Genular: Defining Cellular Identity and Function

Details for: Fzd8

Gene ID: 14370

Symbol: Fzd8

Ensembl ID: ENSMUSG00000036904

Description: frizzled class receptor 8

Associated with

Asymmetric localization of pcp proteins
(R-MMU-4608870)
Beta-catenin independent wnt signaling
(R-MMU-3858494)
Pcp/ce pathway
(R-MMU-4086400)
Regulation of fzd by ubiquitination
(R-MMU-4641263)
Signaling by wnt
(R-MMU-195721)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Angiogenesis
(GO:0001525)
Canonical wnt signaling pathway
(GO:0060070)
Cell surface receptor signaling pathway
(GO:0007166)
Extracellular region
(GO:0005576)
Golgi apparatus
(GO:0005794)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Neuronal dense core vesicle
(GO:0098992)
Non-canonical wnt signaling pathway
(GO:0035567)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
T cell differentiation in thymus
(GO:0033077)
Transmembrane signaling receptor activity
(GO:0004888)
Ubiquitin protein ligase binding
(GO:0031625)
Wnt-frizzled-lrp5/6 complex
(GO:1990851)
Wnt-protein binding
(GO:0017147)
Wnt receptor activity
(GO:0042813)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Frizzled-8

Genular Protein ID: 2432256108

Symbol: FZD8_MOUSE

Name: Frizzled-8

UniProtKB Accession Codes:

Q61091 A2RTK9

Database IDs:

Citations:

PubMed ID: 8626800

Title: A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.

PubMed ID: 8626800

DOI: 10.1074/jbc.271.8.4468

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10395542

Title: Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner.

PubMed ID: 10395542

DOI: 10.1016/s0960-9822(99)80310-8

PubMed ID: 10097073

Title: Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.

PubMed ID: 10097073

DOI: 10.1073/pnas.96.7.3546

PubMed ID: 11520064

Title: Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.

PubMed ID: 11520064

DOI: 10.1006/bbrc.2001.5430

PubMed ID: 15454084

Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

PubMed ID: 15454084

DOI: 10.1016/j.cell.2004.09.019

PubMed ID: 16543246

Title: Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.

PubMed ID: 16543246

DOI: 10.1074/jbc.m508324200

PubMed ID: 11452312

Title: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.

PubMed ID: 11452312

DOI: 10.1038/35083601

PubMed ID: 22653731

Title: Structural basis of Wnt recognition by Frizzled.

PubMed ID: 22653731

DOI: 10.1126/science.1222879

Sequence Information:

Length: 685
Mass: 73045
Checksum: 9DB95F068BC45CD8
Sequence:

MEWGYLLEVT SLLAALAVLQ RSSGAAAASA KELACQEITV PLCKGIGYNY TYMPNQFNHD 
TQDEAGLEVH QFWPLVEIQC SPDLKFFLCS MYTPICLEDY KKPLPPCRSV CERAKAGCAP 
LMRQYGFAWP DRMRCDRLPE QGNPDTLCMD YNRTDLTTAA PSPPRRLPPP PPPGEQPPSG 
SGHSRPPGAR PPHRGGSSRG SGDAAAAPPS RGGKARPPGG GAAPCEPGCQ CRAPMVSVSS 
ERHPLYNRVK TGQIANCALP CHNPFFSQDE RAFTVFWIGL WSVLCFVSTF ATVSTFLIDM 
ERFKYPERPI IFLSACYLFV SVGYLVRLVA GHEKVACSGG APGAGGAGGA GGAAAAGAGA 
AGAGASSPGA RGEYEELGAV EQHVRYETTG PALCTVVFLL VYFFGMASSI WWVILSLTWF 
LAAGMKWGNE AIAGYSQYFH LAAWLVPSVK SIAVLALSSV DGDPVAGICY VGNQSLDNLR 
GFVLAPLVIY LFIGTMFLLA GFVSLFRIRS VIKQQGGPTK THKLEKLMIR LGLFTVLYTV 
PAAVVVACLF YEQHNRPRWE ATHNCPCLRD LQPDQARRPD YAVFMLKYFM CLVVGITSGV 
WVWSGKTLES WRALCTRCCW ASKGAAVGAG AGGSGPGGSG PGPGGGGGHG GGGGSLYSDV 
STGLTWRSGT ASSVSYPKQM PLSQV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fzd8

Associated with

Other Information

A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. PubMed ID: 8626800

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. PubMed ID: 10395542

Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. PubMed ID: 10097073

Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. PubMed ID: 11520064

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. PubMed ID: 15454084

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. PubMed ID: 16543246

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. PubMed ID: 11452312

Structural basis of Wnt recognition by Frizzled. PubMed ID: 22653731