Genular: Defining Cellular Identity and Function

Details for: Gabrb3

Gene ID: 14402

Symbol: Gabrb3

Ensembl ID: ENSMUSG00000033676

Description: GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3

Associated with

Gaba receptor activation
(R-MMU-977443)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Transmission across chemical synapses
(R-MMU-112315)
Ap-2 adaptor complex binding
(GO:0035612)
Brain development
(GO:0007420)
Cell surface
(GO:0009986)
Cellular response to histamine
(GO:0071420)
Cellular response to zinc ion
(GO:0071294)
Cerebellum development
(GO:0021549)
Chemical synaptic transmission
(GO:0007268)
Chloride channel activity
(GO:0005254)
Chloride channel complex
(GO:0034707)
Chloride transmembrane transport
(GO:1902476)
Chloride transport
(GO:0006821)
Circadian sleep/wake cycle, rem sleep
(GO:0042747)
Cochlea development
(GO:0090102)
Cytoplasmic vesicle
(GO:0031410)
Exploration behavior
(GO:0035640)
Extracellular ligand-gated monoatomic ion channel activity
(GO:0005230)
Gaba-a receptor activity
(GO:0004890)
Gaba-a receptor complex
(GO:1902711)
Gaba-ergic synapse
(GO:0098982)
Gaba-gated chloride ion channel activity
(GO:0022851)
Gamma-aminobutyric acid signaling pathway
(GO:0007214)
Hard palate development
(GO:0060022)
Identical protein binding
(GO:0042802)
Inhibitory postsynaptic potential
(GO:0060080)
Inhibitory synapse
(GO:0060077)
Inhibitory synapse assembly
(GO:1904862)
Inner ear receptor cell development
(GO:0060119)
Innervation
(GO:0060384)
Learning
(GO:0007612)
Membrane
(GO:0016020)
Memory
(GO:0007613)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Motor behavior
(GO:0061744)
Nervous system development
(GO:0007399)
Nervous system process
(GO:0050877)
Neuron development
(GO:0048666)
Neuron projection
(GO:0043005)
Neurotransmitter receptor activity
(GO:0030594)
Plasma membrane
(GO:0005886)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization membrane
(GO:0099634)
Protein binding
(GO:0005515)
Regulation of membrane potential
(GO:0042391)
Reproductive behavior
(GO:0019098)
Response to anesthetic
(GO:0072347)
Response to xenobiotic stimulus
(GO:0009410)
Roof of mouth development
(GO:0060021)
Social behavior
(GO:0035176)
Synapse
(GO:0045202)
Synaptic transmission, gabaergic
(GO:0051932)
Terminal bouton
(GO:0043195)
Transmembrane signaling receptor activity
(GO:0004888)
Transmembrane transporter complex
(GO:1902495)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Gamma-aminobutyric acid receptor subunit beta-3
Q8C446_MOUSE

Genular Protein ID: 3508877516

Symbol: GBRB3_MOUSE

Name: Gamma-aminobutyric acid receptor subunit beta-3

UniProtKB Accession Codes:

P63080 P15433 Q3UHR3

Database IDs:

Citations:

PubMed ID: 7893750

Title: GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice.

PubMed ID: 7893750

DOI: 10.1016/0167-4781(95)00009-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9108119

Title: Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.

PubMed ID: 9108119

DOI: 10.1073/pnas.94.8.4143

PubMed ID: 10670447

Title: Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor.

PubMed ID: 10670447

DOI: 10.1016/s0306-4522(99)00481-9

PubMed ID: 27129275

Title: Gamma-aminobutyric acid type A (GABAA) receptor subunits play a direct structural role in synaptic contact formation via their N-terminal extracellular domains.

PubMed ID: 27129275

DOI: 10.1074/jbc.m116.714790

PubMed ID: 28978485

Title: An essential role for the tetraspanin LHFPL4 in the cell-type-specific targeting and clustering of synaptic GABAA ceceptors.

PubMed ID: 28978485

DOI: 10.1016/j.celrep.2017.09.025

Sequence Information:

Length: 473
Mass: 54166
Checksum: 6A5ABD8A9143FE45
Sequence:

MWGFAGGRLF GIFSAPVLVA VVCCAQSVND PGNMSFVKET VDKLLKGYDI RLRPDFGGPP 
VCVGMNIDIA SIDMVSEVNM DYTLTMYFQQ YWRDKRLAYS GIPLNLTLDN RVADQLWVPD 
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE 
SYGYTTDDIE FYWRGGDKAV TGVERIELPQ FSIVEHRLVS RNVVFATGAY PRLSLSFRLK 
RNIGYFILQT YMPSILITIL SWVSFWINYD ASAARVALGI TTVLTMTTIN THLRETLPKI 
PYVKAIDMYL MGCFVFVFLA LLEYAFVNYI FFGRGPQRQK KLAEKTAKAK NDRSKSEINR 
VDAHGNILLA PMDVHNEMNE VAGSVGDTRN SAISFDNSGI QYRKQSMPKE GHGRYMGDRS 
IPHKKTHLRR RSSQLKIKIP DLTDVNAIDR WSRIVFPFTF SLFNLVYWLY YVN

Genular Protein ID: 3964543041

Symbol: Q8C446_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C446

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 473
Mass: 54283
Checksum: 47EE0A3718BAD116
Sequence:

MCSGLQALLL PIWLSWTLGT RGSEPSSVND PGNMSFVKET VDKLLKGYDI RLRPDFGGPP 
VCVGMNIDIA SIDMVSEVNM DYTLTMYFQQ YWRDKRLAYS GIPLNLTLDN RVADQLWVPD 
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE 
SYGYTTDDIE FYWRGGDKAV TGVERIELPQ FSIVEHRLVS RNVVFATGAY PRLSLSFRLK 
RNIGYFILQT YMPSILITIL SWVSFWINYD ASAARVALGI TTVLTMTTIN THLRETLPKI 
PYVKAIDMYL MGCFVFVFLA LLEYAFVNYI FFGRGPQRQK KLAEKTAKAK NDRSKSEINR 
VDAHGNILLA PMDVHNEMNE VAGSVGDTRN SAISFDNSGI QYRKQSMPKE GHGRYMGDRS 
IPHKKTHLRR RSSQLKIKIP DLTDVNAIDR WSRIVFPFTF SLFNLVYWLY YVN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gabrb3

Associated with

Other Information

GABAA receptor beta 1, beta 2, and beta 3 subunits: comparisons in DBA/2J and C57BL/6J mice. PubMed ID: 7893750

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior. PubMed ID: 9108119

Sensory thresholds and the antinociceptive effects of GABA receptor agonists in mice lacking the beta3 subunit of the GABA(A) receptor. PubMed ID: 10670447

Gamma-aminobutyric acid type A (GABAA) receptor subunits play a direct structural role in synaptic contact formation via their N-terminal extracellular domains. PubMed ID: 27129275

An essential role for the tetraspanin LHFPL4 in the cell-type-specific targeting and clustering of synaptic GABAA ceceptors. PubMed ID: 28978485

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303