Genular: Defining Cellular Identity and Function

Details for: Kat2a

Gene ID: 14534

Symbol: Kat2a

Ensembl ID: ENSMUSG00000020918

Description: K(lysine) acetyltransferase 2A

Associated with

B-wich complex positively regulates rrna expression
(R-MMU-5250924)
Deubiquitination
(R-MMU-5688426)
Epigenetic regulation of gene expression
(R-MMU-212165)
Formation of wdr5-containing histone-modifying complexes
(R-MMU-9772755)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Notch-hlh transcription pathway
(R-MMU-350054)
Notch1 intracellular domain regulates transcription
(R-MMU-2122947)
Positive epigenetic regulation of rrna expression
(R-MMU-5250913)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Runx3 regulates notch signaling
(R-MMU-8941856)
Signaling by notch
(R-MMU-157118)
Signaling by notch1
(R-MMU-1980143)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by runx3
(R-MMU-8878159)
Ub-specific processing proteases
(R-MMU-5689880)
Acetyltransferase activity
(GO:0016407)
Acyltransferase activity
(GO:0016746)
Acyltransferase activity, transferring groups other than amino-acyl groups
(GO:0016747)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor binding
(GO:0140297)
Fibroblast proliferation
(GO:0048144)
Gluconeogenesis
(GO:0006094)
Histone acetyltransferase activity
(GO:0004402)
Histone acetyltransferase complex
(GO:0000123)
Histone deacetylase binding
(GO:0042826)
Histone glutaryltransferase activity
(GO:0106229)
Histone h3 acetyltransferase activity
(GO:0010484)
Histone h3k9 acetyltransferase activity
(GO:0043992)
Histone h3k18 acetyltransferase activity
(GO:0043993)
Histone h4k12 acetyltransferase activity
(GO:0043997)
Histone succinylation
(GO:0106077)
Histone succinyltransferase activity
(GO:0106078)
Internal peptidyl-lysine acetylation
(GO:0018393)
Intracellular distribution of mitochondria
(GO:0048312)
In utero embryonic development
(GO:0001701)
Long-term memory
(GO:0007616)
Metencephalon development
(GO:0022037)
Midbrain development
(GO:0030901)
Multicellular organism growth
(GO:0035264)
N-acetyltransferase activity
(GO:0008080)
Negative regulation of centriole replication
(GO:0046600)
Negative regulation of gluconeogenesis
(GO:0045721)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neural tube closure
(GO:0001843)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptide-lysine-n-acetyltransferase activity
(GO:0061733)
Peptidyl-lysine glutarylation
(GO:0106227)
Positive regulation of cardiac muscle cell differentiation
(GO:2000727)
Positive regulation of cell projection organization
(GO:0031346)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gluconeogenesis
(GO:0045722)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein modification process
(GO:0036211)
Protein phosphatase binding
(GO:0019903)
Regulation of bone development
(GO:1903010)
Regulation of cartilage development
(GO:0061035)
Regulation of cell cycle
(GO:0051726)
Regulation of cell division
(GO:0051302)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of dna repair
(GO:0006282)
Regulation of embryonic development
(GO:0045995)
Regulation of protein stability
(GO:0031647)
Regulation of regulatory t cell differentiation
(GO:0045589)
Regulation of rna splicing
(GO:0043484)
Regulation of stem cell population maintenance
(GO:2000036)
Regulation of synaptic plasticity
(GO:0048167)
Regulation of t cell activation
(GO:0050863)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of tubulin deacetylation
(GO:0090043)
Saga complex
(GO:0000124)
Somitogenesis
(GO:0001756)
Telencephalon development
(GO:0021537)
Transcription coactivator activity
(GO:0003713)
Transferase activity
(GO:0016740)

Other Information

Proteins

KAT2A_MOUSE
Q6P3Z8_MOUSE

Genular Protein ID: 2616968500

Symbol: KAT2A_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9JHD2 Q3TZ59

Database IDs:

Citations:

PubMed ID: 9742083

Title: Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates.

PubMed ID: 9742083

DOI: 10.1128/mcb.18.10.5659

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 11017084

Title: Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.

PubMed ID: 11017084

DOI: 10.1038/79973

PubMed ID: 17301242

Title: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.

PubMed ID: 17301242

DOI: 10.1073/pnas.0607378104

PubMed ID: 22886304

Title: A metabolic prosurvival role for PML in breast cancer.

PubMed ID: 22886304

DOI: 10.1172/jci62129

PubMed ID: 25024434

Title: K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation.

PubMed ID: 25024434

DOI: 10.15252/embj.201487870

PubMed ID: 28424240

Title: The histone acetyltransferase Gcn5 positively regulates T cell activation.

PubMed ID: 28424240

DOI: 10.4049/jimmunol.1600312

PubMed ID: 30424580

Title: Kat2a and Kat2b acetyltransferase activity regulates craniofacial cartilage and bone differentiation in zebrafish and mice.

PubMed ID: 30424580

DOI: 10.3390/jdb6040027

PubMed ID: 30270482

Title: Histone acetyltransferase KAT2A stabilizes pluripotency with control of transcriptional heterogeneity.

PubMed ID: 30270482

DOI: 10.1002/stem.2919

PubMed ID: 36112854

Title: The effects of beta-catenin on cardiomyogenesis via Islet-1 and MLIP ubiquitination.

PubMed ID: 36112854

DOI: 10.1177/15353702221119792

Sequence Information:

Length: 830
Mass: 93394
Checksum: 7993CFFEA4734174
Sequence:

MAEPSQAPNP VPAAQPRPLH SPAPAPTSTP APSPASASTP APTPAPAPAP AAAPAGSTGS 
GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK LGVFSACKAN ETCKCNGWKN 
PKPPTAPRMD LQQPAANLSE LCRSCEHPLA DHVSHLENVS EDEINRLLGM VVDVENLFMS 
VHKEEDTDTK QVYFYLFKLL RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH 
LAPRERQTMF ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC 
DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH FPKFLSMLEE 
EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSFS PSMGGGSNSS LSLDSAGTEP 
MPAGEKRKLP ENLTLEDAKR LRVMGDIPME LVNEVMLTIT DPAAMLGPET SLLSANAARD 
ETARLEERRG IIEFHVIGNS LTPKANRRVL LWLVGLQNVF SHQLPRMPKE YIARLVFDPK 
HKTLALIKDG RVIGGICFRM FPTQGFTEIV FCAVTSNEQV KGYGTHLMNH LKEYHIKHSI 
LYFLTYADEY AIGYFKKQGF SKDIKVPKSR YLGYIKDYEG ATLMECELNP RIPYTELSHI 
IKKQKEIIKK LIERKQAQIR KVYPGLSCFK EGVRQIPVES VPGIRETGWK PLGKEKGKEL 
KDPDQLYTTL KNLLAQIKSH PSAWPFMEPV KKSEAPDYYE VIRFPIDLKT MTERLRSRYY 
VTRKLFVADL QRVIANCREY NPPDSEYCRC ASALEKFFYF KLKEGGLIDK

Genular Protein ID: 2908623135

Symbol: Q6P3Z8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6P3Z8

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 829
Mass: 93323
Checksum: BD96914160B14128
Sequence:

MAEPSQAPNP VPAAQPRPLH SPAPAPTSTP APSPASASTP APTPAPAPAP AAAPAGSTGS 
GGAGVGSGGD PARPGLSQQQ RASQRKAQVR GLPRAKKLEK LGVFSACKAN ETCKCNGWKN 
PKPPTAPRMD LQQPAANLSE LCRSCEHPLA DHVSHLENVS EDEINRLLGM VVDVENLFMS 
VHKEEDTDTK QVYFYLFKLL RKCILQMTRP VVEGSLGSPP FEKPNIEQGV LNFVQYKFSH 
LAPRERQTMF ELSKMFLLCL NYWKLETPAQ FRQRSQSEDV ATYKVNYTRW LCYCHVPQSC 
DSLPRYETTH VFGRSLLRSI FTVTRRQLLE KFRVEKDKLV PEKRTLILTH FPKFLSMLEE 
EIYGANSPIW ESGFTMPPSE GTQLVPRPAT VSATVVPSFS PSMGGGSNSS LSLDSAGTEP 
MPGEKRKLPE NLTLEDAKRL RVMGDIPMEL VNEVMLTITD PAAMLGPETS LLSANAARDE 
TARLEERRGI IEFHVIGNSL TPKANRRVLL WLVGLQNVFS HQLPRMPKEY IARLVFDPKH 
KTLALIKDGR VIGGICFRMF PTQGFTEIVF CAVTSNEQVK GYGTHLMNHL KEYHIKHSIL 
YFLTYADEYA IGYFKKQGFS KDIKVPKSRY LGYIKDYEGA TLMECELNPR IPYTELSHII 
KKQKEIIKKL IERKQAQIRK VYPGLSCFKE GVRQIPVESV PGIRETGWKP LGKEKGKELK 
DPDQLYTTLK NLLAQIKSHP SAWPFMEPVK KSEAPDYYEV IRFPIDLKTM TERLRSRYYV 
TRKLFVADLQ RVIANCREYN PPDSEYCRCA SALEKFFYFK LKEGGLIDK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kat2a

Associated with

Other Information

Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. PubMed ID: 9742083

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. PubMed ID: 11017084

Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5. PubMed ID: 17301242

A metabolic prosurvival role for PML in breast cancer. PubMed ID: 22886304

K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. PubMed ID: 25024434

The histone acetyltransferase Gcn5 positively regulates T cell activation. PubMed ID: 28424240

Kat2a and Kat2b acetyltransferase activity regulates craniofacial cartilage and bone differentiation in zebrafish and mice. PubMed ID: 30424580

Histone acetyltransferase KAT2A stabilizes pluripotency with control of transcriptional heterogeneity. PubMed ID: 30270482

The effects of beta-catenin on cardiomyogenesis via Islet-1 and MLIP ubiquitination. PubMed ID: 36112854

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 9742083

PubMed ID: 16141072

PubMed ID: 19468303

PubMed ID: 11017084

PubMed ID: 17301242

PubMed ID: 22886304

PubMed ID: 25024434

PubMed ID: 28424240

PubMed ID: 30424580

PubMed ID: 30270482

PubMed ID: 36112854

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 15489334

PubMed ID: 16141073

PubMed ID: 19468303