Galc | ENSMUSG00000021003 | NCBI 14420

Details for: Galc

Gene ID: 14420

Symbol: Galc

Ensembl ID: ENSMUSG00000021003

Description: galactosylceramidase

Associated with

Glycosphingolipid catabolism
(R-MMU-9840310)
Glycosphingolipid metabolism
(R-MMU-1660662)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Sphingolipid metabolism
(R-MMU-428157)
Galactosylceramidase activity
(GO:0004336)
Galactosylceramide catabolic process
(GO:0006683)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on glycosyl bonds
(GO:0016798)
Lipid catabolic process
(GO:0016042)
Lipid metabolic process
(GO:0006629)
Lysosome
(GO:0005764)
Metabolic process
(GO:0008152)
Mitochondrion
(GO:0005739)
Myelination
(GO:0042552)
Sphingolipid metabolic process
(GO:0006665)

Other Information

Proteins

Galactocerebroside beta-galactosidase

Genular Protein ID: 4187454037

Symbol: GALC_MOUSE

Name: Galactocerebroside beta-galactosidase

UniProtKB Accession Codes:

P54818 O35151 Q3U3H7

Database IDs:

Citations:

PubMed ID: 8769874

Title: Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease.

PubMed ID: 8769874

DOI: 10.1046/j.1471-4159.1996.66031118.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10861297

Title: Paradoxical influence of acid beta-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency).

PubMed ID: 10861297

DOI: 10.1093/hmg/9.11.1699

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21876145

Title: Insights into Krabbe disease from structures of galactocerebrosidase.

PubMed ID: 21876145

DOI: 10.1073/pnas.1105639108

Sequence Information:

Length: 684
Mass: 77256
Checksum: DD4BD45AE898C524
Sequence:

MANSQPKASQ QRQAKVMTAA AGSASRVAVP LLLCALLVPG GAYVLDDSDG LGREFDGIGA 
VSGGGATSRL LVNYPEPYRS EILDYLFKPN FGASLHILKV EIGGDGQTTD GTEPSHMHYE 
LDENYFRGYE WWLMKEAKKR NPDIILMGLP WSFPGWLGKG FSWPYVNLQL TAYYVVRWIL 
GAKHYHDLDI DYIGIWNERP FDANYIKELR KMLDYQGLQR VRIIASDNLW EPISSSLLLD 
QELWKVVDVI GAHYPGTYTV WNAKMSGKKL WSSEDFSTIN SNVGAGCWSR ILNQNYINGN 
MTSTIAWNLV ASYYEELPYG RSGLMTAQEP WSGHYVVASP IWVSAHTTQF TQPGWYYLKT 
VGHLEKGGSY VALTDGLGNL TIIIETMSHQ HSMCIRPYLP YYNVSHQLAT FTLKGSLREI 
QELQVWYTKL GTPQQRLHFK QLDTLWLLDG SGSFTLELEE DEIFTLTTLT TGRKGSYPPP 
PSSKPFPTNY KDDFNVEYPL FSEAPNFADQ TGVFEYYMNN EDREHRFTLR QVLNQRPITW 
AADASSTISV IGDHHWTNMT VQCDVYIETP RSGGVFIAGR VNKGGILIRS ATGVFFWIFA 
NGSYRVTADL GGWITYASGH ADVTAKRWYT LTLGIKGYFA FGMLNGTILW KNVRVKYPGH 
GWAAIGTHTF EFAQFDNFRV EAAR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Galc

Associated with

Other Information

Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease. PubMed ID: 8769874

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Paradoxical influence of acid beta-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency). PubMed ID: 10861297

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079