Details for: CSNK1D

Gene ID: 1453

Symbol: CSNK1D

Ensembl ID: ENSG00000141551

Description: casein kinase 1 delta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 279.3400
    Cell Significance Index: -43.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 164.3646
    Cell Significance Index: -41.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.9243
    Cell Significance Index: -42.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.3418
    Cell Significance Index: -48.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.1488
    Cell Significance Index: -47.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.7241
    Cell Significance Index: -42.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.2195
    Cell Significance Index: -45.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.3233
    Cell Significance Index: -38.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.0757
    Cell Significance Index: -37.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.8359
    Cell Significance Index: -46.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9046
    Cell Significance Index: -17.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8153
    Cell Significance Index: 49.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5232
    Cell Significance Index: 302.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4890
    Cell Significance Index: 42.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2713
    Cell Significance Index: 255.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1093
    Cell Significance Index: 50.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0965
    Cell Significance Index: 51.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0096
    Cell Significance Index: 28.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9474
    Cell Significance Index: 122.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9278
    Cell Significance Index: 114.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8889
    Cell Significance Index: 66.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8674
    Cell Significance Index: 55.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8552
    Cell Significance Index: 23.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8430
    Cell Significance Index: 151.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8261
    Cell Significance Index: 451.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8126
    Cell Significance Index: 17.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7877
    Cell Significance Index: 40.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7477
    Cell Significance Index: 19.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6374
    Cell Significance Index: 33.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5860
    Cell Significance Index: 80.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5656
    Cell Significance Index: 202.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5449
    Cell Significance Index: 492.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4995
    Cell Significance Index: 81.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4841
    Cell Significance Index: 92.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4721
    Cell Significance Index: 22.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4714
    Cell Significance Index: 46.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4224
    Cell Significance Index: 292.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3604
    Cell Significance Index: 42.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3492
    Cell Significance Index: 154.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3048
    Cell Significance Index: 21.0800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2909
    Cell Significance Index: 5.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2854
    Cell Significance Index: 36.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2711
    Cell Significance Index: 7.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2678
    Cell Significance Index: 20.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1839
    Cell Significance Index: 31.4000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1754
    Cell Significance Index: 1.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1658
    Cell Significance Index: 2.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1212
    Cell Significance Index: 2.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0956
    Cell Significance Index: 3.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0588
    Cell Significance Index: 110.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0522
    Cell Significance Index: 3.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0423
    Cell Significance Index: 2.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0397
    Cell Significance Index: 61.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0383
    Cell Significance Index: 70.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0377
    Cell Significance Index: 17.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0322
    Cell Significance Index: 20.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0226
    Cell Significance Index: 30.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0032
    Cell Significance Index: 0.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0017
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0119
    Cell Significance Index: -7.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0203
    Cell Significance Index: -15.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0262
    Cell Significance Index: -0.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0270
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0274
    Cell Significance Index: -20.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0328
    Cell Significance Index: -24.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0485
    Cell Significance Index: -2.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0539
    Cell Significance Index: -5.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0568
    Cell Significance Index: -32.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1075
    Cell Significance Index: -22.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1399
    Cell Significance Index: -40.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1478
    Cell Significance Index: -3.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1596
    Cell Significance Index: -18.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1714
    Cell Significance Index: -24.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2113
    Cell Significance Index: -12.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2461
    Cell Significance Index: -28.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2732
    Cell Significance Index: -8.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2793
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2928
    Cell Significance Index: -33.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3592
    Cell Significance Index: -37.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3822
    Cell Significance Index: -16.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3936
    Cell Significance Index: -24.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4481
    Cell Significance Index: -9.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4569
    Cell Significance Index: -11.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4603
    Cell Significance Index: -13.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4677
    Cell Significance Index: -9.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4938
    Cell Significance Index: -13.2100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.5166
    Cell Significance Index: -4.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5195
    Cell Significance Index: -41.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5270
    Cell Significance Index: -19.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5403
    Cell Significance Index: -9.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5633
    Cell Significance Index: -12.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6250
    Cell Significance Index: -6.4700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6430
    Cell Significance Index: -15.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6652
    Cell Significance Index: -17.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6964
    Cell Significance Index: -17.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6989
    Cell Significance Index: -7.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7075
    Cell Significance Index: -6.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7495
    Cell Significance Index: -45.9500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7637
    Cell Significance Index: -4.7000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8313
    Cell Significance Index: -42.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular localization**: CSNK1D is primarily localized to the cytosol, centrosome, and cilium, suggesting its involvement in protein phosphorylation, vesicle transport, and ciliary function. 2. **Protein phosphorylation**: CSNK1D is a serine/threonine kinase that phosphorylates various substrates, including tau proteins, which are involved in neurodegenerative diseases. 3. **Circadian clock regulation**: CSNK1D is a key regulator of the circadian clock, influencing the expression of clock genes and the timing of various physiological processes. 4. **Wnt signaling pathway**: CSNK1D positively regulates the Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. 5. **Cell cycle regulation**: CSNK1D is involved in the regulation of the cell cycle, particularly during the G2/M transition, where it phosphorylates proteins that control the transition from the G2 phase to mitosis. **Pathways and Functions** 1. **Anchoring of the basal body to the plasma membrane**: CSNK1D is involved in the anchoring of the basal body to the plasma membrane, which is essential for ciliary function and the maintenance of cellular polarity. 2. **Asparagine n-linked glycosylation**: CSNK1D is involved in the regulation of asparagine n-linked glycosylation, which is a post-translational modification that affects protein function and stability. 3. **Aurka activation by tpx2**: CSNK1D phosphorylates Aurora kinase A (Aurka), which is essential for the regulation of the cell cycle and mitotic spindle formation. 4. **Cadherin binding**: CSNK1D interacts with cadherins, which are cell adhesion molecules involved in maintaining tissue structure and cellular polarity. 5. **Ciliary function**: CSNK1D is involved in the regulation of ciliary function, including cilium assembly, maintenance, and motility. **Clinical Significance** 1. **Cancer**: Dysregulation of CSNK1D has been implicated in various cancers, including breast, lung, and colon cancer, where it contributes to tumorigenesis and metastasis. 2. **Neurodegenerative diseases**: CSNK1D has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it phosphorylates tau proteins and contributes to neuronal dysfunction. 3. **Circadian rhythm disorders**: CSNK1D is involved in the regulation of the circadian clock, and dysregulation of this gene has been implicated in circadian rhythm disorders, such as delayed sleep phase syndrome. 4. **Immune system dysfunction**: CSNK1D is expressed in immune cells and has been implicated in immune system dysfunction, including autoimmune diseases and immunodeficiency disorders. In conclusion, CSNK1D is a multifunctional gene that plays a critical role in various cellular processes, including cell cycle regulation, protein phosphorylation, and vesicle transport. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, and circadian rhythm disorders. Further studies are needed to fully understand the mechanisms of CSNK1D and its role in human disease.

Genular Protein ID: 260570094

Symbol: KC1D_HUMAN

Name: Casein kinase I isoform delta

UniProtKB Accession Codes:

P48730 A2I2P2 Q96KZ6 Q9BTN5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 4 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 45 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 2 Rhea 16 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8786104

Title: Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.

PubMed ID: 8786104

DOI: 10.1006/geno.1996.0091

PubMed ID: 15070676

Title: Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.

PubMed ID: 15070676

DOI: 10.1182/blood-2003-08-2768

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632646

Title: Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.

PubMed ID: 9632646

DOI: 10.1074/jbc.273.26.15980

PubMed ID: 10606744

Title: Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.

PubMed ID: 10606744

DOI: 10.1016/s0014-5793(99)01647-6

PubMed ID: 10826492

Title: Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus.

PubMed ID: 10826492

DOI: 10.1078/s0171-9335(04)70027-8

PubMed ID: 11161704

Title: Catalytic activity of protein kinase CK1 delta (casein kinase 1delta) is essential for its normal subcellular localization.

PubMed ID: 11161704

DOI: 10.1006/excr.2000.5100

PubMed ID: 11165242

Title: Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.

PubMed ID: 11165242

DOI: 10.1016/s0014-5793(00)02434-0

PubMed ID: 12270943

Title: Casein kinase 1 regulates connexin-43 gap junction assembly.

PubMed ID: 12270943

DOI: 10.1074/jbc.m209427200

PubMed ID: 12270714

Title: Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.

PubMed ID: 12270714

DOI: 10.1016/s0022-2836(02)00857-4

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14761950

Title: Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.

PubMed ID: 14761950

DOI: 10.1074/jbc.m314116200

PubMed ID: 16027726

Title: Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.

PubMed ID: 16027726

DOI: 10.1038/sj.onc.1208941

PubMed ID: 16618118

Title: Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1.

PubMed ID: 16618118

DOI: 10.1021/bi052354e

PubMed ID: 17962809

Title: Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.

PubMed ID: 17962809

DOI: 10.1038/sj.emboj.7601891

PubMed ID: 17562708

Title: Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

PubMed ID: 17562708

DOI: 10.1074/jbc.m703269200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19591487

Title: 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.

PubMed ID: 19591487

DOI: 10.1021/jm9005127

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19043076

Title: Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

PubMed ID: 19043076

DOI: 10.1093/nar/gkn934

PubMed ID: 19339517

Title: CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.

PubMed ID: 19339517

DOI: 10.1093/nar/gkp136

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20637175

Title: Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity.

PubMed ID: 20637175

DOI: 10.1016/j.abb.2010.07.009

PubMed ID: 20041275

Title: Isoform specific phosphorylation of p53 by protein kinase CK1.

PubMed ID: 20041275

DOI: 10.1007/s00018-009-0236-7

PubMed ID: 20048001

Title: A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).

PubMed ID: 20048001

DOI: 10.1101/gad.1843810

PubMed ID: 20699359

Title: Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.

PubMed ID: 20699359

DOI: 10.1242/jcs.068122

PubMed ID: 20696890

Title: Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.

PubMed ID: 20696890

DOI: 10.1073/pnas.1005101107

PubMed ID: 20407760

Title: Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms.

PubMed ID: 20407760

DOI: 10.1007/s00213-010-1860-5

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21084295

Title: Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.

PubMed ID: 21084295

DOI: 10.1074/jbc.m110.188565

PubMed ID: 21422228

Title: Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

PubMed ID: 21422228

DOI: 10.1083/jcb.201011111

PubMed ID: 21258417

Title: IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1delta/epsilon and Wnt/beta-catenin independent inhibition of mitotic spindle formation.

PubMed ID: 21258417

DOI: 10.1038/onc.2010.627

PubMed ID: 21145983

Title: Casein kinase 1: Complexity in the family.

PubMed ID: 21145983

DOI: 10.1016/j.biocel.2010.12.004

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29222110

Title: A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1epsilon.

PubMed ID: 29222110

DOI: 10.1242/jcs.207316

PubMed ID: 34718754

Title: Retraction of 'CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions'.

PubMed ID: 34718754

DOI: 10.1093/nar/gkab845

PubMed ID: 9761932

Title: Crystallographic studies of casein kinase I delta toward a structural understanding of auto-inhibition.

PubMed ID: 9761932

DOI: 10.1107/s0907444997011724

PubMed ID: 22168824

Title: Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.

PubMed ID: 22168824

DOI: 10.1021/jm201387s

PubMed ID: 23106386

Title: Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.

PubMed ID: 23106386

DOI: 10.1021/jm301336n

PubMed ID: 15800623

Title: Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.

PubMed ID: 15800623

DOI: 10.1038/nature03453

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23636092

Title: Casein kinase idelta mutations in familial migraine and advanced phase.

PubMed ID: 23636092

DOI: 10.1126/scitranslmed.3005784

Sequence Information:

  • Length: 415
  • Mass: 47330
  • Checksum: B97F1717A52466D2
  • Sequence:
    • MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ 
GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 
CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA 
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV 
SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.