Details for: CSNK1A1

Gene ID: 1452

Symbol: CSNK1A1

Ensembl ID: ENSG00000113712

Description: casein kinase 1 alpha 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.6
    Marker Score: 2498.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.51
    Marker Score: 8574
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.49
    Marker Score: 3092.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.47
    Marker Score: 3928
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.26
    Marker Score: 72888
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.16
    Marker Score: 1839
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.01
    Marker Score: 11612
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.01
    Marker Score: 1672
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.99
    Marker Score: 14673.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.96
    Marker Score: 100869
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.93
    Marker Score: 845
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.84
    Marker Score: 2239.5
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.77
    Marker Score: 706
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.77
    Marker Score: 5049
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.74
    Marker Score: 5277
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.72
    Marker Score: 1318.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.71
    Marker Score: 919
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.71
    Marker Score: 3276
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.68
    Marker Score: 20937.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.66
    Marker Score: 56866
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.66
    Marker Score: 3438
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.65
    Marker Score: 3047
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.6
    Marker Score: 9257
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6
    Marker Score: 41709
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.58
    Marker Score: 1537.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.57
    Marker Score: 3737
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.56
    Marker Score: 10712
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.55
    Marker Score: 2206.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.53
    Marker Score: 10557
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.51
    Marker Score: 2179
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.51
    Marker Score: 2933
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.51
    Marker Score: 2705
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5
    Marker Score: 2633.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.49
    Marker Score: 1237
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.48
    Marker Score: 1914
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.48
    Marker Score: 1177
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.48
    Marker Score: 1548
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.48
    Marker Score: 1655
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.47
    Marker Score: 5417.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.46
    Marker Score: 2100
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.45
    Marker Score: 904
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.43
    Marker Score: 1271
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.43
    Marker Score: 1414
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.42
    Marker Score: 83958
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.42
    Marker Score: 42883
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.41
    Marker Score: 1304.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.4
    Marker Score: 2992
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.4
    Marker Score: 6003
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.39
    Marker Score: 5712
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.38
    Marker Score: 859
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.36
    Marker Score: 20704.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.35
    Marker Score: 755
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.35
    Marker Score: 1600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.34
    Marker Score: 10828
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.34
    Marker Score: 973.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.32
    Marker Score: 1297
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.32
    Marker Score: 17265
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.32
    Marker Score: 2210
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.31
    Marker Score: 551
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.27
    Marker Score: 33894
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.27
    Marker Score: 716
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.26
    Marker Score: 1190
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.25
    Marker Score: 2065.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.24
    Marker Score: 908
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.22
    Marker Score: 7642
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.22
    Marker Score: 4040.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.22
    Marker Score: 24982
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.21
    Marker Score: 992
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.21
    Marker Score: 11594
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.19
    Marker Score: 641
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.19
    Marker Score: 1964
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.18
    Marker Score: 2448
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.18
    Marker Score: 3860
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.17
    Marker Score: 758
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.17
    Marker Score: 82366
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.16
    Marker Score: 2316
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.16
    Marker Score: 1263.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.15
    Marker Score: 4292.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.15
    Marker Score: 1060
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.15
    Marker Score: 2372.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.15
    Marker Score: 1060
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.14
    Marker Score: 42645
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.14
    Marker Score: 18597
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.14
    Marker Score: 871
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.13
    Marker Score: 4010
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.13
    Marker Score: 1404
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.13
    Marker Score: 9190.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.13
    Marker Score: 2259
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 2.13
    Marker Score: 626
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.12
    Marker Score: 7856
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.12
    Marker Score: 3471
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.11
    Marker Score: 16174
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.1
    Marker Score: 1979
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.1
    Marker Score: 4379
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.08
    Marker Score: 76776
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.08
    Marker Score: 2569
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.08
    Marker Score: 3058
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.07
    Marker Score: 846
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.07
    Marker Score: 13465
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.06
    Marker Score: 770

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Other Information

**Key characteristics:** * CSNK1A1 is a transmembrane protein with a conserved cysteine-rich domain. * It is expressed in a variety of cell types, including epithelial cells, myocytes, and stem cells. * It is a key regulator of epithelial cell growth and differentiation. * It is involved in the regulation of cell cycle progression and apoptosis. * It is also involved in the regulation of epithelial cell migration, invasion, and metastasis. **Pathways and functions:** * CSNK1A1 is involved in the beta-catenin phosphorylation cascade, a key regulator of epithelial cell growth and differentiation. * It is also involved in the degradation of beta-catenin by the destruction complex. * It is involved in the degradation of gli2 by the proteasome. * It is also involved in the disassembly of the destruction complex and the recruitment of axin to the membrane. * It is involved in the disease, Diseases of signal transduction by growth factor receptors and second messengers. * It is involved in the Hedgehog 'off' state, Hedgehog 'on' state, and signaling by various growth factors. * It is also involved in the regulation of cell cycle progression and apoptosis. **Clinical significance:** * Mutations in CSNK1A1 have been linked to a number of human cancers, including prostate cancer, breast cancer, and colon cancer. * CSNK1A1 inhibitors are being investigated as a potential treatment for cancer. **Additional notes:** * CSNK1A1 is a highly conserved protein with similar sequences in mammals and humans. * It is a key regulator of epithelial cell growth and differentiation. * It is a target for cancer therapy.

Genular Protein ID: 1409055714

Symbol: KC1A_HUMAN

Name: Casein kinase I isoform alpha

UniProtKB Accession Codes:

P48729 D3DQG0 D3DQG1 Q4JJA0 Q5U046 Q5U047 Q6FGA2 Q71TU5 Q96HD2 Q9UDK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 15 EMDB 1 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 15 RefSeq 4 Rhea 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8050587

Title: Cloning and chromosomal localization of the gene coding for human protein kinase CK1.

PubMed ID: 8050587

DOI: 10.1016/0014-5793(94)00679-2

PubMed ID: 7797465

Title: Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.

PubMed ID: 7797465

DOI: 10.1074/jbc.270.25.14875

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1409656

Title: Cell cycle-dependent localization of casein kinase I to mitotic spindles.

PubMed ID: 1409656

DOI: 10.1073/pnas.89.20.9454

PubMed ID: 11955436

Title: Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism.

PubMed ID: 11955436

DOI: 10.1016/s0092-8674(02)00685-2

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18305108

Title: CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs.

PubMed ID: 18305108

DOI: 10.1074/jbc.m800656200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22017875

Title: mTOR drives its own activation via SCF(betaTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.

PubMed ID: 22017875

DOI: 10.1016/j.molcel.2011.08.030

PubMed ID: 22017877

Title: mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR.

PubMed ID: 22017877

DOI: 10.1016/j.molcel.2011.09.005

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23902688

Title: A novel mechanism of keratin cytoskeleton organization through casein kinase Ialpha and FAM83H in colorectal cancer.

PubMed ID: 23902688

DOI: 10.1242/jcs.129684

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31338967

Title: FAM83D directs protein kinase CK1alpha to the mitotic spindle for proper spindle positioning.

PubMed ID: 31338967

DOI: 10.15252/embr.201847495

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 337
  • Mass: 38915
  • Checksum: 1B2085AE33CAFAC2
  • Sequence:
    • MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE 
SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM 
ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKN 
LTGTARYASI NAHLGIEQSR RDDMESLGYV LMYFNRTSLP WQGLKAATKK QKYEKISEKK 
MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE APDYMYLRQL FRILFRTLNH QYDYTFDWTM 
LKQKAAQQAA SSSGQGQQAQ TPTGKQTDKT KSNMKGF

Genular Protein ID: 4000886458

Symbol: B4DER9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DER9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 5 DNASU 1 EC 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 Rhea 3 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 276
  • Mass: 32111
  • Checksum: E70965BC2ACCEC20
  • Sequence:
    • MDLLGPSLED LFNFCSRRFT MKTVLMLADQ MISRIEYVHT KNFIHRDIKP DNFLMGIGRH 
CNKCLESPVG KRKRSMTVST SQDPSFSGLN QLFLIDFGLA KKYRDNRTRQ HIPYREDKNL 
TGTARYASIN AHLGIEQSRR DDMESLGYVL MYFNRTSLPW QGLKAATKKQ KYEKISEKKM 
STPVEVLCKG FPAEFAMYLN YCRGLRFEEA PDYMYLRQLF RILFRTLNHQ YDYTFDWTML 
KQKAAQQAAS SSGQGQQAQT PTGKQTDKTK SNMKGF

Genular Protein ID: 3412915521

Symbol: Q6PJ06_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PJ06

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 4 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 261
  • Mass: 29825
  • Checksum: 593D1C33EAFF6C43
  • Sequence:
    • MASSSGSKAE FIVGGKYKLV RKIGSGSFGD IYLAINITNG EEVAVKLESQ KARHPQLLYE 
SKLYKILQGG VGIPHIRWYG QEKDYNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM 
ISRIEYVHTK NFIHRDIKPD NFLMGIGRHC NKCLESPVGK RKRSMTVSTS QDPSFSGLNQ 
LFLIDFGLAK KYRDNRTRQH IPYREDKNLT GTARYASINA HLGIEQSRRD DMESLGYVLM 
YFNRTSLPWQ GLKAATKKKK K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.