Details for: CSH2

Gene ID: 1443

Symbol: CSH2

Ensembl ID: ENSG00000213218

Description: chorionic somatomammotropin hormone 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.2087
    Cell Significance Index: 7.5100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0736
    Cell Significance Index: 0.6000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.0514
    Cell Significance Index: 0.3700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0378
    Cell Significance Index: 0.4600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0367
    Cell Significance Index: 0.3900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0278
    Cell Significance Index: 0.3600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0211
    Cell Significance Index: 0.2000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0204
    Cell Significance Index: 0.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0105
    Cell Significance Index: 0.2800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0071
    Cell Significance Index: 0.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0123
    Cell Significance Index: -0.3200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0185
    Cell Significance Index: -0.2000
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0200
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0229
    Cell Significance Index: -0.2200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0235
    Cell Significance Index: -0.3100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0256
    Cell Significance Index: -0.3000
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0276
    Cell Significance Index: -0.3200
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0283
    Cell Significance Index: -0.3200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0328
    Cell Significance Index: -0.2900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0360
    Cell Significance Index: -0.3000
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0417
    Cell Significance Index: -0.4100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0432
    Cell Significance Index: -0.3900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0445
    Cell Significance Index: -0.2800
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0446
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0492
    Cell Significance Index: -0.3000
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0513
    Cell Significance Index: -0.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0563
    Cell Significance Index: -7.7300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0690
    Cell Significance Index: -1.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1208
    Cell Significance Index: -24.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1324
    Cell Significance Index: -0.8000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1364
    Cell Significance Index: -0.6300
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1508
    Cell Significance Index: -0.3500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1832
    Cell Significance Index: -2.6600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1991
    Cell Significance Index: -2.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2026
    Cell Significance Index: -5.4300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2040
    Cell Significance Index: -2.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2073
    Cell Significance Index: -5.4500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2527
    Cell Significance Index: -4.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3046
    Cell Significance Index: -11.1800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3065
    Cell Significance Index: -7.8100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3133
    Cell Significance Index: -4.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.3181
    Cell Significance Index: -4.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3223
    Cell Significance Index: -8.0500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3257
    Cell Significance Index: -3.8300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.3303
    Cell Significance Index: -4.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3362
    Cell Significance Index: -5.5400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3554
    Cell Significance Index: -4.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3716
    Cell Significance Index: -10.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3778
    Cell Significance Index: -5.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3807
    Cell Significance Index: -5.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3818
    Cell Significance Index: -4.8900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4030
    Cell Significance Index: -7.8800
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.4185
    Cell Significance Index: -5.3000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.4203
    Cell Significance Index: -4.9900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.4258
    Cell Significance Index: -5.4700
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.4387
    Cell Significance Index: -5.5100
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.4487
    Cell Significance Index: -4.9900
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.4527
    Cell Significance Index: -5.2900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.4586
    Cell Significance Index: -4.8400
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.4623
    Cell Significance Index: -5.6200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4657
    Cell Significance Index: -5.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4780
    Cell Significance Index: -8.0000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.4848
    Cell Significance Index: -3.7300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4902
    Cell Significance Index: -7.9400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5001
    Cell Significance Index: -10.9500
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.5001
    Cell Significance Index: -5.5100
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.5058
    Cell Significance Index: -5.6000
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.5145
    Cell Significance Index: -5.5900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.5234
    Cell Significance Index: -4.3200
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5379
    Cell Significance Index: -5.0500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.5380
    Cell Significance Index: -5.5500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.5416
    Cell Significance Index: -5.6100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5444
    Cell Significance Index: -7.5500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.5446
    Cell Significance Index: -5.5600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.5636
    Cell Significance Index: -7.6000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5766
    Cell Significance Index: -5.0800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.5773
    Cell Significance Index: -7.2300
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.5836
    Cell Significance Index: -7.7800
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.5979
    Cell Significance Index: -5.5400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6020
    Cell Significance Index: -7.7200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.6041
    Cell Significance Index: -7.9000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.6073
    Cell Significance Index: -8.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.6105
    Cell Significance Index: -6.4400
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.6116
    Cell Significance Index: -7.6400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.6235
    Cell Significance Index: -7.5900
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: -0.6349
    Cell Significance Index: -5.6100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.6395
    Cell Significance Index: -5.5900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6448
    Cell Significance Index: -8.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6498
    Cell Significance Index: -8.0600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.6613
    Cell Significance Index: -7.9300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.6633
    Cell Significance Index: -8.0700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.6690
    Cell Significance Index: -7.6000
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.6768
    Cell Significance Index: -8.0700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.6783
    Cell Significance Index: -9.3200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.6886
    Cell Significance Index: -8.0000
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.7047
    Cell Significance Index: -7.7700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.7298
    Cell Significance Index: -7.7500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.7350
    Cell Significance Index: -5.5500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.7478
    Cell Significance Index: -7.6400
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.7507
    Cell Significance Index: -8.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CSH2 is a type of growth factor hormone that belongs to the somatomammotropin family. It is a protein with a molecular weight of approximately 25-30 kDa and is composed of 206 amino acids. The protein's structure is characterized by a signal peptide, which is involved in its secretion from the cell. CSH2 is a homodimeric protein, meaning it consists of two identical subunits. The protein's expression is tightly regulated by various signaling pathways, including the JAK-STAT pathway, which is involved in cell growth, differentiation, and survival. **Pathways and Functions** CSH2 is involved in various cellular processes, including: 1. **Growth and Development**: CSH2 plays a crucial role in fetal development and growth during pregnancy. It stimulates the growth of the fetus and regulates the development of various tissues and organs. 2. **Immune Regulation**: CSH2 is expressed in immune cells, including microglial cells and endothelial cells, and regulates immune responses, including inflammation and cell proliferation. 3. **Neuroprotection**: CSH2 has neuroprotective effects, and its expression is upregulated in response to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Vascular Development**: CSH2 is involved in the regulation of vascular development and angiogenesis, which is the formation of new blood vessels. **Clinical Significance** The dysregulation of CSH2 has been implicated in various diseases, including: 1. **Growth Disorders**: Mutations in the CSH2 gene have been associated with growth disorders, such as dwarfism and growth retardation. 2. **Immune Disorders**: CSH2 has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 3. **Neurodegenerative Diseases**: The dysregulation of CSH2 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: CSH2 has been implicated in cancer development and progression, particularly in tumors of the brain and nervous system. In conclusion, CSH2 is a protein involved in various cellular processes, including growth, development, and regulation of the immune system. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying CSH2 function.

Genular Protein ID: 3978917772

Symbol: A0A0M6L0F6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0M6L0F6

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 11 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 2 Pfam 1 PhylomeDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26697363

Title: Third party data gene data set of eutherian growth hormone genes.

PubMed ID: 26697363

DOI: 10.1016/j.gdata.2015.09.007

PubMed ID: 26862561

Title: Curated eutherian third party data gene data sets.

PubMed ID: 26862561

DOI: 10.1016/j.dib.2015.11.056

Title: Eutherian third-party data gene collections.

DOI: 10.1016/j.genrep.2019.100414

Sequence Information:

  • Length: 217
  • Mass: 24994
  • Checksum: 39FAACDDB6B2E951
  • Sequence:
    • MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFDHAM LQAHRAHQLA IDTYQEFEET 
YIPKDQKYSF LHDSQTSFCF SDSIPTPSNM EETQQKSNLE LLRISLLLIE SWLEPVRFLR 
SMFANNLVYD TSDSDDYHLL KDLEEGIQTL MGRLEDGSRR TGQILKQTYS KFDTNSHNHD 
ALLKNYGLLY CFRKDMDKVE TFLRMVQCRS VEGSCGF

Genular Protein ID: 1065172117

Symbol: A6NIT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NIT4

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 18473352

Title: Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes.

PubMed ID: 18473352

DOI: 10.1002/humu.20767

Sequence Information:

  • Length: 167
  • Mass: 18804
  • Checksum: 42E5D3AA748B0FF9
  • Sequence:
    • MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFDHAM LQAHRAHQLA IDTYQEFEET 
YIPKDQKYSF LHDSQTSFCF SDSIPTPSNM EETQQKSNLE LLRISLLLIE SWLEPVRFLR 
SMFANNLVYD TSDSDDYHLL KDLEEGIQTL MGVRVAPGVA NPGTPLA

Genular Protein ID: 849449144

Symbol: B1A4H9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B1A4H9

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 11 Gene3D 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 18473352

Title: Complex signatures of locus-specific selective pressures and gene conversion on human growth hormone/chorionic somatomammotropin genes.

PubMed ID: 18473352

DOI: 10.1002/humu.20767

Sequence Information:

  • Length: 122
  • Mass: 13914
  • Checksum: 9D3B0B0C811BB619
  • Sequence:
    • MAAGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFDHAM LQAHRAHQLA IDTYQEFRLE 
DGSRRTGQIL KQTYSKFDTN SHNHDALLKN YGLLYCFRKD MDKVETFLRM VQCRSVEGSC 
GF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.