Gcgr | ENSMUSG00000025127 | NCBI 14527

Details for: Gcgr

Gene ID: 14527

Symbol: Gcgr

Ensembl ID: ENSMUSG00000025127

Description: glucagon receptor

Associated with

Class b/2 (secretin family receptors)
(R-MMU-373080)
G alpha (q) signalling events
(R-MMU-416476)
G alpha (s) signalling events
(R-MMU-418555)
Glucagon-type ligand receptors
(R-MMU-420092)
Glucagon signaling in metabolic regulation
(R-MMU-163359)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Integration of energy metabolism
(R-MMU-163685)
Metabolism
(R-MMU-1430728)
Signaling by gpcr
(R-MMU-372790)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to glucagon stimulus
(GO:0071377)
Cellular response to starvation
(GO:0009267)
Endosome
(GO:0005768)
Exocytosis
(GO:0006887)
Glucagon receptor activity
(GO:0004967)
Glucose homeostasis
(GO:0042593)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Hormone-mediated signaling pathway
(GO:0009755)
Membrane
(GO:0016020)
Peptide hormone binding
(GO:0017046)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Regulation of glycogen metabolic process
(GO:0070873)
Response to starvation
(GO:0042594)
Signal transduction
(GO:0007165)
Transmembrane signaling receptor activity
(GO:0004888)

Other Information

Proteins

Glucagon receptor
Q3UN81_MOUSE

Genular Protein ID: 1423024551

Symbol: GLR_MOUSE

Name: Glucagon receptor

UniProtKB Accession Codes:

Q61606 Q63960 Q8K0B5

Database IDs:

Citations:

PubMed ID: 7590348

Title: Cloning and sequence analysis of the murine glucagon receptor-encoding gene.

PubMed ID: 7590348

DOI: 10.1016/0378-1119(95)00472-i

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8156917

Title: Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse.

PubMed ID: 8156917

DOI: 10.1210/endo.134.5.8156917

PubMed ID: 12552113

Title: Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice.

PubMed ID: 12552113

DOI: 10.1073/pnas.0237106100

PubMed ID: 16627579

Title: Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.

PubMed ID: 16627579

DOI: 10.1210/en.2005-1410

PubMed ID: 19046568

Title: The glucagon receptor is required for the adaptive metabolic response to fasting.

PubMed ID: 19046568

DOI: 10.1016/j.cmet.2008.09.008

PubMed ID: 32677665

Title: Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.

PubMed ID: 32677665

DOI: 10.1042/bcj20200235

Sequence Information:

Length: 485
Mass: 54929
Checksum: 578EB30BF281E67A
Sequence:

MPLTQLHCPH LLLLLLVLSC LPEAPSAQVM DFLFEKWKLY SDQCHHNLSL LPPPTELVCN 
RTFDKYSCWP DTPPNTTANI SCPWYLPWYH KVQHRLVFKR CGPDGQWVRG PRGQPWRNAS 
QCQLDDEEIE VQKGVAKMYS SQQVMYTVGY SLSLGALLLA LVILLGLRKL HCTRNYIHGN 
LFASFVLKAG SVLVIDWLLK TRYSQKIGDD LSVSVWLSDG AMAGCRVATV IMQYGIIANY 
CWLLVEGVYL YSLLSLATFS ERSFFSLYLG IGWGAPLLFV IPWVVVKCLF ENVQCWTSND 
NMGFWWILRI PVFLALLINF FIFVHIIHLL VAKLRAHQMH YADYKFRLAR STLTLIPLLG 
VHEVVFAFVT DEHAQGTLRS TKLFFDLFLS SFQGLLVAVL YCFLNKEVQA ELMRRWRQWQ 
EGKALQEERL ASSHGSHMAP AGPCHGDPCE KLQLMSAGSS SGTGCVPSME TSLASSLPRL 
ADSPT

Genular Protein ID: 988537380

Symbol: Q3UN81_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UN81

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 485
Mass: 54871
Checksum: 5148730D3441E67A
Sequence:

MPLTQLHCPH LLLLLLVLSC LPEAPSAQVM DFLFEKWKLY SDQCHHNLSL LPPPTELVCN 
RTFDKYSCWP DTPPNTTANI SCPWYLPWYH KVQHRLVFKR CGPDGQWVRG PRGQPWRNAS 
QCQLDDEEIE VQKGVAKMYS SQQVMYTVGY SLSLGALLLA LVILLGLRKL HCTRNYIHGN 
LFASFVLKAG SVLVIDWLLK TRYSQKIGDD LSVSVWLSDG AMAGCRVATV IMQYGIIANY 
CWLLVEGVYL YSLLSLATFS ERSFFSLYLG IGWGAPLLFV IPWVVVKCLF ENVQCWTSND 
NMGFWWILRI PVFLALLINF FIFVHIIHLL VAKLRAHQMH YADYKFRLAR STLTLIPLLG 
VHEVVFAFVT DEHAQGTLRS TKLFFDLFLS SFQGLLVAVL YCFLNKEVQA ELMRRWRQWQ 
AGKALQEERL ASSHGSHMAP AGPCHGDPCE KLQLMSAGSS SGTGCVPSME TSLASSLPRL 
ADSPT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gcgr

Associated with

Other Information

Cloning and sequence analysis of the murine glucagon receptor-encoding gene. PubMed ID: 7590348

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. PubMed ID: 8156917

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. PubMed ID: 12552113

Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation. PubMed ID: 16627579

The glucagon receptor is required for the adaptive metabolic response to fasting. PubMed ID: 19046568

Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders. PubMed ID: 32677665

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073