Details for: Gata1

Gene ID: 14460

Symbol: Gata1

Ensembl ID: ENSMUSG00000031162

Description: GATA binding protein 1

Associated with

  • Factors involved in megakaryocyte development and platelet production
    (R-MMU-983231)
  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Hemostasis
    (R-MMU-109582)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Runx1 regulates genes involved in megakaryocyte differentiation and platelet function
    (R-MMU-8936459)
  • Runx1 regulates transcription of genes involved in differentiation of hscs
    (R-MMU-8939236)
  • Transcriptional regulation by runx1
    (R-MMU-8878171)
  • Animal organ regeneration
    (GO:0031100)
  • Bone mineralization
    (GO:0030282)
  • C2h2 zinc finger domain binding
    (GO:0070742)
  • Cell-cell signaling
    (GO:0007267)
  • Cell development
    (GO:0048468)
  • Cell fate commitment
    (GO:0045165)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Chromatin binding
    (GO:0003682)
  • Chromatin dna binding
    (GO:0031490)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dendritic cell differentiation
    (GO:0097028)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic hemopoiesis
    (GO:0035162)
  • Eosinophil fate commitment
    (GO:0035854)
  • Erythrocyte development
    (GO:0048821)
  • Erythrocyte differentiation
    (GO:0030218)
  • Homeostasis of number of cells within a tissue
    (GO:0048873)
  • In utero embryonic development
    (GO:0001701)
  • Male gonad development
    (GO:0008584)
  • Megakaryocyte differentiation
    (GO:0030219)
  • Metal ion binding
    (GO:0046872)
  • Myeloid cell apoptotic process
    (GO:0033028)
  • Myeloid cell differentiation
    (GO:0030099)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of bone mineralization
    (GO:0030502)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transcription regulatory region dna binding
    (GO:2000678)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Osteoblast proliferation
    (GO:0033687)
  • P53 binding
    (GO:0002039)
  • Platelet aggregation
    (GO:0070527)
  • Platelet formation
    (GO:0030220)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of erythrocyte differentiation
    (GO:0045648)
  • Positive regulation of mast cell degranulation
    (GO:0043306)
  • Positive regulation of osteoblast proliferation
    (GO:0033690)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Primitive erythrocyte differentiation
    (GO:0060319)
  • Protein binding
    (GO:0005515)
  • Regulation of definitive erythrocyte differentiation
    (GO:0010724)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of glycoprotein biosynthetic process
    (GO:0010559)
  • Regulation of primitive erythrocyte differentiation
    (GO:0010725)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription coregulator binding
    (GO:0001221)
  • Transcription regulator complex
    (GO:0005667)
  • Transcription repressor complex
    (GO:0017053)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 392056260

Symbol: GATA1_MOUSE

Name: Erythroid transcription factor

UniProtKB Accession Codes:

P17679 Q3UIH9 Q7TMX8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 67 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 7 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2725678

Title: Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells.

PubMed ID: 2725678

DOI: 10.1038/339446a0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21536911

Title: Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.

PubMed ID: 21536911

DOI: 10.1073/pnas.1102140108

PubMed ID: 2276623

Title: Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.

PubMed ID: 2276623

DOI: 10.1101/gad.4.11.1886

PubMed ID: 8206977

Title: Phosphorylation of the erythroid transcription factor GATA-1.

PubMed ID: 8206977

DOI: 10.1016/s0021-9258(19)89430-9

PubMed ID: 8524811

Title: Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.

PubMed ID: 8524811

DOI: 10.1073/pnas.92.25.11598

PubMed ID: 10078204

Title: Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex.

PubMed ID: 10078204

DOI: 10.1016/s1097-2765(00)80312-3

PubMed ID: 10207073

Title: CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites.

PubMed ID: 10207073

DOI: 10.1128/mcb.19.5.3496

PubMed ID: 15173587

Title: Modification of the erythroid transcription factor GATA-1 by SUMO-1.

PubMed ID: 15173587

DOI: 10.1073/pnas.0308605101

PubMed ID: 15920471

Title: GATA-1 forms distinct activating and repressive complexes in erythroid cells.

PubMed ID: 15920471

DOI: 10.1038/sj.emboj.7600702

PubMed ID: 16199866

Title: LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.

PubMed ID: 16199866

DOI: 10.1128/mcb.25.20.8864-8873.2005

PubMed ID: 16888089

Title: Acetylation of GATA-1 is required for chromatin occupancy.

PubMed ID: 16888089

DOI: 10.1182/blood-2006-07-032847

PubMed ID: 24245781

Title: CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function.

PubMed ID: 24245781

DOI: 10.1111/gtc.12104

PubMed ID: 10212985

Title: The solution structure of the N-terminal zinc finger of GATA-1 reveals a specific binding face for the transcriptional co-factor FOG.

PubMed ID: 10212985

DOI: 10.1023/a:1008309602929

PubMed ID: 21555453

Title: Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3.

PubMed ID: 21555453

DOI: 10.1128/mcb.05413-11

Sequence Information:

  • Length: 413
  • Mass: 42674
  • Checksum: BB627A92700D557A
  • Sequence:
    • MDFPGLGALG TSEPLPQFVD SALVSSPSDS TGFFSSGPEG LDAASSSTSP NAATAAASAL 
AYYREAEAYR HSPVFQVYPL LNSMEGIPGG SPYASWAYGK TALYPASTVC PSHEDAPSQA 
LEDQEGKSNN TFLDTLKTER LSPDLLTLGT ALPASLPVTG SAYGGADFPS PFFSPTGSPL 
SSAAYSSPKF HGSLPLAPCE ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP 
LIRPKKRMIV SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYFKLHQ VNRPLTMRKD 
GIQTRNRKAS GKGKKKRGSN LAGAGAAEGP AGGFMVVAGS SSSGNCGEVA SGLALGTAGT 
AHLYQGLGPV VLSGPVSHLM PFPGPLLGSP TTSFPTGPAP TTSSTSVIAP LSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.