Gene PARP1P1 - ENSG00000227105 | NCBI Gene ID: 144

Details for: PARP1P1

Gene ID: 144

Symbol: PARP1P1

Ensembl ID: ENSG00000227105

Description: poly(ADP-ribose) polymerase 1 pseudogene 1

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Other Information

Description

**Key characteristics:** * The PARP1P1 gene is located on chromosome 17q21.1. * It is a pseudogene, meaning it is not actively transcribed into a protein. * It is highly expressed in plasma cells, CD4-positive lymphocytes, and malignant cells. * It is also expressed in astrocytes, macrophages, CD4-positive and alpha-beta T cells, innate lymphoid cells, CD8-positive T cells, epithelial cells, and mature NK T cells. **Pathways and functions:** * PARP1P1 is involved in DNA repair pathways by synthesizing PAR fragments that can be used by PARP1 to repair double-strand breaks. * It is also involved in cell cycle regulation by regulating the expression of genes involved in cell cycle checkpoints. * PARP1P1 is a key regulator of cell growth, proliferation, and survival. * It is also involved in inflammation and fibrosis. **Clinical significance:** * Mutations in the PARP1P1 gene have been linked to several human diseases, including breast cancer, lung cancer, and ovarian cancer. * PARP1P1 inhibitors are currently being investigated as potential cancer therapies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.