Details for: CSNK1G3

Gene ID: 1456

Symbol: CSNK1G3

Ensembl ID: ENSG00000151292

Description: casein kinase 1 gamma 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 268.3142
    Cell Significance Index: -41.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 158.1354
    Cell Significance Index: -40.1100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.3762
    Cell Significance Index: -44.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.5030
    Cell Significance Index: -37.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.9923
    Cell Significance Index: -42.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.5499
    Cell Significance Index: -37.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.5957
    Cell Significance Index: -42.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.3274
    Cell Significance Index: -41.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0241
    Cell Significance Index: -33.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8894
    Cell Significance Index: -42.9700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0698
    Cell Significance Index: -19.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.6018
    Cell Significance Index: 455.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8484
    Cell Significance Index: 370.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7413
    Cell Significance Index: 97.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6789
    Cell Significance Index: 87.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5223
    Cell Significance Index: 165.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2030
    Cell Significance Index: 195.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1728
    Cell Significance Index: 420.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1420
    Cell Significance Index: 226.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8807
    Cell Significance Index: 59.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8516
    Cell Significance Index: 588.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8423
    Cell Significance Index: 51.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7604
    Cell Significance Index: 14.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7580
    Cell Significance Index: 136.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7542
    Cell Significance Index: 33.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6939
    Cell Significance Index: 31.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6797
    Cell Significance Index: 52.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6544
    Cell Significance Index: 24.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6444
    Cell Significance Index: 13.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5412
    Cell Significance Index: 66.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5079
    Cell Significance Index: 12.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4759
    Cell Significance Index: 13.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4473
    Cell Significance Index: 12.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4406
    Cell Significance Index: 22.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4257
    Cell Significance Index: 5.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4051
    Cell Significance Index: 221.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3201
    Cell Significance Index: 43.9700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3193
    Cell Significance Index: 141.1500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2128
    Cell Significance Index: 3.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1938
    Cell Significance Index: 174.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1463
    Cell Significance Index: 5.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1039
    Cell Significance Index: 1.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0682
    Cell Significance Index: 11.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0569
    Cell Significance Index: 107.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0539
    Cell Significance Index: 34.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0520
    Cell Significance Index: 23.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0339
    Cell Significance Index: 52.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0328
    Cell Significance Index: 60.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0238
    Cell Significance Index: 32.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0184
    Cell Significance Index: 2.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0224
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0230
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0252
    Cell Significance Index: -18.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0343
    Cell Significance Index: -4.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0351
    Cell Significance Index: -25.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0415
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0430
    Cell Significance Index: -26.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0465
    Cell Significance Index: -35.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0487
    Cell Significance Index: -27.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0582
    Cell Significance Index: -1.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0861
    Cell Significance Index: -4.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0971
    Cell Significance Index: -11.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1003
    Cell Significance Index: -1.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1011
    Cell Significance Index: -4.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1014
    Cell Significance Index: -2.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1251
    Cell Significance Index: -36.0000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1258
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1373
    Cell Significance Index: -28.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1394
    Cell Significance Index: -14.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1420
    Cell Significance Index: -10.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1431
    Cell Significance Index: -16.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1653
    Cell Significance Index: -10.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1701
    Cell Significance Index: -21.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1786
    Cell Significance Index: -4.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1981
    Cell Significance Index: -5.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2131
    Cell Significance Index: -15.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2357
    Cell Significance Index: -5.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2400
    Cell Significance Index: -6.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2898
    Cell Significance Index: -7.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2992
    Cell Significance Index: -34.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3328
    Cell Significance Index: -7.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3570
    Cell Significance Index: -5.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3608
    Cell Significance Index: -37.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4082
    Cell Significance Index: -11.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4441
    Cell Significance Index: -4.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4733
    Cell Significance Index: -37.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5609
    Cell Significance Index: -14.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5798
    Cell Significance Index: -7.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5957
    Cell Significance Index: -20.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6206
    Cell Significance Index: -9.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6226
    Cell Significance Index: -38.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6380
    Cell Significance Index: -14.7400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6581
    Cell Significance Index: -9.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6619
    Cell Significance Index: -21.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6697
    Cell Significance Index: -16.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6817
    Cell Significance Index: -22.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6956
    Cell Significance Index: -22.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6994
    Cell Significance Index: -10.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7078
    Cell Significance Index: -14.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7177
    Cell Significance Index: -8.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Specificity:** CSNK1G3 exhibits specificity towards phosphorylating serine and threonine residues on target proteins, which is a hallmark of CK1 enzymes. 2. **Widespread expression:** CSNK1G3 is expressed in various neuronal and interneuronal populations throughout the brain, including germ cells, neurons, and GABAergic cortical interneurons. 3. **Phosphorylation activity:** CSNK1G3 is a protein kinase that phosphorylates serine and threonine residues on target proteins, which can modulate their activity, localization, or stability. 4. **Regulation of Wnt signaling:** CSNK1G3 is involved in the regulation of canonical Wnt signaling, a critical pathway involved in neural development, plasticity, and disease. **Pathways and Functions:** 1. **Wnt signaling pathway:** CSNK1G3 is a key regulator of canonical Wnt signaling, which is involved in neural development, cell fate determination, and tissue homeostasis. 2. **Signal transduction:** CSNK1G3 is involved in signal transduction pathways that regulate various cellular processes, including cell proliferation, differentiation, and survival. 3. **Protein modification:** CSNK1G3 phosphorylates serine and threonine residues on target proteins, which can modulate their activity, localization, or stability. 4. **Endocytosis and plasma membrane regulation:** CSNK1G3 is involved in the regulation of endocytosis and plasma membrane dynamics, which is critical for maintaining cellular homeostasis and responding to environmental cues. **Clinical Significance:** 1. **Neurological disorders:** Dysregulation of the Wnt signaling pathway, mediated by CSNK1G3, has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. 2. **Cancer:** CSNK1G3 has been shown to be overexpressed in certain types of cancer, including glioblastoma and breast cancer, where it may contribute to tumor progression and metastasis. 3. **Neurodevelopmental disorders:** CSNK1G3 is involved in the regulation of neural development and plasticity, and dysregulation of its activity may contribute to neurodevelopmental disorders, such as schizophrenia and bipolar disorder. 4. **Therapeutic targeting:** Understanding the role of CSNK1G3 in disease mechanisms may lead to the development of novel therapeutic strategies, including the targeting of its kinase activity or its downstream effectors. In conclusion, CSNK1G3 is a multifaceted regulator of cellular signaling and Wnt pathway, with significant implications for our understanding of neural development, plasticity, and disease. Further research is needed to fully elucidate its role in various disease mechanisms and to explore its potential as a therapeutic target.

Genular Protein ID: 3402785418

Symbol: KC1G3_HUMAN

Name: Casein kinase I isoform gamma-3

UniProtKB Accession Codes:

Q9Y6M4 A8K040 B4DSH2 B7Z9Q4 E7EVD0 Q86WZ7 Q9Y6M3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 3 EMBL 9 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 10 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9925945

Title: Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3).

PubMed ID: 9925945

DOI: 10.1159/000015143

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 447
  • Mass: 51389
  • Checksum: 6FAEDD605579ED3A
  • Sequence:
    • MENKKKDKDK SDDRMARPSG RSGHNTRGTG SSSSGVLMVG PNFRVGKKIG CGNFGELRLG 
KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP QVYYFGPCGK YNAMVLELLG 
PSLEDLFDLC DRTFSLKTVL MIAIQLISRM EYVHSKNLIY RDVKPENFLI GRPGNKTQQV 
IHIIDFGLAK EYIDPETKKH IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM 
YFLRGSLPWQ GLKADTLKER YQKIGDTKRA TPIEVLCENF PEMATYLRYV RRLDFFEKPD 
YDYLRKLFTD LFDRKGYMFD YEYDWIGKQL PTPVGAVQQD PALSSNREAH QHRDKMQQSK 
NQSADHRAAW DSQQANPHHL RAHLAADRHG GSVQVVSSTN GELNTDDPTA GRSNAPITAP 
TEVEVMDETK CCCFFKRRKR KTIQRHK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.