CSF2RB | ENSG00000100368 | NCBI 1439

Details for: CSF2RB

Gene ID: 1439

Symbol: CSF2RB

Ensembl ID: ENSG00000100368

Description: colony stimulating factor 2 receptor subunit beta

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Defective csf2ra causes smdp4
(R-HSA-5688890)
Defective csf2rb causes smdp5
(R-HSA-5688849)
Disease
(R-HSA-1643685)
Diseases associated with surfactant metabolism
(R-HSA-5687613)
Diseases of metabolism
(R-HSA-5668914)
Immune system
(R-HSA-168256)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin receptor shc signaling
(R-HSA-912526)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism of proteins
(R-HSA-392499)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by interleukins
(R-HSA-449147)
Surfactant metabolism
(R-HSA-5683826)
Cellular response to interleukin-3
(GO:0036016)
Coreceptor activity
(GO:0015026)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine receptor activity
(GO:0004896)
External side of plasma membrane
(GO:0009897)
Granulocyte-macrophage colony-stimulating factor signaling pathway
(GO:0038157)
Granulocyte macrophage colony-stimulating factor receptor complex
(GO:0030526)
Immunoglobulin mediated immune response
(GO:0016064)
Interleukin-3 receptor activity
(GO:0004912)
Interleukin-3-mediated signaling pathway
(GO:0038156)
Interleukin-5 receptor activity
(GO:0004914)
Interleukin-5-mediated signaling pathway
(GO:0038043)
Plasma membrane
(GO:0005886)
Positive regulation of leukocyte proliferation
(GO:0070665)
Protein binding
(GO:0005515)
Receptor signaling pathway via jak-stat
(GO:0007259)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Response to lipopolysaccharide
(GO:0032496)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)

Other Information

Proteins

Cytokine receptor common subunit beta
Q6NSJ8_HUMAN

Genular Protein ID: 1404934905

Symbol: IL3RB_HUMAN

Name: Cytokine receptor common subunit beta

UniProtKB Accession Codes:

P32927 Q5JZI1 Q6ICE0

Database IDs:

Citations:

PubMed ID: 1702217

Title: Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

PubMed ID: 1702217

DOI: 10.1073/pnas.87.24.9655

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 17828305

Title: CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction.

PubMed ID: 17828305

DOI: 10.1038/sj.onc.1210778

PubMed ID: 21075760

Title: Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB.

PubMed ID: 21075760

DOI: 10.1136/jmg.2010.082586

PubMed ID: 1495999

Title: Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

PubMed ID: 1495999

DOI: 10.1073/pnas.89.15.7041

PubMed ID: 9516124

Title: JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.

PubMed ID: 9516124

PubMed ID: 10736232

Title: The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5.

PubMed ID: 10736232

DOI: 10.1006/jmbi.2000.3610

PubMed ID: 10753826

Title: Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist.

PubMed ID: 10753826

PubMed ID: 11207369

Title: Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration.

PubMed ID: 11207369

DOI: 10.1016/s0092-8674(01)00213-6

PubMed ID: 16754968

Title: An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope.

PubMed ID: 16754968

DOI: 10.1107/s1744309106016812

PubMed ID: 18692472

Title: The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

PubMed ID: 18692472

DOI: 10.1016/j.cell.2008.05.053

PubMed ID: 9410898

Title: Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression.

PubMed ID: 9410898

DOI: 10.1172/jci119758

Sequence Information:

Length: 897
Mass: 97336
Checksum: 3398E37FDB8F393A
Sequence:

MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT QDAQRLVNVT 
LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC QSFVVTDVDY FSFQPDRPLG 
TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD 
SWEDAAILLS NTSQATLGPE HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG 
DEAQPQNLEC FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL 
HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD GDSYSLRWET 
MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP ALEPSTRYWA RVRVRTSRTG 
YNGIWSEWSE ARSWDTESVL PMWVLALIVI FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN 
PSKSHLFQNG SAELWPPGSM SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE 
DPKHVCDPPS GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR 
SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ AVEVERRPSQ 
GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG DTEDPGVASG YVSSADLVFT 
PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS GPPGAPGPVK SGFEGYVELP PIEGRSPRSP 
RNNPVPPEAK SPVLNPGERP ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS 
SPGPGPEIKN LDQAFQVKKP PGQAVPQVPV IQLFKALKQQ DYLSLPPWEV NKPGEVC

Genular Protein ID: 1864063333

Symbol: Q6NSJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NSJ8

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 889
Mass: 96173
Checksum: 1BD57B91E8CC079F
Sequence:

MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT QDAQRLVNVT 
LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC QSFVVTDVDY FSFQPDRPLG 
TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD 
SWEDAAILLS NTSQATLGPE HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG 
DEAQPQNLEC FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL 
HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD GDSYSLRWET 
MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP ALEPSTRYWA RVRVRTSRTG 
YNGIWSEWSE ARSWDTESVL PMWVLALIVI FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN 
PSKSHLFQNG SAELWPPGSM SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE 
DPKHVCDPPS GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR 
SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ AVEVERRPSQ 
GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG DTEDPGVASG YVSSADLVFT 
PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS GPPGAPGPVK SGFEGYVELP PIEGRSPRSP 
RNNPVPPEAK SPVLNPGERP ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS 
SPGPGPEIKN LDQAFQVKKP PGQAVPQVPV IQLFKALVVS VMSVGPPVP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CSF2RB

Associated with

Other Information

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. PubMed ID: 1702217

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The DNA sequence of human chromosome 22. PubMed ID: 10591208

CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. PubMed ID: 17828305

Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB. PubMed ID: 21075760

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. PubMed ID: 1495999

JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. PubMed ID: 9516124

The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5. PubMed ID: 10736232

Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist. PubMed ID: 10753826

Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. PubMed ID: 11207369

An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. PubMed ID: 16754968

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. PubMed ID: 18692472

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. PubMed ID: 9410898

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334