Details for: CSN1S1

Gene ID: 1446

Symbol: CSN1S1

Ensembl ID: ENSG00000126545

Description: casein alpha s1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 68.2550
    Cell Significance Index: 293.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 8.4028
    Cell Significance Index: 214.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 2.6021
    Cell Significance Index: -0.6600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.2091
    Cell Significance Index: 10.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.8355
    Cell Significance Index: 25.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5991
    Cell Significance Index: 38.7400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7604
    Cell Significance Index: 9.8400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.7028
    Cell Significance Index: 4.3300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.5973
    Cell Significance Index: 2.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4067
    Cell Significance Index: 19.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3738
    Cell Significance Index: 48.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2196
    Cell Significance Index: 3.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1397
    Cell Significance Index: 10.4100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0429
    Cell Significance Index: 0.6100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0256
    Cell Significance Index: 0.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0251
    Cell Significance Index: 0.2600
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0046
    Cell Significance Index: -2.6200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0079
    Cell Significance Index: -1.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0085
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0112
    Cell Significance Index: -1.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0128
    Cell Significance Index: -2.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0137
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0152
    Cell Significance Index: -2.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0160
    Cell Significance Index: -0.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0194
    Cell Significance Index: -0.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0195
    Cell Significance Index: -2.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0210
    Cell Significance Index: -0.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0403
    Cell Significance Index: -1.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0430
    Cell Significance Index: -2.8900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0435
    Cell Significance Index: -0.5600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0450
    Cell Significance Index: -0.5700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0456
    Cell Significance Index: -0.5500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0486
    Cell Significance Index: -0.9500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0505
    Cell Significance Index: -0.6600
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0510
    Cell Significance Index: -0.6000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0545
    Cell Significance Index: -0.8800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0550
    Cell Significance Index: -0.6500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0580
    Cell Significance Index: -0.6200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0595
    Cell Significance Index: -0.6400
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0598
    Cell Significance Index: -0.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0605
    Cell Significance Index: -1.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0616
    Cell Significance Index: -1.6500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0665
    Cell Significance Index: -1.1300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0772
    Cell Significance Index: -1.3200
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0790
    Cell Significance Index: -0.5900
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.0798
    Cell Significance Index: -0.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0832
    Cell Significance Index: -2.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0852
    Cell Significance Index: -2.7900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0854
    Cell Significance Index: -0.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0861
    Cell Significance Index: -2.2000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0867
    Cell Significance Index: -2.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0909
    Cell Significance Index: -1.3200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0926
    Cell Significance Index: -1.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0945
    Cell Significance Index: -2.0700
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.0991
    Cell Significance Index: -0.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1009
    Cell Significance Index: -2.8800
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1014
    Cell Significance Index: -1.1500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1019
    Cell Significance Index: -1.4900
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: -0.1031
    Cell Significance Index: -0.7000
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1096
    Cell Significance Index: -1.1400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1100
    Cell Significance Index: -1.5300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1111
    Cell Significance Index: -1.5600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1129
    Cell Significance Index: -1.3100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1155
    Cell Significance Index: -2.8800
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1169
    Cell Significance Index: -1.3800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1188
    Cell Significance Index: -1.2900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.1213
    Cell Significance Index: -1.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1251
    Cell Significance Index: -3.0000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1254
    Cell Significance Index: -2.5000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1262
    Cell Significance Index: -1.8400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1276
    Cell Significance Index: -1.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1290
    Cell Significance Index: -2.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1300
    Cell Significance Index: -2.7600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1308
    Cell Significance Index: -2.8300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1356
    Cell Significance Index: -1.3700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1366
    Cell Significance Index: -1.7200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1387
    Cell Significance Index: -2.7300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1394
    Cell Significance Index: -1.6200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1394
    Cell Significance Index: -2.9100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1402
    Cell Significance Index: -2.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1415
    Cell Significance Index: -2.8400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1416
    Cell Significance Index: -1.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1431
    Cell Significance Index: -3.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1446
    Cell Significance Index: -2.8600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1467
    Cell Significance Index: -1.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1488
    Cell Significance Index: -2.7500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1497
    Cell Significance Index: -1.7900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1515
    Cell Significance Index: -2.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1523
    Cell Significance Index: -2.5100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1533
    Cell Significance Index: -1.9200
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1549
    Cell Significance Index: -1.9600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1580
    Cell Significance Index: -2.1700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1602
    Cell Significance Index: -1.9500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1621
    Cell Significance Index: -2.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The CSN1S1 gene is a single-copy gene with an Ensembl ID of ENSG00000126545. It is located on chromosome 6q11.2 and encodes for a protein with a molecular weight of approximately 18 kDa. The alpha-S1-casein protein is a calcium-binding protein that plays a crucial role in milk protein structure and function. The CSN1S1 gene is expressed in a wide range of cell types, including those in the immune system, nervous system, and hematopoietic system. **Pathways and Functions:** The CSN1S1 gene is involved in several cellular pathways, including: 1. **Protein binding:** The alpha-S1-casein protein binds to calcium ions and other molecules, which regulates its activity and interactions with other proteins. 2. **Transport of small molecules:** The CSN1S1 gene is involved in the transport of small molecules, such as steroids, hormones, and other signaling molecules, across cell membranes. 3. **Response to steroid hormones:** The CSN1S1 gene is responsive to steroid hormones, such as 11-deoxycorticosterone, dehydroepiandrosterone, estradiol, and progesterone, which regulate various cellular processes. 4. **Immune function:** The CSN1S1 gene is expressed in immune cells, such as T cells and B cells, and may play a role in immune function and regulation. **Clinical Significance:** The clinical significance of the CSN1S1 gene is still unclear, but it may play a role in various diseases and conditions, including: 1. **Immunodeficiency disorders:** Abnormalities in the CSN1S1 gene may contribute to immunodeficiency disorders, such as autoimmune diseases and allergic reactions. 2. **Neurological disorders:** The CSN1S1 gene is expressed in certain neural cells, and abnormalities in this gene may contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** The CSN1S1 gene may play a role in cancer development and progression, particularly in tissues with high levels of immune activity, such as the tumor microenvironment. In conclusion, the CSN1S1 gene is a multifunctional gene that plays a crucial role in various cellular processes, including protein binding, transport, and response to steroid hormones. Its clinical significance is still unclear, but it may play a role in immune function, cellular differentiation, and tissue development. Further research is needed to fully understand the function and clinical significance of the CSN1S1 gene.

Genular Protein ID: 3208651380

Symbol: CASA1_HUMAN

Name: Alpha-S1-casein

UniProtKB Accession Codes:

P47710 A1A510 A1A511 E9PB60 Q4PNR5

Database IDs:

AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7619062

Title: Characterization of three types of human alpha s1-casein mRNA transcripts.

PubMed ID: 7619062

DOI: 10.1042/bj3090237

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8192860

Title: Human alpha S1-casein like protein: purification and N-terminal sequence determination.

PubMed ID: 8192860

DOI: 10.1515/bchm3.1994.375.2.149

PubMed ID: 7749638

Title: Human alpha s1-casein: purification and characterization.

PubMed ID: 7749638

DOI: 10.1016/0305-0491(94)00225-j

PubMed ID: 17646876

Title: On studying protein phosphorylation patterns using bottom-up LC-MS/MS: the case of human alpha-casein.

PubMed ID: 17646876

DOI: 10.1039/b701902e

PubMed ID: 18847231

Title: Analysis of the human casein phosphoproteome by 2-D electrophoresis and MALDI-TOF/TOF MS reveals new phosphoforms.

PubMed ID: 18847231

DOI: 10.1021/pr800387s

PubMed ID: 12919330

Title: The phosphorylation pattern of human alphas1-casein is markedly different from the ruminant species.

PubMed ID: 12919330

DOI: 10.1046/j.1432-1033.2003.03755.x

PubMed ID: 9050925

Title: Genomic organization and chromosomal localization of the human casein gene family.

PubMed ID: 9050925

DOI: 10.1007/s004390050374

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 185
  • Mass: 21671
  • Checksum: A7717899CDC7D563
  • Sequence:
    • MRLLILTCLV AVALARPKLP LRYPERLQNP SESSEPIPLE SREEYMNGMN RQRNILREKQ 
TDEIKDTRNE STQNCVVAEP EKMESSISSS SEEMSLSKCA EQFCRLNEYN QLQLQAAHAQ 
EQIRRMNENS HVQVPFQQLN QLAAYPYAVW YYPQIMQYVP FPPFSDISNP TAHENYEKNN 
VMLQW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.