Details for: ADRA1D

Gene ID: 146

Symbol: ADRA1D

Ensembl ID: ENSG00000171873

Description: adrenoceptor alpha 1D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.2207
    Cell Significance Index: 49.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.4619
    Cell Significance Index: 21.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0594
    Cell Significance Index: 33.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7780
    Cell Significance Index: 18.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6631
    Cell Significance Index: 14.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4216
    Cell Significance Index: 12.0300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3576
    Cell Significance Index: 4.6200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3226
    Cell Significance Index: 2.7100
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.3029
    Cell Significance Index: 2.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2478
    Cell Significance Index: 40.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2346
    Cell Significance Index: 3.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2159
    Cell Significance Index: 12.9600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.1508
    Cell Significance Index: 2.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1189
    Cell Significance Index: 42.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1052
    Cell Significance Index: 2.2400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0697
    Cell Significance Index: 0.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0668
    Cell Significance Index: 46.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0598
    Cell Significance Index: 5.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0552
    Cell Significance Index: 10.9600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0403
    Cell Significance Index: 0.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0350
    Cell Significance Index: 0.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0259
    Cell Significance Index: 4.9300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0146
    Cell Significance Index: 0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0098
    Cell Significance Index: 1.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0078
    Cell Significance Index: 0.8500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0006
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0034
    Cell Significance Index: -6.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0039
    Cell Significance Index: -5.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0067
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0068
    Cell Significance Index: -4.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0073
    Cell Significance Index: -4.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0089
    Cell Significance Index: -0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0124
    Cell Significance Index: -5.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0126
    Cell Significance Index: -3.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0130
    Cell Significance Index: -0.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0132
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0167
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0174
    Cell Significance Index: -2.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0199
    Cell Significance Index: -2.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0226
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0235
    Cell Significance Index: -4.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0250
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0281
    Cell Significance Index: -3.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0342
    Cell Significance Index: -0.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0351
    Cell Significance Index: -4.3200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0393
    Cell Significance Index: -0.5800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0444
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0472
    Cell Significance Index: -0.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0485
    Cell Significance Index: -4.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0490
    Cell Significance Index: -5.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0517
    Cell Significance Index: -0.3500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0542
    Cell Significance Index: -2.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0549
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0595
    Cell Significance Index: -4.0000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0686
    Cell Significance Index: -0.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0687
    Cell Significance Index: -5.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0700
    Cell Significance Index: -1.7500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0748
    Cell Significance Index: -0.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0749
    Cell Significance Index: -4.8300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0783
    Cell Significance Index: -1.1800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0783
    Cell Significance Index: -0.4100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0802
    Cell Significance Index: -1.0400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0829
    Cell Significance Index: -1.0000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0846
    Cell Significance Index: -1.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0865
    Cell Significance Index: -1.9000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0866
    Cell Significance Index: -1.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0871
    Cell Significance Index: -4.8900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0890
    Cell Significance Index: -1.0300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0893
    Cell Significance Index: -1.2700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0898
    Cell Significance Index: -0.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0922
    Cell Significance Index: -3.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0922
    Cell Significance Index: -2.5100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.0923
    Cell Significance Index: -0.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1014
    Cell Significance Index: -4.7700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1055
    Cell Significance Index: -2.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1074
    Cell Significance Index: -4.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1081
    Cell Significance Index: -2.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1093
    Cell Significance Index: -2.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1105
    Cell Significance Index: -2.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1116
    Cell Significance Index: -2.2400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1135
    Cell Significance Index: -1.6600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1170
    Cell Significance Index: -0.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1171
    Cell Significance Index: -2.9200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1192
    Cell Significance Index: -1.1300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1245
    Cell Significance Index: -0.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1252
    Cell Significance Index: -4.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1270
    Cell Significance Index: -4.8100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1275
    Cell Significance Index: -1.6500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1276
    Cell Significance Index: -1.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1328
    Cell Significance Index: -4.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1452
    Cell Significance Index: -3.0300
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.1462
    Cell Significance Index: -1.8000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1509
    Cell Significance Index: -3.0700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1514
    Cell Significance Index: -2.9800
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1518
    Cell Significance Index: -1.5700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1569
    Cell Significance Index: -1.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADRA1D is a G protein-coupled receptor (GPCR) that belongs to the class A/1 rhodopsin-like receptors. It is a membrane-bound receptor that is activated by the endogenous ligand adrenochrome, which is produced from the breakdown of catecholamines. ADRA1D is primarily expressed in hematopoietic stem cells, megakaryocytes, and endothelial cells, suggesting its involvement in immune cell development and vascular function. **Pathways and Functions:** ADRA1D is involved in several signaling pathways, including adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating g protein-coupled receptor signaling pathway, and phospholipase c-activating g protein-coupled receptor signaling pathway. The activation of ADRA1D leads to an increase in intracellular cyclic AMP (cAMP) levels, which in turn activates protein kinase A (PKA) and modulates various downstream targets, including calcium channels, phosphodiesterases, and ion channels. The primary functions of ADRA1D include: 1. **Immune regulation:** ADRA1D plays a role in regulating immune cell development and function, particularly in hematopoietic stem cells and megakaryocytes. 2. **Vascular function:** ADRA1D is involved in regulating vascular tone and blood pressure, primarily through its effects on smooth muscle cells and endothelial cells. 3. **Cell proliferation:** ADRA1D is a positive regulator of cell proliferation, particularly in intestinal crypt stem cells and transit amplifying cells. **Clinical Significance:** ADRA1D has been implicated in various diseases and disorders, including: 1. **Autoimmune disorders:** ADRA1D has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, where its dysregulation may contribute to immune dysfunction. 2. **Cardiovascular disease:** ADRA1D has been implicated in the pathogenesis of cardiovascular disease, particularly in hypertension and atherosclerosis, where its dysregulation may contribute to vascular dysfunction. 3. **Cancer:** ADRA1D has been shown to play a role in cancer development and progression, particularly in intestinal cancer, where its dysregulation may contribute to tumor growth and metastasis. In conclusion, the alpha-1D adrenergic receptor is a critical player in immune regulation, vascular function, and cell proliferation. Its dysregulation has been implicated in various diseases and disorders, highlighting the need for further research into the molecular mechanisms underlying its function and the development of therapeutic strategies targeting ADRA1D.

Genular Protein ID: 1249601347

Symbol: ADA1D_HUMAN

Name: Alpha-1D adrenergic receptor

UniProtKB Accession Codes:

P25100 Q9NPY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 78 DrugCentral 1 EMBL 7 EMDB 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1656955

Title: Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor.

PubMed ID: 1656955

DOI: 10.1016/0006-291x(91)91740-4

PubMed ID: 8183249

Title: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

PubMed ID: 8183249

PubMed ID: 7815325

Title: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

PubMed ID: 7815325

PubMed ID: 8024574

Title: Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.

PubMed ID: 8024574

DOI: 10.1006/bbrc.1994.1845

PubMed ID: 7746284

Title: Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.

PubMed ID: 7746284

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 26460884

Title: G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation.

PubMed ID: 26460884

DOI: 10.1021/acs.biochem.5b00975

Sequence Information:

  • Length: 572
  • Mass: 60463
  • Checksum: EBEB134CF20A4988
  • Sequence:
    • MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA GGGGGVVGAG 
SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG VFLAAFILMA VAGNLLVILS 
VACNRHLQTV TNYFIVNLAV ADLLLSATVL PFSATMEVLG FWAFGRAFCD VWAAVDVLCC 
TASILSLCTI SVDRYVGVRH SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP 
PDERFCGITE EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS 
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL AIVVGVFVLC 
WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL IYPCSSREFK RAFLRLLRCQ 
CRRRRRRRPL WRVYGHHWRA STSGLRQDCA PSSGDAPPGA PLALTALPDP DPEPPGTPEM 
QAPVASRRKP PSAFREWRLL GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE 
AVSLGVPHEV AEGATCQAYE LADYSNLRET DI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.