Genular: Defining Cellular Identity and Function

Details for: Gab1

Gene ID: 14388

Symbol: Gab1

Ensembl ID: ENSMUSG00000031714

Description: growth factor receptor bound protein 2-associated protein 1

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Downstream signaling of activated fgfr1
(R-MMU-5654687)
Downstream signaling of activated fgfr2
(R-MMU-5654696)
Downstream signaling of activated fgfr3
(R-MMU-5654708)
Downstream signaling of activated fgfr4
(R-MMU-5654716)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-MMU-9027276)
Gab1 signalosome
(R-MMU-180292)
Igf1r signaling cascade
(R-MMU-2428924)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs-mediated signalling
(R-MMU-112399)
Irs-related events triggered by igf1r
(R-MMU-2428928)
Met activates pi3k/akt signaling
(R-MMU-8851907)
Met activates ptpn11
(R-MMU-8865999)
Met activates rap1 and rac1
(R-MMU-8875555)
Met promotes cell motility
(R-MMU-8875878)
Met receptor recycling
(R-MMU-8875656)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nervous system development
(R-MMU-9675108)
Pi-3k cascade:fgfr1
(R-MMU-5654689)
Pi-3k cascade:fgfr2
(R-MMU-5654695)
Pi-3k cascade:fgfr3
(R-MMU-5654710)
Pi-3k cascade:fgfr4
(R-MMU-5654720)
Pi3k cascade
(R-MMU-109704)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Ret signaling
(R-MMU-8853659)
Signaling by egfr
(R-MMU-177929)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erythropoietin
(R-MMU-9006335)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by met
(R-MMU-6806834)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-MMU-2404192)
Angiogenesis
(GO:0001525)
Cell-cell junction
(GO:0005911)
Cell cortex
(GO:0005938)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endothelial cell chemotaxis to vascular endothelial growth factor
(GO:0090668)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epidermis development
(GO:0008544)
Heart development
(GO:0007507)
Interleukin-6-mediated signaling pathway
(GO:0070102)
Labyrinthine layer development
(GO:0060711)
Mapk cascade
(GO:0000165)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway
(GO:0038089)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Response to hepatocyte growth factor
(GO:0035728)
Response to oxidative stress
(GO:0006979)
Signaling adaptor activity
(GO:0035591)
Signal transduction
(GO:0007165)
Vascular endothelial growth factor signaling pathway
(GO:0038084)

Other Information

Proteins

GRB2-associated-binding protein 1
A0A1B0GS41_MOUSE

Genular Protein ID: 3653133749

Symbol: GAB1_MOUSE

Name: GRB2-associated-binding protein 1

UniProtKB Accession Codes:

Q9QYY0 Q91VW7

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11353842

Title: Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.

PubMed ID: 11353842

DOI: 10.1073/pnas.111114298

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 29408807

Title: Modifier variant of METTL13 suppresses human GAB1-associated profound deafness.

PubMed ID: 29408807

DOI: 10.1172/jci97350

Sequence Information:

Length: 695
Mass: 76812
Checksum: F0A567896E058C58
Sequence:

MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII 
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEDMNKWVRC ICDICGFNPT 
EEDPVKPLTG SSQAPVDSPF AISTAPASSQ MEASSVALPP PYQVISLPPH PDTLGLQDDP 
QDYLLLINCQ SKKPEPNRTL FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM 
MYDCPPSRLT SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM 
RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP THDRSPVETC 
GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD ASSQDCYDIP RTFPSDRSSS 
LEGFHSQYKI KSVLTAGGVS GEELDENYVP MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT 
FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL 
SEWEELQAPV RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE 
DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG SSMADERVDY 
VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK

Genular Protein ID: 3841355057

Symbol: A0A1B0GS41_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A1B0GS41

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 725
Mass: 80185
Checksum: A8FFD95E68AF4D4C
Sequence:

MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII 
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEDMNKWVRC ICDICGFNPT 
EEDPVKPLTG SSQAPVDSPF AISTAPASSQ MEASSVALPP PYQVISLPPH PDTLGLQDDP 
QDYLLLINCQ SKKPEPNRTL FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM 
MYDCPPSRLT SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM 
RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP THDRSPVETC 
GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD ASSQDCYDIP RTFPSDRSSS 
LEGFHSQYKI KSVLTAGGVS GEELDENYVP MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT 
FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV PVADCEPPPV DRNLKPDRKG QSPKILRPKP 
HGLERTDSQT IGDFATRRKV KPAPLDIKPL SEWEELQAPV RSPITRSFAR DSSRFPMSPR 
PDSVHSTTSS SDSHDSEENY VPMNPNLSGE DPNLFASNSL DGGSSPMNKP KGDKQVEYLD 
LDLDSGKSTP PRKQKSSGSG SSMADERVDY VVVDQQKTLA LKSTREAWTD GRQSTESETP 
TKNVK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gab1

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. PubMed ID: 11353842

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

Modifier variant of METTL13 suppresses human GAB1-associated profound deafness. PubMed ID: 29408807

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 15489334

PubMed ID: 11353842

PubMed ID: 21183079

PubMed ID: 20094046

PubMed ID: 29408807

PubMed ID: 19468303

PubMed ID: 21183079