Details for: PARP1P1

Gene ID: 144

Symbol: PARP1P1

Ensembl ID: ENSG00000227105

Description: poly(ADP-ribose) polymerase 1 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8221
    Cell Significance Index: 8.5100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.3748
    Cell Significance Index: 3.3900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.2484
    Cell Significance Index: 3.1200
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1537
    Cell Significance Index: 1.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1033
    Cell Significance Index: 1.4100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0955
    Cell Significance Index: 1.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0720
    Cell Significance Index: 0.7600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0588
    Cell Significance Index: 0.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0264
    Cell Significance Index: 0.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0260
    Cell Significance Index: 1.2100
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0197
    Cell Significance Index: 0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0011
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0017
    Cell Significance Index: -0.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0022
    Cell Significance Index: -0.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0092
    Cell Significance Index: -0.4800
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0164
    Cell Significance Index: -0.1900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0217
    Cell Significance Index: -0.3000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0226
    Cell Significance Index: -0.2900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0236
    Cell Significance Index: -0.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0239
    Cell Significance Index: -0.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0296
    Cell Significance Index: -0.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0311
    Cell Significance Index: -0.6800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0395
    Cell Significance Index: -0.5000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0400
    Cell Significance Index: -0.6000
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0417
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0426
    Cell Significance Index: -0.4300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0564
    Cell Significance Index: -0.7500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0569
    Cell Significance Index: -0.7000
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0577
    Cell Significance Index: -0.6100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0579
    Cell Significance Index: -0.6100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0610
    Cell Significance Index: -0.5900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0616
    Cell Significance Index: -0.7000
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0620
    Cell Significance Index: -0.4300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0621
    Cell Significance Index: -0.6600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0627
    Cell Significance Index: -0.6400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0634
    Cell Significance Index: -0.8900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0680
    Cell Significance Index: -0.7900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0694
    Cell Significance Index: -0.7600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0724
    Cell Significance Index: -0.6800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0735
    Cell Significance Index: -1.0100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0747
    Cell Significance Index: -0.8600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0749
    Cell Significance Index: -0.7200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0767
    Cell Significance Index: -0.9200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0803
    Cell Significance Index: -0.4300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0809
    Cell Significance Index: -0.7300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0840
    Cell Significance Index: -1.0200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0847
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0863
    Cell Significance Index: -0.9600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0875
    Cell Significance Index: -0.8100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0877
    Cell Significance Index: -0.7400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0904
    Cell Significance Index: -1.0100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0909
    Cell Significance Index: -1.0800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0920
    Cell Significance Index: -1.1000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0950
    Cell Significance Index: -1.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0965
    Cell Significance Index: -1.1500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0969
    Cell Significance Index: -1.2100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0987
    Cell Significance Index: -1.0500
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0995
    Cell Significance Index: -1.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1006
    Cell Significance Index: -1.2200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1019
    Cell Significance Index: -1.1100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1042
    Cell Significance Index: -1.3600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1049
    Cell Significance Index: -1.3800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1054
    Cell Significance Index: -1.2000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1063
    Cell Significance Index: -1.1800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1067
    Cell Significance Index: -1.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1067
    Cell Significance Index: -1.2600
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1069
    Cell Significance Index: -1.1600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1070
    Cell Significance Index: -1.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1075
    Cell Significance Index: -1.2700
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1092
    Cell Significance Index: -1.2400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1118
    Cell Significance Index: -1.2800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.1135
    Cell Significance Index: -1.3800
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1147
    Cell Significance Index: -1.3200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1177
    Cell Significance Index: -1.3300
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1192
    Cell Significance Index: -1.3800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1212
    Cell Significance Index: -1.3000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1221
    Cell Significance Index: -1.1100
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1242
    Cell Significance Index: -1.3800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1264
    Cell Significance Index: -1.3600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1310
    Cell Significance Index: -1.4200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1310
    Cell Significance Index: -1.4500
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1321
    Cell Significance Index: -1.2300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1342
    Cell Significance Index: -1.1100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1357
    Cell Significance Index: -1.1200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1358
    Cell Significance Index: -1.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1366
    Cell Significance Index: -1.3000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1366
    Cell Significance Index: -1.4200
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.1370
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1403
    Cell Significance Index: -1.3300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1491
    Cell Significance Index: -1.9500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1533
    Cell Significance Index: -1.3500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1555
    Cell Significance Index: -1.3700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1579
    Cell Significance Index: -1.3800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1647
    Cell Significance Index: -1.9400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1706
    Cell Significance Index: -1.1100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1716
    Cell Significance Index: -1.3200
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1757
    Cell Significance Index: -2.1400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1799
    Cell Significance Index: -1.1300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2157
    Cell Significance Index: -1.2800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.3616
    Cell Significance Index: -2.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** PARP1P1 is a pseudogene, implying that it lacks the ability to produce a functional protein. However, its expression in various cell types suggests that it may play a regulatory or modulatory role in cellular processes. 2. **Widespread expression:** PARP1P1 is significantly expressed in plasma cells, CD4-positive and alpha-beta T cells, macrophages, astrocytes, epithelial cells, and innate lymphoid cells, among others. This broad expression pattern hints at a potential role in maintaining cellular homeostasis and immune function. 3. **Tissue-specific expression:** The expression of PARP1P1 in specific cell types, such as plasma cells and macrophages, suggests that it may be involved in tissue-specific processes, such as immune response and inflammation. **Pathways and Functions:** 1. **DNA repair and repair:** PARP1P1 has been implicated in the regulation of DNA repair pathways, particularly in the context of base excision repair (BER) and nucleotide excision repair (NER). Its expression in cells with high DNA repair capacity, such as macrophages, highlights its potential role in maintaining genome stability. 2. **Cellular stress response:** PARP1P1 has been shown to regulate the cellular response to stress, including oxidative stress and endoplasmic reticulum stress. Its expression in cells exposed to stress suggests that it may play a protective role in maintaining cellular homeostasis. 3. **Immune regulation:** The expression of PARP1P1 in immune cells, such as T cells and macrophages, suggests that it may regulate immune responses, including the activation and proliferation of immune cells. **Clinical Significance:** 1. **Cancer association:** The expression of PARP1P1 in cancer cells, particularly in the context of BRCA1-mutated tumors, has significant implications for cancer therapy. PARP1P1 inhibitors have been shown to enhance the efficacy of chemotherapy in these patients. 2. **Autoimmune diseases:** The expression of PARP1P1 in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, suggests that it may play a role in the pathogenesis of these conditions. Further investigation into the role of PARP1P1 in autoimmune diseases may lead to the development of novel therapeutic strategies. 3. **Infectious diseases:** The expression of PARP1P1 in macrophages and other immune cells suggests that it may play a role in the regulation of immune responses to infectious diseases. Further investigation into the role of PARP1P1 in infectious diseases may lead to the development of novel therapeutic strategies. In conclusion, the PARP1P1 gene, despite its pseudogene status, exhibits intriguing characteristics that warrant further investigation. Its widespread expression in various cell types, regulation of DNA repair and cellular stress response pathways, and potential role in immune regulation and cancer make it an enigmatic gene with significant clinical implications. Further research is needed to fully elucidate the role of PARP1P1 in the immune system and beyond.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.