CSNK2A1 | ENSG00000101266 | NCBI 1457

Details for: CSNK2A1

Gene ID: 1457

Symbol: CSNK2A1

Ensembl ID: ENSG00000101266

Description: casein kinase 2 alpha 1

Associated with

Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Chaperonin-mediated protein folding
(R-HSA-390466)
Condensation of prometaphase chromosomes
(R-HSA-2514853)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glycerophospholipid biosynthesis
(R-HSA-1483206)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
L1cam interactions
(R-HSA-373760)
Macroautophagy
(R-HSA-1632852)
Maturation of hrsv a proteins
(R-HSA-9828806)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Mitophagy
(R-HSA-5205647)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Phospholipid metabolism
(R-HSA-1483257)
Pip3 activates akt signaling
(R-HSA-1257604)
Protein folding
(R-HSA-391251)
Pten regulation
(R-HSA-6807070)
Receptor mediated mitophagy
(R-HSA-8934903)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Respiratory syncytial virus (rsv) genome replication, transcription and translation
(R-HSA-9820965)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Selective autophagy
(R-HSA-9663891)
Signaling by wnt
(R-HSA-195721)
Signal transduction by l1
(R-HSA-445144)
Synthesis of pc
(R-HSA-1483191)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Viral infection pathways
(R-HSA-9824446)
Wnt mediated activation of dvl
(R-HSA-201688)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Chaperone-mediated protein folding
(GO:0061077)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Double-strand break repair
(GO:0006302)
Hsp90 protein binding
(GO:0051879)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of translation
(GO:0017148)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Plasma membrane
(GO:0005886)
Pml body
(GO:0016605)
Positive regulation of aggrephagy
(GO:1905337)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein binding
(GO:0005515)
Protein kinase ck2 complex
(GO:0005956)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein stabilization
(GO:0050821)
Regulation of cell cycle
(GO:0051726)
Regulation of chromosome separation
(GO:1905818)
Rhythmic process
(GO:0048511)
Signal transduction
(GO:0007165)
Sin3-type complex
(GO:0070822)
Symbiont-mediated disruption of host cell pml body
(GO:0075342)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Casein kinase II subunit alpha

Genular Protein ID: 2858816751

Symbol: CSK21_HUMAN

Name: Casein kinase II subunit alpha

UniProtKB Accession Codes:

P68400 B4DYS6 D3DVV8 P19138 P20426 Q14013 Q5U065

Database IDs:

Citations:

PubMed ID: 2752008

Title: Molecular cloning of the human casein kinase II alpha subunit.

PubMed ID: 2752008

DOI: 10.1021/bi00435a066

PubMed ID: 2174700

Title: Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.

PubMed ID: 2174700

DOI: 10.1021/bi00488a034

PubMed ID: 8420794

Title: Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.

PubMed ID: 8420794

DOI: 10.1016/0014-5793(93)81197-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7592773

Title: Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro.

PubMed ID: 7592773

DOI: 10.1074/jbc.270.43.25872

PubMed ID: 11239457

Title: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

PubMed ID: 11239457

DOI: 10.1016/s1097-2765(01)00176-9

PubMed ID: 11704824

Title: Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.

PubMed ID: 11704824

DOI: 10.1038/sj.onc.1204894

PubMed ID: 12393879

Title: p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

PubMed ID: 12393879

DOI: 10.1074/jbc.m209820200

PubMed ID: 16193064

Title: Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.

PubMed ID: 16193064

DOI: 10.1038/sj.emboj.7600827

PubMed ID: 15684395

Title: Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.

PubMed ID: 15684395

DOI: 10.1128/mcb.25.4.1446-1457.2005

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19188443

Title: Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha.

PubMed ID: 19188443

DOI: 10.1128/mcb.01563-08

PubMed ID: 12631575

Title: One-thousand-and-one substrates of protein kinase CK2?

PubMed ID: 12631575

DOI: 10.1096/fj.02-0473rev

PubMed ID: 19387553

Title: Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights.

PubMed ID: 19387553

DOI: 10.1007/s00018-009-9149-8

PubMed ID: 19387552

Title: Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival.

PubMed ID: 19387552

DOI: 10.1007/s00018-009-9150-2

PubMed ID: 19387551

Title: Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

PubMed ID: 19387551

DOI: 10.1007/s00018-009-9151-1

PubMed ID: 19387550

Title: Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery.

PubMed ID: 19387550

DOI: 10.1007/s00018-009-9152-0

PubMed ID: 19387549

Title: Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.

PubMed ID: 19387549

DOI: 10.1007/s00018-009-9153-z

PubMed ID: 20545769

Title: Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.

PubMed ID: 20545769

DOI: 10.1111/j.1365-2443.2010.01418.x

PubMed ID: 19923321

Title: Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.

PubMed ID: 19923321

DOI: 10.1091/mbc.e09-06-0504

PubMed ID: 20625391

Title: Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.

PubMed ID: 20625391

DOI: 10.1371/journal.pone.0011418

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21482717

Title: MDC1 collaborates with TopBP1 in DNA replication checkpoint control.

PubMed ID: 21482717

DOI: 10.1083/jcb.201010026

PubMed ID: 22406621

Title: The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.

PubMed ID: 22406621

DOI: 10.1158/0008-5472.can-11-3159

PubMed ID: 22325354

Title: Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

PubMed ID: 22325354

DOI: 10.1016/j.molcel.2011.12.028

PubMed ID: 22184066

Title: Phosphorylation of the transcription factor YY1 by CK2alpha prevents cleavage by caspase 7 during apoptosis.

PubMed ID: 22184066

DOI: 10.1128/mcb.06466-11

PubMed ID: 23123191

Title: Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response.

PubMed ID: 23123191

DOI: 10.1016/j.bbamcr.2012.10.025

PubMed ID: 24962073

Title: CK2alpha phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients.

PubMed ID: 24962073

DOI: 10.1002/ijc.29043

PubMed ID: 27048600

Title: De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features.

PubMed ID: 27048600

DOI: 10.1007/s00439-016-1661-y

PubMed ID: 26811421

Title: TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.

PubMed ID: 26811421

DOI: 10.1083/jcb.201507042

PubMed ID: 30699359

Title: Post-translational regulation of FNIP1 creates a rheostat for the molecular chaperone Hsp90.

PubMed ID: 30699359

DOI: 10.1016/j.celrep.2019.01.018

PubMed ID: 30765518

Title: Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.

PubMed ID: 30765518

DOI: 10.1073/pnas.1814385116

PubMed ID: 30898438

Title: MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis.

PubMed ID: 30898438

DOI: 10.1016/j.molcel.2019.02.014

PubMed ID: 31439799

Title: Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.

PubMed ID: 31439799

DOI: 10.1126/science.aax4240

PubMed ID: 35597237

Title: A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.

PubMed ID: 35597237

DOI: 10.1016/j.molcel.2022.04.031

PubMed ID: 11092945

Title: Crystallization and preliminary characterization of crystals of human protein kinase CK2.

PubMed ID: 11092945

DOI: 10.1107/s0907444900013627

PubMed ID: 11574463

Title: Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.

PubMed ID: 11574463

DOI: 10.1093/emboj/20.19.5320

PubMed ID: 14646071

Title: Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.

PubMed ID: 14646071

DOI: 10.1107/s0907444903018900

PubMed ID: 12860116

Title: Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.

PubMed ID: 12860116

DOI: 10.1016/s0022-2836(03)00638-7

Sequence Information:

Length: 391
Mass: 45144
Checksum: D3B6F5D13FF7422D
Sequence:

MSGPVPSRAR VYTDVNTHRP REYWDYESHV VEWGNQDDYQ LVRKLGRGKY SEVFEAINIT 
NNEKVVVKIL KPVKKKKIKR EIKILENLRG GPNIITLADI VKDPVSRTPA LVFEHVNNTD 
FKQLYQTLTD YDIRFYMYEI LKALDYCHSM GIMHRDVKPH NVMIDHEHRK LRLIDWGLAE 
FYHPGQEYNV RVASRYFKGP ELLVDYQMYD YSLDMWSLGC MLASMIFRKE PFFHGHDNYD 
QLVRIAKVLG TEDLYDYIDK YNIELDPRFN DILGRHSRKR WERFVHSENQ HLVSPEALDF 
LDKLLRYDHQ SRLTAREAME HPYFYTVVKD QARMGSSSMP GGSTPVSSAN MMSGISSVPT 
PSPLGPLAGS PVIAAANPLG MPVPAAAGAQ Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CSNK2A1

Associated with

Other Information

Molecular cloning of the human casein kinase II alpha subunit. PubMed ID: 2752008

Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. PubMed ID: 2174700

Structure and sequence of an intronless gene for human casein kinase II-alpha subunit. PubMed ID: 8420794

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro. PubMed ID: 7592773

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. PubMed ID: 11239457

Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells. PubMed ID: 11704824

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. PubMed ID: 12393879

Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. PubMed ID: 16193064

Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation. PubMed ID: 15684395

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha. PubMed ID: 19188443

One-thousand-and-one substrates of protein kinase CK2? PubMed ID: 12631575

Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights. PubMed ID: 19387553

Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival. PubMed ID: 19387552

Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair. PubMed ID: 19387551

Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery. PubMed ID: 19387550

Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer. PubMed ID: 19387549

Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1. PubMed ID: 20545769

Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. PubMed ID: 19923321

Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PubMed ID: 20625391

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

MDC1 collaborates with TopBP1 in DNA replication checkpoint control. PubMed ID: 21482717

The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA. PubMed ID: 22406621

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair. PubMed ID: 22325354

Phosphorylation of the transcription factor YY1 by CK2alpha prevents cleavage by caspase 7 during apoptosis. PubMed ID: 22184066

Functional interaction of protein kinase CK2 and activating transcription factor 4 (ATF4), a key player in the cellular stress response. PubMed ID: 23123191

CK2alpha phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients. PubMed ID: 24962073

De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features. PubMed ID: 27048600

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. PubMed ID: 26811421

Post-translational regulation of FNIP1 creates a rheostat for the molecular chaperone Hsp90. PubMed ID: 30699359

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation. PubMed ID: 30765518

MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis. PubMed ID: 30898438

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation. PubMed ID: 31439799

A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination. PubMed ID: 35597237

Crystallization and preliminary characterization of crystals of human protein kinase CK2. PubMed ID: 11092945

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. PubMed ID: 11574463

Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2. PubMed ID: 14646071

Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit. PubMed ID: 12860116