Details for: CSF3R
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 85.9557
Cell Significance Index: -13.3700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 30.1533
Cell Significance Index: -12.2500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 26.5754
Cell Significance Index: -13.6700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 12.6003
Cell Significance Index: -12.0300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 10.7952
Cell Significance Index: -13.3100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 9.1648
Cell Significance Index: 244.7200 - Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.2180
Cell Significance Index: 33.3100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.7996
Cell Significance Index: 88.7100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 3.6337
Cell Significance Index: 97.2000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.4693
Cell Significance Index: -13.6900 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.0991
Cell Significance Index: 20.5600 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 2.0341
Cell Significance Index: 31.4700 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.2420
Cell Significance Index: 20.8900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7268
Cell Significance Index: 144.2400 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.6823
Cell Significance Index: 17.4300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3164
Cell Significance Index: 36.8700 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.2591
Cell Significance Index: 2.8300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1788
Cell Significance Index: 135.3600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0833
Cell Significance Index: 6.2100 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.0168
Cell Significance Index: 0.1600 - Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.0121
Cell Significance Index: 0.1000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0005
Cell Significance Index: 0.0600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0031
Cell Significance Index: -0.5500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0037
Cell Significance Index: -7.0100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0094
Cell Significance Index: -17.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0103
Cell Significance Index: -15.8400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0131
Cell Significance Index: -17.8600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0179
Cell Significance Index: -11.3600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0179
Cell Significance Index: -13.1300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0189
Cell Significance Index: -5.4500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0200
Cell Significance Index: -14.8500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0226
Cell Significance Index: -12.3400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0234
Cell Significance Index: -2.3900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0236
Cell Significance Index: -14.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0263
Cell Significance Index: -14.8500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0285
Cell Significance Index: -3.9100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0305
Cell Significance Index: -13.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0320
Cell Significance Index: -11.4900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0326
Cell Significance Index: -14.4300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0481
Cell Significance Index: -9.6600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0707
Cell Significance Index: -14.8900 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.0728
Cell Significance Index: -0.5900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0753
Cell Significance Index: -10.9400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0808
Cell Significance Index: -13.7900 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.0923
Cell Significance Index: -1.3500 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: -0.0928
Cell Significance Index: -1.1200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0935
Cell Significance Index: -4.7200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0989
Cell Significance Index: -12.7800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1146
Cell Significance Index: -13.5200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1155
Cell Significance Index: -12.0300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1192
Cell Significance Index: -5.6000 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1231
Cell Significance Index: -15.7800 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.1238
Cell Significance Index: -2.4200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1414
Cell Significance Index: -9.1200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1418
Cell Significance Index: -16.2500 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.1452
Cell Significance Index: -1.9300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1498
Cell Significance Index: -6.1400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1526
Cell Significance Index: -7.9500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1654
Cell Significance Index: -8.5900 - Cell Name: trophoblast giant cell (CL0002488)
Fold Change: -0.1693
Cell Significance Index: -1.2200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1727
Cell Significance Index: -13.2600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1739
Cell Significance Index: -7.5600 - Cell Name: classical monocyte (CL0000860)
Fold Change: -0.1955
Cell Significance Index: -1.8200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1997
Cell Significance Index: -5.5800 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: -0.2029
Cell Significance Index: -2.5100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2047
Cell Significance Index: -14.4800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2198
Cell Significance Index: -14.7800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2206
Cell Significance Index: -13.5600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2354
Cell Significance Index: -14.4300 - Cell Name: microglial cell (CL0000129)
Fold Change: -0.2500
Cell Significance Index: -2.9400 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.2532
Cell Significance Index: -4.3000 - Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: -0.2538
Cell Significance Index: -2.1500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2679
Cell Significance Index: -15.0400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2796
Cell Significance Index: -14.6800 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2857
Cell Significance Index: -6.9200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3172
Cell Significance Index: -14.0300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3184
Cell Significance Index: -14.4300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3210
Cell Significance Index: -11.1600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3231
Cell Significance Index: -2.6400 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.3356
Cell Significance Index: -4.7100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.3560
Cell Significance Index: -13.0700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3611
Cell Significance Index: -12.6500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3673
Cell Significance Index: -23.1500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3697
Cell Significance Index: -14.0000 - Cell Name: macrophage (CL0000235)
Fold Change: -0.3702
Cell Significance Index: -3.7800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3739
Cell Significance Index: -12.2400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3862
Cell Significance Index: -12.3000 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.3875
Cell Significance Index: -4.9900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4082
Cell Significance Index: -19.0300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4192
Cell Significance Index: -14.7300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4512
Cell Significance Index: -13.2900 - Cell Name: blood cell (CL0000081)
Fold Change: -0.4652
Cell Significance Index: -3.9700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4747
Cell Significance Index: -13.9400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4781
Cell Significance Index: -13.7100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4828
Cell Significance Index: -12.4100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4963
Cell Significance Index: -14.3000 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.4973
Cell Significance Index: -7.2200 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4985
Cell Significance Index: -12.4300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5132
Cell Significance Index: -13.7500 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5172
Cell Significance Index: -13.6000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1665202947
Symbol: CSF3R_HUMAN
Name: Granulocyte colony-stimulating factor receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2147944
Title: Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains.
PubMed ID: 2147944
PubMed ID: 1701053
Title: Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.
PubMed ID: 1701053
PubMed ID: 1530796
Title: Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor.
PubMed ID: 1530796
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8554326
Title: Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region.
PubMed ID: 8554326
PubMed ID: 1717255
Title: Functional domains of the granulocyte colony-stimulating factor receptor.
PubMed ID: 1717255
PubMed ID: 7514305
Title: Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia.
PubMed ID: 7514305
PubMed ID: 17127321
Title: Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders.
PubMed ID: 17127321
DOI: 10.2741/2103
PubMed ID: 19120359
Title: Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia.
PubMed ID: 19120359
PubMed ID: 9187659
Title: Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand.
PubMed ID: 9187659
DOI: 10.1038/nsb0697-498
PubMed ID: 9368043
Title: Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis.
PubMed ID: 9368043
PubMed ID: 16492764
Title: Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex.
PubMed ID: 16492764
PubMed ID: 10449521
Title: Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment.
PubMed ID: 10449521
PubMed ID: 19620628
Title: An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.
PubMed ID: 19620628
DOI: 10.1084/jem.20090693
PubMed ID: 24753537
Title: Inherited biallelic CSF3R mutations in severe congenital neutropenia.
PubMed ID: 24753537
PubMed ID: 26324699
Title: GM-CSF stimulates granulopoiesis in a congenital neutropenia patient with loss-of-function biallelic heterozygous CSF3R mutations.
PubMed ID: 26324699
Sequence Information:
- Length: 836
- Mass: 92156
- Checksum: 3531ADDC979D4BC3
- Sequence:
MARLGNCSLT WAALIILLLP GSLEECGHIS VSAPIVHLGD PITASCIIKQ NCSHLDPEPQ ILWRLGAELQ PGGRQQRLSD GTQESIITLP HLNHTQAFLS CCLNWGNSLQ ILDQVELRAG YPPAIPHNLS CLMNLTTSSL ICQWEPGPET HLPTSFTLKS FKSRGNCQTQ GDSILDCVPK DGQSHCCIPR KHLLLYQNMG IWVQAENALG TSMSPQLCLD PMDVVKLEPP MLRTMDPSPE AAPPQAGCLQ LCWEPWQPGL HINQKCELRH KPQRGEASWA LVGPLPLEAL QYELCGLLPA TAYTLQIRCI RWPLPGHWSD WSPSLELRTT ERAPTVRLDT WWRQRQLDPR TVQLFWKPVP LEEDSGRIQG YVVSWRPSGQ AGAILPLCNT TELSCTFHLP SEAQEVALVA YNSAGTSRPT PVVFSESRGP ALTRLHAMAR DPHSLWVGWE PPNPWPQGYV IEWGLGPPSA SNSNKTWRME QNGRATGFLL KENIRPFQLY EIIVTPLYQD TMGPSQHVYA YSQEMAPSHA PELHLKHIGK TWAQLEWVPE PPELGKSPLT HYTIFWTNAQ NQSFSAILNA SSRGFVLHGL EPASLYHIHL MAASQAGATN STVLTLMTLT PEGSELHIIL GLFGLLLLLT CLCGTAWLCC SPNRKNPLWP SVPDPAHSSL GSWVPTIMEE DAFQLPGLGT PPITKLTVLE EDEKKPVPWE SHNSSETCGL PTLVQTYVLQ GDPRAVSTQP QSQSGTSDQV LYGQLLGSPT SPGPGHYLRC DSTQPLLAGL TPSPKSYENL WFQASPLGTL VTPAPSQEDD CVFGPLLNFP LLQGIRVHGM EALGSF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.