Genular: Defining Cellular Identity and Function

Details for: Gabra2

Gene ID: 14395

Symbol: Gabra2

Ensembl ID: ENSMUSG00000000560

Description: gamma-aminobutyric acid type A receptor subunit alpha 2

Associated with

Gaba receptor activation
(R-MMU-977443)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Transmission across chemical synapses
(R-MMU-112315)
Axon
(GO:0030424)
Benzodiazepine receptor activity
(GO:0008503)
Cell projection
(GO:0042995)
Chloride channel activity
(GO:0005254)
Chloride channel complex
(GO:0034707)
Chloride transmembrane transport
(GO:1902476)
Chloride transport
(GO:0006821)
Cytoplasmic vesicle
(GO:0031410)
Dendrite
(GO:0030425)
Dendrite membrane
(GO:0032590)
Extracellular ligand-gated monoatomic ion channel activity
(GO:0005230)
Gaba-a receptor activity
(GO:0004890)
Gaba-a receptor complex
(GO:1902711)
Gaba-ergic synapse
(GO:0098982)
Gaba-gated chloride ion channel activity
(GO:0022851)
Gamma-aminobutyric acid signaling pathway
(GO:0007214)
Inhibitory synapse
(GO:0060077)
Inhibitory synapse assembly
(GO:1904862)
Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
(GO:0099507)
Membrane
(GO:0016020)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Nervous system process
(GO:0050877)
Neuronal cell body
(GO:0043025)
Neuron projection
(GO:0043005)
Plasma membrane
(GO:0005886)
Postsynapse
(GO:0098794)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization membrane
(GO:0099634)
Presynaptic active zone membrane
(GO:0048787)
Protein binding
(GO:0005515)
Regulation of postsynaptic membrane potential
(GO:0060078)
Synapse
(GO:0045202)
Synaptic transmission, gabaergic
(GO:0051932)
Synaptic vesicle membrane
(GO:0030672)
Transmembrane signaling receptor activity
(GO:0004888)
Transmembrane transporter complex
(GO:1902495)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Gamma-aminobutyric acid receptor subunit alpha-2

Genular Protein ID: 865443107

Symbol: GBRA2_MOUSE

Name: Gamma-aminobutyric acid receptor subunit alpha-2

UniProtKB Accession Codes:

P26048

Database IDs:

Citations:

PubMed ID: 1356407

Title: The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development.

PubMed ID: 1356407

PubMed ID: 11528422

Title: GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1.

PubMed ID: 11528422

DOI: 10.1038/nn0901-908

PubMed ID: 27129275

Title: Gamma-aminobutyric acid type A (GABAA) receptor subunits play a direct structural role in synaptic contact formation via their N-terminal extracellular domains.

PubMed ID: 27129275

DOI: 10.1074/jbc.m116.714790

PubMed ID: 28978485

Title: An essential role for the tetraspanin LHFPL4 in the cell-type-specific targeting and clustering of synaptic GABAA ceceptors.

PubMed ID: 28978485

DOI: 10.1016/j.celrep.2017.09.025

PubMed ID: 31601770

Title: Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions.

PubMed ID: 31601770

DOI: 10.1126/science.aax5719

Sequence Information:

Length: 451
Mass: 51139
Checksum: C5E47898963A36CF
Sequence:

MKTKLSTCNV WSLLLVLLVW DPVRLVLANI QEDEAKNNIT IFTRILDRLL DGYDNRLRPG 
LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE RLKFKGPMNI LRLNNLMASK 
IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD DGTLLYTMRL TVQAECPMHL EDFPMDAHSC 
PLKFGSYAYT TSEVTYIWTY NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM 
TAHFHLKRKI GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA 
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV NDKKKEKGSV 
MIQNNAYAVA VANYAPNLSK DPVLSTISKS ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM 
SRIVFPVLFG TFNLVYWATY LNREPVLGVS P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gabra2

Associated with

Other Information

The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development. PubMed ID: 1356407

GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. PubMed ID: 11528422

Gamma-aminobutyric acid type A (GABAA) receptor subunits play a direct structural role in synaptic contact formation via their N-terminal extracellular domains. PubMed ID: 27129275