Details for: Gas6

Gene ID: 14456

Symbol: Gas6

Ensembl ID: ENSMUSG00000031451

Description: growth arrest specific 6

Associated with

  • Cell surface interactions at the vascular wall
    (R-MMU-202733)
  • Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
    (R-MMU-159854)
  • Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
    (R-MMU-163841)
  • Hemostasis
    (R-MMU-109582)
  • Metabolism of proteins
    (R-MMU-392499)
  • Platelet activation, signaling and aggregation
    (R-MMU-76002)
  • Platelet degranulation
    (R-MMU-114608)
  • Post-translational protein modification
    (R-MMU-597592)
  • Post-translational protein phosphorylation
    (R-MMU-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-MMU-381426)
  • Removal of aminoterminal propeptides from gamma-carboxylated proteins
    (R-MMU-159782)
  • Response to elevated platelet cytosolic ca2+
    (R-MMU-76005)
  • Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the golgi apparatus
    (R-MMU-159763)
  • Apoptotic cell clearance
    (GO:0043277)
  • Apoptotic process
    (GO:0006915)
  • B cell chemotaxis
    (GO:0035754)
  • Blood coagulation
    (GO:0007596)
  • Calcium ion binding
    (GO:0005509)
  • Calcium ion transmembrane transport
    (GO:0070588)
  • Cell-substrate adhesion
    (GO:0031589)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to interferon-alpha
    (GO:0035457)
  • Cellular response to starvation
    (GO:0009267)
  • Cellular response to vitamin k
    (GO:0071307)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
    (GO:0043027)
  • Cytoplasm
    (GO:0005737)
  • Enzyme-linked receptor protein signaling pathway
    (GO:0007167)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibroblast apoptotic process
    (GO:0044346)
  • Fusion of virus membrane with host plasma membrane
    (GO:0019064)
  • Hematopoietic stem cell migration to bone marrow
    (GO:0097241)
  • Macrophage cytokine production
    (GO:0010934)
  • Metal ion binding
    (GO:0046872)
  • Myeloid cell apoptotic process
    (GO:0033028)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of biomineral tissue development
    (GO:0070168)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of dendritic cell apoptotic process
    (GO:2000669)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of fibroblast apoptotic process
    (GO:2000270)
  • Negative regulation of interleukin-1 production
    (GO:0032692)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Negative regulation of oligodendrocyte apoptotic process
    (GO:1900142)
  • Negative regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010804)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Neuron migration
    (GO:0001764)
  • Phagocytosis
    (GO:0006909)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Phosphatidylserine binding
    (GO:0001786)
  • Positive regulation of cytokine-mediated signaling pathway
    (GO:0001961)
  • Positive regulation of dendritic cell chemotaxis
    (GO:2000510)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of natural killer cell differentiation
    (GO:0032825)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein export from nucleus
    (GO:0046827)
  • Positive regulation of protein kinase activity
    (GO:0045860)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of tor signaling
    (GO:0032008)
  • Protein-macromolecule adaptor activity
    (GO:0030674)
  • Protein localization to plasma membrane
    (GO:0072659)
  • Protein phosphorylation
    (GO:0006468)
  • Receptor-mediated virion attachment to host cell
    (GO:0046813)
  • Receptor ligand activity
    (GO:0048018)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)
  • Symbiont entry into host cell
    (GO:0046718)
  • Viral genome replication
    (GO:0019079)

Other Information

Genular Protein ID: 808790157

Symbol: GAS6_MOUSE

Name: Growth arrest-specific protein 6

UniProtKB Accession Codes:

Q61592 Q99K57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 1 GO 69 Gene3D 3 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 11 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 8 PROSITE-ProRule 3 PaxDb 1 Pfam 4 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 8336730

Title: The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.

PubMed ID: 8336730

DOI: 10.1128/mcb.13.8.4976-4985.1993

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11175853

Title: Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.

PubMed ID: 11175853

DOI: 10.1038/84667

Sequence Information:

  • Length: 674
  • Mass: 74610
  • Checksum: 7C41F7693903F401
  • Sequence:
    • MPPPPGPAAA LGTALLLLLL ASESSHTVLL RAREAAQFLR PRQRRAYQVF EEAKQGHLER 
ECVEEVCSKE EAREVFENDP ETEYFYPRYQ ECMRKYGRPE EKNPDFAKCV QNLPDQCTPN 
PCDKKGTHIC QDLMGNFFCV CTDGWGGRLC DKDVNECVQK NGGCSQVCHN KPGSFQCACH 
SGFSLASDGQ TCQDIDECTD SDTCGDARCK NLPGSYSCLC DEGYTYSSKE KTCQDVDECQ 
QDRCEQTCVN SPGSYTCHCD GRGGLKLSPD MDTCEDILPC VPFSMAKSVK SLYLGRMFSG 
TPVIRLRFKR LQPTRLLAEF DFRTFDPEGV LFFAGGRSDS TWIVLGLRAG RLELQLRYNG 
VGRITSSGPT INHGMWQTIS VEELERNLVI KVNKDAVMKI AVAGELFQLE RGLYHLNLTV 
GGIPFKESEL VQPINPRLDG CMRSWNWLNG EDSAIQETVK ANTKMQCFSV TERGSFFPGN 
GFATYRLNYT RTSLDVGTET TWEVKVVARI RPATDTGVLL ALVGDDDVVP ISVALVDYHS 
TKKLKKQLVV LAVEDVALAL MEIKVCDSQE HTVTVSLREG EATLEVDGTK GQSEVSTAQL 
QERLDTLKTH LQGSVHTYVG GLPEVSVISA PVTAFYRGCM TLEVNGKILD LDTASYKHSD 
ITSHSCPPVE HATP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.