CSK | ENSG00000103653 | NCBI 1445

Details for: CSK

Gene ID: 1445

Symbol: CSK

Ensembl ID: ENSG00000103653

Description: C-terminal Src kinase

Associated with

Adaptive immune system
(R-HSA-1280218)
Costimulation by the cd28 family
(R-HSA-388841)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Flt3 signaling
(R-HSA-9607240)
Gab1 signalosome
(R-HSA-180292)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Integrin signaling
(R-HSA-354192)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of flt3
(R-HSA-9706369)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Pd-1 signaling
(R-HSA-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-HSA-202427)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Raf/map kinase cascade
(R-HSA-5673001)
Rho gtpase cycle
(R-HSA-9012999)
Rhoh gtpase cycle
(R-HSA-9013407)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by egfr
(R-HSA-177929)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signal transduction
(R-HSA-162582)
Tcr signaling
(R-HSA-202403)
Adaptive immune response
(GO:0002250)
Adherens junction organization
(GO:0034332)
Atp binding
(GO:0005524)
Cell-cell junction
(GO:0005911)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Negative regulation of bone resorption
(GO:0045779)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of golgi to plasma membrane protein transport
(GO:0042997)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of low-density lipoprotein particle clearance
(GO:0010989)
Negative regulation of phagocytosis
(GO:0050765)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Oligodendrocyte differentiation
(GO:0048709)
Plasma membrane
(GO:0005886)
Proline-rich region binding
(GO:0070064)
Protein binding
(GO:0005515)
Protein kinase a catalytic subunit binding
(GO:0034236)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of fc receptor mediated stimulatory signaling pathway
(GO:0060368)
T cell costimulation
(GO:0031295)
T cell receptor signaling pathway
(GO:0050852)

Other Information

Proteins

Tyrosine-protein kinase CSK
A8K3B6_HUMAN

Genular Protein ID: 3016774573

Symbol: CSK_HUMAN

Name: Tyrosine-protein kinase CSK

UniProtKB Accession Codes:

P41240 Q2M3N2 Q6FGZ6

Database IDs:

Citations:

PubMed ID: 1945408

Title: CYL encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src).

PubMed ID: 1945408

PubMed ID: 1720539

Title: Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.

PubMed ID: 1720539

DOI: 10.1073/pnas.88.23.10411

PubMed ID: 1371489

Title: Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases.

PubMed ID: 1371489

DOI: 10.1016/0378-1119(92)90649-a

PubMed ID: 7683131

Title: Characterization of the human CSK locus.

PubMed ID: 7683131

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1639064

Title: The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

PubMed ID: 1639064

DOI: 10.1002/j.1460-2075.1992.tb05361.x

PubMed ID: 7683130

Title: Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s).

PubMed ID: 7683130

PubMed ID: 9281320

Title: Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system.

PubMed ID: 9281320

DOI: 10.1006/abbi.1997.0236

PubMed ID: 9148770

Title: Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure.

PubMed ID: 9148770

DOI: 10.1042/bj3220927

PubMed ID: 10838081

Title: Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.

PubMed ID: 10838081

DOI: 10.1016/s0014-5793(00)01597-0

PubMed ID: 10790433

Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

PubMed ID: 10790433

DOI: 10.1084/jem.191.9.1591

PubMed ID: 11433379

Title: Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).

PubMed ID: 11433379

DOI: 10.1002/1521-4141(200106)31:6<1825::aid-immu1825>3.0.co;2-v

PubMed ID: 11181701

Title: Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.

PubMed ID: 11181701

DOI: 10.1084/jem.193.4.497

PubMed ID: 14610046

Title: LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.

PubMed ID: 14610046

DOI: 10.1084/jem.20031484

PubMed ID: 15208781

Title: A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

PubMed ID: 15208781

DOI: 10.1086/422827

PubMed ID: 16243715

Title: C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) -- endogenous negative regulators of Src-family protein kinases.

PubMed ID: 16243715

DOI: 10.1080/08977190500178877

PubMed ID: 17525734

Title: p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.

PubMed ID: 17525734

DOI: 10.1038/sj.emboj.7601724

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19888460

Title: The tyrosine kinase Csk dimerizes through Its SH3 domain.

PubMed ID: 19888460

DOI: 10.1371/journal.pone.0007683

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20851766

Title: RhoH modulates pre-TCR and TCR signalling by regulating LCK.

PubMed ID: 20851766

DOI: 10.1016/j.cellsig.2010.09.009

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 23526378

Title: Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

PubMed ID: 23526378

DOI: 10.1002/jbmr.1935

PubMed ID: 7511113

Title: The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop.

PubMed ID: 7511113

DOI: 10.1016/0014-5793(94)80244-0

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 450
Mass: 50704
Checksum: 431023A88C54E00C
Sequence:

MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 
PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 
SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 
DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 
NCWHLDAAMR PSFLQLREQL EHIKTHELHL

Genular Protein ID: 1149517020

Symbol: A8K3B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3B6

Database IDs:

Sequence Information:

Length: 450
Mass: 50702
Checksum: E3A95BA08D589732
Sequence:

MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 
PANYVQKREG VKAGAKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 
SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 
DEFYRSGWAL NMKELRLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 
NCWHLDAAMR PSFLQLREQL EHIKTHELHL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CSK

Associated with

Other Information

CYL encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src). PubMed ID: 1945408

Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase. PubMed ID: 1720539

Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases. PubMed ID: 1371489

Characterization of the human CSK locus. PubMed ID: 7683131

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. PubMed ID: 1639064

Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s). PubMed ID: 7683130

Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system. PubMed ID: 9281320

Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure. PubMed ID: 9148770

Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn. PubMed ID: 10838081

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation. PubMed ID: 10790433

Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein). PubMed ID: 11433379

Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. PubMed ID: 11181701

LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. PubMed ID: 14610046

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. PubMed ID: 15208781

C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) -- endogenous negative regulators of Src-family protein kinases. PubMed ID: 16243715

p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. PubMed ID: 17525734

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The tyrosine kinase Csk dimerizes through Its SH3 domain. PubMed ID: 19888460

Initial characterization of the human central proteome. PubMed ID: 21269460

RhoH modulates pre-TCR and TCR signalling by regulating LCK. PubMed ID: 20851766

SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling. PubMed ID: 21930792

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. PubMed ID: 23526378

The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop. PubMed ID: 7511113

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846