Details for: Gfi1

Gene ID: 14581

Symbol: Gfi1

Ensembl ID: ENSMUSG00000029275

Description: growth factor independent 1 transcription repressor

Associated with

  • Cell fate commitment
    (GO:0045165)
  • Cell fate specification
    (GO:0001708)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Inner ear auditory receptor cell differentiation
    (GO:0042491)
  • Inner ear morphogenesis
    (GO:0042472)
  • Mechanosensory behavior
    (GO:0007638)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of calcidiol 1-monooxygenase activity
    (GO:0010956)
  • Negative regulation of cell fate specification
    (GO:0009996)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of neuron projection development
    (GO:0010977)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear body
    (GO:0016604)
  • Nuclear matrix
    (GO:0016363)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell fate specification
    (GO:0042660)
  • Positive regulation of interleukin-6-mediated signaling pathway
    (GO:0070105)
  • Protein binding
    (GO:0005515)
  • Regulation of toll-like receptor signaling pathway
    (GO:0034121)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription repressor complex
    (GO:0017053)

Other Information

Genular Protein ID: 2844360174

Symbol: GFI1_MOUSE

Name: Zinc finger protein Gfi-1

UniProtKB Accession Codes:

P70338 O09063

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 DNASU 1 EMBL 4 EPD 1 GO 27 Gene3D 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UniProtKB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8985317

Title: Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice.

PubMed ID: 8985317

DOI: 10.1128/jvi.71.1.9-16.1997

PubMed ID: 8622900

Title: Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2.

PubMed ID: 8622900

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8887656

Title: The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal.

PubMed ID: 8887656

DOI: 10.1128/mcb.16.11.6263

PubMed ID: 12441305

Title: The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival.

PubMed ID: 12441305

DOI: 10.1242/dev.00190

PubMed ID: 16819553

Title: Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing.

PubMed ID: 16819553

DOI: 10.1038/ni1361

PubMed ID: 17197705

Title: The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction.

PubMed ID: 17197705

DOI: 10.1074/jbc.m607613200

PubMed ID: 17707228

Title: Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1.

PubMed ID: 17707228

DOI: 10.1016/j.molcel.2007.06.039

PubMed ID: 20547752

Title: Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65.

PubMed ID: 20547752

DOI: 10.1128/mcb.00087-10

Sequence Information:

  • Length: 423
  • Mass: 45944
  • Checksum: 63AB726025300B6B
  • Sequence:
    • MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE TVPAPGRAEG GAVSAGESKM EPRERLSPDS 
QLTEAPDRAS ASPNSCEGSV CDPCSEFEDF WRPPSPSVSP ASEKSLCRSL DEAQPYTLPF 
KPYAWSGLAG SDLRHLVQSY RQCSALERSA GLSLFCERGS EPGRPAARYG PEQAAGGAGA 
GQPGRCGVAG GATSAAGLGL YGDFAPAAAG LYERPSTAAG RLYQDHGHEL HADKSVGVKV 
ESELLCTRLL LGGGSYKCIK CSKVFSTPHG LEVHVRRSHS GTRPFACEMC GKTFGHAVSL 
EQHKAVHSQE RSFDCKICGK SFKRSSTLST HLLIHSDTRP YPCQYCGKRF HQKSDMKKHT 
FIHTGEKPHK CQVCGKAFSQ SSNLITHSRK HTGFKPFGCD LCGKGFQRKV DLRRHRETQH 
GLK

Genular Protein ID: 3732500649

Symbol: A0A0R4J292_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J292

Database IDs:

AGR 1 ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EPD 1 Ensembl 3 ExpressionAtlas 1 Gene3D 1 GeneTree 1 InterPro 2 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 6 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 423
  • Mass: 45875
  • Checksum: 8FDAB5BB4886D056
  • Sequence:
    • MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE TVPAPGRAEG GAVSAGESKM EPRERLSPDS 
QLTEAPDRAS ASPNSCEGSV CDPCSEFEDF WRPPSPSVSP ASEKSLCRSL DEAQPYTLPF 
KPYAWSGLAG SDLRHLVQSY RQCSALERSA GLSLFCERGS EPGRPAARYG PEQAAGGAGA 
GQPGSCGVAG GATSAAGLGL YGDFAPAAAG LYERPSTAAG RLYQDHGHEL HADKSVGVKV 
ESELLCTRLL LGGGSYKCIK CSKVFSTPHG LEVHVRRSHS GTRPFACEMC GKTFGHAVSL 
EQHKAVHSQE RSFDCKICGK SFKRSSTLST HLLIHSDTRP YPCQYCGKRF HQKSDMKKHT 
FIHTGEKPHK CQVCGKAFSQ SSNLITHSRK HTGFKPFGCD LCGKGFQRKV DLRRHRETQH 
GLK

Genular Protein ID: 2859798254

Symbol: H3BJM0_MOUSE

Name: N/A

UniProtKB Accession Codes:

H3BJM0

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneTree 1 InterPro 2 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 489
  • Mass: 53085
  • Checksum: 92471118DA43FC82
  • Sequence:
    • MWRQRASGGL LLSALPSAPE FPASDDQGKP GGPLCQERAA PPPGRQLQHE NSEYPRVQTF 
VQRLTTMPRS FLVKSKKAHS YHQPRSPGPD YSLRLETVPA PGRAEGGAVS AGESKMEPRE 
RLSPDSQLTE APDRASASPN SCEGSVCDPC SEFEDFWRPP SPSVSPASEK SLCRSLDEAQ 
PYTLPFKPYA WSGLAGSDLR HLVQSYRQCS ALERSAGLSL FCERGSEPGR PAARYGPEQA 
AGGAGAGQPG SCGVAGGATS AAGLGLYGDF APAAAGLYER PSTAAGRLYQ DHGHELHADK 
SVGVKVESEL LCTRLLLGGG SYKCIKCSKV FSTPHGLEVH VRRSHSGTRP FACEMCGKTF 
GHAVSLEQHK AVHSQERSFD CKICGKSFKR SSTLSTHLLI HSDTRPYPCQ YCGKRFHQKS 
DMKKHTFIHT GEKPHKCQVC GKAFSQSSNL ITHSRKHTGF KPFGCDLCGK GFQRKVDLRR 
HRETQHGLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.