Details for: CSH1

Gene ID: 1442

Symbol: CSH1

Ensembl ID: ENSG00000136488

Description: chorionic somatomammotropin hormone 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.96
    Marker Score: 3853
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8271
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 5
    Marker Score: 32223
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 4.16
    Marker Score: 5737
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.6
    Marker Score: 1897
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 3.24
    Marker Score: 1050
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.39
    Marker Score: 2407
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.9
    Marker Score: 794
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.87
    Marker Score: 1087
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10802
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.57
    Marker Score: 1038
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.28
    Marker Score: 1050
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.23
    Marker Score: 7474
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3646
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32714.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48046
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.95
    Marker Score: 849
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2399
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.91
    Marker Score: 516
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 734
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1248
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.44
    Marker Score: 1901
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.4
    Marker Score: 730
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.38
    Marker Score: 208
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.33
    Marker Score: 191
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.27
    Marker Score: 514
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.27
    Marker Score: 206
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.25
    Marker Score: 213
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.21
    Marker Score: 822
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 107
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 376
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.17
    Marker Score: 2702.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.16
    Marker Score: 98
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 783
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 114
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.12
    Marker Score: 29
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.11
    Marker Score: 1154
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.11
    Marker Score: 313
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 107.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 41
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.08
    Marker Score: 113
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 83
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 77
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.07
    Marker Score: 295
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.06
    Marker Score: 192
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.04
    Marker Score: 92
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.04
    Marker Score: 68
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 65
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.04
    Marker Score: 29
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.04
    Marker Score: 153
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.04
    Marker Score: 28
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.04
    Marker Score: 24
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.03
    Marker Score: 22
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.03
    Marker Score: 76
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.03
    Marker Score: 37
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.03
    Marker Score: 29
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.03
    Marker Score: 51
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.03
    Marker Score: 118
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.03
    Marker Score: 70
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 28.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 28
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 58
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.02
    Marker Score: 24

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Other Information

**Key characteristics:** * CSH1 is a transmembrane protein with a molecular weight of approximately 150 kDa. * It is expressed in a variety of cell types, including erythrocyte, oligodendrocyte precursor cell, progenitor cell, double negative thymocyte, hematopoietic stem cell, trophoblast giant cell, blood vessel endothelial cell, megakaryocyte-erythroid progenitor cell, mast cell, and goblet cell. * It is a key regulator of fetal development, and its expression is upregulated in many tissues during the third and fourth trimesters of pregnancy. **Pathways and functions:** * CSH1 is a key regulator of fetal development. It is expressed in the developing embryo and is involved in the regulation of the growth and differentiation of various tissues. * It is a key regulator of placental development. It is expressed in the placenta and is involved in the regulation of fetal growth and development. * It is involved in the regulation of blood volume and pressure. * It is involved in the regulation of calcium and phosphate metabolism. * It is involved in the regulation of the immune system. **Clinical significance:** * Mutations in the CSH1 gene have been linked to a number of human diseases, including growth disorders, developmental abnormalities, and infertility. * CSH1 is a potential therapeutic target for a number of human diseases, including growth disorders and developmental abnormalities. **Additional notes:** * CSH1 is a pleiotropic protein that can have both positive and negative effects on cell growth and differentiation. * It is a key regulator of fetal development, and its expression is upregulated in many tissues during the third and fourth trimesters of pregnancy. * It is a potential therapeutic target for a number of human diseases, including growth disorders and developmental abnormalities.

Genular Protein ID: 4279424744

Symbol: CSH1_HUMAN

Name: Chorionic somatomammotropin hormone 1

UniProtKB Accession Codes:

P0DML2 P01243 Q0VDB1 Q14407

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6208192

Title: Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements.

PubMed ID: 6208192

DOI: 10.1016/s0021-9258(18)90667-8

PubMed ID: 6300056

Title: Two structurally different genes produce the same secreted human placental lactogen hormone.

PubMed ID: 6300056

DOI: 10.1016/s0021-9258(18)32734-0

PubMed ID: 2744760

Title: The human growth hormone locus: nucleotide sequence, biology, and evolution.

PubMed ID: 2744760

DOI: 10.1016/0888-7543(89)90271-1

PubMed ID: 7169009

Title: The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone.

PubMed ID: 7169009

DOI: 10.1089/dna.1.1982.1.239

PubMed ID: 18473352

Title: Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes.

PubMed ID: 18473352

DOI: 10.1002/humu.20767

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 593368

Title: Construction and analysis of recombinant DNA for human chorionic somatomammotropin.

PubMed ID: 593368

DOI: 10.1038/270494a0

PubMed ID: 4712450

Title: Amino acid sequence of human chorionic somatomammotropin.

PubMed ID: 4712450

DOI: 10.1016/s0003-9861(73)80012-8

PubMed ID: 5286363

Title: Amino-acid sequence of human placental lactogen.

PubMed ID: 5286363

DOI: 10.1038/newbio233059a0

PubMed ID: 438159

Title: Identification of the interchain disulfide bonds of dimeric human placental lactogen.

PubMed ID: 438159

DOI: 10.1016/s0021-9258(18)50655-4

PubMed ID: 16546209

Title: Crystal structure and site 1 binding energetics of human placental lactogen.

PubMed ID: 16546209

DOI: 10.1016/j.jmb.2006.02.038

Sequence Information:

  • Length: 217
  • Mass: 25020
  • Checksum: 235B0DC7A713F431
  • Sequence:
    • MAPGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFDHAM LQAHRAHQLA IDTYQEFEET 
YIPKDQKYSF LHDSQTSFCF SDSIPTPSNM EETQQKSNLE LLRISLLLIE SWLEPVRFLR 
SMFANNLVYD TSDSDDYHLL KDLEEGIQTL MGRLEDGSRR TGQILKQTYS KFDTNSHNHD 
ALLKNYGLLY CFRKDMDKVE TFLRMVQCRS VEGSCGF

Genular Protein ID: 3978917771

Symbol: CSH2_HUMAN

Name: Chorionic somatomammotropin hormone 2

UniProtKB Accession Codes:

P0DML3 P01243 Q0VDB1 Q14407

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 3 CDD 1 CTD 2 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 2 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 2 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3030680

Title: The human growth hormone gene locus: structure, evolution, and allelic variations.

PubMed ID: 3030680

DOI: 10.1089/dna.1987.6.59

PubMed ID: 6300056

Title: Two structurally different genes produce the same secreted human placental lactogen hormone.

PubMed ID: 6300056

DOI: 10.1016/s0021-9258(18)32734-0

PubMed ID: 2744760

Title: The human growth hormone locus: nucleotide sequence, biology, and evolution.

PubMed ID: 2744760

DOI: 10.1016/0888-7543(89)90271-1

PubMed ID: 7169009

Title: The human growth hormone gene family: nucleotide sequences show recent divergence and predict a new polypeptide hormone.

PubMed ID: 7169009

DOI: 10.1089/dna.1.1982.1.239

PubMed ID: 18473352

Title: Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes.

PubMed ID: 18473352

DOI: 10.1002/humu.20767

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 593368

Title: Construction and analysis of recombinant DNA for human chorionic somatomammotropin.

PubMed ID: 593368

DOI: 10.1038/270494a0

PubMed ID: 4712450

Title: Amino acid sequence of human chorionic somatomammotropin.

PubMed ID: 4712450

DOI: 10.1016/s0003-9861(73)80012-8

PubMed ID: 5286363

Title: Amino-acid sequence of human placental lactogen.

PubMed ID: 5286363

DOI: 10.1038/newbio233059a0

PubMed ID: 438159

Title: Identification of the interchain disulfide bonds of dimeric human placental lactogen.

PubMed ID: 438159

DOI: 10.1016/s0021-9258(18)50655-4

PubMed ID: 16546209

Title: Crystal structure and site 1 binding energetics of human placental lactogen.

PubMed ID: 16546209

DOI: 10.1016/j.jmb.2006.02.038

Sequence Information:

  • Length: 217
  • Mass: 24994
  • Checksum: 39FAACDDB6B2E951
  • Sequence:
    • MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFDHAM LQAHRAHQLA IDTYQEFEET 
YIPKDQKYSF LHDSQTSFCF SDSIPTPSNM EETQQKSNLE LLRISLLLIE SWLEPVRFLR 
SMFANNLVYD TSDSDDYHLL KDLEEGIQTL MGRLEDGSRR TGQILKQTYS KFDTNSHNHD 
ALLKNYGLLY CFRKDMDKVE TFLRMVQCRS VEGSCGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.