Details for: CSF2RB

Gene ID: 1439

Symbol: CSF2RB

Ensembl ID: ENSG00000100368

Description: colony stimulating factor 2 receptor subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1156
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 843.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.23
    Marker Score: 922
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 478
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.15
    Marker Score: 1387
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4799
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2188
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.07
    Marker Score: 494
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251791
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.03
    Marker Score: 487
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.95
    Marker Score: 304
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.89
    Marker Score: 49970
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.88
    Marker Score: 848
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.81
    Marker Score: 2010.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.73
    Marker Score: 496
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.73
    Marker Score: 455
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.72
    Marker Score: 190
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.67
    Marker Score: 160
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.66
    Marker Score: 17004
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.65
    Marker Score: 3924
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.64
    Marker Score: 729
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.63
    Marker Score: 1200.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.59
    Marker Score: 326
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.59
    Marker Score: 590
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.58
    Marker Score: 563
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 380
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.54
    Marker Score: 912
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.54
    Marker Score: 128
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.52
    Marker Score: 169
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.49
    Marker Score: 956
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.48
    Marker Score: 409
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.47
    Marker Score: 1124
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 189.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.45
    Marker Score: 274
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.43
    Marker Score: 3764
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.43
    Marker Score: 150
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.43
    Marker Score: 248
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 113
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.43
    Marker Score: 191
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 254
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.41
    Marker Score: 596
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 178
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.41
    Marker Score: 368
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.4
    Marker Score: 1036
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.4
    Marker Score: 85
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.39
    Marker Score: 1154
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.38
    Marker Score: 101
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.38
    Marker Score: 247
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.38
    Marker Score: 251
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.38
    Marker Score: 610
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.36
    Marker Score: 324
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.36
    Marker Score: 319
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.36
    Marker Score: 4138
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.35
    Marker Score: 1470
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.35
    Marker Score: 108
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.35
    Marker Score: 114
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.35
    Marker Score: 5409
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.35
    Marker Score: 500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.34
    Marker Score: 341
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.34
    Marker Score: 446
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.34
    Marker Score: 235
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.34
    Marker Score: 182
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.33
    Marker Score: 212
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.33
    Marker Score: 114
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.33
    Marker Score: 162
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.33
    Marker Score: 365
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.33
    Marker Score: 223
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.32
    Marker Score: 158
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.31
    Marker Score: 288
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.29
    Marker Score: 88
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.29
    Marker Score: 390.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.29
    Marker Score: 325
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.29
    Marker Score: 302
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.28
    Marker Score: 148
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.28
    Marker Score: 1837
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.28
    Marker Score: 119
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.27
    Marker Score: 76
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.27
    Marker Score: 117
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.26
    Marker Score: 131

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Other Information

**Key characteristics:** * The CSF2RB gene is located on chromosome 17q21.1. * It is a single copy gene. * It encodes a protein of 145 amino acids. * It is a member of the cytokine receptor superfamily. **Pathways and functions:** * CSF2RB is a ligand for the colony stimulating factor 2 (CSF2) receptor. * It is a key component of the cytokine receptor complex, which is responsible for the signaling pathway of CSF. * CSF2RB signaling is involved in a variety of cellular processes, including cell growth, differentiation, migration, and proliferation. * It is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the CSF2RB gene have been linked to a number of human diseases, including Crohn's disease, ulcerative colitis, and rheumatoid arthritis. * CSF2RB is a potential therapeutic target for these diseases. **Additional information:** * The CSF2RB gene is also known as CD115. * It is a highly conserved protein, with similar sequences found in mammals, birds, and reptiles. * It is a well-characterized protein that has been extensively studied in research.

Genular Protein ID: 1404934905

Symbol: IL3RB_HUMAN

Name: Cytokine receptor common subunit beta

UniProtKB Accession Codes:

P32927 Q5JZI1 Q6ICE0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 2 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 ELM 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 6 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1702217

Title: Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

PubMed ID: 1702217

DOI: 10.1073/pnas.87.24.9655

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 17828305

Title: CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction.

PubMed ID: 17828305

DOI: 10.1038/sj.onc.1210778

PubMed ID: 21075760

Title: Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB.

PubMed ID: 21075760

DOI: 10.1136/jmg.2010.082586

PubMed ID: 1495999

Title: Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

PubMed ID: 1495999

DOI: 10.1073/pnas.89.15.7041

PubMed ID: 9516124

Title: JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation.

PubMed ID: 9516124

PubMed ID: 10736232

Title: The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5.

PubMed ID: 10736232

DOI: 10.1006/jmbi.2000.3610

PubMed ID: 10753826

Title: Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist.

PubMed ID: 10753826

PubMed ID: 11207369

Title: Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration.

PubMed ID: 11207369

DOI: 10.1016/s0092-8674(01)00213-6

PubMed ID: 16754968

Title: An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope.

PubMed ID: 16754968

DOI: 10.1107/s1744309106016812

PubMed ID: 18692472

Title: The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.

PubMed ID: 18692472

DOI: 10.1016/j.cell.2008.05.053

PubMed ID: 9410898

Title: Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression.

PubMed ID: 9410898

DOI: 10.1172/jci119758

Sequence Information:

  • Length: 897
  • Mass: 97336
  • Checksum: 3398E37FDB8F393A
  • Sequence:
    • MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT QDAQRLVNVT 
LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC QSFVVTDVDY FSFQPDRPLG 
TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD 
SWEDAAILLS NTSQATLGPE HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG 
DEAQPQNLEC FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL 
HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD GDSYSLRWET 
MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP ALEPSTRYWA RVRVRTSRTG 
YNGIWSEWSE ARSWDTESVL PMWVLALIVI FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN 
PSKSHLFQNG SAELWPPGSM SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE 
DPKHVCDPPS GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR 
SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ AVEVERRPSQ 
GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG DTEDPGVASG YVSSADLVFT 
PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS GPPGAPGPVK SGFEGYVELP PIEGRSPRSP 
RNNPVPPEAK SPVLNPGERP ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS 
SPGPGPEIKN LDQAFQVKKP PGQAVPQVPV IQLFKALKQQ DYLSLPPWEV NKPGEVC

Genular Protein ID: 1864063333

Symbol: Q6NSJ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NSJ8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 6 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 889
  • Mass: 96173
  • Checksum: 1BD57B91E8CC079F
  • Sequence:
    • MVLAQGLLSM ALLALCWERS LAGAEETIPL QTLRCYNDYT SHITCRWADT QDAQRLVNVT 
LIRRVNEDLL EPVSCDLSDD MPWSACPHPR CVPRRCVIPC QSFVVTDVDY FSFQPDRPLG 
TRLTVTLTQH VQPPEPRDLQ ISTDQDHFLL TWSVALGSPQ SHWLSPGDLE FEVVYKRLQD 
SWEDAAILLS NTSQATLGPE HLMPSSTYVA RVRTRLAPGS RLSGRPSKWS PEVCWDSQPG 
DEAQPQNLEC FFDGAAVLSC SWEVRKEVAS SVSFGLFYKP SPDAGEEECS PVLREGLGSL 
HTRHHCQIPV PDPATHGQYI VSVQPRRAEK HIKSSVNIQM APPSLNVTKD GDSYSLRWET 
MKMRYEHIDH TFEIQYRKDT ATWKDSKTET LQNAHSMALP ALEPSTRYWA RVRVRTSRTG 
YNGIWSEWSE ARSWDTESVL PMWVLALIVI FLTIAVLLAL RFCGIYGYRL RRKWEEKIPN 
PSKSHLFQNG SAELWPPGSM SAFTSGSPPH QGPWGSRFPE LEGVFPVGFG DSEVSPLTIE 
DPKHVCDPPS GPDTTPAASD LPTEQPPSPQ PGPPAASHTP EKQASSFDFN GPYLGPPHSR 
SLPDILGQPE PPQEGGSQKS PPPGSLEYLC LPAGGQVQLV PLAQAMGPGQ AVEVERRPSQ 
GAAGSPSLES GGGPAPPALG PRVGGQDQKD SPVAIPMSSG DTEDPGVASG YVSSADLVFT 
PNSGASSVSL VPSLGLPSDQ TPSLCPGLAS GPPGAPGPVK SGFEGYVELP PIEGRSPRSP 
RNNPVPPEAK SPVLNPGERP ADVSPTSPQP EGLLVLQQVG DYCFLPGLGP GPLSLRSKPS 
SPGPGPEIKN LDQAFQVKKP PGQAVPQVPV IQLFKALVVS VMSVGPPVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.