Details for: CSNK2A2

Gene ID: 1459

Symbol: CSNK2A2

Ensembl ID: ENSG00000070770

Description: casein kinase 2 alpha 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.66
    Marker Score: 3504
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.52
    Marker Score: 2240
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.34
    Marker Score: 11539
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.26
    Marker Score: 2880
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.25
    Marker Score: 11840
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.25
    Marker Score: 76601
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.23
    Marker Score: 2180
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.14
    Marker Score: 1213
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.07
    Marker Score: 1656
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.06
    Marker Score: 36117
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.06
    Marker Score: 4319
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.05
    Marker Score: 36385
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.05
    Marker Score: 709
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.02
    Marker Score: 1072
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.01
    Marker Score: 10188
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71691
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47915
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.98
    Marker Score: 669
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.94
    Marker Score: 8842
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.92
    Marker Score: 9467
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2697
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.88
    Marker Score: 3383
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.87
    Marker Score: 907
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.86
    Marker Score: 198
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4786
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.84
    Marker Score: 9417
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.83
    Marker Score: 1349
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.83
    Marker Score: 31536
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.82
    Marker Score: 1185
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.82
    Marker Score: 411
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.81
    Marker Score: 29875
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.81
    Marker Score: 1985
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.81
    Marker Score: 281
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8
    Marker Score: 882
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.8
    Marker Score: 2953
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.79
    Marker Score: 3888
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.79
    Marker Score: 299
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.79
    Marker Score: 12358
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.79
    Marker Score: 498
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.78
    Marker Score: 271
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.78
    Marker Score: 1008
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.78
    Marker Score: 15528
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.77
    Marker Score: 546
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.77
    Marker Score: 186
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.77
    Marker Score: 222
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.77
    Marker Score: 222
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.76
    Marker Score: 320
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.76
    Marker Score: 16273
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.76
    Marker Score: 236
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 690
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.75
    Marker Score: 350
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.75
    Marker Score: 797
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.74
    Marker Score: 469
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.74
    Marker Score: 504
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.73
    Marker Score: 180
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.73
    Marker Score: 837
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.73
    Marker Score: 359
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.72
    Marker Score: 4724
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.71
    Marker Score: 487
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.71
    Marker Score: 764
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.71
    Marker Score: 296
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 342
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.7
    Marker Score: 470
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.7
    Marker Score: 400
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.7
    Marker Score: 210
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2886.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.69
    Marker Score: 254
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.68
    Marker Score: 2831
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.68
    Marker Score: 152
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.68
    Marker Score: 763.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.68
    Marker Score: 5213
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.67
    Marker Score: 10085
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.67
    Marker Score: 676
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 442
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 610
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.67
    Marker Score: 151
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.67
    Marker Score: 382
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.66
    Marker Score: 569
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.66
    Marker Score: 791
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.64
    Marker Score: 641
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.64
    Marker Score: 605
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.64
    Marker Score: 987
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.64
    Marker Score: 386
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.64
    Marker Score: 599
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.63
    Marker Score: 796
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 544
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.63
    Marker Score: 391
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.62
    Marker Score: 222
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.62
    Marker Score: 873

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Other Information

**Key characteristics:** - CSNK2A2 is a serine/threonine kinase. - It is a key regulator of autophagy. - It is involved in cell cycle regulation and progression. - It is involved in metabolism and lipid metabolism. - It is involved in signaling pathways that are important for development and tissue maintenance. **Pathways and functions:** - CSNK2A2 is involved in the regulation of autophagy. It is a key regulator of the initiation and execution of autophagy. - It is involved in cell cycle regulation and progression. It is a key regulator of cell cycle entry into mitosis and the G1/S transition. - It is involved in metabolism and lipid metabolism. - It is involved in signaling pathways that are important for development and tissue maintenance. **Clinical significance:** - Mutations in CSNK2A2 have been linked to a number of human diseases, including cancer and neurodegenerative diseases. - Targeting CSNK2A2 has been investigated as a therapeutic strategy for these diseases. **Additional information:** - CSNK2A2 is a highly conserved protein. It is found in organisms from yeast to humans. - It is a well-characterized protein that has been extensively studied. - It is a promising target for cancer therapy.

Genular Protein ID: 3533576615

Symbol: CSK22_HUMAN

Name: Casein kinase II subunit alpha'

UniProtKB Accession Codes:

P19784

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 26 PIR 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 10 RefSeq 1 Rhea 8 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2174700

Title: Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.

PubMed ID: 2174700

DOI: 10.1021/bi00488a034

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11239457

Title: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

PubMed ID: 11239457

DOI: 10.1016/s1097-2765(01)00176-9

PubMed ID: 11704824

Title: Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.

PubMed ID: 11704824

DOI: 10.1038/sj.onc.1204894

PubMed ID: 12393879

Title: p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

PubMed ID: 12393879

DOI: 10.1074/jbc.m209820200

PubMed ID: 16193064

Title: Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.

PubMed ID: 16193064

DOI: 10.1038/sj.emboj.7600827

PubMed ID: 12631575

Title: One-thousand-and-one substrates of protein kinase CK2?

PubMed ID: 12631575

DOI: 10.1096/fj.02-0473rev

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19387553

Title: Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights.

PubMed ID: 19387553

DOI: 10.1007/s00018-009-9149-8

PubMed ID: 19387552

Title: Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival.

PubMed ID: 19387552

DOI: 10.1007/s00018-009-9150-2

PubMed ID: 19387551

Title: Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

PubMed ID: 19387551

DOI: 10.1007/s00018-009-9151-1

PubMed ID: 19387550

Title: Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery.

PubMed ID: 19387550

DOI: 10.1007/s00018-009-9152-0

PubMed ID: 19387549

Title: Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.

PubMed ID: 19387549

DOI: 10.1007/s00018-009-9153-z

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20545769

Title: Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.

PubMed ID: 20545769

DOI: 10.1111/j.1365-2443.2010.01418.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21482717

Title: MDC1 collaborates with TopBP1 in DNA replication checkpoint control.

PubMed ID: 21482717

DOI: 10.1083/jcb.201010026

PubMed ID: 22325354

Title: Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

PubMed ID: 22325354

DOI: 10.1016/j.molcel.2011.12.028

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26811421

Title: TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.

PubMed ID: 26811421

DOI: 10.1083/jcb.201507042

PubMed ID: 30898438

Title: MDC1 interacts with TOPBP1 to maintain chromosomal stability during mitosis.

PubMed ID: 30898438

DOI: 10.1016/j.molcel.2019.02.014

PubMed ID: 35597237

Title: A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination.

PubMed ID: 35597237

DOI: 10.1016/j.molcel.2022.04.031

PubMed ID: 19193990

Title: Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor.

PubMed ID: 19193990

DOI: 10.1107/s1744309108043194

PubMed ID: 21241709

Title: Structure of the human protein kinase CK2 catalytic subunit CK2alpha' and interaction thermodynamics with the regulatory subunit CK2beta.

PubMed ID: 21241709

DOI: 10.1016/j.jmb.2011.01.020

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 350
  • Mass: 41213
  • Checksum: 3ECB92F6BD3DD7F1
  • Sequence:
    • MPGPAAGSRA RVYAEVNSLR SREYWDYEAH VPSWGNQDDY QLVRKLGRGK YSEVFEAINI 
TNNERVVVKI LKPVKKKKIK REVKILENLR GGTNIIKLID TVKDPVSKTP ALVFEYINNT 
DFKQLYQILT DFDIRFYMYE LLKALDYCHS KGIMHRDVKP HNVMIDHQQK KLRLIDWGLA 
EFYHPAQEYN VRVASRYFKG PELLVDYQMY DYSLDMWSLG CMLASMIFRR EPFFHGQDNY 
DQLVRIAKVL GTEELYGYLK KYHIDLDPHF NDILGQHSRK RWENFIHSEN RHLVSPEALD 
LLDKLLRYDH QQRLTAKEAM EHPYFYPVVK EQSQPCADNA VLSSGLTAAR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.