Details for: CSNK1D

Gene ID: 1453

Symbol: CSNK1D

Ensembl ID: ENSG00000141551

Description: casein kinase 1 delta

Associated with

Other Information

Genular Protein ID: 260570094

Symbol: KC1D_HUMAN

Name: Casein kinase I isoform delta

UniProtKB Accession Codes:

P48730 A2I2P2 Q96KZ6 Q9BTN5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 4 EMBL 7 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 46 PDBsum 42 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 2 Rhea 16 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8786104

Title: Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.

PubMed ID: 8786104

DOI: 10.1006/geno.1996.0091

PubMed ID: 15070676

Title: Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.

PubMed ID: 15070676

DOI: 10.1182/blood-2003-08-2768

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632646

Title: Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.

PubMed ID: 9632646

DOI: 10.1074/jbc.273.26.15980

PubMed ID: 10606744

Title: Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15.

PubMed ID: 10606744

DOI: 10.1016/s0014-5793(99)01647-6

PubMed ID: 10826492

Title: Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus.

PubMed ID: 10826492

DOI: 10.1078/s0171-9335(04)70027-8

PubMed ID: 11161704

Title: Catalytic activity of protein kinase CK1 delta (casein kinase 1delta) is essential for its normal subcellular localization.

PubMed ID: 11161704

DOI: 10.1006/excr.2000.5100

PubMed ID: 11165242

Title: Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.

PubMed ID: 11165242

DOI: 10.1016/s0014-5793(00)02434-0

PubMed ID: 12270943

Title: Casein kinase 1 regulates connexin-43 gap junction assembly.

PubMed ID: 12270943

DOI: 10.1074/jbc.m209427200

PubMed ID: 12270714

Title: Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.

PubMed ID: 12270714

DOI: 10.1016/s0022-2836(02)00857-4

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 14761950

Title: Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.

PubMed ID: 14761950

DOI: 10.1074/jbc.m314116200

PubMed ID: 16027726

Title: Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells.

PubMed ID: 16027726

DOI: 10.1038/sj.onc.1208941

PubMed ID: 16618118

Title: Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1.

PubMed ID: 16618118

DOI: 10.1021/bi052354e

PubMed ID: 17962809

Title: Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.

PubMed ID: 17962809

DOI: 10.1038/sj.emboj.7601891

PubMed ID: 17562708

Title: Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.

PubMed ID: 17562708

DOI: 10.1074/jbc.m703269200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19591487

Title: 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.

PubMed ID: 19591487

DOI: 10.1021/jm9005127

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19043076

Title: Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

PubMed ID: 19043076

DOI: 10.1093/nar/gkn934

PubMed ID: 19339517

Title: CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.

PubMed ID: 19339517

DOI: 10.1093/nar/gkp136

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20637175

Title: Casein kinase 1delta activates human recombinant deoxycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity.

PubMed ID: 20637175

DOI: 10.1016/j.abb.2010.07.009

PubMed ID: 20041275

Title: Isoform specific phosphorylation of p53 by protein kinase CK1.

PubMed ID: 20041275

DOI: 10.1007/s00018-009-0236-7

PubMed ID: 20048001

Title: A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).

PubMed ID: 20048001

DOI: 10.1101/gad.1843810

PubMed ID: 20699359

Title: Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.

PubMed ID: 20699359

DOI: 10.1242/jcs.068122

PubMed ID: 20696890

Title: Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes.

PubMed ID: 20696890

DOI: 10.1073/pnas.1005101107

PubMed ID: 20407760

Title: Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms.

PubMed ID: 20407760

DOI: 10.1007/s00213-010-1860-5

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21084295

Title: Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.

PubMed ID: 21084295

DOI: 10.1074/jbc.m110.188565

PubMed ID: 21422228

Title: Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.

PubMed ID: 21422228

DOI: 10.1083/jcb.201011111

PubMed ID: 21258417

Title: IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1delta/epsilon and Wnt/beta-catenin independent inhibition of mitotic spindle formation.

PubMed ID: 21258417

DOI: 10.1038/onc.2010.627

PubMed ID: 21145983

Title: Casein kinase 1: Complexity in the family.

PubMed ID: 21145983

DOI: 10.1016/j.biocel.2010.12.004

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29222110

Title: A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1epsilon.

PubMed ID: 29222110

DOI: 10.1242/jcs.207316

PubMed ID: 34718754

Title: Retraction of 'CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions'.

PubMed ID: 34718754

DOI: 10.1093/nar/gkab845

PubMed ID: 9761932

Title: Crystallographic studies of casein kinase I delta toward a structural understanding of auto-inhibition.

PubMed ID: 9761932

DOI: 10.1107/s0907444997011724

PubMed ID: 22168824

Title: Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.

PubMed ID: 22168824

DOI: 10.1021/jm201387s

PubMed ID: 23106386

Title: Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.

PubMed ID: 23106386

DOI: 10.1021/jm301336n

PubMed ID: 15800623

Title: Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.

PubMed ID: 15800623

DOI: 10.1038/nature03453

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23636092

Title: Casein kinase idelta mutations in familial migraine and advanced phase.

PubMed ID: 23636092

DOI: 10.1126/scitranslmed.3005784

Sequence Information:

  • Length: 415
  • Mass: 47330
  • Checksum: B97F1717A52466D2
  • Sequence:
    • MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ 
GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 
CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA 
ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV 
SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQI PGRVASSGLQ SVVHR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.