Details for: CSNK1G2

Gene ID: 1455

Symbol: CSNK1G2

Ensembl ID: ENSG00000133275

Description: casein kinase 1 gamma 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.44
    Marker Score: 4934
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.38
    Marker Score: 13979
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.37
    Marker Score: 825
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.32
    Marker Score: 4878
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.3
    Marker Score: 870
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.25
    Marker Score: 1845
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.25
    Marker Score: 539
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.21
    Marker Score: 1194
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.18
    Marker Score: 1102
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.16
    Marker Score: 412
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.15
    Marker Score: 39994
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.11
    Marker Score: 547
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.11
    Marker Score: 37710
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2603
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.1
    Marker Score: 751
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1
    Marker Score: 1918
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.05
    Marker Score: 344
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.04
    Marker Score: 709
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.03
    Marker Score: 320
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.02
    Marker Score: 1078
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1
    Marker Score: 499
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71651
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.99
    Marker Score: 4886
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47876
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15415
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.98
    Marker Score: 299
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30382
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.97
    Marker Score: 1046
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.97
    Marker Score: 2038
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.95
    Marker Score: 2668
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.95
    Marker Score: 554
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2387
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.93
    Marker Score: 8113
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.92
    Marker Score: 2268
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.92
    Marker Score: 321
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.92
    Marker Score: 845
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.9
    Marker Score: 9313
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.9
    Marker Score: 3672
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.9
    Marker Score: 757
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2687
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5109
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.89
    Marker Score: 308
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.88
    Marker Score: 54369
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.88
    Marker Score: 530
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.88
    Marker Score: 946
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.87
    Marker Score: 354
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.86
    Marker Score: 270
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.86
    Marker Score: 48128
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.85
    Marker Score: 883
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.85
    Marker Score: 574
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.84
    Marker Score: 1484
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.84
    Marker Score: 1011
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.83
    Marker Score: 7828
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.83
    Marker Score: 266
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1337
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.82
    Marker Score: 9260
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.81
    Marker Score: 1855
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.81
    Marker Score: 465
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.81
    Marker Score: 6938
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.8
    Marker Score: 7585
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.79
    Marker Score: 876
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.79
    Marker Score: 276
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.79
    Marker Score: 281
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.79
    Marker Score: 1215
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.78
    Marker Score: 456
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.77
    Marker Score: 184
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 586.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.77
    Marker Score: 29132
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.76
    Marker Score: 987
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.76
    Marker Score: 371
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.76
    Marker Score: 219
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.76
    Marker Score: 535
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 516
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.75
    Marker Score: 564
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.75
    Marker Score: 807
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.74
    Marker Score: 742
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.74
    Marker Score: 1404
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.74
    Marker Score: 254
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.73
    Marker Score: 799
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.73
    Marker Score: 164
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.73
    Marker Score: 182
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.73
    Marker Score: 160
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.73
    Marker Score: 1239
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.72
    Marker Score: 190
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.72
    Marker Score: 301
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.72
    Marker Score: 327
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.72
    Marker Score: 838
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.71
    Marker Score: 188
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.71
    Marker Score: 140
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 472
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.71
    Marker Score: 797
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.71
    Marker Score: 165

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Other Information

**Key characteristics:** * CSNK1G2 is a serine/threonine kinase. * It is expressed in a variety of cell types, including epithelial cells, immune cells, and cancer cells. * It is a key regulator of the Wnt signaling pathway. * It is involved in the regulation of cell growth, differentiation, and apoptosis. * It is also involved in the regulation of metabolism, endocytosis, and protein phosphorylation. **Pathways and functions:** * CSNK1G2 is involved in the Wnt signaling pathway. * The Wnt signaling pathway is a complex network of signaling pathways that is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. * CSNK1G2 is a key regulator of the Wnt signaling pathway. It is a downstream effector of the Wnt receptor complex, and it is responsible for the phosphorylation of beta-catenin, a key regulator of the Wnt signaling pathway. * CSNK1G2 is also involved in the regulation of other cellular processes, including metabolism, endocytosis, and protein phosphorylation. **Clinical significance:** * Mutations in CSNK1G2 have been linked to a number of human diseases, including cancer and developmental disorders. * CSNK1G2 inhibitors are being investigated as potential treatments for cancer and other diseases that are characterized by abnormal cell growth.

Genular Protein ID: 67114616

Symbol: KC1G2_HUMAN

Name: Casein kinase I isoform gamma-2

UniProtKB Accession Codes:

P78368 B5BU42 O00704 Q8WUB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 3 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9403068

Title: Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2).

PubMed ID: 9403068

DOI: 10.1006/geno.1997.4991

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15077195

Title: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.

PubMed ID: 15077195

DOI: 10.1038/sj.onc.1207569

PubMed ID: 15917222

Title: SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.

PubMed ID: 15917222

DOI: 10.1074/jbc.m502862200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18794808

Title: Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.

PubMed ID: 18794808

DOI: 10.1038/onc.2008.337

PubMed ID: 19005213

Title: Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.

PubMed ID: 19005213

DOI: 10.1091/mbc.e08-07-0669

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26481050

Title: Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.

PubMed ID: 26481050

DOI: 10.1016/j.devcel.2015.09.016

PubMed ID: 37099597

Title: Casein kinase 1 gamma regulates oxidative stress response via interacting with the NADPH dual oxidase complex.

PubMed ID: 37099597

DOI: 10.1371/journal.pgen.1010740

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 415
  • Mass: 47457
  • Checksum: 036A39148A1DA038
  • Sequence:
    • MDFDKKGGKG ETEEGRRMSK AGGGRSSHGI RSSGTSSGVL MVGPNFRVGK KIGCGNFGEL 
RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSATE GVPQVYYFGP CGKYNAMVLE 
LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI TRMEYVHTKS LIYRDVKPEN FLVGRPGTKR 
QHAIHIIDFG LAKEYIDPET KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH 
MFMYFLRGSL PWQGLKADTL KERYQKIGDT KRATPIEVLC ENFPEEMATY LRYVRRLDFF 
EKPDYDYLRK LFTDLFDRSG FVFDYEYDWA GKPLPTPIGT VHTDLPSQPQ LRDKTQPHSK 
NQALNSTNGE LNADDPTAGH SNAPITAPAE VEVADETKCC CFFKRRKRKS LQRHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.