Details for: CSF2

Gene ID: 1437

Symbol: CSF2

Ensembl ID: ENSG00000164400

Description: colony stimulating factor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.57
    Marker Score: 2973
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.93
    Marker Score: 561
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.88
    Marker Score: 690
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 501
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1430
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.69
    Marker Score: 10866
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 485
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.51
    Marker Score: 3046
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.45
    Marker Score: 2914
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.45
    Marker Score: 299
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 434
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 182
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.41
    Marker Score: 146
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 212
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.33
    Marker Score: 2163
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.32
    Marker Score: 567
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.32
    Marker Score: 507
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3
    Marker Score: 1936
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.29
    Marker Score: 191
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.29
    Marker Score: 209
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.28
    Marker Score: 1842
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.27
    Marker Score: 275
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.26
    Marker Score: 712
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.24
    Marker Score: 107
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: 0.21
    Marker Score: 76
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.21
    Marker Score: 93
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.19
    Marker Score: 81
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.18
    Marker Score: 70
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.18
    Marker Score: 182
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.17
    Marker Score: 109
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 92
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.14
    Marker Score: 80
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.14
    Marker Score: 31
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.13
    Marker Score: 228
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.13
    Marker Score: 99
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.13
    Marker Score: 2021
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.12
    Marker Score: 196
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.12
    Marker Score: 248.5
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.11
    Marker Score: 184
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.11
    Marker Score: 601
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.11
    Marker Score: 140
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 111
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.09
    Marker Score: 1197
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 247
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.08
    Marker Score: 228
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.06
    Marker Score: 21.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 51
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.05
    Marker Score: 38
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.05
    Marker Score: 64
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.05
    Marker Score: 46
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.05
    Marker Score: 51
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.04
    Marker Score: 111

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * Type: Protein * Ensembl ID: ENSG00000164400 * Protein length: 112 amino acids * Function: Cytokine that plays a crucial role in the regulation of immune responses * Pathway/Ontology: Cytokine activity, Cytokine signaling in immune system * Expression: Significantly expressed cells: cardiac endothelial cell, granulocyte monocyte progenitor cell, early T lineage precursor, absorptive cell, intestinal crypt stem cell of colon, transit amplifying cell, lymphoid lineage restricted progenitor cell, abnormal cell, type I NK T cell, neoplastic cell **Pathways and functions** CSF2 binds to the receptor for the cytokine receptor for macrophage colony-stimulating factor (CSF-1R), which is expressed on macrophages, monocytes, and dendritic cells. This binding activates the receptor-mediated signaling pathway, which leads to the activation of the transcription factor Runx1. Runx1 then regulates the transcription of genes involved in myeloid cell differentiation, including those that are responsible for the development of macrophages and dendritic cells. **Clinical significance** Mutations in the CSF2 gene have been linked to several human diseases, including rheumatoid arthritis, inflammatory bowel disease, and cancer. In rheumatoid arthritis, mutations in the CSF2 gene are associated with the development of joint inflammation and damage. In inflammatory bowel disease, mutations in the CSF2 gene are associated with the development of inflammatory bowel disease. In cancer, mutations in the CSF2 gene are associated with the development of certain types of cancer, such as breast cancer and lung cancer.

Genular Protein ID: 3032058552

Symbol: CSF2_HUMAN

Name: Granulocyte-macrophage colony-stimulating factor

UniProtKB Accession Codes:

P04141 Q14CE8 Q2VPI8 Q8NFI6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3925454

Title: Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.

PubMed ID: 3925454

DOI: 10.1073/pnas.82.13.4360

PubMed ID: 3486413

Title: Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor.

PubMed ID: 3486413

DOI: 10.1073/pnas.83.10.3101

PubMed ID: 3898082

Title: Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor.

PubMed ID: 3898082

DOI: 10.1073/pnas.82.18.6250

PubMed ID: 3923623

Title: Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins.

PubMed ID: 3923623

DOI: 10.1126/science.3923623

PubMed ID: 3876930

Title: Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes.

PubMed ID: 3876930

DOI: 10.1002/j.1460-2075.1985.tb03971.x

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1737041

Title: Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells.

PubMed ID: 1737041

DOI: 10.1021/bi00121a042

PubMed ID: 1837174

Title: Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor.

PubMed ID: 1837174

DOI: 10.1126/science.1837174

PubMed ID: 1569568

Title: Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor.

PubMed ID: 1569568

DOI: 10.1016/0022-2836(92)90470-5

PubMed ID: 18692472

Title: The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

PubMed ID: 18692472

DOI: 10.1016/j.cell.2008.05.053

Sequence Information:

  • Length: 144
  • Mass: 16295
  • Checksum: 75D1E50506BCA7A8
  • Sequence:
    • MWLQSLLLLG TVACSISAPA RSPSPSTQPW EHVNAIQEAR RLLNLSRDTA AEMNETVEVI 
SEMFDLQEPT CLQTRLELYK QGLRGSLTKL KGPLTMMASH YKQHCPPTPE TSCATQIITF 
ESFKENLKDF LLVIPFDCWE PVQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.