Genular: Defining Cellular Identity and Function

Details for: Gata6

Gene ID: 14465

Symbol: Gata6

Ensembl ID: ENSMUSG00000005836

Description: GATA binding protein 6

Associated with

Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Hemostasis
(R-MMU-109582)
Metabolism of proteins
(R-MMU-392499)
Surfactant metabolism
(R-MMU-5683826)
Animal organ formation
(GO:0048645)
Cardiac muscle cell differentiation
(GO:0055007)
Cardiac muscle cell proliferation
(GO:0060038)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cardiac muscle tissue development
(GO:0048738)
Cardiac vascular smooth muscle cell differentiation
(GO:0060947)
Cell fate commitment
(GO:0045165)
Cellular response to bmp stimulus
(GO:0071773)
Cellular response to gonadotropin stimulus
(GO:0071371)
Cellular response to hypoxia
(GO:0071456)
Chromatin binding
(GO:0003682)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Club cell differentiation
(GO:0060486)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Endodermal cell differentiation
(GO:0035987)
Endodermal cell fate determination
(GO:0007493)
Epithelial cell differentiation
(GO:0030855)
G1 to g0 transition involved in cell differentiation
(GO:0070315)
Gene expression
(GO:0010467)
Heart contraction
(GO:0060047)
Intestinal epithelial cell differentiation
(GO:0060575)
In utero embryonic development
(GO:0001701)
Liver development
(GO:0001889)
Lung saccule development
(GO:0060430)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of mirna transcription
(GO:1902894)
Negative regulation of sebum secreting cell proliferation
(GO:1904003)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta1 production
(GO:0032911)
Negative regulation of transforming growth factor beta2 production
(GO:0032912)
Nfat protein binding
(GO:0051525)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Outflow tract septum morphogenesis
(GO:0003148)
Pancreas development
(GO:0031016)
Pancreatic a cell differentiation
(GO:0003310)
Phospholipid metabolic process
(GO:0006644)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of cardiac muscle myoblast proliferation
(GO:0110024)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transforming growth factor beta activation
(GO:1901390)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of antimicrobial humoral response
(GO:0002759)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to estrogen
(GO:0043627)
Response to growth factor
(GO:0070848)
Response to retinoic acid
(GO:0032526)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sebaceous gland cell differentiation
(GO:0001949)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Sinoatrial node development
(GO:0003163)
Skin epidermis development
(GO:0098773)
Smooth muscle cell differentiation
(GO:0051145)
Stem cell differentiation
(GO:0048863)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription factor binding
(GO:0008134)
Transcription regulator complex
(GO:0005667)
Tube morphogenesis
(GO:0035239)
Type b pancreatic cell differentiation
(GO:0003309)
Type ii pneumocyte differentiation
(GO:0060510)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Transcription factor GATA-6

Genular Protein ID: 289973388

Symbol: GATA6_MOUSE

Name: Transcription factor GATA-6

UniProtKB Accession Codes:

Q61169 P97729 Q3UQJ2 Q9QZK3

Database IDs:

Citations:

PubMed ID: 8660897

Title: GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm.

PubMed ID: 8660897

DOI: 10.1006/dbio.1996.0165

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 8812463

Title: The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle.

PubMed ID: 8812463

DOI: 10.1006/geno.1996.0472

PubMed ID: 10608869

Title: The human and mouse GATA-6 genes utilize two promoters and two initiation codons.

PubMed ID: 10608869

DOI: 10.1074/jbc.274.53.38004

PubMed ID: 15329343

Title: SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer.

PubMed ID: 15329343

DOI: 10.1242/dev.01344

PubMed ID: 16199866

Title: LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.

PubMed ID: 16199866

DOI: 10.1128/mcb.25.20.8864-8873.2005

PubMed ID: 19666519

Title: GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.

PubMed ID: 19666519

DOI: 10.1073/pnas.0904744106

Sequence Information:

Length: 589
Mass: 59307
Checksum: 1A55474DA65EC6ED
Sequence:

MALTDGGWCL PKRFGAAAAD AGDSGPFPAR EPSSPLSPIS SSSSSCSRGG DRGPCGASNC 
RTPQLDAEAV AGPPGRSLLL SPYASHPFAA AHGAAAPGVA GPGSALSTWE DLLLFTDLDQ 
AATASKLLWS SRGAKLSPFA AEQPEEMYQT LAALSSQGPA AYDGAPGGFV HSAAAAAAAA 
AAASSPVYVP TTRVGSMLSG LPYLQGAGSG PSNHAGGAGA HPGWSQASAD SPPYGGGGAA 
GGGAAGPGGA GSATAHASAR FPYSPSPPMA NGAARDPGGY VAAGGTGAGS VSGGGGSLAA 
MGGREHQYSS LSAARPLNGT YHHHHHHHPT YSPYMAAPLT PAWPAGPFET PVLHSLQGRA 
GAPLPVPRGP STDLLEDLSE SRECVNCGSI QTPLWRRDGT GHYLCNACGL YSKMNGLSRP 
LIKPQKRVPS SRRLGLSCAN CHTTTTTLWR RNAEGEPVCN ACGLYMKLHG VPRPLAMKKE 
GIQTRKRKPK NINKSKACSG NSSGSVPMTP TSSSSNSDDC TKNTSPSTQA TTSGVGASVM 
SAVGENANPE NSDLKYSGQD GLYIGVSLSS PAEVTSSVRQ DSWCALALA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gata6

Associated with

Other Information

GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. PubMed ID: 8660897

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle. PubMed ID: 8812463

The human and mouse GATA-6 genes utilize two promoters and two initiation codons. PubMed ID: 10608869

SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. PubMed ID: 15329343

LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding. PubMed ID: 16199866

GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling. PubMed ID: 19666519