Details for: CSF3R

Gene ID: 1441

Symbol: CSF3R

Ensembl ID: ENSG00000119535

Description: colony stimulating factor 3 receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.9557
    Cell Significance Index: -13.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.1533
    Cell Significance Index: -12.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.5754
    Cell Significance Index: -13.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.6003
    Cell Significance Index: -12.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7952
    Cell Significance Index: -13.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 9.1648
    Cell Significance Index: 244.7200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.2180
    Cell Significance Index: 33.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.7996
    Cell Significance Index: 88.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.6337
    Cell Significance Index: 97.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4693
    Cell Significance Index: -13.6900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.0991
    Cell Significance Index: 20.5600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.0341
    Cell Significance Index: 31.4700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.2420
    Cell Significance Index: 20.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7268
    Cell Significance Index: 144.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6823
    Cell Significance Index: 17.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3164
    Cell Significance Index: 36.8700
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.2591
    Cell Significance Index: 2.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1788
    Cell Significance Index: 135.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0833
    Cell Significance Index: 6.2100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0168
    Cell Significance Index: 0.1600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0121
    Cell Significance Index: 0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0005
    Cell Significance Index: 0.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0031
    Cell Significance Index: -0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -7.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0094
    Cell Significance Index: -17.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0103
    Cell Significance Index: -15.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0189
    Cell Significance Index: -5.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0226
    Cell Significance Index: -12.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0234
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0236
    Cell Significance Index: -14.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0263
    Cell Significance Index: -14.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0285
    Cell Significance Index: -3.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0305
    Cell Significance Index: -13.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0320
    Cell Significance Index: -11.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0326
    Cell Significance Index: -14.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0481
    Cell Significance Index: -9.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0707
    Cell Significance Index: -14.8900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0728
    Cell Significance Index: -0.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0753
    Cell Significance Index: -10.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0808
    Cell Significance Index: -13.7900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0923
    Cell Significance Index: -1.3500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0928
    Cell Significance Index: -1.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0935
    Cell Significance Index: -4.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0989
    Cell Significance Index: -12.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1146
    Cell Significance Index: -13.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1155
    Cell Significance Index: -12.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1192
    Cell Significance Index: -5.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1231
    Cell Significance Index: -15.7800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1238
    Cell Significance Index: -2.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1414
    Cell Significance Index: -9.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1418
    Cell Significance Index: -16.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1452
    Cell Significance Index: -1.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1498
    Cell Significance Index: -6.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1526
    Cell Significance Index: -7.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1654
    Cell Significance Index: -8.5900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.1693
    Cell Significance Index: -1.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1727
    Cell Significance Index: -13.2600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1739
    Cell Significance Index: -7.5600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1955
    Cell Significance Index: -1.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1997
    Cell Significance Index: -5.5800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2029
    Cell Significance Index: -2.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2047
    Cell Significance Index: -14.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2198
    Cell Significance Index: -14.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2206
    Cell Significance Index: -13.5600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2354
    Cell Significance Index: -14.4300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2500
    Cell Significance Index: -2.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2532
    Cell Significance Index: -4.3000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2538
    Cell Significance Index: -2.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2679
    Cell Significance Index: -15.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2796
    Cell Significance Index: -14.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2857
    Cell Significance Index: -6.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3172
    Cell Significance Index: -14.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3184
    Cell Significance Index: -14.4300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3210
    Cell Significance Index: -11.1600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3231
    Cell Significance Index: -2.6400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3356
    Cell Significance Index: -4.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3560
    Cell Significance Index: -13.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3611
    Cell Significance Index: -12.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3673
    Cell Significance Index: -23.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3697
    Cell Significance Index: -14.0000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3702
    Cell Significance Index: -3.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3739
    Cell Significance Index: -12.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3862
    Cell Significance Index: -12.3000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3875
    Cell Significance Index: -4.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4082
    Cell Significance Index: -19.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4192
    Cell Significance Index: -14.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4512
    Cell Significance Index: -13.2900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.4652
    Cell Significance Index: -3.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4747
    Cell Significance Index: -13.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4781
    Cell Significance Index: -13.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4828
    Cell Significance Index: -12.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4963
    Cell Significance Index: -14.3000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4973
    Cell Significance Index: -7.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4985
    Cell Significance Index: -12.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5132
    Cell Significance Index: -13.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5172
    Cell Significance Index: -13.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The CSF3R gene encodes a receptor protein that is critical for the binding and signaling of G-CSF, a cytokine that stimulates the production and maturation of neutrophils and monocytes. The receptor consists of two subunits, α and β, which are composed of immunoglobulin-like domains and are responsible for ligand binding and signal transduction. The CSF3R gene is characterized by its high expression in cells of the myeloid lineage, including early promyelocytes, monocytes, and microglial cells, which suggests its role in the regulation of myeloid cell differentiation. **Pathways and Functions** The CSF3R gene is involved in several signaling pathways, including: 1. **G-CSF signaling pathway**: The CSF3R receptor is the primary component of the G-CSF signaling pathway, which regulates the production and maturation of neutrophils and monocytes. 2. **Cytokine-mediated signaling pathway**: The CSF3R receptor is also involved in the signaling of other cytokines, including interleukins and granulocyte-macrophage colony-stimulating factor (GM-CSF). 3. **Cell adhesion**: The CSF3R receptor plays a role in cell adhesion, particularly in the interaction between neutrophils and endothelial cells. 4. **Immune system regulation**: The CSF3R gene is involved in the regulation of immune responses, including the activation of macrophages and the production of cytokines. **Clinical Significance** The CSF3R gene has significant clinical implications, particularly in the treatment of hematological disorders. Dysregulation of the G-CSF signaling pathway has been implicated in various conditions, including: 1. **Acute myeloid leukemia**: Abnormal expression of the CSF3R gene has been observed in acute myeloid leukemia (AML), suggesting its role in the development and progression of this disease. 2. **Chronic neutrophilic leukemia**: The CSF3R gene has been identified as a potential target for therapy in chronic neutrophilic leukemia (CNL), a rare type of leukemia characterized by an overproduction of neutrophils. 3. **Autoimmune disorders**: The CSF3R gene may also play a role in the development of autoimmune disorders, such as rheumatoid arthritis, where abnormal expression of the receptor has been observed. In conclusion, the CSF3R gene is a critical regulator of myeloid cell differentiation and the immune system, and its dysregulation has significant clinical implications in various hematological disorders. Further research is needed to fully understand the role of the CSF3R gene in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 1665202947

Symbol: CSF3R_HUMAN

Name: Granulocyte colony-stimulating factor receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2147944

Title: Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.

PubMed ID: 2147944

DOI: 10.1084/jem.172.6.1559

PubMed ID: 1701053

Title: Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.

PubMed ID: 1701053

DOI: 10.1073/pnas.87.22.8702

PubMed ID: 1530796

Title: Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor.

PubMed ID: 1530796

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8554326

Title: Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region.

PubMed ID: 8554326

DOI: 10.1006/abbi.1995.0047

PubMed ID: 1717255

Title: Functional domains of the granulocyte colony-stimulating factor receptor.

PubMed ID: 1717255

DOI: 10.1002/j.1460-2075.1991.tb07835.x

PubMed ID: 7514305

Title: Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.

PubMed ID: 7514305

DOI: 10.1073/pnas.91.10.4480

PubMed ID: 17127321

Title: Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders.

PubMed ID: 17127321

DOI: 10.2741/2103

PubMed ID: 19120359

Title: Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia.

PubMed ID: 19120359

DOI: 10.1111/j.1365-2141.2008.07425.x

PubMed ID: 9187659

Title: Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.

PubMed ID: 9187659

DOI: 10.1038/nsb0697-498

PubMed ID: 9368043

Title: Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis.

PubMed ID: 9368043

DOI: 10.1074/jbc.272.47.29735

PubMed ID: 16492764

Title: Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex.

PubMed ID: 16492764

DOI: 10.1073/pnas.0511264103

PubMed ID: 10449521

Title: Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment.

PubMed ID: 10449521

DOI: 10.1084/jem.190.4.497

PubMed ID: 19620628

Title: An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.

PubMed ID: 19620628

DOI: 10.1084/jem.20090693

PubMed ID: 24753537

Title: Inherited biallelic CSF3R mutations in severe congenital neutropenia.

PubMed ID: 24753537

DOI: 10.1182/blood-2013-11-535419

PubMed ID: 26324699

Title: GM-CSF stimulates granulopoiesis in a congenital neutropenia patient with loss-of-function biallelic heterozygous CSF3R mutations.

PubMed ID: 26324699

DOI: 10.1182/blood-2015-07-661264

Sequence Information:

  • Length: 836
  • Mass: 92156
  • Checksum: 3531ADDC979D4BC3
  • Sequence:
  • MARLGNCSLT WAALIILLLP GSLEECGHIS VSAPIVHLGD PITASCIIKQ NCSHLDPEPQ 
    ILWRLGAELQ PGGRQQRLSD GTQESIITLP HLNHTQAFLS CCLNWGNSLQ ILDQVELRAG 
    YPPAIPHNLS CLMNLTTSSL ICQWEPGPET HLPTSFTLKS FKSRGNCQTQ GDSILDCVPK 
    DGQSHCCIPR KHLLLYQNMG IWVQAENALG TSMSPQLCLD PMDVVKLEPP MLRTMDPSPE 
    AAPPQAGCLQ LCWEPWQPGL HINQKCELRH KPQRGEASWA LVGPLPLEAL QYELCGLLPA 
    TAYTLQIRCI RWPLPGHWSD WSPSLELRTT ERAPTVRLDT WWRQRQLDPR TVQLFWKPVP 
    LEEDSGRIQG YVVSWRPSGQ AGAILPLCNT TELSCTFHLP SEAQEVALVA YNSAGTSRPT 
    PVVFSESRGP ALTRLHAMAR DPHSLWVGWE PPNPWPQGYV IEWGLGPPSA SNSNKTWRME 
    QNGRATGFLL KENIRPFQLY EIIVTPLYQD TMGPSQHVYA YSQEMAPSHA PELHLKHIGK 
    TWAQLEWVPE PPELGKSPLT HYTIFWTNAQ NQSFSAILNA SSRGFVLHGL EPASLYHIHL 
    MAASQAGATN STVLTLMTLT PEGSELHIIL GLFGLLLLLT CLCGTAWLCC SPNRKNPLWP 
    SVPDPAHSSL GSWVPTIMEE DAFQLPGLGT PPITKLTVLE EDEKKPVPWE SHNSSETCGL 
    PTLVQTYVLQ GDPRAVSTQP QSQSGTSDQV LYGQLLGSPT SPGPGHYLRC DSTQPLLAGL 
    TPSPKSYENL WFQASPLGTL VTPAPSQEDD CVFGPLLNFP LLQGIRVHGM EALGSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.