Details for: CSNK2A2

Gene ID: 1459

Symbol: CSNK2A2

Ensembl ID: ENSG00000070770

Description: casein kinase 2 alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 202.0634
    Cell Significance Index: -31.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.6919
    Cell Significance Index: -31.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.0409
    Cell Significance Index: -33.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.8911
    Cell Significance Index: -27.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.6658
    Cell Significance Index: -31.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.6648
    Cell Significance Index: -27.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.6108
    Cell Significance Index: -32.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.1955
    Cell Significance Index: -32.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.4008
    Cell Significance Index: -33.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7623
    Cell Significance Index: -20.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.2278
    Cell Significance Index: -13.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2361
    Cell Significance Index: 16.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2201
    Cell Significance Index: 132.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1529
    Cell Significance Index: 59.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0966
    Cell Significance Index: 219.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0807
    Cell Significance Index: 975.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0140
    Cell Significance Index: 124.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9845
    Cell Significance Index: 160.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9055
    Cell Significance Index: 163.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8913
    Cell Significance Index: 176.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6931
    Cell Significance Index: 95.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6622
    Cell Significance Index: 42.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6087
    Cell Significance Index: 332.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5639
    Cell Significance Index: 15.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5406
    Cell Significance Index: 38.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5189
    Cell Significance Index: 13.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5151
    Cell Significance Index: 14.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5129
    Cell Significance Index: 23.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4509
    Cell Significance Index: 199.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3964
    Cell Significance Index: 142.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3580
    Cell Significance Index: 8.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3482
    Cell Significance Index: 24.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3369
    Cell Significance Index: 15.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3079
    Cell Significance Index: 6.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2910
    Cell Significance Index: 2.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2886
    Cell Significance Index: 54.9300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2731
    Cell Significance Index: 188.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2358
    Cell Significance Index: 6.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2070
    Cell Significance Index: 20.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1947
    Cell Significance Index: 5.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1747
    Cell Significance Index: 8.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1598
    Cell Significance Index: 12.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1359
    Cell Significance Index: 3.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1161
    Cell Significance Index: 6.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0955
    Cell Significance Index: 5.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0570
    Cell Significance Index: 9.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0265
    Cell Significance Index: 0.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0202
    Cell Significance Index: 38.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0184
    Cell Significance Index: 0.8200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0163
    Cell Significance Index: 1.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0077
    Cell Significance Index: 0.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0055
    Cell Significance Index: 0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0011
    Cell Significance Index: 1.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0012
    Cell Significance Index: -0.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0116
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0138
    Cell Significance Index: -18.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0152
    Cell Significance Index: -11.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0152
    Cell Significance Index: -0.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0186
    Cell Significance Index: -8.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0189
    Cell Significance Index: -2.4200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0280
    Cell Significance Index: -21.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0318
    Cell Significance Index: -23.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0444
    Cell Significance Index: -6.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0543
    Cell Significance Index: -30.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0606
    Cell Significance Index: -37.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0713
    Cell Significance Index: -8.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0821
    Cell Significance Index: -5.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0889
    Cell Significance Index: -25.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0946
    Cell Significance Index: -7.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0959
    Cell Significance Index: -1.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0996
    Cell Significance Index: -10.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1517
    Cell Significance Index: -17.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1630
    Cell Significance Index: -18.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1753
    Cell Significance Index: -36.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2028
    Cell Significance Index: -5.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2890
    Cell Significance Index: -30.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3046
    Cell Significance Index: -7.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3170
    Cell Significance Index: -25.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4128
    Cell Significance Index: -25.3100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4219
    Cell Significance Index: -3.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4743
    Cell Significance Index: -4.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5206
    Cell Significance Index: -11.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5263
    Cell Significance Index: -15.0200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5334
    Cell Significance Index: -10.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5345
    Cell Significance Index: -8.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5427
    Cell Significance Index: -14.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5568
    Cell Significance Index: -19.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5594
    Cell Significance Index: -29.3700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5858
    Cell Significance Index: -14.0500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6124
    Cell Significance Index: -20.0500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6168
    Cell Significance Index: -14.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6239
    Cell Significance Index: -19.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6577
    Cell Significance Index: -9.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6880
    Cell Significance Index: -14.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6897
    Cell Significance Index: -11.8200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6939
    Cell Significance Index: -24.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6967
    Cell Significance Index: -10.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7290
    Cell Significance Index: -26.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Localization:** CSNK2A2 is expressed in various cell types, including pancreatic acinar cells, bladder urothelial cells, and neurons. 2. **Protein Phosphorylation:** The gene encodes a subunit of the CK2 enzyme, which is responsible for the phosphorylation of numerous substrates, including proteins and lipids. 3. **Cell Cycle Regulation:** CSNK2A2 is involved in regulating the cell cycle, particularly during the G2/M phase, where it phosphorylates and activates key proteins involved in mitosis. 4. **Apoptosis Regulation:** The gene also plays a role in regulating apoptosis, particularly through the phosphorylation and activation of pro-apoptotic proteins. 5. **Signaling Pathways:** CSNK2A2 is involved in various signaling pathways, including the Wnt/β-catenin pathway, the PI3K/Akt pathway, and the MAPK/ERK pathway. **Pathways and Functions:** 1. **Cell Cycle Regulation:** CSNK2A2 phosphorylates and activates key proteins involved in the G2/M phase, including cyclin-dependent kinases and cyclin-dependent kinase inhibitors. 2. **Apoptosis Regulation:** The gene phosphorylates and activates pro-apoptotic proteins, such as p53 and Bax, leading to the induction of apoptosis. 3. **Protein Phosphorylation:** CSNK2A2 phosphorylates and activates numerous substrates, including proteins and lipids, leading to the regulation of various cellular processes. 4. **Signaling Pathways:** The gene is involved in various signaling pathways, including the Wnt/β-catenin pathway, the PI3K/Akt pathway, and the MAPK/ERK pathway. 5. **Autophagy Regulation:** CSNK2A2 phosphorylates and activates key proteins involved in autophagy, including LC3 and Beclin-1. **Clinical Significance:** 1. **Cancer:** CSNK2A2 is overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer, suggesting its potential role as a tumor suppressor. 2. **Neurological Disorders:** The gene is involved in the regulation of neuronal function and is implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Regenerative Medicine:** CSNK2A2 is involved in the regulation of cellular proliferation and differentiation, making it a potential target for regenerative medicine therapies. 4. **Infectious Diseases:** The gene is involved in the regulation of immune responses and is implicated in the pathogenesis of various infectious diseases, including HIV and influenza. In conclusion, CSNK2A2 is a multifaceted gene involved in regulating various cellular processes, including cell cycle progression, apoptosis, and protein phosphorylation. Its clinical significance is evident in its involvement in various diseases, including cancer, neurological disorders, and infectious diseases. Further research is needed to fully elucidate the gene's role in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3533576615

Symbol: CSK22_HUMAN

Name: Casein kinase II subunit alpha'

UniProtKB Accession Codes:

P19784

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 32 PDBsum 32 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 1 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2174700

Title: Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.

PubMed ID: 2174700

DOI: 10.1021/bi00488a034

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11239457

Title: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

PubMed ID: 11239457

DOI: 10.1016/s1097-2765(01)00176-9

PubMed ID: 11704824

Title: Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.

PubMed ID: 11704824

DOI: 10.1038/sj.onc.1204894

PubMed ID: 12393879

Title: p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

PubMed ID: 12393879

DOI: 10.1074/jbc.m209820200

PubMed ID: 16193064

Title: Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.

PubMed ID: 16193064

DOI: 10.1038/sj.emboj.7600827

PubMed ID: 12631575

Title: One-thousand-and-one substrates of protein kinase CK2?

PubMed ID: 12631575

DOI: 10.1096/fj.02-0473rev

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19387553

Title: Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights.

PubMed ID: 19387553

DOI: 10.1007/s00018-009-9149-8

PubMed ID: 19387552

Title: Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival.

PubMed ID: 19387552

DOI: 10.1007/s00018-009-9150-2

PubMed ID: 19387551

Title: Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

PubMed ID: 19387551

DOI: 10.1007/s00018-009-9151-1

PubMed ID: 19387550

Title: Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery.

PubMed ID: 19387550

DOI: 10.1007/s00018-009-9152-0

PubMed ID: 19387549

Title: Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.

PubMed ID: 19387549

DOI: 10.1007/s00018-009-9153-z

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20545769

Title: Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.

PubMed ID: 20545769

DOI: 10.1111/j.1365-2443.2010.01418.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21482717

Title: MDC1 collaborates with TopBP1 in DNA replication checkpoint control.

PubMed ID: 21482717

DOI: 10.1083/jcb.201010026

PubMed ID: 22325354

Title: Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

PubMed ID: 22325354

DOI: 10.1016/j.molcel.2011.12.028

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26811421

Title: TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.

PubMed ID: 26811421

DOI: 10.1083/jcb.201507042

PubMed ID: 30898438

Title: MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis.

PubMed ID: 30898438

DOI: 10.1016/j.molcel.2019.02.014

PubMed ID: 35597237

Title: A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.

PubMed ID: 35597237

DOI: 10.1016/j.molcel.2022.04.031

PubMed ID: 38334665

Title: Identification and Characterization of HIRIP3 as a Histone H2A Chaperone.

PubMed ID: 38334665

DOI: 10.3390/cells13030273

PubMed ID: 19193990

Title: Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor.

PubMed ID: 19193990

DOI: 10.1107/s1744309108043194

PubMed ID: 21241709

Title: Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta.

PubMed ID: 21241709

DOI: 10.1016/j.jmb.2011.01.020

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 350
  • Mass: 41213
  • Checksum: 3ECB92F6BD3DD7F1
  • Sequence:
    • MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI 
TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID TVKDPVSKTP ALVFEYINNT 
DFKQLYQILT DFDIRFYMYE LLKALDYCHS KGIMHRDVKP HNVMIDHQQK KLRLIDWGLA 
EFYHPAQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRR EPFFHGQDNY 
DQLVRIAKVL GTEELYGYLK KYHIDLDPHF NDILGQHSRK RWENFIHSEN RHLVSPEALD 
LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPCADNA VLSSGLTAAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.