Genular: Defining Cellular Identity and Function

Details for: Gfra1

Gene ID: 14585

Symbol: Gfra1

Ensembl ID: ENSMUSG00000025089

Description: glial cell line derived neurotrophic factor family receptor alpha 1

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Raf/map kinase cascade
(R-MMU-5673001)
Ret signaling
(R-MMU-8853659)
Signal transduction
(R-MMU-162582)
Anatomical structure morphogenesis
(GO:0009653)
Axon
(GO:0030424)
Cell migration
(GO:0016477)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Extrinsic component of membrane
(GO:0019898)
Golgi apparatus
(GO:0005794)
Integrin binding
(GO:0005178)
Membrane
(GO:0016020)
Nervous system development
(GO:0007399)
Neuronal cell body
(GO:0043025)
Neuron differentiation
(GO:0030182)
Neuron projection development
(GO:0031175)
Neurotrophin receptor activity
(GO:0005030)
Plasma membrane
(GO:0005886)
Plasma membrane protein complex
(GO:0098797)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Receptor complex
(GO:0043235)
Side of membrane
(GO:0098552)
Signaling receptor activity
(GO:0038023)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

GDNF family receptor alpha-1

Genular Protein ID: 1344544339

Symbol: GFRA1_MOUSE

Name: GDNF family receptor alpha-1

UniProtKB Accession Codes:

P97785 O35246 O35252

Database IDs:

Citations:

PubMed ID: 9592044

Title: Cloning of a novel murine isoform of the glial cell line-derived neurotrophic factor receptor.

PubMed ID: 9592044

DOI: 10.1097/00001756-199801050-00008

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23333276

Title: SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRalpha1 and RET.

PubMed ID: 23333276

DOI: 10.1016/j.celrep.2012.12.011

Sequence Information:

Length: 468
Mass: 51752
Checksum: 997105C2A6DD6446
Sequence:

MFLATLYFVL PLLDLLMSAE VSGGDRLDCV KASDQCLKEQ SCSTKYRTLR QCVAGKETNF 
SLTSGLEAKD ECRSAMEALK QKSLYNCRCK RGMKKEKNCL RIYWSMYQSL QGNDLLEDSP 
YEPVNSRLSD IFRAVPFISD VFQQVEHISK GNNCLDAAKA CNLDDTCKKY RSAYITPCTT 
SMSNEVCNRR KCHKALRQFF DKVPAKHSYG MLFCSCRDVA CTERRRQTIV PVCSYEERER 
PNCLNLQDSC KTNYICRSRL ADFFTNCQPE SRSVSNCLKE NYADCLLAYS GLIGTVMTPN 
YIDSSSLSVA PWCDCSNSGN DLEDCLKFLN FFKDNTCLKN AIQAFGNGSD VTMWQPAPPV 
QTTTATTTTA FRIKNKPLGP AGSENEIPTH VLPPCANLQA QKLKSNVSGS THLCLSDNDY 
GKDGLAGASS HITTKSMAAP PSCGLSSLPV MVFTALAALL SVSLAETS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.