CSNK2A2 | ENSG00000070770 | NCBI 1459

Details for: CSNK2A2

Gene ID: 1459

Symbol: CSNK2A2

Ensembl ID: ENSG00000070770

Description: casein kinase 2 alpha 2

Associated with

Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Chaperonin-mediated protein folding
(R-HSA-390466)
Condensation of prometaphase chromosomes
(R-HSA-2514853)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glycerophospholipid biosynthesis
(R-HSA-1483206)
Infectious disease
(R-HSA-5663205)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
L1cam interactions
(R-HSA-373760)
Macroautophagy
(R-HSA-1632852)
Maturation of hrsv a proteins
(R-HSA-9828806)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Mitophagy
(R-HSA-5205647)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Phospholipid metabolism
(R-HSA-1483257)
Pip3 activates akt signaling
(R-HSA-1257604)
Protein folding
(R-HSA-391251)
Pten regulation
(R-HSA-6807070)
Receptor mediated mitophagy
(R-HSA-8934903)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Respiratory syncytial virus (rsv) genome replication, transcription and translation
(R-HSA-9820965)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Selective autophagy
(R-HSA-9663891)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Signal transduction by l1
(R-HSA-445144)
Synthesis of pc
(R-HSA-1483191)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Viral infection pathways
(R-HSA-9824446)
Wnt mediated activation of dvl
(R-HSA-201688)
Acrosomal vesicle
(GO:0001669)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Cerebral cortex development
(GO:0021987)
Chromatin
(GO:0000785)
Cytosol
(GO:0005829)
Double-strand break repair
(GO:0006302)
Liver regeneration
(GO:0097421)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Positive regulation of protein targeting to mitochondrion
(GO:1903955)
Protein binding
(GO:0005515)
Protein kinase ck2 complex
(GO:0005956)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of chromosome separation
(GO:1905818)
Regulation of mitophagy
(GO:1901524)
Spermatogenesis
(GO:0007283)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Casein kinase II subunit alpha'

Genular Protein ID: 3533576615

Symbol: CSK22_HUMAN

Name: Casein kinase II subunit alpha'

UniProtKB Accession Codes:

P19784

Database IDs:

Citations:

PubMed ID: 2174700

Title: Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.

PubMed ID: 2174700

DOI: 10.1021/bi00488a034

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11239457

Title: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

PubMed ID: 11239457

DOI: 10.1016/s1097-2765(01)00176-9

PubMed ID: 11704824

Title: Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.

PubMed ID: 11704824

DOI: 10.1038/sj.onc.1204894

PubMed ID: 12393879

Title: p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

PubMed ID: 12393879

DOI: 10.1074/jbc.m209820200

PubMed ID: 16193064

Title: Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.

PubMed ID: 16193064

DOI: 10.1038/sj.emboj.7600827

PubMed ID: 12631575

Title: One-thousand-and-one substrates of protein kinase CK2?

PubMed ID: 12631575

DOI: 10.1096/fj.02-0473rev

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19387553

Title: Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights.

PubMed ID: 19387553

DOI: 10.1007/s00018-009-9149-8

PubMed ID: 19387552

Title: Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival.

PubMed ID: 19387552

DOI: 10.1007/s00018-009-9150-2

PubMed ID: 19387551

Title: Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

PubMed ID: 19387551

DOI: 10.1007/s00018-009-9151-1

PubMed ID: 19387550

Title: Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery.

PubMed ID: 19387550

DOI: 10.1007/s00018-009-9152-0

PubMed ID: 19387549

Title: Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.

PubMed ID: 19387549

DOI: 10.1007/s00018-009-9153-z

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20545769

Title: Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.

PubMed ID: 20545769

DOI: 10.1111/j.1365-2443.2010.01418.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21482717

Title: MDC1 collaborates with TopBP1 in DNA replication checkpoint control.

PubMed ID: 21482717

DOI: 10.1083/jcb.201010026

PubMed ID: 22325354

Title: Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

PubMed ID: 22325354

DOI: 10.1016/j.molcel.2011.12.028

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26811421

Title: TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.

PubMed ID: 26811421

DOI: 10.1083/jcb.201507042

PubMed ID: 30898438

Title: MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis.

PubMed ID: 30898438

DOI: 10.1016/j.molcel.2019.02.014

PubMed ID: 35597237

Title: A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.

PubMed ID: 35597237

DOI: 10.1016/j.molcel.2022.04.031

PubMed ID: 19193990

Title: Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor.

PubMed ID: 19193990

DOI: 10.1107/s1744309108043194

PubMed ID: 21241709

Title: Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta.

PubMed ID: 21241709

DOI: 10.1016/j.jmb.2011.01.020

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 350
Mass: 41213
Checksum: 3ECB92F6BD3DD7F1
Sequence:

MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI 
TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID TVKDPVSKTP ALVFEYINNT 
DFKQLYQILT DFDIRFYMYE LLKALDYCHS KGIMHRDVKP HNVMIDHQQK KLRLIDWGLA 
EFYHPAQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRR EPFFHGQDNY 
DQLVRIAKVL GTEELYGYLK KYHIDLDPHF NDILGQHSRK RWENFIHSEN RHLVSPEALD 
LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPCADNA VLSSGLTAAR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CSNK2A2

Associated with

Other Information

Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. PubMed ID: 2174700

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. PubMed ID: 11239457

Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells. PubMed ID: 11704824

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. PubMed ID: 12393879

Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. PubMed ID: 16193064

One-thousand-and-one substrates of protein kinase CK2? PubMed ID: 12631575

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights. PubMed ID: 19387553

Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival. PubMed ID: 19387552

Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair. PubMed ID: 19387551

Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery. PubMed ID: 19387550

Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer. PubMed ID: 19387549

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1. PubMed ID: 20545769

Initial characterization of the human central proteome. PubMed ID: 21269460

MDC1 collaborates with TopBP1 in DNA replication checkpoint control. PubMed ID: 21482717

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair. PubMed ID: 22325354

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. PubMed ID: 26811421

MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis. PubMed ID: 30898438

A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination. PubMed ID: 35597237

Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor. PubMed ID: 19193990

Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta. PubMed ID: 21241709

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846