Details for: Gata2

Gene ID: 14461

Symbol: Gata2

Ensembl ID: ENSMUSG00000015053

Description: GATA binding protein 2

Associated with

  • Factors involved in megakaryocyte development and platelet production
    (R-MMU-983231)
  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Hemostasis
    (R-MMU-109582)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Runx1 regulates transcription of genes involved in differentiation of hscs
    (R-MMU-8939236)
  • Transcriptional regulation by runx1
    (R-MMU-8878171)
  • Angiogenesis
    (GO:0001525)
  • Brown fat cell differentiation
    (GO:0050873)
  • C2h2 zinc finger domain binding
    (GO:0070742)
  • Cell differentiation in hindbrain
    (GO:0021533)
  • Cell fate commitment
    (GO:0045165)
  • Cell fate determination
    (GO:0001709)
  • Central nervous system neuron development
    (GO:0021954)
  • Chromatin binding
    (GO:0003682)
  • Commitment of neuronal cell to specific neuron type in forebrain
    (GO:0021902)
  • Cytoplasm
    (GO:0005737)
  • Definitive hemopoiesis
    (GO:0060216)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic placenta development
    (GO:0001892)
  • Eosinophil fate commitment
    (GO:0035854)
  • Fat cell differentiation
    (GO:0045444)
  • Gabaergic neuron differentiation
    (GO:0097154)
  • Glandular epithelial cell differentiation
    (GO:0002067)
  • Glandular epithelial cell maturation
    (GO:0002071)
  • Hematopoietic progenitor cell differentiation
    (GO:0002244)
  • Hematopoietic stem cell homeostasis
    (GO:0061484)
  • Homeostasis of number of cells within a tissue
    (GO:0048873)
  • Inner ear morphogenesis
    (GO:0042472)
  • Metal ion binding
    (GO:0046872)
  • Myeloid cell differentiation
    (GO:0030099)
  • Negative regulation of brown fat cell differentiation
    (GO:1903444)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of hematopoietic progenitor cell differentiation
    (GO:1901533)
  • Negative regulation of macrophage differentiation
    (GO:0045650)
  • Negative regulation of myeloid cell differentiation
    (GO:0045638)
  • Negative regulation of neural precursor cell proliferation
    (GO:2000178)
  • Negative regulation of neuroblast proliferation
    (GO:0007406)
  • Negative regulation of notch signaling pathway
    (GO:0045746)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neural precursor cell proliferation
    (GO:0061351)
  • Neuroblast proliferation
    (GO:0007405)
  • Neuroendocrine cell differentiation
    (GO:0061101)
  • Neuron differentiation
    (GO:0030182)
  • Neuron fate commitment
    (GO:0048663)
  • Neuron maturation
    (GO:0042551)
  • Neuron migration
    (GO:0001764)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Phagocytosis
    (GO:0006909)
  • Pituitary gland development
    (GO:0021983)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903589)
  • Positive regulation of cell migration involved in sprouting angiogenesis
    (GO:0090050)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of erythrocyte differentiation
    (GO:0045648)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of mast cell degranulation
    (GO:0043306)
  • Positive regulation of megakaryocyte differentiation
    (GO:0045654)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of phagocytosis, engulfment
    (GO:0060100)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of forebrain neuron differentiation
    (GO:2000977)
  • Regulation of primitive erythrocyte differentiation
    (GO:0010725)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Semicircular canal development
    (GO:0060872)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Thyroid-stimulating hormone-secreting cell differentiation
    (GO:0060129)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription coactivator binding
    (GO:0001223)
  • Transcription coregulator binding
    (GO:0001221)
  • Transcription regulator complex
    (GO:0005667)
  • Urogenital system development
    (GO:0001655)
  • Vascular wound healing
    (GO:0061042)
  • Ventral spinal cord interneuron differentiation
    (GO:0021514)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 2594522302

Symbol: GATA2_MOUSE

Name: Endothelial transcription factor GATA-2

UniProtKB Accession Codes:

O09100

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 81 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9452491

Title: Alternative promoters regulate transcription of the mouse GATA-2 gene.

PubMed ID: 9452491

DOI: 10.1074/jbc.273.6.3625

PubMed ID: 21536911

Title: Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes.

PubMed ID: 21536911

DOI: 10.1073/pnas.1102140108

PubMed ID: 35235341

Title: Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema.

PubMed ID: 35235341

DOI: 10.1126/scitranslmed.abm4869

Sequence Information:

  • Length: 480
  • Mass: 50468
  • Checksum: 7E0DCE9B53F49C8A
  • Sequence:
    • MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY 
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP 
FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE 
VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP 
ATHHPIPTYP SYVPAAAHDY GSSLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA 
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW 
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC 
MQEKSPPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.