Details for: CSF3

Gene ID: 1440

Symbol: CSF3

Ensembl ID: ENSG00000108342

Description: colony stimulating factor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.12
    Marker Score: 1409
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.1
    Marker Score: 1108
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.75
    Marker Score: 2961
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.66
    Marker Score: 645
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.25
    Marker Score: 519
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.25
    Marker Score: 615
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.23
    Marker Score: 305
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.21
    Marker Score: 305
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4801
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.13
    Marker Score: 288
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1
    Marker Score: 802.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.05
    Marker Score: 440
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34817
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.01
    Marker Score: 863
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48034.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.94
    Marker Score: 1362
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5312
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.89
    Marker Score: 2270
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.88
    Marker Score: 405
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.88
    Marker Score: 1272
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.84
    Marker Score: 750
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.8
    Marker Score: 180
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.78
    Marker Score: 909
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 510
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 565.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.66
    Marker Score: 705
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.66
    Marker Score: 564.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.62
    Marker Score: 1277
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 385
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1138
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.59
    Marker Score: 633.5
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.58
    Marker Score: 208.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.58
    Marker Score: 319
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.57
    Marker Score: 3746
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.53
    Marker Score: 153
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.53
    Marker Score: 127
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.51
    Marker Score: 146
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.48
    Marker Score: 172
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.45
    Marker Score: 7110
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 254
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.41
    Marker Score: 236
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.41
    Marker Score: 436
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 391
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.4
    Marker Score: 135
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.38
    Marker Score: 6124
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.38
    Marker Score: 164
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.38
    Marker Score: 118
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.37
    Marker Score: 667
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.35
    Marker Score: 314
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.35
    Marker Score: 245
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.32
    Marker Score: 513
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.32
    Marker Score: 317
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 284
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.31
    Marker Score: 178
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.3
    Marker Score: 605
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.28
    Marker Score: 712
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.28
    Marker Score: 75
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.28
    Marker Score: 129
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.28
    Marker Score: 89
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.28
    Marker Score: 357
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.27
    Marker Score: 100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.27
    Marker Score: 264
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.27
    Marker Score: 265
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.27
    Marker Score: 270
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 136
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.26
    Marker Score: 688
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.25
    Marker Score: 130
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.25
    Marker Score: 321
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.25
    Marker Score: 247
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 387
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.24
    Marker Score: 234
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.24
    Marker Score: 50
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.23
    Marker Score: 336
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.23
    Marker Score: 99
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.22
    Marker Score: 1095
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.22
    Marker Score: 365
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.22
    Marker Score: 98

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Other Information

**Key characteristics** * It is a glycoprotein with a molecular weight of approximately 140 kDa. * It is a cytokine that is produced by a variety of cell types in response to inflammatory signals. * It is a key regulator of the immune response. * It is involved in the regulation of inflammation, cell proliferation, and differentiation. **Pathways and functions** * CSF3 is a key regulator of the immune response. It is produced by immune cells, including macrophages, dendritic cells, and neutrophils. * It binds to the Granulocyte Colony-Stimulating Factor Receptor (G-CSF-R) on neutrophils and macrophages. * Upon binding to G-CSF-R, CSF3 is internalized and translocated to the nucleus. * It then binds to the DNA of target genes and activates transcription factors, which leads to the expression of inflammatory genes. * CSF3 also inhibits the activity of the anti-apoptotic protein Bcl-2, which can lead to the survival of damaged cells. **Clinical significance** CSF3 is a critical cytokine in the regulation of inflammation. Mutations in the CSF3 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease. **Conclusion** CSF3 is a key cytokine that plays a critical role in the regulation of inflammation. Its overexpression is associated with a number of inflammatory diseases.

Genular Protein ID: 4015001817

Symbol: CSF3_HUMAN

Name: Granulocyte colony-stimulating factor

UniProtKB Accession Codes:

P09919 A8MXR7

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 CarbonylDB 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3484805

Title: Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor.

PubMed ID: 3484805

DOI: 10.1038/319415a0

PubMed ID: 2423327

Title: The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor.

PubMed ID: 2423327

DOI: 10.1002/j.1460-2075.1986.tb04249.x

PubMed ID: 3494801

Title: Expression of granulocyte colony-stimulating factor by human cell lines.

PubMed ID: 3494801

DOI: 10.1002/jlb.41.4.302

PubMed ID: 15028279

Title: PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.

PubMed ID: 15028279

DOI: 10.1016/j.ygeno.2003.09.023

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 2420009

Title: Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells.

PubMed ID: 2420009

DOI: 10.1126/science.2420009

PubMed ID: 8554326

Title: Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region.

PubMed ID: 8554326

DOI: 10.1006/abbi.1995.0047

PubMed ID: 7685769

Title: Glycosidase digestion, electrophoresis and chromatographic analysis of recombinant human granulocyte colony-stimulating factor glycoforms produced in Chinese hamster ovary cells.

PubMed ID: 7685769

DOI: 10.1016/0021-9673(93)83098-d

PubMed ID: 1281794

Title: Secondary structure of human granulocyte colony-stimulating factor derived from NMR spectroscopy.

PubMed ID: 1281794

DOI: 10.1016/0014-5793(92)81521-m

PubMed ID: 7518249

Title: Structure and dynamics of the human granulocyte colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix-bundle protein.

PubMed ID: 7518249

DOI: 10.1021/bi00194a009

PubMed ID: 7685117

Title: The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.

PubMed ID: 7685117

DOI: 10.1073/pnas.90.11.5167

PubMed ID: 10537111

Title: Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme.

PubMed ID: 10537111

DOI: 10.1038/44394

PubMed ID: 16492764

Title: Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex.

PubMed ID: 16492764

DOI: 10.1073/pnas.0511264103

Sequence Information:

  • Length: 207
  • Mass: 22293
  • Checksum: 421F635ECC776996
  • Sequence:
    • MAGPATQSPM KLMALQLLLW HSALWTVQEA TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA 
LQEKLVSECA TYKLCHPEEL VLLGHSLGIP WAPLSSCPSQ ALQLAGCLSQ LHSGLFLYQG 
LLQALEGISP ELGPTLDTLQ LDVADFATTI WQQMEELGMA PALQPTQGAM PAFASAFQRR 
AGGVLVASHL QSFLEVSYRV LRHLAQP

Genular Protein ID: 142117710

Symbol: Q8N4W3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N4W3

Database IDs:

ARBA 6 Allergome 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 4 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 200
  • Mass: 21543
  • Checksum: 8648AA55B329A96C
  • Sequence:
    • MSPEPALSPA LQLLLWHSAL WTVQEATPLG PASSLPQSFL LKCLEQVRKI QGDGAALQEK 
LCATYKLCHP EELVLLGHSL GIPWAPLSSC PSQALQLAGC LSQLHSGLFL YQGLLQALEG 
ISPELGPTLD TLQLDVADFA TTIWQQMEEL GMAPALQPTQ GAMPAFASAF QRRAGGVLVA 
SHLQSFLEVS YRVLRHLAQP

Genular Protein ID: 1276945798

Symbol: Q6FH65_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6FH65

Database IDs:

ARBA 6 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 ExpressionAtlas 1 GO 9 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 204
  • Mass: 21978
  • Checksum: 5F07C52F13D6A6D3
  • Sequence:
    • MAGPATQSPM KLMALQLLLW HSALWTVQEA TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA 
LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ 
ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG 
VLVASHLQSF LEVSYRVLRH LAQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.