Genular: Defining Cellular Identity and Function

Details for: Gfra2

Gene ID: 14586

Symbol: Gfra2

Ensembl ID: ENSMUSG00000022103

Description: glial cell line derived neurotrophic factor family receptor alpha 2

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Raf/map kinase cascade
(R-MMU-5673001)
Ret signaling
(R-MMU-8853659)
Signal transduction
(R-MMU-162582)
External side of plasma membrane
(GO:0009897)
Glial cell-derived neurotrophic factor receptor activity
(GO:0016167)
Membrane
(GO:0016020)
Negative regulation of protein autophosphorylation
(GO:0031953)
Nervous system development
(GO:0007399)
Plasma membrane
(GO:0005886)
Receptor complex
(GO:0043235)
Side of membrane
(GO:0098552)
Signaling receptor activity
(GO:0038023)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

GDNF family receptor alpha-2
Q3UET6_MOUSE

Genular Protein ID: 2029945377

Symbol: GFRA2_MOUSE

Name: GDNF family receptor alpha-2

UniProtKB Accession Codes:

O08842 Q3UUD8 Q920Y3 Q9Z2A2 Q9Z2A3

Database IDs:

Citations:

PubMed ID: 9182803

Title: TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

PubMed ID: 9182803

DOI: 10.1016/s0896-6273(00)80318-9

PubMed ID: 9875703

Title: Identification of mammalian GFRalpha-2 splice isoforms.

PubMed ID: 9875703

DOI: 10.1097/00001756-199812010-00002

PubMed ID: 12829325

Title: Real time PCR quantification of GFRalpha-2 alternatively spliced isoforms in murine brain and peripheral tissues.

PubMed ID: 12829325

DOI: 10.1016/s0169-328x(03)00169-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23872421

Title: GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRalpha2 and RET.

PubMed ID: 23872421

DOI: 10.1016/j.bbamcr.2013.07.004

Sequence Information:

Length: 464
Mass: 51727
Checksum: 3A7FB495FA58C61F
Sequence:

MILANAFCLF FFLDETLRSL ASPSSPQGSE LHGWRPQVDC VRANELCAAE SNCSSRYRTL 
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE 
EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS 
YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS 
CSYEDKEKPN CLDLRSLCRT DHLCRSRLAD FHANCRASYR TITSCPADNY QACLGSYAGM 
IGFDMTPNYV DSNPTGIVVS PWCNCRGSGN MEEECEKFLK DFTENPCLRN AIQAFGNGTD 
VNMSPKGPTF SATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSIQEQGL KANNSKELSM 
CFTELTTNIS PGSKKVIKLY SGSCRARLST ALTALPLLMV TLAQ

Genular Protein ID: 2267023988

Symbol: Q3UET6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UET6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 246
Mass: 26912
Checksum: C1459690B6C2F578
Sequence:

MLFCSCQDQA CAERRRQTIL PSCSYEDKEK PNCLDLRSLC RTDHLCRSRL ADFHANCRAS 
YRTITSCPAD NYQACLGSYA GMIGFDMTPN YVDSNPTGIV VSPWCNCRGS GNMEEECEKF 
LKDFTENPCL RNAIQAFGNG TDVNMSPKGP TFSATQAPRV EKTPSLPDDL SDSTSLGTSV 
ITTCTSIQEQ GLKANNSKEL SMCFTELTTN ISPGSKKVIK LYSGSCRARL STALTALPLL 
MVTLAQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gfra2

Associated with

Other Information

TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. PubMed ID: 9182803

Identification of mammalian GFRalpha-2 splice isoforms. PubMed ID: 9875703

Real time PCR quantification of GFRalpha-2 alternatively spliced isoforms in murine brain and peripheral tissues. PubMed ID: 12829325

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRalpha2 and RET. PubMed ID: 23872421

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073