Genular: Defining Cellular Identity and Function

Details for: Gfap

Gene ID: 14580

Symbol: Gfap

Ensembl ID: ENSMUSG00000020932

Description: glial fibrillary acidic protein

Associated with

Astrocyte development
(GO:0014002)
Astrocyte end-foot
(GO:0097450)
Astrocyte projection
(GO:0097449)
Bergmann glial cell differentiation
(GO:0060020)
Cell body
(GO:0044297)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Cytoplasmic side of lysosomal membrane
(GO:0098574)
Cytoskeleton
(GO:0005856)
D-aspartate import across plasma membrane
(GO:0070779)
Extracellular matrix organization
(GO:0030198)
Gene expression
(GO:0010467)
Glial cell projection
(GO:0097386)
Identical protein binding
(GO:0042802)
Integrin binding
(GO:0005178)
Intermediate filament
(GO:0005882)
Intermediate filament-based process
(GO:0045103)
Intermediate filament cytoskeleton
(GO:0045111)
Intermediate filament organization
(GO:0045109)
Intracellular protein transport
(GO:0006886)
Kinase binding
(GO:0019900)
Long-term synaptic potentiation
(GO:0060291)
Membrane
(GO:0016020)
Myelin sheath
(GO:0043209)
Negative regulation of neuron projection development
(GO:0010977)
Neuron projection development
(GO:0031175)
Neuron projection regeneration
(GO:0031102)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of schwann cell proliferation
(GO:0010625)
Protein binding
(GO:0005515)
Regulation of chaperone-mediated autophagy
(GO:1904714)
Regulation of neurotransmitter uptake
(GO:0051580)
Schwann cell proliferation
(GO:0014010)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Glial fibrillary acidic protein

Genular Protein ID: 259003880

Symbol: GFAP_MOUSE

Name: Glial fibrillary acidic protein

UniProtKB Accession Codes:

P03995 A1E2H7 A2AH87 B2RTI7 Q09J71 Q3USS4 Q496R4 Q496S3 Q7TQ30 Q80VX6 Q925K2 Q925K3

Database IDs:

Citations:

PubMed ID: 2994002

Title: Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family.

PubMed ID: 2994002

DOI: 10.1093/nar/13.15.5527

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7983160

Title: Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic protein.

PubMed ID: 7983160

DOI: 10.1242/jcs.107.7.1935

PubMed ID: 6585825

Title: Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments.

PubMed ID: 6585825

DOI: 10.1073/pnas.81.9.2743

PubMed ID: 3866511

Title: Structural implications of a cDNA clone encoding mouse glial fibrillary acidic protein.

PubMed ID: 3866511

DOI: 10.1111/j.1749-6632.1985.tb50437.x

PubMed ID: 2163003

Title: Characterization of human cDNA and genomic clones for glial fibrillary acidic protein.

PubMed ID: 2163003

DOI: 10.1016/0169-328x(90)90078-r

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 12837269

Title: Genetic polymorphism and sequence evolution of an alternatively spliced exon of the glial fibrillary acidic protein gene, GFAP.

PubMed ID: 12837269

DOI: 10.1016/s0888-7543(03)00106-x

PubMed ID: 12058025

Title: A new splice variant of glial fibrillary acidic protein GFAPepsilon, interacts with the presenilin proteins.

PubMed ID: 12058025

DOI: 10.1074/jbc.m112121200

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17356066

Title: Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks.

PubMed ID: 17356066

DOI: 10.1242/jcs.03423

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 430
Mass: 49900
Checksum: C0FB500AE1588377
Sequence:

MERRRITSAR RSYASETVVR GLGPSRQLGT MPRFSLSRMT PPLPARVDFS LAGALNAGFK 
ETRASERAEM MELNDRFASY IEKVRFLEQQ NKALAAELNQ LRAKEPTKLA DVYQAELREL 
RLRLDQLTAN SARLEVERDN FAQDLGTLRQ KLQDETNLRL EAENNLAAYR QEADEATLAR 
VDLERKVESL EEEIQFLRKI YEEEVRELRE QLAQQQVHVE MDVAKPDLTA ALREIRTQYE 
AVATSNMQET EEWYRSKFAD LTDAASRNAE LLRQAKHEAN DYRRQLQALT CDLESLRGTN 
ESLERQMREQ EERHARESAS YQEALARLEE EGQSLKEEMA RHLQEYQDLL NVKLALDIEI 
ATYRKLLEGE ENRITIPVQT FSNLQIRETS LDTKSVSEGH LKRNIVVKTV EMRDGEVIKD 
SKQEHKDVVM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gfap

Associated with

Other Information

Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family. PubMed ID: 2994002

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of two N-terminal non-alpha-helical domain motifs important in the assembly of glial fibrillary acidic protein. PubMed ID: 7983160

Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments. PubMed ID: 6585825

Structural implications of a cDNA clone encoding mouse glial fibrillary acidic protein. PubMed ID: 3866511

Characterization of human cDNA and genomic clones for glial fibrillary acidic protein. PubMed ID: 2163003

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

Genetic polymorphism and sequence evolution of an alternatively spliced exon of the glial fibrillary acidic protein gene, GFAP. PubMed ID: 12837269

A new splice variant of glial fibrillary acidic protein GFAPepsilon, interacts with the presenilin proteins. PubMed ID: 12058025

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. PubMed ID: 17356066

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315