Genular: Defining Cellular Identity and Function

Details for: Gbp2

Gene ID: 14469

Symbol: Gbp2

Ensembl ID: ENSMUSG00000028270

Description: guanylate binding protein 2

Associated with

Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Activation of innate immune response
(GO:0002218)
Adhesion of symbiont to host
(GO:0044406)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to type ii interferon
(GO:0071346)
Cytokine binding
(GO:0019955)
Cytolysis in another organism
(GO:0051715)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Defense response to gram-positive bacterium
(GO:0050830)
Defense response to protozoan
(GO:0042832)
Endopeptidase inhibitor activity
(GO:0004866)
Enzyme binding
(GO:0019899)
Gdp binding
(GO:0019003)
Gdp phosphatase activity
(GO:0004382)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtpase regulator activity
(GO:0030695)
Gtp binding
(GO:0005525)
Hsp90 protein binding
(GO:0051879)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Membrane
(GO:0016020)
Molecular function inhibitor activity
(GO:0140678)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of aim2 inflammasome complex assembly
(GO:0140973)
Positive regulation of pyroptosis
(GO:0140639)
Protein homodimerization activity
(GO:0042803)
Protein targeting
(GO:0006605)
Response to bacterium
(GO:0009617)
Spectrin binding
(GO:0030507)
Symbiont-containing vacuole membrane
(GO:0020005)
Symbiont cell surface
(GO:0106139)
Vesicle membrane
(GO:0012506)

Other Information

Proteins

Guanylate-binding protein 2

Genular Protein ID: 1196224230

Symbol: GBP2_MOUSE

Name: Guanylate-binding protein 2

UniProtKB Accession Codes:

Q9Z0E6 Q4FK03 Q8CIC6 Q921N2 Q9R1I0

Database IDs:

Citations:

PubMed ID: 9862701

Title: Two families of GTPases dominate the complex cellular response to IFN-gamma.

PubMed ID: 9862701

PubMed ID: 9858320

Title: Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages.

PubMed ID: 9858320

DOI: 10.1089/jir.1998.18.977

PubMed ID: 10386861

Title: Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family.

PubMed ID: 10386861

DOI: 10.1089/107999099313938

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18025219

Title: Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense.

PubMed ID: 18025219

DOI: 10.4049/jimmunol.179.11.7729

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 31964735

Title: Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection.

PubMed ID: 31964735

DOI: 10.1128/mbio.02993-19

PubMed ID: 24739961

Title: Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

PubMed ID: 24739961

DOI: 10.1038/nature13157

PubMed ID: 24715728

Title: Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

PubMed ID: 24715728

DOI: 10.1073/pnas.1321700111

PubMed ID: 25774715

Title: The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

PubMed ID: 25774715

DOI: 10.1038/ni.3118

PubMed ID: 25774716

Title: Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

PubMed ID: 25774716

DOI: 10.1038/ni.3119

PubMed ID: 27693356

Title: IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes.

PubMed ID: 27693356

DOI: 10.1016/j.cell.2016.09.012

PubMed ID: 30062052

Title: Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.

PubMed ID: 30062052

DOI: 10.1038/s41420-018-0068-z

Sequence Information:

Length: 589
Mass: 66739
Checksum: 8E68B0A3BC5F3AE3
Sequence:

MASEIHMSEP MCLIENTEAQ LVINQEALRI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG 
KRTGFSLGST VQSHTKGIWM WCVPHPKKAG QTLVLLDTEG LEDVEKGDNQ NDCWIFALAV 
LLSSTFIYNS IGTINQQAMD QLHYVTELTD LIKSKSSPDQ SGVDDSANFV GFFPTFVWTL 
RDFSLELEVN GKPVTSDEYL EHSLTLKKGA DKKTKSFNEP RLCIRKFFPK RKCFIFDRPA 
QRKQLSKLET LREEELCGEF VEQVAEFTSY ILSYSSVKTL CGGIIVNGPR LKSLVQTYVG 
AISNGSLPCM ESAVLTLAQI ENSAAVQKAI THYEEQMNQK IQMPTETLQE LLDLHRPIES 
EAIEVFLKNS FKDVDQKFQT ELGNLLVAKR DAFIKKNMDV SSARCSDLLE DIFGPLEEEV 
KLGTFSKPGG YYLFLQMRQE LEKKYNQAPG KGLQAEAMLK NYFDSKADVV ETLLQTDQSL 
TEAAKEVEEE RTKAEAAEAA NRELEKKQKE FELMMQQKEK SYQEHVKKLT EKMKDEQKQL 
LAEQENIIAA KLREQEKFLK EGFENESKKL IREIDTLKQN KSSGKCTIL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gbp2

Associated with

Other Information

Two families of GTPases dominate the complex cellular response to IFN-gamma. PubMed ID: 9862701

Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages. PubMed ID: 9858320

Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family. PubMed ID: 10386861

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. PubMed ID: 18025219

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection. PubMed ID: 31964735

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. PubMed ID: 24739961

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. PubMed ID: 24715728

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. PubMed ID: 25774715

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. PubMed ID: 25774716

IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes. PubMed ID: 27693356

Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa. PubMed ID: 30062052