Genular: Defining Cellular Identity and Function

Details for: Gch1

Gene ID: 14528

Symbol: Gch1

Ensembl ID: ENSMUSG00000037580

Description: GTP cyclohydrolase 1

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of cofactors
(R-MMU-8978934)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Tetrahydrobiopterin (bh4) synthesis, recycling, salvage and regulation
(R-MMU-1474151)
Calcium ion binding
(GO:0005509)
Catalytic activity
(GO:0003824)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Dihydrobiopterin metabolic process
(GO:0051066)
Dopamine biosynthetic process
(GO:0042416)
Gtp-dependent protein binding
(GO:0030742)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Gtp cyclohydrolase i activity
(GO:0003934)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Metabolic process
(GO:0008152)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Mitogen-activated protein kinase binding
(GO:0051019)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cellular senescence
(GO:2000773)
Neuromuscular process controlling posture
(GO:0050884)
Nuclear membrane
(GO:0031965)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of nitric-oxide synthase activity
(GO:0051000)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein-containing complex
(GO:0032991)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein homodimerization activity
(GO:0042803)
Pteridine-containing compound biosynthetic process
(GO:0042559)
Regulation of blood pressure
(GO:0008217)
Regulation of lung blood pressure
(GO:0014916)
Regulation of removal of superoxide radicals
(GO:2000121)
Regulation of serotonin biosynthetic process
(GO:1905627)
Response to pain
(GO:0048265)
Response to tumor necrosis factor
(GO:0034612)
Response to type ii interferon
(GO:0034341)
Tetrahydrobiopterin biosynthetic process
(GO:0006729)
Tetrahydrofolate biosynthetic process
(GO:0046654)
Vasodilation
(GO:0042311)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

GTP cyclohydrolase 1

Genular Protein ID: 1088179343

Symbol: GCH1_MOUSE

Name: GTP cyclohydrolase 1

UniProtKB Accession Codes:

Q05915

Database IDs:

Citations:

PubMed ID: 8461009

Title: Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I.

PubMed ID: 8461009

DOI: 10.1006/bbrc.1993.1249

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8304101

Title: Detection and quantification of GTP cyclohydrolase I mRNA.

PubMed ID: 8304101

DOI: 10.1007/978-1-4615-2960-6_32

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 241
Mass: 27014
Checksum: B4366F102B4A6FE6
Sequence:

MEKPRGVRCT NGFSERELPR PGASPPAEKS RPPEAKGAQP ADAWKAGRHR SEEENQVNLP 
KLAAAYSSIL LSLGEDPQRQ GLLKTPWRAA TAMQYFTKGY QETISDVLND AIFDEDHDEM 
VIVKDIDMFS MCEHHLVPFV GRVHIGYLPN KQVLGLSKLA RIVEIYSRRL QVQERLTKQI 
AVAITEALQP AGVGVVIEAT HMCMVMRGVQ KMNSKTVTST MLGVFREDPK TREEFLTLIR 
S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gch1

Associated with

Other Information

Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase I. PubMed ID: 8461009

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Detection and quantification of GTP cyclohydrolase I mRNA. PubMed ID: 8304101