Genular: Defining Cellular Identity and Function

Details for: B4galt1

Gene ID: 14595

Symbol: B4galt1

Ensembl ID: ENSMUSG00000028413

Description: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1

Associated with

Asparagine n-linked glycosylation
(R-MMU-446203)
Fertilization
(R-MMU-1187000)
Glycosaminoglycan metabolism
(R-MMU-1630316)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interaction with cumulus cells and the zona pellucida
(R-MMU-2534343)
Keratan sulfate/keratin metabolism
(R-MMU-1638074)
Keratan sulfate biosynthesis
(R-MMU-2022854)
Lactose synthesis
(R-MMU-5653890)
Metabolism
(R-MMU-1430728)
Metabolism of carbohydrates
(R-MMU-71387)
Metabolism of proteins
(R-MMU-392499)
N-glycan antennae elongation
(R-MMU-975577)
N-glycan antennae elongation in the medial/trans-golgi
(R-MMU-975576)
Neutrophil degranulation
(R-MMU-6798695)
Post-translational protein modification
(R-MMU-597592)
Reproduction
(R-MMU-1474165)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Acute inflammatory response
(GO:0002526)
Alpha-tubulin binding
(GO:0043014)
Angiogenesis involved in wound healing
(GO:0060055)
Basolateral plasma membrane
(GO:0016323)
Beta-n-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
(GO:0003831)
Beta-tubulin binding
(GO:0048487)
Binding of sperm to zona pellucida
(GO:0007339)
Brush border membrane
(GO:0031526)
Carbohydrate metabolic process
(GO:0005975)
Cell adhesion
(GO:0007155)
Cell population proliferation
(GO:0008283)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cytoskeletal protein binding
(GO:0008092)
Desmosome
(GO:0030057)
Development of secondary sexual characteristics
(GO:0045136)
Epithelial cell development
(GO:0002064)
Epithelial cell proliferation
(GO:0050673)
External side of plasma membrane
(GO:0009897)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Galactose metabolic process
(GO:0006012)
Galactosyltransferase activity
(GO:0008378)
Glycoprotein biosynthetic process
(GO:0009101)
Glycosyltransferase activity
(GO:0016757)
Golgi apparatus
(GO:0005794)
Golgi trans cisterna
(GO:0000138)
Identical protein binding
(GO:0042802)
Lactose biosynthetic process
(GO:0005989)
Lactose synthase activity
(GO:0004461)
Lipid metabolic process
(GO:0006629)
Macrophage migration
(GO:1905517)
Manganese ion binding
(GO:0030145)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
N-acetyllactosamine synthase activity
(GO:0003945)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Oligosaccharide biosynthetic process
(GO:0009312)
Penetration of zona pellucida
(GO:0007341)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of circulating fibrinogen levels
(GO:0061755)
Positive regulation of epithelial cell proliferation involved in wound healing
(GO:0060054)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein glycosylation
(GO:0006486)
Protein n-linked glycosylation
(GO:0006487)
Regulation of acrosome reaction
(GO:0060046)
Transferase activity
(GO:0016740)
Udp-galactosyltransferase activity
(GO:0035250)
Wound healing
(GO:0042060)

Other Information

Proteins

Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase

Genular Protein ID: 2413506585

Symbol: B4GT1_MOUSE

Name: Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase

UniProtKB Accession Codes:

P15535

Database IDs:

Citations:

PubMed ID: 3134348

Title: Characterization of the full length cDNA for murine beta-1,4-galactosyltransferase. Novel features at the 5'-end predict two translational start sites at two in-frame AUGs.

PubMed ID: 3134348

DOI: 10.1016/s0021-9258(19)81533-8

PubMed ID: 1689054

Title: Murine beta 1,4-galactosyltransferase: both the amounts and structure of the mRNA are regulated during spermatogenesis.

PubMed ID: 1689054

DOI: 10.1073/pnas.87.2.791

PubMed ID: 2504153

Title: Genomic structure of murine beta-1,4-galactosyltransferase.

PubMed ID: 2504153

DOI: 10.1016/0006-291x(89)90782-1

PubMed ID: 3141392

Title: Cloning and sequencing of a full-length cDNA of mouse N-acetylglucosamine (beta 1-4)galactosyltransferase.

PubMed ID: 3141392

DOI: 10.1093/oxfordjournals.jbchem.a122434

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3149531

Title: Evidence for two forms of murine beta-1,4-galactosyltransferase based on cloning studies.

PubMed ID: 3149531

DOI: 10.1016/0300-9084(88)90303-3

PubMed ID: 1384819

Title: Murine beta 1,4-galactosyltransferase: round spermatid transcripts are characterized by an extended 5'-untranslated region.

PubMed ID: 1384819

DOI: 10.1093/glycob/2.4.361

PubMed ID: 8314795

Title: Characterization of two cis-regulatory regions in the murine beta 1,4-galactosyltransferase gene. Evidence for a negative regulatory element that controls initiation at the proximal site.

PubMed ID: 8314795

DOI: 10.1016/s0021-9258(19)85247-x

PubMed ID: 11145975

Title: Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development.

PubMed ID: 11145975

DOI: 10.1046/j.1471-4159.2001.00004.x

PubMed ID: 18511602

Title: Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells.

PubMed ID: 18511602

DOI: 10.1634/stemcells.2007-1080

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 34855475

Title: Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen.

PubMed ID: 34855475

DOI: 10.1126/science.abe0348

Sequence Information:

Length: 399
Mass: 44411
Checksum: 084E3437115F4BDD
Sequence:

MRFREQFLGG SAAMPGATLQ RACRLLVAVC ALHLGVTLVY YLSGRDLSRL PQLVGVSSTL 
QGGTNGAAAS KQPPGEQRPR GARPPPPLGV SPKPRPGLDS SPGAASGPGL KSNLSSLPVP 
TTTGLLSLPA CPEESPLLVG PMLIDFNIAV DLELLAKKNP EIKTGGRYSP KDCVSPHKVA 
IIIPFRNRQE HLKYWLYYLH PILQRQQLDY GIYVINQAGD TMFNRAKLLN IGFQEALKDY 
DYNCFVFSDV DLIPMDDRNA YRCFSQPRHI SVAMDKFGFS LPYVQYFGGV SALSKQQFLA 
INGFPNNYWG WGGEDDDIFN RLVHKGMSIS RPNAVVGRCR MIRHSRDKKN EPNPQRFDRI 
AHTKETMRFD GLNSLTYKVL DVQRYPLYTQ ITVDIGTPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: B4galt1

Associated with

Other Information

Characterization of the full length cDNA for murine beta-1,4-galactosyltransferase. Novel features at the 5'-end predict two translational start sites at two in-frame AUGs. PubMed ID: 3134348

Murine beta 1,4-galactosyltransferase: both the amounts and structure of the mRNA are regulated during spermatogenesis. PubMed ID: 1689054

Genomic structure of murine beta-1,4-galactosyltransferase. PubMed ID: 2504153

Cloning and sequencing of a full-length cDNA of mouse N-acetylglucosamine (beta 1-4)galactosyltransferase. PubMed ID: 3141392

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Evidence for two forms of murine beta-1,4-galactosyltransferase based on cloning studies. PubMed ID: 3149531

Murine beta 1,4-galactosyltransferase: round spermatid transcripts are characterized by an extended 5'-untranslated region. PubMed ID: 1384819

Characterization of two cis-regulatory regions in the murine beta 1,4-galactosyltransferase gene. Evidence for a negative regulatory element that controls initiation at the proximal site. PubMed ID: 8314795

Differential gene expression of beta-1,4-galactosyltransferases I, II and V during mouse brain development. PubMed ID: 11145975

Characterization of a novel ubiquitin-conjugating enzyme that regulates beta1,4-galactosyltransferase-1 in embryonic stem cells. PubMed ID: 18511602

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Genetic and functional evidence links a missense variant in B4GALT1 to lower LDL and fibrinogen. PubMed ID: 34855475