Genular: Defining Cellular Identity and Function

Details for: Gdf5

Gene ID: 14563

Symbol: Gdf5

Ensembl ID: ENSMUSG00000038259

Description: growth differentiation factor 5

Associated with

Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Molecules associated with elastic fibres
(R-MMU-2129379)
Bmp binding
(GO:0036122)
Bmp signaling pathway
(GO:0030509)
Cartilage development
(GO:0051216)
Chondroblast differentiation
(GO:0060591)
Chondrocyte differentiation
(GO:0002062)
Cytokine activity
(GO:0005125)
Embryonic limb morphogenesis
(GO:0030326)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Forelimb morphogenesis
(GO:0035136)
Growth factor activity
(GO:0008083)
Hindlimb morphogenesis
(GO:0035137)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Mesenchymal cell apoptotic process
(GO:0097152)
Negative regulation of chondrocyte differentiation
(GO:0032331)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of mesenchymal cell apoptotic process
(GO:2001054)
Negative regulation of neuron apoptotic process
(GO:0043524)
Plasma membrane
(GO:0005886)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of chondrocyte differentiation
(GO:0032332)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of smad protein signal transduction
(GO:0060391)
Protein binding
(GO:0005515)
Regulation of multicellular organism growth
(GO:0040014)
Signaling receptor binding
(GO:0005102)
Smad protein signal transduction
(GO:0060395)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)

Other Information

Proteins

Growth/differentiation factor 5
Q8BRW9_MOUSE

Genular Protein ID: 1097693768

Symbol: GDF5_MOUSE

Name: Growth/differentiation factor 5

UniProtKB Accession Codes:

P43027 A2ARK2

Database IDs:

Citations:

PubMed ID: 8145850

Title: Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.

PubMed ID: 8145850

DOI: 10.1038/368639a0

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15206957

Title: Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling.

PubMed ID: 15206957

DOI: 10.1111/j.1440-169x.2004.00743.x

PubMed ID: 14973287

Title: HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins.

PubMed ID: 14973287

DOI: 10.1242/dev.00999

PubMed ID: 24076600

Title: BMP signaling controls muscle mass.

PubMed ID: 24076600

DOI: 10.1038/ng.2772

Sequence Information:

Length: 495
Mass: 54895
Checksum: 8FAECD5A9C996D6E
Sequence:

MRLPKLLTLL LWHLAWLDLE LICTVLGAPD LGQRTPGAKP GLTKAEAKER PPLARNVFRP 
GGHIYGVGAT NARAKGSSGQ TQAKKDEPRK MPPRSGGPET KPGPSSQTRQ AAARTVTPKG 
QLPGGKASSK AGSAPSSFLL KKTREPGTPR EPKEPFRPPP ITPHEYMLSL YRTLSDADRK 
GGNSSVKLEA GLANTITSFI DKGQDDRGPA VRKQRYVFDI SALEKDGLLG AELRILRKKP 
LDVAKPAVPS SGRVAQLKLS SCPSGRQPAA LLDVRSVPGL DGSGWEVFDI WKLFRNFKNS 
AQLCLELEAW ERGRAVDLRG LGFERTARQV HEKALFLVFG RTKKRDLFFN EIKARSGQDD 
KTVYEYLFSQ RRKRRAPLAN RQGKRPSKNL KARCSRKALH VNFKDMGWDD WIIAPLEYEA 
FHCEGLCEFP LRSHLEPTNH AVIQTLMNSM DPESTPPTCC VPTRLSPISI LFIDSANNVV 
YKQYEDMVVE SCGCR

Genular Protein ID: 4006241443

Symbol: Q8BRW9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BRW9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 249
Mass: 28410
Checksum: E6EA047F06B57189
Sequence:

AVPSSGRVAQ LKLSSCPSGR QPAALLDVRS VPGLDGSGWE VFDIWKLFRN FKNSAQLCLE 
LEAWERGRAV DLRGLGFERT ARQVHEKALF LVFGRTKKRD LFFNEIKARS GQDDKTVYEY 
LFSQRRKRRA PLANRQGKRP SKNLKARCSR KALHVNFKDM GWDDWIIAPL EYEAFHCEGL 
CEFPLRSHLE PTNHAVIQTL MNSMDPESTP PTCCVPTRLS PISILFIDSA NNVVYKQYED 
MVVESCGCR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gdf5

Associated with

Other Information

Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. PubMed ID: 8145850

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. PubMed ID: 15206957

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. PubMed ID: 14973287

BMP signaling controls muscle mass. PubMed ID: 24076600

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073