Genular: Defining Cellular Identity and Function

Details for: Gata4

Gene ID: 14463

Symbol: Gata4

Ensembl ID: ENSMUSG00000021944

Description: GATA binding protein 4

Associated with

Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Hemostasis
(R-MMU-109582)
Aortic valve morphogenesis
(GO:0003180)
Atrial septum primum morphogenesis
(GO:0003289)
Atrial septum secundum morphogenesis
(GO:0003290)
Atrioventricular canal development
(GO:0036302)
Atrioventricular valve formation
(GO:0003190)
Atrioventricular valve morphogenesis
(GO:0003181)
Cardiac muscle cell differentiation
(GO:0055007)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cardiac muscle tissue development
(GO:0048738)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cardiac septum development
(GO:0003279)
Cell-cell signaling
(GO:0007267)
Cell fate commitment
(GO:0045165)
Chromatin binding
(GO:0003682)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Co-smad binding
(GO:0070410)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Embryonic digestive tract morphogenesis
(GO:0048557)
Embryonic foregut morphogenesis
(GO:0048617)
Embryonic heart tube anterior/posterior pattern specification
(GO:0035054)
Embryonic heart tube development
(GO:0035050)
Embryonic morphogenesis
(GO:0048598)
Endocardial cushion development
(GO:0003197)
Endoderm formation
(GO:0001706)
Gastrulation with mouth forming second
(GO:0001702)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Heart morphogenesis
(GO:0003007)
In utero embryonic development
(GO:0001701)
Male gonad development
(GO:0008584)
Metal ion binding
(GO:0046872)
Mitral valve formation
(GO:0003192)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nfat protein binding
(GO:0051525)
Outflow tract morphogenesis
(GO:0003151)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to estrogen
(GO:0043627)
Response to mechanical stimulus
(GO:0009612)
Response to retinoic acid
(GO:0032526)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Skeletal muscle cell differentiation
(GO:0035914)
Spermatogenesis
(GO:0007283)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Tricuspid valve formation
(GO:0003195)
Tube morphogenesis
(GO:0035239)
Ventricular cardiac muscle tissue development
(GO:0003229)
Ventricular septum development
(GO:0003281)
Wound healing
(GO:0042060)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Genular Protein ID: 3840066829

Symbol: GATA4_MOUSE

Name: Transcription factor GATA-4

UniProtKB Accession Codes:

Q08369 B9EHF7 P97491 Q9QZK4

Database IDs:

Citations:

PubMed ID: 8455608

Title: Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.

PubMed ID: 8455608

DOI: 10.1128/mcb.13.4.2235-2246.1993

PubMed ID: 8083222

Title: GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.

PubMed ID: 8083222

DOI: 10.1016/s0021-9258(17)31636-8

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7717974

Title: Regulation of J6 gene expression by transcription factor GATA-4.

PubMed ID: 7717974

DOI: 10.1042/bj3070183

PubMed ID: 9568714

Title: A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.

PubMed ID: 9568714

DOI: 10.1016/s0092-8674(00)81573-1

PubMed ID: 9584153

Title: The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression.

PubMed ID: 9584153

DOI: 10.1128/mcb.18.6.3120

PubMed ID: 15542826

Title: Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.

PubMed ID: 15542826

DOI: 10.1128/mcb.24.23.10151-10160.2004

PubMed ID: 16199866

Title: LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.

PubMed ID: 16199866

DOI: 10.1128/mcb.25.20.8864-8873.2005

PubMed ID: 17584735

Title: Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.

PubMed ID: 17584735

DOI: 10.1074/jbc.m703724200

PubMed ID: 22215809

Title: PRC2 directly methylates GATA4 and represses its transcriptional activity.

PubMed ID: 22215809

DOI: 10.1101/gad.173930.111

PubMed ID: 35182466

Title: Transcription factor protein interactomes reveal genetic determinants in heart disease.

PubMed ID: 35182466

DOI: 10.1016/j.cell.2022.01.021

Sequence Information:

Length: 441
Mass: 44580
Checksum: E9521771741DD08E
Sequence:

MYQSLAMAAN HGPPPGAYEA GGPGAFMHSA GAASSPVYVP TPRVPSSVLG LSYLQGGGSA 
AAAGTTSGGS SGAGPSGAGP GTQQGSPGWS QAGAEGAAYT PPPVSPRFSF PGTTGSLAAA 
AAAAAAREAA AYGSGGGAAG AGLAGREQYG RPGFAGSYSS PYPAYMADVG ASWAAAAAAS 
AGPFDSPVLH SLPGRANPGR HPNLDMFDDF SEGRECVNCG AMSTPLWRRD GTGHYLCNAC 
GLYHKMNGIN RPLIKPQRRL SASRRVGLSC ANCQTTTTTL WRRNAEGEPV CNACGLYMKL 
HGVPRPLAMR KEGIQTRKRK PKNLNKSKTP AGPAGETLPP SSGASSGNSS NATSSSSSSE 
EMRPIKTEPG LSSHYGHSSS MSQTFSTVSG HGPSIHPVLS ALKLSPQGYA SPVTQTSQAS 
SKQDSWNSLV LADSHGDIIT A

Genular Protein ID: 1080107926

Symbol: Q3UYJ1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UYJ1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 236
Mass: 25264
Checksum: CBD78457158543BE
Sequence:

MFDDFSEGRE CVNCGAMSTP LWRRDGTGHY LCNACGLYHK MNGINRPLIK PQRRLSASRR 
VGLSCANCQT TTTTLWRRNA EGEPVCNACG LYMKLHGVPR PLAMRKEGIQ TRKRKPKNLN 
KSKTPAGPAG ETLPPSSGAS SGNSSNATSS SSSSEEMRPI KTEPGLSSHY GHSSSMSQTF 
STVSGHGPSI HPVLSALKLS PQGYASPVTQ TSQASSKQDS WNSLVLADSH GDIITA

Genular Protein ID: 3038733257

Symbol: E9PXW9_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9PXW9

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 442
Mass: 44680
Checksum: 00B1DAA9907F03B0
Sequence:

MYQSLAMAAN HGPPPGAYEA GGPGAFMHSA GAASSPVYVP TPRVPSSVLG LSYLQGGGSA 
AAAGTTSGGS SGAGPSGAGP GTQQGSPGWS QAGAEGAAYT PPPVSPRFSF PGTTGSLAAA 
AAAAAAREAA AYGSGGGAAG AGLAGREQYG RPGFAGSYSS PYPAYMADVG ASWAAAAAAS 
AGPFDSPVLH SLPGRANPGR HPNLVDMFDD FSEGRECVNC GAMSTPLWRR DGTGHYLCNA 
CGLYHKMNGI NRPLIKPQRR LSASRRVGLS CANCQTTTTT LWRRNAEGEP VCNACGLYMK 
LHGVPRPLAM RKEGIQTRKR KPKNLNKSKT PAGPAGETLP PSSGASSGNS SNATSSSSSS 
EEMRPIKTEP GLSSHYGHSS SMSQTFSTVS GHGPSIHPVL SALKLSPQGY ASPVTQTSQA 
SSKQDSWNSL VLADSHGDII TA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gata4

Associated with

Other Information

Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. PubMed ID: 8455608

GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. PubMed ID: 8083222

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Regulation of J6 gene expression by transcription factor GATA-4. PubMed ID: 7717974

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. PubMed ID: 9568714

The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. PubMed ID: 9584153

Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. PubMed ID: 15542826

LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. PubMed ID: 16199866

Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors. PubMed ID: 17584735

PRC2 directly methylates GATA4 and represses its transcriptional activity. PubMed ID: 22215809

Transcription factor protein interactomes reveal genetic determinants in heart disease. PubMed ID: 35182466

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 8455608

PubMed ID: 8083222

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 7717974

PubMed ID: 9568714

PubMed ID: 9584153

PubMed ID: 15542826

PubMed ID: 16199866

PubMed ID: 17584735

PubMed ID: 22215809

PubMed ID: 35182466

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19468303

PubMed ID: 19468303