Details for: CSK

Gene ID: 1445

Symbol: CSK

Ensembl ID: ENSG00000103653

Description: C-terminal Src kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.47
    Marker Score: 7330
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.27
    Marker Score: 3958
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.07
    Marker Score: 115913
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.03
    Marker Score: 1913
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.01
    Marker Score: 1221
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.93
    Marker Score: 3752.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.92
    Marker Score: 1713
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.83
    Marker Score: 904
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.8
    Marker Score: 1083
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.79
    Marker Score: 425
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.75
    Marker Score: 1326
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.72
    Marker Score: 609
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.71
    Marker Score: 19917
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.71
    Marker Score: 10930
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.71
    Marker Score: 393
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.7
    Marker Score: 4779
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.66
    Marker Score: 5253
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.65
    Marker Score: 2944
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.63
    Marker Score: 16178
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.63
    Marker Score: 1604
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.59
    Marker Score: 1916
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.53
    Marker Score: 2259
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.53
    Marker Score: 4230
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.53
    Marker Score: 3734
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.53
    Marker Score: 3687
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.53
    Marker Score: 894
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.51
    Marker Score: 1323
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.47
    Marker Score: 6312.5
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.47
    Marker Score: 1070.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.46
    Marker Score: 2073
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.46
    Marker Score: 1623
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.45
    Marker Score: 440
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.45
    Marker Score: 723
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.45
    Marker Score: 4219
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.43
    Marker Score: 14490
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.42
    Marker Score: 612
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.39
    Marker Score: 799
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.39
    Marker Score: 73421
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.39
    Marker Score: 1088
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.36
    Marker Score: 3387.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.36
    Marker Score: 2327
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.35
    Marker Score: 1118
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.33
    Marker Score: 1594
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.3
    Marker Score: 951
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.29
    Marker Score: 424
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.26
    Marker Score: 1287
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.26
    Marker Score: 837
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.25
    Marker Score: 1062
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.22
    Marker Score: 1175.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.2
    Marker Score: 1126
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.2
    Marker Score: 825
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.17
    Marker Score: 955
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.16
    Marker Score: 1288
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.16
    Marker Score: 2439.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.16
    Marker Score: 359
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.15
    Marker Score: 291.5
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.12
    Marker Score: 392
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.1
    Marker Score: 353
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.09
    Marker Score: 653
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.08
    Marker Score: 1439
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.08
    Marker Score: 1233
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16859
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.08
    Marker Score: 372
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.08
    Marker Score: 631
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.05
    Marker Score: 232
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.04
    Marker Score: 992
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.04
    Marker Score: 2036
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.04
    Marker Score: 697
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.02
    Marker Score: 859
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 1.02
    Marker Score: 244
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.02
    Marker Score: 848
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.01
    Marker Score: 2630
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1
    Marker Score: 345
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71635.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1
    Marker Score: 486
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47859
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.99
    Marker Score: 996
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30379
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.97
    Marker Score: 2644.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.95
    Marker Score: 466
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.95
    Marker Score: 644
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.94
    Marker Score: 680
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2388
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.94
    Marker Score: 184
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.94
    Marker Score: 680
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.94
    Marker Score: 328
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.94
    Marker Score: 1018
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.93
    Marker Score: 325
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.93
    Marker Score: 572
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.93
    Marker Score: 1203
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.92
    Marker Score: 3771.5
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.92
    Marker Score: 3826.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.92
    Marker Score: 1565
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.92
    Marker Score: 13754
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.92
    Marker Score: 817
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.91
    Marker Score: 469
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.91
    Marker Score: 1659
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.9
    Marker Score: 600

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Other Information

**Key characteristics** * CSK is a protein of the Src family of kinases. * It is expressed in a variety of cell types, including tonsil germinal center B cells, B-1 B cells, CD14-positive and CD16-negative classical monocytes, class switched memory B cells, germinal center B cells, CD14-positive and CD16-positive monocytes, naive B cells, centroblast, IgG memory B cells, and centrocytes. * It is a highly conserved protein, with a similar sequence in mice and humans. **Pathways and functions** * CSK is involved in the regulation of B cell development and function. * It is a key regulator of the activation of naive B cells and the development of plasma cells. * It is also involved in the regulation of B cell differentiation and the generation of antibody-secreting plasma cells. * CSK is also involved in the regulation of the adaptive immune response. * It is a key regulator of the activation of T cells and the production of cytokines. * It is also involved in the regulation of the activation of natural killer (NK) cells. **Clinical significance** * Mutations in the CSK gene have been linked to a number of human diseases, including cancer and autoimmune disorders. * CSK inhibitors are being investigated as potential treatments for these diseases. **Additional notes** * CSK is a highly important protein in the adaptive immune system. * It is a key regulator of the activation of B cells and the development of plasma cells. * It is also involved in the regulation of the adaptive immune response.

Genular Protein ID: 3016774573

Symbol: CSK_HUMAN

Name: Tyrosine-protein kinase CSK

UniProtKB Accession Codes:

P41240 Q2M3N2 Q6FGZ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 ELM 1 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PIR 1 PRINTS 2 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 4 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1945408

Title: CYL encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src).

PubMed ID: 1945408

PubMed ID: 1720539

Title: Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.

PubMed ID: 1720539

DOI: 10.1073/pnas.88.23.10411

PubMed ID: 1371489

Title: Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases.

PubMed ID: 1371489

DOI: 10.1016/0378-1119(92)90649-a

PubMed ID: 7683131

Title: Characterization of the human CSK locus.

PubMed ID: 7683131

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1639064

Title: The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

PubMed ID: 1639064

DOI: 10.1002/j.1460-2075.1992.tb05361.x

PubMed ID: 7683130

Title: Recombinant Csk expressed in Escherichia coli is autophosphorylated on tyrosine residue(s).

PubMed ID: 7683130

PubMed ID: 9281320

Title: Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system.

PubMed ID: 9281320

DOI: 10.1006/abbi.1997.0236

PubMed ID: 9148770

Title: Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure.

PubMed ID: 9148770

DOI: 10.1042/bj3220927

PubMed ID: 10838081

Title: Phosphorylation of Hic-5 at tyrosine 60 by CAKbeta and Fyn.

PubMed ID: 10838081

DOI: 10.1016/s0014-5793(00)01597-0

PubMed ID: 10790433

Title: Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.

PubMed ID: 10790433

DOI: 10.1084/jem.191.9.1591

PubMed ID: 11433379

Title: Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).

PubMed ID: 11433379

DOI: 10.1002/1521-4141(200106)31:6<1825::aid-immu1825>3.0.co;2-v

PubMed ID: 11181701

Title: Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor.

PubMed ID: 11181701

DOI: 10.1084/jem.193.4.497

PubMed ID: 14610046

Title: LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.

PubMed ID: 14610046

DOI: 10.1084/jem.20031484

PubMed ID: 15208781

Title: A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

PubMed ID: 15208781

DOI: 10.1086/422827

PubMed ID: 16243715

Title: C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) -- endogenous negative regulators of Src-family protein kinases.

PubMed ID: 16243715

DOI: 10.1080/08977190500178877

PubMed ID: 17525734

Title: p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.

PubMed ID: 17525734

DOI: 10.1038/sj.emboj.7601724

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19888460

Title: The tyrosine kinase Csk dimerizes through Its SH3 domain.

PubMed ID: 19888460

DOI: 10.1371/journal.pone.0007683

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20851766

Title: RhoH modulates pre-TCR and TCR signalling by regulating LCK.

PubMed ID: 20851766

DOI: 10.1016/j.cellsig.2010.09.009

PubMed ID: 21930792

Title: SCIMP, a transmembrane adapter protein involved in major histocompatibility complex class II signaling.

PubMed ID: 21930792

DOI: 10.1128/mcb.05817-11

PubMed ID: 23526378

Title: Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

PubMed ID: 23526378

DOI: 10.1002/jbmr.1935

PubMed ID: 7511113

Title: The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop.

PubMed ID: 7511113

DOI: 10.1016/0014-5793(94)80244-0

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 450
  • Mass: 50704
  • Checksum: 431023A88C54E00C
  • Sequence:
    • MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 
PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 
SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 
DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 
NCWHLDAAMR PSFLQLREQL EHIKTHELHL

Genular Protein ID: 1149517020

Symbol: A8K3B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K3B6

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 ChEBI 8 DNASU 1 EC 1 EMBL 2 GO 4 Gene3D 3 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 11 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 8 PROSITE-ProRule 3 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 Rhea 3 RuleBase 1 SMART 3 SUPFAM 3

Sequence Information:

  • Length: 450
  • Mass: 50702
  • Checksum: E3A95BA08D589732
  • Sequence:
    • MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 
PANYVQKREG VKAGAKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 
SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTSDA DGLCTRLIKP KVMEGTVAAQ 
DEFYRSGWAL NMKELRLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 
TQLRHSNLVQ LLGVIVEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 
AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 
KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 
NCWHLDAAMR PSFLQLREQL EHIKTHELHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.