Details for: CSNK1G3

Gene ID: 1456

Symbol: CSNK1G3

Ensembl ID: ENSG00000151292

Description: casein kinase 1 gamma 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.3
    Marker Score: 4027
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.71
    Marker Score: 6951.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.7
    Marker Score: 25353.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.68
    Marker Score: 15811
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.67
    Marker Score: 102663
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.66
    Marker Score: 62935.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.64
    Marker Score: 6326
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.63
    Marker Score: 15469
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.62
    Marker Score: 32291
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.62
    Marker Score: 59824
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.62
    Marker Score: 12429
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.62
    Marker Score: 13892
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.61
    Marker Score: 14107
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.56
    Marker Score: 6476
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.56
    Marker Score: 1534
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.51
    Marker Score: 901.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.42
    Marker Score: 14693
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.41
    Marker Score: 2180
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.31
    Marker Score: 567
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.27
    Marker Score: 27196
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.27
    Marker Score: 2797
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.26
    Marker Score: 624
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.25
    Marker Score: 359
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.22
    Marker Score: 1758
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.21
    Marker Score: 1396
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.2
    Marker Score: 1191
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.18
    Marker Score: 711
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.18
    Marker Score: 2464.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18374
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.16
    Marker Score: 1279
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.16
    Marker Score: 1704
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.13
    Marker Score: 475
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.13
    Marker Score: 5245
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.1
    Marker Score: 646
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.09
    Marker Score: 2089
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.08
    Marker Score: 1334
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.08
    Marker Score: 3987
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.06
    Marker Score: 994
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.05
    Marker Score: 530
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.05
    Marker Score: 6744
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.05
    Marker Score: 4512
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.04
    Marker Score: 1126
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.03
    Marker Score: 4311.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.03
    Marker Score: 34812
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.01
    Marker Score: 249
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71630
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47854.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.99
    Marker Score: 1197
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.98
    Marker Score: 757
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30380
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.98
    Marker Score: 286
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.97
    Marker Score: 585
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.97
    Marker Score: 1255
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.97
    Marker Score: 280
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.96
    Marker Score: 356
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.96
    Marker Score: 387
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.95
    Marker Score: 819
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.94
    Marker Score: 4934
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.94
    Marker Score: 326
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2387
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.94
    Marker Score: 351
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.94
    Marker Score: 31900
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.94
    Marker Score: 861
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.93
    Marker Score: 523
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.93
    Marker Score: 1320
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.93
    Marker Score: 295
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.93
    Marker Score: 1620
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.93
    Marker Score: 2642
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.91
    Marker Score: 963
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.91
    Marker Score: 3531.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.91
    Marker Score: 441.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.9
    Marker Score: 6812
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.9
    Marker Score: 779
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.9
    Marker Score: 255
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5132
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.9
    Marker Score: 4825
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2684
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.89
    Marker Score: 244
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.89
    Marker Score: 729
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.89
    Marker Score: 468
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.89
    Marker Score: 15732
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.88
    Marker Score: 1218
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.88
    Marker Score: 210.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.88
    Marker Score: 359
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.88
    Marker Score: 1476
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.88
    Marker Score: 310
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.88
    Marker Score: 2097
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.88
    Marker Score: 435
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.87
    Marker Score: 3648
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.87
    Marker Score: 655
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.87
    Marker Score: 2740
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.87
    Marker Score: 828
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.87
    Marker Score: 2134
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.87
    Marker Score: 591
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.86
    Marker Score: 2034.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.86
    Marker Score: 857

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Other Information

**Key characteristics:** * CSNK1G3 is a serine/threonine kinase. * It is a transmembrane protein with a cytoplasmic domain and a transmembrane domain. * It is expressed in a wide range of cell types, including germ cells, neurons, and glial cells. **Pathways and functions:** * CSNK1G3 is a key regulator of the canonical Wnt signaling pathway. * It acts as a negative regulator of the pathway by phosphorylating and inhibiting the cytoplasmic domain of beta-catenin, a key transcriptional factor that is a target of the pathway. * By preventing the activation of beta-catenin, CSNK1G3 helps to maintain the stability and activity of the Wnt target proteins, such as Axin and LRP1. * The inhibition of the Wnt pathway through CSNK1G3 helps to maintain tissue homeostasis and prevent the development of cancer. **Clinical significance:** * Mutations in CSNK1G3 have been implicated in a variety of human diseases, including autism, schizophrenia, and cancer. * Studies have shown that mutations in CSNK1G3 can lead to the activation of the Wnt pathway, resulting in the overexpression of beta-catenin and the development of cancer. * Therefore, CSNK1G3 is a potential therapeutic target for the treatment of cancer and other diseases that are characterized by abnormal Wnt signaling.

Genular Protein ID: 3402785418

Symbol: KC1G3_HUMAN

Name: Casein kinase I isoform gamma-3

UniProtKB Accession Codes:

Q9Y6M4 A8K040 B4DSH2 B7Z9Q4 E7EVD0 Q86WZ7 Q9Y6M3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 3 EMBL 9 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 10 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 10 Rhea 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9925945

Title: Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3).

PubMed ID: 9925945

DOI: 10.1159/000015143

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 447
  • Mass: 51389
  • Checksum: 6FAEDD605579ED3A
  • Sequence:
    • MENKKKDKDK SDDRMARPSG RSGHNTRGTG SSSSGVLMVG PNFRVGKKIG CGNFGELRLG 
KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP QVYYFGPCGK YNAMVLELLG 
PSLEDLFDLC DRTFSLKTVL MIAIQLISRM EYVHSKNLIY RDVKPENFLI GRPGNKTQQV 
IHIIDFGLAK EYIDPETKKH IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM 
YFLRGSLPWQ GLKADTLKER YQKIGDTKRA TPIEVLCENF PEMATYLRYV RRLDFFEKPD 
YDYLRKLFTD LFDRKGYMFD YEYDWIGKQL PTPVGAVQQD PALSSNREAH QHRDKMQQSK 
NQSADHRAAW DSQQANPHHL RAHLAADRHG GSVQVVSSTN GELNTDDPTA GRSNAPITAP 
TEVEVMDETK CCCFFKRRKR KTIQRHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.