Genular: Defining Cellular Identity and Function

Details for: Gcg

Gene ID: 14526

Symbol: Gcg

Ensembl ID: ENSMUSG00000000394

Description: glucagon

Associated with

Class b/2 (secretin family receptors)
(R-MMU-373080)
G alpha (q) signalling events
(R-MMU-416476)
G alpha (s) signalling events
(R-MMU-418555)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-MMU-381676)
Glucagon-type ligand receptors
(R-MMU-420092)
Glucagon signaling in metabolic regulation
(R-MMU-163359)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Incretin synthesis, secretion, and inactivation
(R-MMU-400508)
Integration of energy metabolism
(R-MMU-163685)
Metabolism
(R-MMU-1430728)
Metabolism of proteins
(R-MMU-392499)
Peptide hormone metabolism
(R-MMU-2980736)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Synthesis, secretion, and deacylation of ghrelin
(R-MMU-422085)
Synthesis, secretion, and inactivation of glucagon-like peptide-1 (glp-1)
(R-MMU-381771)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Cellular response to glucagon stimulus
(GO:0071377)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Gastric inhibitory polypeptide receptor binding
(GO:0031767)
Glucagon receptor binding
(GO:0031769)
Gluconeogenesis
(GO:0006094)
Glucose homeostasis
(GO:0042593)
Hormone activity
(GO:0005179)
Identical protein binding
(GO:0042802)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of appetite
(GO:0032099)
Negative regulation of execution phase of apoptosis
(GO:1900118)
Negative regulation of intrinsic apoptotic signaling pathway
(GO:2001243)
Plasma membrane
(GO:0005886)
Positive regulation of calcium ion import
(GO:0090280)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein kinase activity
(GO:0045860)
Protein kinase a signaling
(GO:0010737)
Receptor ligand activity
(GO:0048018)
Regulation of insulin secretion
(GO:0050796)
Response to activity
(GO:0014823)
Secretory granule lumen
(GO:0034774)

Other Information

Proteins

Pro-glucagon

Genular Protein ID: 4108243809

Symbol: GLUC_MOUSE

Name: Pro-glucagon

UniProtKB Accession Codes:

P55095 Q3UFE9

Database IDs:

Citations:

PubMed ID: 7730317

Title: Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro.

PubMed ID: 7730317

DOI: 10.1074/jbc.270.17.10136

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1886889

Title: GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse.

PubMed ID: 1886889

PubMed ID: 9407057

Title: Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1.

PubMed ID: 9407057

DOI: 10.1074/jbc.272.52.32810

PubMed ID: 11356850

Title: Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.

PubMed ID: 11356850

DOI: 10.1074/jbc.m103362200

PubMed ID: 10605628

Title: The glucagon-like peptides.

PubMed ID: 10605628

DOI: 10.1210/edrv.20.6.0385

PubMed ID: 10322410

Title: Glucagon-like peptide 2.

PubMed ID: 10322410

DOI: 10.1016/s1043-2760(98)00136-2

PubMed ID: 12626323

Title: Glucagon and regulation of glucose metabolism.

PubMed ID: 12626323

DOI: 10.1152/ajpendo.00492.2002

PubMed ID: 14719035

Title: Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2.

PubMed ID: 14719035

DOI: 10.1139/y03-107

PubMed ID: 12554744

Title: Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis.

PubMed ID: 12554744

DOI: 10.1210/me.2002-0306

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22037645

Title: Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

PubMed ID: 22037645

DOI: 10.1038/nm.2513

Sequence Information:

Length: 180
Mass: 20906
Checksum: 595AA6DD9A589950
Sequence:

MKTIYFVAGL LIMLVQGSWQ HALQDTEENP RSFPASQTEA HEDPDEMNED KRHSQGTFTS 
DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI 
AWLVKGRGRR DFPEEVAIAE ELGRRHADGS FSDEMSTILD NLATRDFINW LIQTKITDKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gcg

Associated with

Other Information

Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro. PubMed ID: 7730317

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse. PubMed ID: 1886889

Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1. PubMed ID: 9407057

Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice. PubMed ID: 11356850

The glucagon-like peptides. PubMed ID: 10605628

Glucagon-like peptide 2. PubMed ID: 10322410

Glucagon and regulation of glucose metabolism. PubMed ID: 12626323

Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2. PubMed ID: 14719035

Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. PubMed ID: 12554744

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. PubMed ID: 22037645