Genular: Defining Cellular Identity and Function

Details for: Gad2

Gene ID: 14417

Symbol: Gad2

Ensembl ID: ENSMUSG00000026787

Description: glutamic acid decarboxylase 2

Associated with

Gaba synthesis
(R-MMU-888568)
Gaba synthesis, release, reuptake and degradation
(R-MMU-888590)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Transmission across chemical synapses
(R-MMU-112315)
Axon
(GO:0030424)
Carbon-carbon lyase activity
(GO:0016830)
Carboxy-lyase activity
(GO:0016831)
Carboxylic acid metabolic process
(GO:0019752)
Cell projection
(GO:0042995)
Clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
(GO:0061202)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Gaba-ergic synapse
(GO:0098982)
Gamma-aminobutyric acid biosynthetic process
(GO:0009449)
Glutamate binding
(GO:0016595)
Glutamate decarboxylase activity
(GO:0004351)
Glutamate decarboxylation to succinate
(GO:0006540)
Golgi apparatus
(GO:0005794)
Inhibitory synapse
(GO:0060077)
Lyase activity
(GO:0016829)
Membrane
(GO:0016020)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Presynapse
(GO:0098793)
Protein-containing complex binding
(GO:0044877)
Pyridoxal phosphate binding
(GO:0030170)
Synapse
(GO:0045202)
Synaptic vesicle membrane
(GO:0030672)

Other Information

Proteins

Glutamate decarboxylase 2

Genular Protein ID: 1679522009

Symbol: DCE2_MOUSE

Name: Glutamate decarboxylase 2

UniProtKB Accession Codes:

P48320 O35519

Database IDs:

Citations:

PubMed ID: 8218409

Title: Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65).

PubMed ID: 8218409

DOI: 10.1016/0167-4781(93)90056-j

PubMed ID: 8954991

Title: Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures.

PubMed ID: 8954991

DOI: 10.1006/bbrc.1996.1898

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8243324

Title: Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat.

PubMed ID: 8243324

DOI: 10.1210/endo.133.6.8243324

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 585
Mass: 65224
Checksum: C2F486E85123B057
Sequence:

MASPGSGFWS FGSEDGSADP ENPGTARAWC QVAQKFTGGI GNKLCALLYG DSGKPAEGGG 
SVTSRAATGK VACTCDQKPC NCPKGDVNYA FLHATDLLPA CDGERPTLAF LQDVMNILLQ 
YVVKSFDRST KVIDFHYPNE LLQEYNWELA DQPQNLEEIL THCQTTLKYA IKTGHPRYFN 
QLSTGLDMVG LAADWLTSTA NTNMFTYEIA PVFVLLEYVT LKKMREIIGW PGGSGDGIFS 
PGGAISNMYA MLIARYKMFP EVKEKGMAAV PRLIAFTSEH SHFSLKKGAA ALGIGTDSVI 
LIKCDERGKM IPSDLERRIL EVKQKGFVPF LVSATAGTTV YGAFDPLLAV ADICKKYKIW 
MHVDAAWGGG LLMSRKHKWK LSGVERANSV TWNPHKMMGV PLQCSALLVR EEGLMQSCNQ 
MHASYLFQQD KHYDLSYDTG DKALQCGRHV DVFKLWLMWR AKGTTGFEAH IDKCLELAEY 
LYTIIKNREG YEMVFDGKPQ HTNVCFWFVP PSLRTLEDNE ERMSRLSKVA PVIKARMMEY 
GTTMVSYQPL GDKVNFFRMV ISNPAATHQD IDFLIEEIER LGQDL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gad2

Associated with

Other Information

Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65). PubMed ID: 8218409

Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. PubMed ID: 8954991

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334