Details for: Gdnf

Gene ID: 14573

Symbol: Gdnf

Ensembl ID: ENSMUSG00000022144

Description: glial cell line derived neurotrophic factor

Associated with

  • Axon guidance
    (R-MMU-422475)
  • Developmental biology
    (R-MMU-1266738)
  • Mapk1/mapk3 signaling
    (R-MMU-5684996)
  • Mapk family signaling cascades
    (R-MMU-5683057)
  • Raf/map kinase cascade
    (R-MMU-5673001)
  • Ret signaling
    (R-MMU-8853659)
  • Signal transduction
    (R-MMU-162582)
  • Branching involved in ureteric bud morphogenesis
    (GO:0001658)
  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Commissural neuron axon guidance
    (GO:0071679)
  • Dorsal spinal cord development
    (GO:0021516)
  • Embryonic organ development
    (GO:0048568)
  • Enteric nervous system development
    (GO:0048484)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Glial cell-derived neurotrophic factor receptor binding
    (GO:0030116)
  • Golgi apparatus
    (GO:0005794)
  • Growth factor activity
    (GO:0008083)
  • Mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0003337)
  • Metanephros development
    (GO:0001656)
  • Mrna stabilization
    (GO:0048255)
  • Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    (GO:2001240)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Nervous system development
    (GO:0007399)
  • Neural crest cell migration
    (GO:0001755)
  • Neural crest cell migration involved in autonomic nervous system development
    (GO:1901166)
  • Neuron differentiation
    (GO:0030182)
  • Neuron projection development
    (GO:0031175)
  • Organ induction
    (GO:0001759)
  • Peripheral nervous system development
    (GO:0007422)
  • Peristalsis
    (GO:0030432)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0072108)
  • Positive regulation of monooxygenase activity
    (GO:0032770)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of ureteric bud formation
    (GO:0072107)
  • Postganglionic parasympathetic fiber development
    (GO:0021784)
  • Postsynaptic membrane organization
    (GO:0001941)
  • Protein homodimerization activity
    (GO:0042803)
  • Receptor complex
    (GO:0043235)
  • Receptor ligand activity
    (GO:0048018)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Regulation of dopamine uptake involved in synaptic transmission
    (GO:0051584)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of morphogenesis of a branching structure
    (GO:0060688)
  • Regulation of semaphorin-plexin signaling pathway
    (GO:2001260)
  • Regulation of ureteric bud formation
    (GO:0072106)
  • Sympathetic nervous system development
    (GO:0048485)
  • Transforming growth factor beta receptor binding
    (GO:0005160)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)
  • Transmembrane receptor protein tyrosine kinase signaling pathway
    (GO:0007169)
  • Ureteric bud development
    (GO:0001657)
  • Ureteric bud formation
    (GO:0060676)

Other Information

Genular Protein ID: 1835299568

Symbol: GDNF_MOUSE

Name: Glial cell line-derived neurotrophic factor

UniProtKB Accession Codes:

P48540 O09058 P70446 P97919 P97920 Q6LEL9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 DNASU 1 EMBL 9 Ensembl 1 GO 49 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 3 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7650763

Title: Spontaneously immortalized adult mouse Schwann cells secrete autocrine and paracrine growth-promoting activities.

PubMed ID: 7650763

DOI: 10.1002/jnr.490410215

PubMed ID: 8808409

Title: Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions.

PubMed ID: 8808409

DOI: 10.1016/0925-4773(95)00464-5

PubMed ID: 9426245

Title: Cloning and structural organization of the gene encoding the mouse glial cell line-derived neurotrophic factor, GDNF.

PubMed ID: 9426245

DOI: 10.1016/s0378-1119(97)00506-4

PubMed ID: 12168040

Title: Cloning and characterization of mouse glial cell line-derived neurotrophic growth factor (GDNF).

PubMed ID: 12168040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21994944

Title: Sorting protein-related receptor SorLA controls regulated secretion of glial cell line-derived neurotrophic factor.

PubMed ID: 21994944

DOI: 10.1074/jbc.m111.246413

Sequence Information:

  • Length: 211
  • Mass: 23662
  • Checksum: B6731C767A3A95B7
  • Sequence:
    • MKLWDVVAVC LVLLHTASAF PLPAGKRLLE APAEDHSLGH RRVPFALTSD SNMPEDYPDQ 
FDDVMDFIQA TIKRLKRSPD KQAAALPRRE RNRQAAAASP ENSRGKGRRG QRGKNRGCVL 
TAIHLNVTDL GLGYETKEEL IFRYCSGSCE SAETMYDKIL KNLSRSRRLT SDKVGQACCR 
PVAFDDDLSF LDDNLVYHIL RKHSAKRCGC I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.