Genular: Defining Cellular Identity and Function

Details for: Gata3

Gene ID: 14462

Symbol: Gata3

Ensembl ID: ENSMUSG00000015619

Description: GATA binding protein 3

Associated with

Deubiquitination
(R-MMU-5688426)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hemostasis
(R-MMU-109582)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-MMU-8939236)
Signaling by nuclear receptors
(R-MMU-9006931)
Transcriptional regulation by runx1
(R-MMU-8878171)
Ub-specific processing proteases
(R-MMU-5689880)
Aortic valve morphogenesis
(GO:0003180)
Axon guidance
(GO:0007411)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cell activation
(GO:0001775)
Cell fate determination
(GO:0001709)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Chromatin remodeling
(GO:0006338)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
E-box binding
(GO:0070888)
Erythrocyte differentiation
(GO:0030218)
Gene expression
(GO:0010467)
Histone methyltransferase binding
(GO:1990226)
Hmg box domain binding
(GO:0071837)
Humoral immune response
(GO:0006959)
Identical protein binding
(GO:0042802)
Immune system development
(GO:0002520)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Interleukin-2 receptor binding
(GO:0005134)
Interleukin-4 production
(GO:0032633)
Interleukin-5 production
(GO:0032634)
Interleukin-13 production
(GO:0032616)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Lens development in camera-type eye
(GO:0002088)
Macrophage differentiation
(GO:0030225)
Male gonad development
(GO:0008584)
Mesonephros development
(GO:0001823)
Metal ion binding
(GO:0046872)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type ii interferon production
(GO:0032689)
Nervous system development
(GO:0007399)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-13 production
(GO:0032736)
Positive regulation of signal transduction
(GO:0009967)
Post-embryonic development
(GO:0009791)
Pro-t cell differentiation
(GO:0002572)
Protein binding
(GO:0005515)
Regulation of cytokine production
(GO:0001817)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of epithelial cell differentiation
(GO:0030856)
Regulation of neuron projection development
(GO:0010975)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction
(GO:0007165)
T cell differentiation
(GO:0030217)
Tor signaling
(GO:0031929)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Type ii interferon production
(GO:0032609)
Ventricular septum development
(GO:0003281)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Trans-acting T-cell-specific transcription factor GATA-3

Genular Protein ID: 4280597995

Symbol: GATA3_MOUSE

Name: Trans-acting T-cell-specific transcription factor GATA-3

UniProtKB Accession Codes:

P23772

Database IDs:

Citations:

PubMed ID: 2017177

Title: Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.

PubMed ID: 2017177

DOI: 10.1128/mcb.11.5.2778-2784.1991

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15662016

Title: T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

PubMed ID: 15662016

DOI: 10.1126/science.1103336

PubMed ID: 17056504

Title: Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function.

PubMed ID: 17056504

DOI: 10.4049/jimmunol.177.9.5801

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21690296

Title: c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation.

PubMed ID: 21690296

DOI: 10.1128/mcb.05383-11

PubMed ID: 23616576

Title: Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet.

PubMed ID: 23616576

DOI: 10.4049/jimmunol.1203403

PubMed ID: 31175139

Title: The E3 Ubiquitin Ligase Asb2alpha in T Helper 2 Cells Negatively Regulates Antitumor Immunity in Colorectal Cancer.

PubMed ID: 31175139

DOI: 10.1158/2326-6066.cir-18-0562

PubMed ID: 34644537

Title: IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.

PubMed ID: 34644537

DOI: 10.1016/j.immuni.2021.09.010

PubMed ID: 18621058

Title: Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA.

PubMed ID: 18621058

DOI: 10.1016/j.jmb.2008.06.072

Sequence Information:

Length: 443
Mass: 47968
Checksum: 980E58FB9872E560
Sequence:

MEVTADQPRW VSHHHPAVLN GQHPDTHHPG LGHSYMEAQY PLTEEVDVLF NIDGQGNHVP 
SYYGNSVRAT VQRYPPTHHG SQVCRPPLLH GSLPWLDGGK ALSSHHTASP WNLSPFSKTS 
IHHGSPGPLS VYPPASSSSL AAGHSSPHLF TFPPTPPKDV SPDPSLSTPG SAGSARQDEK 
ECLKYQVQLP DSMKLETSHS RGSMTTLGGA SSSAHHPITT YPPYVPEYSS GLFPPSSLLG 
GSPTGFGCKS RPKARSSTEG RECVNCGATS TPLWRRDGTG HYLCNACGLY HKMNGQNRPL 
IKPKRRLSAA RRAGTSCANC QTTTTTLWRR NANGDPVCNA CGLYYKLHNI NRPLTMKKEG 
IQTRNRKMSS KSKKCKKVHD ALEDFPKSSS FNPAALSRHM SSLSHISPFS HSSHMLTTPT 
PMHPPSGLSF GPHHPSSMVT AMG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gata3

Associated with

Other Information

Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer. PubMed ID: 2017177

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. PubMed ID: 15662016

Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function. PubMed ID: 17056504

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation. PubMed ID: 21690296

Lysine 313 of T-box is crucial for modulation of protein stability, DNA binding, and threonine phosphorylation of T-bet. PubMed ID: 23616576

The E3 Ubiquitin Ligase Asb2alpha in T Helper 2 Cells Negatively Regulates Antitumor Immunity in Colorectal Cancer. PubMed ID: 31175139

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. PubMed ID: 34644537

Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA. PubMed ID: 18621058