Details for: CSNK1G2

Gene ID: 1455

Symbol: CSNK1G2

Ensembl ID: ENSG00000133275

Description: casein kinase 1 gamma 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 164.5824
    Cell Significance Index: -25.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.1479
    Cell Significance Index: -23.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.2421
    Cell Significance Index: -23.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.3307
    Cell Significance Index: -26.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.8568
    Cell Significance Index: -26.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 39.6336
    Cell Significance Index: -26.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.4673
    Cell Significance Index: -23.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.2822
    Cell Significance Index: -26.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9702
    Cell Significance Index: -24.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9446
    Cell Significance Index: -21.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7232
    Cell Significance Index: -26.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1403
    Cell Significance Index: -11.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.1086
    Cell Significance Index: 362.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7935
    Cell Significance Index: 24.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3230
    Cell Significance Index: 85.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2674
    Cell Significance Index: 137.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2281
    Cell Significance Index: 73.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1270
    Cell Significance Index: 183.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8089
    Cell Significance Index: 23.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7625
    Cell Significance Index: 39.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7034
    Cell Significance Index: 139.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6970
    Cell Significance Index: 85.7000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6918
    Cell Significance Index: 377.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6628
    Cell Significance Index: 119.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6404
    Cell Significance Index: 87.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6161
    Cell Significance Index: 17.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6157
    Cell Significance Index: 13.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5434
    Cell Significance Index: 24.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5071
    Cell Significance Index: 101.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4915
    Cell Significance Index: 23.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4827
    Cell Significance Index: 13.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4495
    Cell Significance Index: 12.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4338
    Cell Significance Index: 30.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4328
    Cell Significance Index: 20.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4217
    Cell Significance Index: 186.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4011
    Cell Significance Index: 39.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3535
    Cell Significance Index: 9.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2954
    Cell Significance Index: 105.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2866
    Cell Significance Index: 10.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2480
    Cell Significance Index: 47.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2469
    Cell Significance Index: 6.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2329
    Cell Significance Index: 2.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2108
    Cell Significance Index: 14.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1684
    Cell Significance Index: 152.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1493
    Cell Significance Index: 2.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1348
    Cell Significance Index: 3.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1346
    Cell Significance Index: 3.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1328
    Cell Significance Index: 7.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1220
    Cell Significance Index: 7.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0768
    Cell Significance Index: 4.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0741
    Cell Significance Index: 8.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0540
    Cell Significance Index: 6.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0424
    Cell Significance Index: 65.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0381
    Cell Significance Index: 71.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0284
    Cell Significance Index: 52.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0237
    Cell Significance Index: 15.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0211
    Cell Significance Index: 28.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0205
    Cell Significance Index: 3.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0108
    Cell Significance Index: 1.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0186
    Cell Significance Index: -8.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0187
    Cell Significance Index: -1.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0192
    Cell Significance Index: -14.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0241
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0317
    Cell Significance Index: -23.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0442
    Cell Significance Index: -24.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0458
    Cell Significance Index: -3.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0466
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0482
    Cell Significance Index: -30.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0766
    Cell Significance Index: -22.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0831
    Cell Significance Index: -1.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1157
    Cell Significance Index: -4.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1357
    Cell Significance Index: -28.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1486
    Cell Significance Index: -17.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1536
    Cell Significance Index: -10.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1984
    Cell Significance Index: -3.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2168
    Cell Significance Index: -22.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2232
    Cell Significance Index: -7.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2497
    Cell Significance Index: -19.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2515
    Cell Significance Index: -13.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2638
    Cell Significance Index: -7.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2814
    Cell Significance Index: -7.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2824
    Cell Significance Index: -7.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3176
    Cell Significance Index: -14.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3181
    Cell Significance Index: -16.7000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3550
    Cell Significance Index: -2.9000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3855
    Cell Significance Index: -11.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3876
    Cell Significance Index: -19.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3965
    Cell Significance Index: -6.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4006
    Cell Significance Index: -24.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4042
    Cell Significance Index: -8.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4194
    Cell Significance Index: -15.8800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4353
    Cell Significance Index: -2.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4407
    Cell Significance Index: -10.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4447
    Cell Significance Index: -11.3600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4717
    Cell Significance Index: -3.0800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.5186
    Cell Significance Index: -8.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5233
    Cell Significance Index: -15.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5327
    Cell Significance Index: -11.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/Threonine Kinase Activity:** CSNK1G2 exhibits protein serine/threonine kinase activity, allowing it to phosphorylate specific amino acid residues on target proteins. 2. **Wnt Signaling Pathway:** CSNK1G2 is a key regulator of the canonical Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and survival. 3. **Protein Binding:** CSNK1G2 interacts with various proteins, including axin, β-catenin, and β-catenin-independent factors, to modulate signaling pathways. 4. **Sphingolipid Metabolism:** CSNK1G2 is involved in the regulation of sphingolipid biosynthesis, de novo synthesis, and metabolism, which are essential for cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Positive Regulation of Canonical Wnt Signaling Pathway:** CSNK1G2 phosphorylates and activates β-catenin, the central effector molecule of the Wnt/β-catenin pathway, promoting cell proliferation and survival. 2. **Disassembly of the Destruction Complex:** CSNK1G2 interacts with the destruction complex, a multi-protein complex that regulates β-catenin levels, to prevent its degradation. 3. **Recruitment of Axin to the Membrane:** CSNK1G2 facilitates the recruitment of axin to the plasma membrane, where it interacts with β-catenin and other signaling molecules. 4. **Peptidyl-Serine Phosphorylation:** CSNK1G2 phosphorylates specific serine residues on target proteins, regulating their activity and localization. **Clinical Significance:** Dysregulation of CSNK1G2 has been implicated in various diseases, including: 1. **Cancer:** Altered Wnt signaling, mediated by CSNK1G2, contributes to tumorigenesis, metastasis, and resistance to therapy. 2. **Autoimmunity:** CSNK1G2's role in regulating immune cell function and signaling pathways may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurodegenerative Diseases:** CSNK1G2's involvement in sphingolipid metabolism and Wnt signaling may be linked to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, CSNK1G2 is a multifunctional enzyme that plays a critical role in regulating Wnt signaling, protein binding, and sphingolipid metabolism. Further research is necessary to fully elucidate the molecular mechanisms underlying CSNK1G2's functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 67114616

Symbol: KC1G2_HUMAN

Name: Casein kinase I isoform gamma-2

UniProtKB Accession Codes:

P78368 B5BU42 O00704 Q8WUB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 3 EMBL 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9403068

Title: Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2).

PubMed ID: 9403068

DOI: 10.1006/geno.1997.4991

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15077195

Title: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.

PubMed ID: 15077195

DOI: 10.1038/sj.onc.1207569

PubMed ID: 15917222

Title: SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.

PubMed ID: 15917222

DOI: 10.1074/jbc.m502862200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18794808

Title: Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.

PubMed ID: 18794808

DOI: 10.1038/onc.2008.337

PubMed ID: 19005213

Title: Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.

PubMed ID: 19005213

DOI: 10.1091/mbc.e08-07-0669

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26481050

Title: Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.

PubMed ID: 26481050

DOI: 10.1016/j.devcel.2015.09.016

PubMed ID: 37099597

Title: Casein kinase 1 gamma regulates oxidative stress response via interacting with the NADPH dual oxidase complex.

PubMed ID: 37099597

DOI: 10.1371/journal.pgen.1010740

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 415
  • Mass: 47457
  • Checksum: 036A39148A1DA038
  • Sequence:
    • MDFDKKGGKG ETEEGRRMSK AGGGRSSHGI RSSGTSSGVL MVGPNFRVGK KIGCGNFGEL 
RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSATE GVPQVYYFGP CGKYNAMVLE 
LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI TRMEYVHTKS LIYRDVKPEN FLVGRPGTKR 
QHAIHIIDFG LAKEYIDPET KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH 
MFMYFLRGSL PWQGLKADTL KERYQKIGDT KRATPIEVLC ENFPEEMATY LRYVRRLDFF 
EKPDYDYLRK LFTDLFDRSG FVFDYEYDWA GKPLPTPIGT VHTDLPSQPQ LRDKTQPHSK 
NQALNSTNGE LNADDPTAGH SNAPITAPAE VEVADETKCC CFFKRRKRKS LQRHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.