Details for: CSK

Gene ID: 1445

Symbol: CSK

Ensembl ID: ENSG00000103653

Description: C-terminal Src kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 142.0809
    Cell Significance Index: -22.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.3995
    Cell Significance Index: -18.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 61.5374
    Cell Significance Index: -25.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.9868
    Cell Significance Index: -27.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.1172
    Cell Significance Index: -25.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.2083
    Cell Significance Index: -22.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5344
    Cell Significance Index: -20.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8438
    Cell Significance Index: -23.0600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 5.7992
    Cell Significance Index: 13.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1677
    Cell Significance Index: -11.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 5.1518
    Cell Significance Index: 509.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5784
    Cell Significance Index: -12.2700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.0353
    Cell Significance Index: 10.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.2157
    Cell Significance Index: 379.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4525
    Cell Significance Index: 398.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.3038
    Cell Significance Index: 42.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1690
    Cell Significance Index: 63.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3762
    Cell Significance Index: 88.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8008
    Cell Significance Index: 55.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5615
    Cell Significance Index: 15.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3324
    Cell Significance Index: 9.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3289
    Cell Significance Index: 117.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2990
    Cell Significance Index: 59.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2818
    Cell Significance Index: 50.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2764
    Cell Significance Index: 150.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2669
    Cell Significance Index: 53.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2639
    Cell Significance Index: 32.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2591
    Cell Significance Index: 49.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2400
    Cell Significance Index: 6.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1706
    Cell Significance Index: 8.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1408
    Cell Significance Index: 19.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1338
    Cell Significance Index: 59.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1277
    Cell Significance Index: 6.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0609
    Cell Significance Index: 2.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0596
    Cell Significance Index: 2.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0587
    Cell Significance Index: 40.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0081
    Cell Significance Index: 15.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0138
    Cell Significance Index: -21.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0169
    Cell Significance Index: -23.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0210
    Cell Significance Index: -15.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0328
    Cell Significance Index: -24.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0331
    Cell Significance Index: -24.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0345
    Cell Significance Index: -21.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0420
    Cell Significance Index: -19.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0428
    Cell Significance Index: -24.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0442
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0464
    Cell Significance Index: -2.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0495
    Cell Significance Index: -6.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0553
    Cell Significance Index: -4.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0705
    Cell Significance Index: -20.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0827
    Cell Significance Index: -10.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0892
    Cell Significance Index: -10.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0946
    Cell Significance Index: -16.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0989
    Cell Significance Index: -2.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1010
    Cell Significance Index: -14.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1056
    Cell Significance Index: -7.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1285
    Cell Significance Index: -27.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1344
    Cell Significance Index: -15.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1562
    Cell Significance Index: -9.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1615
    Cell Significance Index: -9.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1687
    Cell Significance Index: -4.3100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1747
    Cell Significance Index: -4.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1986
    Cell Significance Index: -14.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2004
    Cell Significance Index: -20.8700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2063
    Cell Significance Index: -1.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2187
    Cell Significance Index: -5.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2285
    Cell Significance Index: -6.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2382
    Cell Significance Index: -15.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2604
    Cell Significance Index: -13.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2698
    Cell Significance Index: -18.1400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2795
    Cell Significance Index: -6.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3141
    Cell Significance Index: -10.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3269
    Cell Significance Index: -14.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3384
    Cell Significance Index: -26.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3577
    Cell Significance Index: -7.7500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3595
    Cell Significance Index: -3.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3709
    Cell Significance Index: -5.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3968
    Cell Significance Index: -10.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4070
    Cell Significance Index: -24.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4088
    Cell Significance Index: -15.4800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4345
    Cell Significance Index: -7.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4356
    Cell Significance Index: -7.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4846
    Cell Significance Index: -10.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5104
    Cell Significance Index: -16.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5249
    Cell Significance Index: -11.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5279
    Cell Significance Index: -7.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5316
    Cell Significance Index: -15.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5417
    Cell Significance Index: -8.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5458
    Cell Significance Index: -19.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5623
    Cell Significance Index: -17.9100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5645
    Cell Significance Index: -14.5100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5700
    Cell Significance Index: -7.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5808
    Cell Significance Index: -8.3200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5840
    Cell Significance Index: -8.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5909
    Cell Significance Index: -21.6900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5922
    Cell Significance Index: -20.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Tyrosine kinase activity**: CSK is a non-receptor tyrosine kinase, meaning it phosphorylates tyrosine residues on target proteins. 2. **Expression in immune cells**: CSK is specifically expressed in immune cells, including B cells, monocytes, and T cells. 3. **Regulation of immune cell activation**: CSK regulates immune cell activation, proliferation, and differentiation through its signaling pathways. 4. **Phosphorylation-dependent activation**: CSK is activated by phosphorylation, which then phosphorylates and activates downstream targets. 5. **Proline-rich region binding**: CSK binds to proline-rich regions of target proteins, facilitating its interaction and activation. **Pathways and Functions** CSK is involved in several signaling pathways, including: 1. **Adaptive immune response**: CSK regulates the adaptive immune response by activating immune cells and promoting immune cell activation and proliferation. 2. **T cell receptor signaling pathway**: CSK is involved in the T cell receptor signaling pathway, regulating T cell activation and proliferation. 3. **Cytokine signaling**: CSK regulates cytokine signaling, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 4. **Cell-cell junction organization**: CSK is involved in the organization of cell-cell junctions, regulating immune cell adhesion and migration. 5. **Raf MAPK signaling cascade**: CSK activates the Raf MAPK signaling cascade, regulating cell proliferation and differentiation. CSK's functions include: 1. **Regulation of immune cell activation**: CSK regulates immune cell activation, proliferation, and differentiation. 2. **Influence on cytokine production**: CSK regulates cytokine production, influencing the balance between pro-inflammatory and anti-inflammatory cytokines. 3. **Regulation of cell-cell junctions**: CSK regulates cell-cell junctions, influencing immune cell adhesion and migration. 4. **Activation of downstream targets**: CSK activates downstream targets, including proteins involved in cell signaling, adhesion, and migration. **Clinical Significance** Dysregulation of CSK has been implicated in several immunological disorders, including: 1. **Autoimmune diseases**: Abnormal expression or activity of CSK has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: CSK is overexpressed in several types of cancer, including breast cancer and lung cancer. 3. **Immunodeficiency disorders**: CSK is involved in the regulation of immune cell function, and its dysregulation can lead to immunodeficiency disorders. 4. **Infectious diseases**: CSK regulates immune cell activation and cytokine production, influencing the host's response to infections. In summary, CSK is a critical regulator of immune cell function and signaling pathways, and its dysregulation has been implicated in several immunological disorders. Further research is needed to fully understand the role of CSK in immune function and disease.

Genular Protein ID: 3016774573

Symbol: CSK_HUMAN

Name: Tyrosine-protein kinase CSK

UniProtKB Accession Codes:

P41240 Q2M3N2 Q6FGZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 ELM 1 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 4 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1945408

Title: CYL encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src).

PubMed ID: 1945408

PubMed ID: 1720539

Title: Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.

PubMed ID: 1720539

DOI: 10.1073/pnas.88.23.10411

PubMed ID: 1371489

Title: Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases.

PubMed ID: 1371489

DOI: 10.1016/0378-1119(92)90649-a

PubMed ID: 7683131

Title: Characterization of the human CSK locus.

PubMed ID: 7683131

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1639064

Title: The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

PubMed ID: 1639064

DOI: 10.1002/j.1460-2075.1992.tb05361.x

PubMed ID: 7683130

Title: Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s).

PubMed ID: 7683130

PubMed ID: 9281320

Title: Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system.

PubMed ID: 9281320

DOI: 10.1006/abbi.1997.0236

PubMed ID: 9148770

Title: Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure.

PubMed ID: 9148770

DOI: 10.1042/bj3220927

PubMed ID: 10838081

Title: Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.

PubMed ID: 10838081

DOI: 10.1016/s0014-5793(00)01597-0

PubMed ID: 10790433

Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

PubMed ID: 10790433

DOI: 10.1084/jem.191.9.1591

PubMed ID: 11433379

Title: Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).

PubMed ID: 11433379

DOI: 10.1002/1521-4141(200106)31:6<1825::aid-immu1825>3.0.co;2-v

PubMed ID: 11181701

Title: Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.

PubMed ID: 11181701

DOI: 10.1084/jem.193.4.497

PubMed ID: 14610046

Title: LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.

PubMed ID: 14610046

DOI: 10.1084/jem.20031484

PubMed ID: 15208781

Title: A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

PubMed ID: 15208781

DOI: 10.1086/422827

PubMed ID: 16243715

Title: C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) -- endogenous negative regulators of Src-family protein kinases.

PubMed ID: 16243715

DOI: 10.1080/08977190500178877

PubMed ID: 17525734

Title: p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.

PubMed ID: 17525734

DOI: 10.1038/sj.emboj.7601724

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19888460

Title: The tyrosine kinase Csk dimerizes through Its SH3 domain.

PubMed ID: 19888460

DOI: 10.1371/journal.pone.0007683

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20851766

Title: RhoH modulates pre-TCR and TCR signalling by regulating LCK.

PubMed ID: 20851766

DOI: 10.1016/j.cellsig.2010.09.009

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 23526378

Title: Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

PubMed ID: 23526378

DOI: 10.1002/jbmr.1935

PubMed ID: 7511113

Title: The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop.

PubMed ID: 7511113

DOI: 10.1016/0014-5793(94)80244-0

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 450
  • Mass: 50704
  • Checksum: 431023A88C54E00C
  • Sequence:
    • MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 
PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 
SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 
DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 
NCWHLDAAMR PSFLQLREQL EHIKTHELHL

Genular Protein ID: 1149517020

Symbol: A8K3B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3B6

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 8 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 5 Gene3D 3 IntAct 1 InterPro 12 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 8 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 Rhea 3 RuleBase 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 450
  • Mass: 50702
  • Checksum: E3A95BA08D589732
  • Sequence:
    • MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 
PANYVQKREG VKAGAKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 
SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 
DEFYRSGWAL NMKELRLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 
NCWHLDAAMR PSFLQLREQL EHIKTHELHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.