CSF2RA | ENSG00000198223 | NCBI 1438

Details for: CSF2RA

Gene ID: 1438

Symbol: CSF2RA

Ensembl ID: ENSG00000198223

Description: colony stimulating factor 2 receptor subunit alpha

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Defective csf2ra causes smdp4
(R-HSA-5688890)
Defective csf2rb causes smdp5
(R-HSA-5688849)
Disease
(R-HSA-1643685)
Diseases associated with surfactant metabolism
(R-HSA-5687613)
Diseases of metabolism
(R-HSA-5668914)
Immune system
(R-HSA-168256)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin receptor shc signaling
(R-HSA-912526)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism of proteins
(R-HSA-392499)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Surfactant metabolism
(R-HSA-5683826)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine binding
(GO:0019955)
Cytokine receptor activity
(GO:0004896)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Granulocyte-macrophage colony-stimulating factor signaling pathway
(GO:0038157)
Granulocyte macrophage colony-stimulating factor receptor complex
(GO:0030526)
Plasma membrane
(GO:0005886)
Positive regulation of leukocyte proliferation
(GO:0070665)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Receptor signaling pathway via jak-stat
(GO:0007259)
Signaling receptor activity
(GO:0038023)

Other Information

Proteins

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Genular Protein ID: 171822143

Symbol: CSF2R_HUMAN

Name: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

UniProtKB Accession Codes:

P15509 A7J003 A8KAM1 B4DW68 J3JS76 J3JS77 O00207 Q14429 Q14430 Q14431 Q16564

Database IDs:

Citations:

PubMed ID: 2555171

Title: Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

PubMed ID: 2555171

DOI: 10.1002/j.1460-2075.1989.tb08541.x

PubMed ID: 8144676

Title: Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily.

PubMed ID: 8144676

DOI: 10.1016/s0021-9258(17)34144-3

PubMed ID: 1715577

Title: A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain.

PubMed ID: 1715577

DOI: 10.1073/pnas.88.17.7744

PubMed ID: 2148207

Title: Cloning of a potentially soluble receptor for human GM-CSF.

PubMed ID: 2148207

DOI: 10.1093/nar/18.23.7178

PubMed ID: 1832774

Title: Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor.

PubMed ID: 1832774

DOI: 10.1073/pnas.88.18.8203

PubMed ID: 8086503

Title: Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor.

PubMed ID: 8086503

DOI: 10.1016/0167-4889(94)90241-0

PubMed ID: 17681666

Title: Discovery and characterization of a novel splice variant of the GM-CSF receptor alpha subunit.

PubMed ID: 17681666

DOI: 10.1016/j.exphem.2007.06.008

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1358805

Title: Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region.

PubMed ID: 1358805

DOI: 10.1016/s0888-7543(05)80241-1

PubMed ID: 18955567

Title: Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1.

PubMed ID: 18955567

DOI: 10.1084/jem.20080759

PubMed ID: 18692472

Title: The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

PubMed ID: 18692472

DOI: 10.1016/j.cell.2008.05.053

PubMed ID: 18955570

Title: Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.

PubMed ID: 18955570

DOI: 10.1084/jem.20080990

Sequence Information:

Length: 400
Mass: 46207
Checksum: D9025B981E41311D
Sequence:

MLLLVTSLLL CELPHPAFLL IPEKSDLRTV APASSLNVRF DSRTMNLSWD CQENTTFSKC 
FLTDKKNRVV EPRLSNNECS CTFREICLHE GVTFEVHVNT SQRGFQQKLL YPNSGREGTA 
AQNFSCFIYN ADLMNCTWAR GPTAPRDVQY FLYIRNSKRR REIRCPYYIQ DSGTHVGCHL 
DNLSGLTSRN YFLVNGTSRE IGIQFFDSLL DTKKIERFNP PSNVTVRCNT THCLVRWKQP 
RTYQKLSYLD FQYQLDVHRK NTQPGTENLL INVSGDLENR YNFPSSEPRA KHSVKIRAAD 
VRILNWSSWS EAIEFGSDDG NLGSVYIYVL LIVGTLVCGI VLGFLFKRFL RIQRLFPPVP 
QIKDKLNDNH EVEDEIIWEE FTPEEGKGYR EEVLTVKEIT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CSF2RA

Associated with

Other Information

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. PubMed ID: 2555171

Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily. PubMed ID: 8144676

A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain. PubMed ID: 1715577

Cloning of a potentially soluble receptor for human GM-CSF. PubMed ID: 2148207

Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. PubMed ID: 1832774

Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor. PubMed ID: 8086503

Discovery and characterization of a novel splice variant of the GM-CSF receptor alpha subunit. PubMed ID: 17681666

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region. PubMed ID: 1358805

Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1. PubMed ID: 18955567

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. PubMed ID: 18692472

Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. PubMed ID: 18955570