Genular: Defining Cellular Identity and Function

Details for: Gabrg2

Gene ID: 14406

Symbol: Gabrg2

Ensembl ID: ENSMUSG00000020436

Description: gamma-aminobutyric acid type A receptor, subunit gamma 2

Associated with

Gaba receptor activation
(R-MMU-977443)
Neuronal system
(R-MMU-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-MMU-112314)
Transmission across chemical synapses
(R-MMU-112315)
Adult behavior
(GO:0030534)
Axon
(GO:0030424)
Benzodiazepine receptor activity
(GO:0008503)
Cell projection
(GO:0042995)
Cellular response to histamine
(GO:0071420)
Chemical synaptic transmission
(GO:0007268)
Chemical synaptic transmission, postsynaptic
(GO:0099565)
Chloride channel activity
(GO:0005254)
Chloride channel complex
(GO:0034707)
Chloride transmembrane transport
(GO:1902476)
Chloride transport
(GO:0006821)
Cytoplasmic vesicle
(GO:0031410)
Dendrite membrane
(GO:0032590)
Extracellular ligand-gated monoatomic ion channel activity
(GO:0005230)
Gaba-a receptor activity
(GO:0004890)
Gaba-a receptor complex
(GO:1902711)
Gaba-ergic synapse
(GO:0098982)
Gaba-gated chloride ion channel activity
(GO:0022851)
Gaba receptor activity
(GO:0016917)
Gaba receptor complex
(GO:1902710)
Gamma-aminobutyric acid signaling pathway
(GO:0007214)
Glutamatergic synapse
(GO:0098978)
Inhibitory synapse
(GO:0060077)
Inhibitory synapse assembly
(GO:1904862)
Membrane
(GO:0016020)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Nervous system process
(GO:0050877)
Neuron projection
(GO:0043005)
Neurotransmitter receptor activity
(GO:0030594)
Plasma membrane
(GO:0005886)
Post-embryonic development
(GO:0009791)
Postsynapse
(GO:0098794)
Postsynaptic membrane
(GO:0045211)
Postsynaptic specialization membrane
(GO:0099634)
Protein binding
(GO:0005515)
Regulation of postsynaptic membrane potential
(GO:0060078)
Synapse
(GO:0045202)
Synaptic transmission, gabaergic
(GO:0051932)
Transmembrane signaling receptor activity
(GO:0004888)
Transmembrane transporter complex
(GO:1902495)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Other Information

Proteins

Gamma-aminobutyric acid receptor subunit gamma-2

Genular Protein ID: 1023677651

Symbol: GBRG2_MOUSE

Name: Gamma-aminobutyric acid receptor subunit gamma-2

UniProtKB Accession Codes:

P22723 Q91V50 Q91VA8

Database IDs:

Citations:

PubMed ID: 1846404

Title: Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.

PubMed ID: 1846404

DOI: 10.1111/j.1471-4159.1991.tb08209.x

PubMed ID: 11003197

Title: Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice.

PubMed ID: 11003197

DOI: 10.1111/j.1530-0277.2000.tb02100.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15229235

Title: The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ.

PubMed ID: 15229235

DOI: 10.1523/jneurosci.1037-04.2004

PubMed ID: 15207850

Title: Palmitoylation regulates the clustering and cell surface stability of GABAA receptors.

PubMed ID: 15207850

DOI: 10.1016/j.mcn.2004.01.012

PubMed ID: 17151279

Title: GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses.

PubMed ID: 17151279

DOI: 10.1523/jneurosci.4214-06.2006

PubMed ID: 18281286

Title: Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses.

PubMed ID: 18281286

DOI: 10.1074/jbc.m709993200

PubMed ID: 25172774

Title: The kinesin KIF21B participates in the cell surface delivery of gamma2 subunit-containing GABAA receptors.

PubMed ID: 25172774

DOI: 10.1016/j.ejcb.2014.07.007

PubMed ID: 27129275

Title: Gamma-aminobutyric acid type A (GABAA) receptor subunits play a direct structural role in synaptic contact formation via their N-terminal extracellular domains.

PubMed ID: 27129275

DOI: 10.1074/jbc.m116.714790

PubMed ID: 28978485

Title: An essential role for the tetraspanin LHFPL4 in the cell-type-specific targeting and clustering of synaptic GABAA ceceptors.

PubMed ID: 28978485

DOI: 10.1016/j.celrep.2017.09.025

PubMed ID: 28279354

Title: GARLH family proteins stabilize GABAA receptors at synapses.

PubMed ID: 28279354

DOI: 10.1016/j.neuron.2017.02.023

PubMed ID: 29742426

Title: Impairment of inhibitory synapse formation and motor behavior in mice lacking the NL2 binding partner LHFPL4/GARLH4.

PubMed ID: 29742426

DOI: 10.1016/j.celrep.2018.04.015

PubMed ID: 31601770

Title: Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions.

PubMed ID: 31601770

DOI: 10.1126/science.aax5719

Sequence Information:

Length: 474
Mass: 55099
Checksum: 45BD61649C296EA9
Sequence:

MSSPNTWSIG SSVYSPVFSQ KMTLWILLLL SLYPGFTSQK SDDDYEDYAS NKTWVLTPKV 
PEGDVTVILN NLLEGYDNKL RPDIGVKPTL IHTDMYVNSI GPVNAINMEY TIDIFFAQTW 
YDRRLKFNST IKVLRLNSNM VGKIWIPDTF FRNSKKADAH WITTPNRMLR IWNDGRVLYT 
LRLTIDAECQ LQLHNFPMDE HSCPLEFSSY GYPREEIVYQ WKRSSVEVGD TRSWRLYQFS 
FVGLRNTTEV VKTTSGDYVV MSVYFDLSRR MGYFTIQTYI PCTLIVVLSW VSFWINKDAV 
PARTSLGITT VLTMTTLSTI ARKSLPKVSY VTAMDLFVSV CFIFVFSALV EYGTLHYFVS 
NRKPSKDKDK KKKNPLLRMF SFKAPTIDIR PRSATIQMNN ATHLQERDEE YGYECLDGKD 
CASFFCCFED CRTGAWRHGR IHIRIAKMDS YARIFFPTAF CLFNLVYWVS YLYL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gabrg2

Associated with

Other Information

Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing. PubMed ID: 1846404

Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice. PubMed ID: 11003197

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. PubMed ID: 15229235

Palmitoylation regulates the clustering and cell surface stability of GABAA receptors. PubMed ID: 15207850

GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. PubMed ID: 17151279

Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses. PubMed ID: 18281286

The kinesin KIF21B participates in the cell surface delivery of gamma2 subunit-containing GABAA receptors. PubMed ID: 25172774

Gamma-aminobutyric acid type A (GABAA) receptor subunits play a direct structural role in synaptic contact formation via their N-terminal extracellular domains. PubMed ID: 27129275

An essential role for the tetraspanin LHFPL4 in the cell-type-specific targeting and clustering of synaptic GABAA ceceptors. PubMed ID: 28978485

GARLH family proteins stabilize GABAA receptors at synapses. PubMed ID: 28279354

Impairment of inhibitory synapse formation and motor behavior in mice lacking the NL2 binding partner LHFPL4/GARLH4. PubMed ID: 29742426

Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions. PubMed ID: 31601770