CSF2 | ENSG00000164400 | NCBI 1437

Details for: CSF2

Gene ID: 1437

Symbol: CSF2

Ensembl ID: ENSG00000164400

Description: colony stimulating factor 2

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin-10 signaling
(R-HSA-6783783)
Interleukin receptor shc signaling
(R-HSA-912526)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Raf/map kinase cascade
(R-HSA-5673001)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of myeloid cells
(R-HSA-8939246)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx1
(R-HSA-8878171)
Cell population proliferation
(GO:0008283)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus
(GO:0097011)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytokine activity
(GO:0005125)
Dendritic cell differentiation
(GO:0097028)
Embryonic placenta development
(GO:0001892)
Epithelial fluid transport
(GO:0042045)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Granulocyte-macrophage colony-stimulating factor signaling pathway
(GO:0038157)
Granulocyte macrophage colony-stimulating factor receptor binding
(GO:0005129)
Granulocyte macrophage colony-stimulating factor receptor complex
(GO:0030526)
Growth factor activity
(GO:0008083)
Histamine secretion
(GO:0001821)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Macrophage differentiation
(GO:0030225)
Monocyte differentiation
(GO:0030224)
Myeloid cell differentiation
(GO:0030099)
Myeloid dendritic cell differentiation
(GO:0043011)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Neutrophil differentiation
(GO:0030223)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-23 production
(GO:0032747)
Positive regulation of leukocyte proliferation
(GO:0070665)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of podosome assembly
(GO:0071803)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein binding
(GO:0005515)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of circadian sleep/wake cycle, sleep
(GO:0045187)
Response to fluid shear stress
(GO:0034405)
Response to silicon dioxide
(GO:0034021)

Other Information

Proteins

Granulocyte-macrophage colony-stimulating factor

Genular Protein ID: 3032058552

Symbol: CSF2_HUMAN

Name: Granulocyte-macrophage colony-stimulating factor

UniProtKB Accession Codes:

P04141 Q14CE8 Q2VPI8 Q8NFI6

Database IDs:

Citations:

PubMed ID: 3925454

Title: Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.

PubMed ID: 3925454

DOI: 10.1073/pnas.82.13.4360

PubMed ID: 3486413

Title: Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.

PubMed ID: 3486413

DOI: 10.1073/pnas.83.10.3101

PubMed ID: 3898082

Title: Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor.

PubMed ID: 3898082

DOI: 10.1073/pnas.82.18.6250

PubMed ID: 3923623

Title: Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins.

PubMed ID: 3923623

DOI: 10.1126/science.3923623

PubMed ID: 3876930

Title: Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.

PubMed ID: 3876930

DOI: 10.1002/j.1460-2075.1985.tb03971.x

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1737041

Title: Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells.

PubMed ID: 1737041

DOI: 10.1021/bi00121a042

PubMed ID: 1837174

Title: Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.

PubMed ID: 1837174

DOI: 10.1126/science.1837174

PubMed ID: 1569568

Title: Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.

PubMed ID: 1569568

DOI: 10.1016/0022-2836(92)90470-5

PubMed ID: 18692472

Title: The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

PubMed ID: 18692472

DOI: 10.1016/j.cell.2008.05.053

Sequence Information:

Length: 144
Mass: 16295
Checksum: 75D1E50506BCA7A8
Sequence:

MWLQSLLLLG TVACSISAPA RSPSPSTQPW EHVNAIQEAR RLLNLSRDTA AEMNETVEVI 
SEMFDLQEPT CLQTRLELYK QGLRGSLTKL KGPLTMMASH YKQHCPPTPE TSCATQIITF 
ESFKENLKDF LLVIPFDCWE PVQE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CSF2

Associated with

Other Information

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells. PubMed ID: 3925454

Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor. PubMed ID: 3486413

Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. PubMed ID: 3898082

Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. PubMed ID: 3923623

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. PubMed ID: 3876930

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells. PubMed ID: 1737041

Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor. PubMed ID: 1837174

Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor. PubMed ID: 1569568

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. PubMed ID: 18692472