Details for: CSNK1G2
Gene ID: 1455
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CSNK1G2
Ensembl ID: ENSG00000133275
Description: casein kinase 1 gamma 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 11.91rCSI 18.19%PRS 48.01
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CSI 10.28rCSI 8.36%PRS 40.39
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CSI 8.34rCSI 11.8%PRS 48.8
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CSI 7.15rCSI 12.8%PRS 37.87
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CSI 6.96rCSI 12.3%PRS 24.68
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CSI 6.32rCSI 11.08%PRS 32.57
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CSI 5.46rCSI 5.7%PRS 70.57
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CSI 5rCSI 8.19%PRS 31.28
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CSI 4.91rCSI 14.58%PRS 50.83
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CSI 4.78rCSI 4.42%PRS 59.54
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CSI 4.69rCSI 12.11%PRS 36.07
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CSI 3.71rCSI 5.07%PRS 42.08
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CSI 3.5rCSI 2.81%PRS 60.58
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CSI 3.35rCSI 2.55%PRS 49.87
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CSI 3.26rCSI 4.78%PRS 39.82
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CSI 3.25rCSI 4.34%PRS 61.83
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CSI 3.23rCSI 4%PRS 35.49
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CSI 3.18rCSI 1.88%PRS 53.18
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CSI 3.17rCSI 4.87%PRS 45.82
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CSI 3.13rCSI 2.25%PRS 51.51
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CSI 3.13rCSI 3.9%PRS 50.38
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CSI 3.08rCSI 2.97%PRS 30.95
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CSI 3.07rCSI 6.99%PRS 38.37
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CSI 3rCSI 3.52%PRS 54.04
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CSI 2.95rCSI 2.05%PRS 47.2
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CSI 2.9rCSI 11.28%PRS 59.07
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CSI 2.66rCSI 4.78%PRS 33.62
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CSI 2.55rCSI 3.27%PRS 37.64
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CSI 2.54rCSI 2.02%PRS 60.65
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CSI 2.53rCSI 7.34%PRS 31.98
-
CSI 2.47rCSI 2.9%PRS 43.23
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CSI 2.46rCSI 2.27%PRS 40.47
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CSI 2.42rCSI 1.69%PRS 41.11
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CSI 2.31rCSI 3.53%PRS 43.86
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CSI 2.3rCSI 1.7%PRS 33.85
-
CSI 2.27rCSI 3.32%PRS 42.14
-
CSI 2.23rCSI 1.84%PRS 40.22
-
CSI 2.22rCSI 1.95%PRS 48.79
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CSI 2.21rCSI 6.34%PRS 55.98
-
CSI 2.08rCSI 3.57%PRS 48.5
-
CSI 2.08rCSI 4.66%PRS 26.16
-
CSI 2.05rCSI 1.8%PRS 44.2
-
CSI 2.01rCSI 5.24%PRS 38.61
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CSI 1.98rCSI 4.43%PRS 45.39
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CSI 1.96rCSI 3.66%PRS 30.4
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CSI 1.96rCSI 1.7%PRS 47.76
-
CSI 1.9rCSI 4.33%PRS 33.86
-
CSI 1.87rCSI 1.69%PRS 36.25
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CSI 1.86rCSI 1.3%PRS 51.64
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CSI 1.86rCSI 2.55%PRS 43.9
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CSI 1.85rCSI 1.39%PRS 42.35
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CSI 1.85rCSI 2.32%PRS 48.47
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CSI 1.84rCSI 3.5%PRS 55.77
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CSI 1.78rCSI 1.86%PRS 40.02
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CSI 1.78rCSI 1.9%PRS 37.33
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CSI 1.77rCSI 1.34%PRS 50.91
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CSI 1.77rCSI 1.37%PRS 39.51
-
CSI 1.75rCSI 1.52%PRS 43.17
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CSI 1.72rCSI 1.75%PRS 51.6
-
CSI 1.71rCSI 3.4%PRS 39.27
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CSI 1.71rCSI 2.2%PRS 43.95
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CSI 1.68rCSI 2.83%PRS 25.6
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CSI 1.67rCSI 1.75%PRS 36.98
-
CSI 1.64rCSI 3.5%PRS 54.48
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CSI 1.64rCSI 2.84%PRS 31.11
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CSI 1.62rCSI 1.21%PRS 57.52
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CSI 1.61rCSI 1.53%PRS 40.56
-
CSI 1.6rCSI 1.23%PRS 37.96
-
CSI 1.58rCSI 1.63%PRS 56.6
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CSI 1.54rCSI 2.21%PRS 47
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CSI 1.53rCSI 1.91%PRS 24.26
-
CSI 1.53rCSI 1.03%PRS 48.72
-
CSI 1.51rCSI 1.33%PRS 29.77
-
CSI 1.51rCSI 3.33%PRS 43.17
-
CSI 1.5rCSI 1.94%PRS 26.47
-
CSI 1.49rCSI 1.25%PRS 44.47
-
CSI 1.49rCSI 1.48%PRS 34.18
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CSI 1.48rCSI 2.36%PRS 33.44
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CSI 1.47rCSI 2.38%PRS 38.3
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CSI 1.46rCSI 3.69%PRS 47.19
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CSI 1.43rCSI 1.3%PRS 53.92
-
CSI 1.42rCSI 1.15%PRS 39.91
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CSI 1.4rCSI 3.33%PRS 45.09
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CSI 1.4rCSI 1.67%PRS 25.56
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CSI 1.38rCSI 4.06%PRS 43.71
-
CSI 1.33rCSI 1.03%PRS 55.24
-
CSI 1.3rCSI 1.16%PRS 38.65
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CSI 1.28rCSI 1.89%PRS 56.32
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CSI 1.27rCSI 2.81%PRS 36.72
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CSI 1.24rCSI 1.79%PRS 55.03
-
CSI 1.21rCSI 2.15%PRS 25.2
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CSI 1.19rCSI 4.01%PRS 49.96
-
CSI 1.17rCSI 2.33%PRS 57.18
-
CSI 1.16rCSI 1.44%PRS 41.95
-
CSI 1.16rCSI 3.78%PRS 72.02
-
CSI 1.15rCSI 1.53%PRS 43.68
-
CSI 1.15rCSI 1.85%PRS 27.6
-
CSI 1.11rCSI 1.48%PRS 41.17
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CSI 1.08rCSI 1.67%PRS 37.51
-
CSI 1.04rCSI 2.02%PRS 41.13
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CSI 0.1rCSI 0.5%PRS 51.6%
-
CSI 0.3rCSI 1.7%PRS 64.8%
-
CSI 0.4rCSI 1.3%PRS 24.6%
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CSI 0.4rCSI 0.6%PRS 31.3%
-
CSI 0.4rCSI 1.7%PRS 61.4%
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CSI 0.5rCSI 1.0%PRS 29.2%
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CSI 0.5rCSI 2.1%PRS 34.2%
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CSI 0.5rCSI 1.6%PRS 26.7%
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CSI 0.6rCSI 3.2%PRS 50.6%
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CSI 0.6rCSI 2.2%PRS 26.5%
-
CSI 0.6rCSI 1.5%PRS 24.8%
-
CSI 0.6rCSI 1.6%PRS 31.1%
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CSI 0.7rCSI 1.0%PRS 50.0%
-
CSI 0.7rCSI 4.0%PRS 27.3%
-
CSI 0.7rCSI 2.6%PRS 58.2%
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CSI 0.7rCSI 3.8%PRS 63.5%
-
CSI 0.8rCSI 1.8%PRS 56.5%
-
CSI 0.8rCSI 1.7%PRS 49.2%
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CSI 0.8rCSI 2.0%PRS 36.2%
-
CSI 0.9rCSI 1.0%PRS 46.3%
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CSI 0.9rCSI 4.3%PRS 49.7%
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CSI 1.0rCSI 1.6%PRS 42.7%
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CSI 1.0rCSI 2.0%PRS 46.8%
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CSI 1.0rCSI 2.7%PRS 52.7%
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CSI 1.0rCSI 1.2%PRS 30.5%
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CSI 1.0rCSI 2.7%PRS 33.4%
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CSI 1.0rCSI 1.8%PRS 38.3%
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CSI 1.0rCSI 2.0%PRS 41.1%
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CSI 1.1rCSI 1.7%PRS 37.5%
-
CSI 1.1rCSI 1.5%PRS 41.2%
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CSI 1.2rCSI 1.9%PRS 27.6%
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CSI 1.2rCSI 1.5%PRS 43.7%
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CSI 1.2rCSI 3.8%PRS 72.0%
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CSI 1.2rCSI 1.4%PRS 42.0%
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CSI 1.2rCSI 2.3%PRS 57.2%
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CSI 1.2rCSI 4.0%PRS 50.0%
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CSI 1.2rCSI 2.2%PRS 25.2%
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CSI 1.2rCSI 1.8%PRS 55.0%
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CSI 1.3rCSI 2.8%PRS 36.7%
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CSI 1.3rCSI 1.9%PRS 56.3%
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CSI 1.3rCSI 1.2%PRS 38.7%
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CSI 1.3rCSI 1.0%PRS 55.2%
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CSI 1.4rCSI 4.1%PRS 43.7%
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CSI 1.4rCSI 1.7%PRS 25.6%
-
CSI 1.4rCSI 3.3%PRS 45.1%
-
CSI 1.4rCSI 1.2%PRS 39.9%
-
CSI 1.4rCSI 1.3%PRS 53.9%
-
CSI 1.5rCSI 3.7%PRS 47.2%
-
CSI 1.5rCSI 2.4%PRS 38.3%
-
CSI 1.5rCSI 2.4%PRS 33.4%
-
CSI 1.5rCSI 1.5%PRS 34.2%
-
CSI 1.5rCSI 1.3%PRS 44.5%
-
CSI 1.5rCSI 1.9%PRS 26.5%
-
CSI 1.5rCSI 3.3%PRS 43.2%
-
CSI 1.5rCSI 1.3%PRS 29.8%
-
CSI 1.5rCSI 1.0%PRS 48.7%
-
CSI 1.5rCSI 1.9%PRS 24.3%
-
CSI 1.5rCSI 2.2%PRS 47.0%
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CSI 1.6rCSI 1.6%PRS 56.6%
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CSI 1.6rCSI 1.2%PRS 38.0%
-
CSI 1.6rCSI 1.5%PRS 40.6%
-
CSI 1.6rCSI 1.2%PRS 57.5%
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CSI 1.6rCSI 2.8%PRS 31.1%
-
CSI 1.6rCSI 3.5%PRS 54.5%
-
CSI 1.7rCSI 1.8%PRS 37.0%
-
CSI 1.7rCSI 2.8%PRS 25.6%
-
CSI 1.7rCSI 2.2%PRS 44.0%
-
CSI 1.7rCSI 3.4%PRS 39.3%
-
CSI 1.7rCSI 1.8%PRS 51.6%
-
CSI 1.8rCSI 1.5%PRS 43.2%
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CSI 1.8rCSI 1.4%PRS 39.5%
-
CSI 1.8rCSI 1.3%PRS 50.9%
-
CSI 1.8rCSI 1.9%PRS 37.3%
-
CSI 1.8rCSI 1.9%PRS 40.0%
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CSI 1.8rCSI 3.5%PRS 55.8%
-
CSI 1.9rCSI 2.3%PRS 48.5%
-
CSI 1.9rCSI 1.4%PRS 42.4%
-
CSI 1.9rCSI 2.6%PRS 43.9%
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CSI 1.9rCSI 1.3%PRS 51.6%
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CSI 1.9rCSI 1.7%PRS 36.3%
-
CSI 1.9rCSI 4.3%PRS 33.9%
-
CSI 2.0rCSI 1.7%PRS 47.8%
-
CSI 2.0rCSI 3.7%PRS 30.4%
-
CSI 2.0rCSI 4.4%PRS 45.4%
-
CSI 2.0rCSI 5.2%PRS 38.6%
-
CSI 2.1rCSI 1.8%PRS 44.2%
-
CSI 2.1rCSI 4.7%PRS 26.2%
-
CSI 2.1rCSI 3.6%PRS 48.5%
-
CSI 2.2rCSI 6.3%PRS 56.0%
-
CSI 2.2rCSI 2.0%PRS 48.8%
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CSI 2.2rCSI 1.8%PRS 40.2%
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CSI 2.3rCSI 3.3%PRS 42.1%
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CSI 2.3rCSI 1.7%PRS 33.9%
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CSI 2.3rCSI 3.5%PRS 43.9%
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CSI 2.4rCSI 1.7%PRS 41.1%
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CSI 2.5rCSI 2.3%PRS 40.5%
-
CSI 2.5rCSI 2.9%PRS 43.2%
-
CSI 2.5rCSI 7.3%PRS 32.0%
-
CSI 2.5rCSI 2.0%PRS 60.7%
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CSI 2.6rCSI 3.3%PRS 37.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 67114616
Symbol: KC1G2_HUMAN
Name: Casein kinase I isoform gamma-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9403068
Title: Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2).
PubMed ID: 9403068
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15077195
Title: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.
PubMed ID: 15077195
PubMed ID: 15917222
Title: SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein.
PubMed ID: 15917222
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18794808
Title: Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling.
PubMed ID: 18794808
DOI: 10.1038/onc.2008.337
PubMed ID: 19005213
Title: Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.
PubMed ID: 19005213
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26481050
Title: Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.
PubMed ID: 26481050
PubMed ID: 37099597
Title: Casein kinase 1 gamma regulates oxidative stress response via interacting with the NADPH dual oxidase complex.
PubMed ID: 37099597
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 415
- Mass: 47457
- Checksum: 036A39148A1DA038
- Sequence:
MDFDKKGGKG ETEEGRRMSK AGGGRSSHGI RSSGTSSGVL MVGPNFRVGK KIGCGNFGEL RLGKNLYTNE YVAIKLEPIK SRAPQLHLEY RFYKQLSATE GVPQVYYFGP CGKYNAMVLE LLGPSLEDLF DLCDRTFTLK TVLMIAIQLI TRMEYVHTKS LIYRDVKPEN FLVGRPGTKR QHAIHIIDFG LAKEYIDPET KKHIPYREHK SLTGTARYMS INTHLGKEQS RRDDLEALGH MFMYFLRGSL PWQGLKADTL KERYQKIGDT KRATPIEVLC ENFPEEMATY LRYVRRLDFF EKPDYDYLRK LFTDLFDRSG FVFDYEYDWA GKPLPTPIGT VHTDLPSQPQ LRDKTQPHSK NQALNSTNGE LNADDPTAGH SNAPITAPAE VEVADETKCC CFFKRRKRKS LQRHK