: 01374A9EC9122484
Sequence:

MERSPFLLAC ILLPLVRGHS LFTCEPITVP RCMKMTYNMT FFPNLMGHYD QGIAAVEMGH 
FLHLANLECS PNIEMFLCQA FIPTCTEQIH VVLPCRKLCE KIVSDCKKLM DTFGIRWPEE 
LECNRLPHCD DTVPVTSHPH TELSGPQKKS DQVPRDIGFW CPKHLRTSGD QGYRFLGIEQ 
CAPPCPNMYF KSDELDFAKS FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC 
YSIVSLMYFV GFLLGNSTAC NKADEKLELG DTVVLGSKNK ACSVVFMFLY FFTMAGTVWW 
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGAPGFLTV MLLAMNKVEG DNISGVCFVG 
LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI QHDGRNQEKL KKFMIRIGVF 
SGLYLVPLVT LLGCYVYELV NRITWEMTWF SDHCHQYRIP CPYQANPKAR PELALFMIKY 
LMTLIVGISA VFWVGSKKTC TEWAGFFKRN RKRDPISESR RVLQESCEFF LKHNSKVKHK 
KKHGAPGPHR LKVISKSMGT STGATTNHGT SAMAIADHDY LGQETSTEVH TSPEASVKEG 
RADRANTPSA KDRDCGESAG PSSKLSGNRN GRESRAGGLK ERSNGSEGAP SEGRVSPKSS 
VPETGLIDCS TSQAASSPEP TSLKGSTSLP VHSASRARKE QGAGSHSDA

Genular Protein ID: 938799339

Symbol: Q3UTZ0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UTZ0

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 386
Mass: 42124
Checksum: 038413B4EDC0B2FB
Sequence:

AVWFHAVAWG APGFLTVMLL AMNKVEGDNI SGVCFVGLYD LDASRYFVLL PLCLCVFVGL 
SLLLAGIISL NHVRQVIQHD GRNQEKLKKF MIRIGVFSGL YLVPLVTLLG CYVYELVNRI 
TWEMTWFSDH CHQYRIPCPY QANPKARPEL ALFMIKYLMT LIVGISAVFW VGSKKTCTEW 
AGFFKRNRKR DPISESRRVL QESCEFFLKH NSKVKHKKKH GAPGPHRLKV ISKSMGTSTG 
ATTNHGTSAM AIADHDYLGQ ETSTEVHTSP EASVKEGRAD RANTPSAKDR DCGESAGPSS 
KLSGNRNGRE SRAGGLKERS NGSEGAPSEG RVSPKSSVPE TGLIDCSTSQ AASSPEPTSL 
KGSTSLPVHS ASRARKEQGA GSHSDA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fzd6

Associated with

Other Information

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. PubMed ID: 8626800

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. PubMed ID: 10395542

Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. PubMed ID: 10097073

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia. PubMed ID: 21665003

The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. PubMed ID: 16495441

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073