Gene ADRA1D - ENSG00000171873 | NCBI Gene ID: 146

Details for: ADRA1D

Gene ID: 146

Symbol: ADRA1D

Ensembl ID: ENSG00000171873

Description: adrenoceptor alpha 1D

Associated with

Adrenoceptors
(R-HSA-390696)
Amine ligand-binding receptors
(R-HSA-375280)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071880)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Alpha1-adrenergic receptor activity
(GO:0004937)
Cell-cell signaling
(GO:0007267)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Neuron-glial cell signaling
(GO:0150099)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 4.97
Marker Score: 2617
Cell Name: megakaryocyte (CL0000556)
Fold Change: 4.24
Marker Score: 2410
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.55
Marker Score: 1064
Cell Name: precursor B cell (CL0000817)
Fold Change: 2.18
Marker Score: 1444
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1172
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 169071
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.39
Marker Score: 1401
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.36
Marker Score: 2584
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 856
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 487
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4815.5
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 503
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71828
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48052
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30408
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: goblet cell (CL0000160)
Fold Change: 0.98
Marker Score: 6488
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5350
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.9
Marker Score: 1838
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5286
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.87
Marker Score: 13568
Cell Name: mast cell (CL0000097)
Fold Change: 0.85
Marker Score: 494
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: plasma cell (CL0000786)
Fold Change: 0.64
Marker Score: 711
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.62
Marker Score: 989
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.61
Marker Score: 292
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 475
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.58
Marker Score: 1205.5
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 173
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.52
Marker Score: 313
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.51
Marker Score: 393
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.4
Marker Score: 105
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.4
Marker Score: 500.5
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.38
Marker Score: 3226
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.35
Marker Score: 2679
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.34
Marker Score: 229
Cell Name: interneuron (CL0000099)
Fold Change: 0.34
Marker Score: 157
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.26
Marker Score: 139.5
Cell Name: pericyte (CL0000669)
Fold Change: 0.26
Marker Score: 153
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.26
Marker Score: 114
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.26
Marker Score: 138
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.25
Marker Score: 953
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.24
Marker Score: 135
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.21
Marker Score: 7958
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.21
Marker Score: 125
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.2
Marker Score: 198
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.19
Marker Score: 454
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.19
Marker Score: 145
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.17
Marker Score: 55
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.17
Marker Score: 49
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 42
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.17
Marker Score: 2499
Cell Name: astrocyte (CL0000127)
Fold Change: 0.16
Marker Score: 140
Cell Name: neuron (CL0000540)
Fold Change: 0.16
Marker Score: 647
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.15
Marker Score: 39
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.14
Marker Score: 42
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.14
Marker Score: 5104
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.14
Marker Score: 170
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.14
Marker Score: 211
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.14
Marker Score: 1282
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.14
Marker Score: 561
Cell Name: podocyte (CL0000653)
Fold Change: 0.13
Marker Score: 49
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.13
Marker Score: 58
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.12
Marker Score: 39
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.12
Marker Score: 39
Cell Name: melanocyte (CL0000148)
Fold Change: 0.12
Marker Score: 47
Cell Name: macrophage (CL0000235)
Fold Change: 0.12
Marker Score: 129
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.11
Marker Score: 476
Cell Name: T cell (CL0000084)
Fold Change: 0.1
Marker Score: 174
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.1
Marker Score: 66
Cell Name: tendon cell (CL0000388)
Fold Change: 0.1
Marker Score: 24
Cell Name: precursor cell (CL0011115)
Fold Change: 0.09
Marker Score: 23
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.09
Marker Score: 24
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.09
Marker Score: 32
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.09
Marker Score: 40
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.09
Marker Score: 23
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.09
Marker Score: 105
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.08
Marker Score: 23
Cell Name: B cell (CL0000236)
Fold Change: 0.08
Marker Score: 78
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.08
Marker Score: 23
Cell Name: muscle cell (CL0000187)
Fold Change: 0.08
Marker Score: 23
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.08
Marker Score: 39
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.08
Marker Score: 130.5
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.08
Marker Score: 24
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.08
Marker Score: 75.5
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.08
Marker Score: 24
Cell Name: erythroblast (CL0000765)
Fold Change: 0.07
Marker Score: 45
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.07
Marker Score: 33
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.07
Marker Score: 21
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.07
Marker Score: 72

Hover over a box to see details here...

**Key characteristics:** - ADRA1D is a G protein-coupled receptor. - It is a member of the adrenoceptor family of cell surface receptors. - It is expressed in high levels in hematopoietic stem cells and megakaryocytes, where it plays a role in regulating cell proliferation and survival. - It is also expressed in other cell types, where it has been shown to have a variety of effects on cell behavior. **Pathways and functions:** - ADRA1D is a key regulator of cell proliferation and survival in hematopoietic stem cells and megakaryocytes. - It is involved in the regulation of megakaryocyte differentiation and survival. - It is also involved in the regulation of the development and survival of blood vessel endothelial cells. - It is involved in the regulation of angiogenesis and lymphangiogenesis. - It is also involved in the regulation of inflammation. **Clinical significance:** - Mutations in the ADRA1D gene have been linked to a number of human diseases, including asthma, hypertension, and cancer. - ADRA1D is a potential target for the treatment of these diseases. **Conclusion:** The ADRA1D gene is a key regulator of cell proliferation and survival in a variety of cell types. It is a promising target for the treatment of a variety of human diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Alpha-1D adrenergic receptor

Genular Protein ID: 1249601347

Symbol: ADA1D_HUMAN

Name: Alpha-1D adrenergic receptor

UniProtKB Accession Codes:

P25100 Q9NPY0

Database IDs:

Citations:

PubMed ID: 1656955

Title: Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor.

PubMed ID: 1656955

DOI: 10.1016/0006-291x(91)91740-4

PubMed ID: 8183249

Title: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

PubMed ID: 8183249

PubMed ID: 7815325

Title: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

PubMed ID: 7815325

PubMed ID: 8024574

Title: Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.

PubMed ID: 8024574

DOI: 10.1006/bbrc.1994.1845

PubMed ID: 7746284

Title: Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells.

PubMed ID: 7746284

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 26460884

Title: G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation.

PubMed ID: 26460884

DOI: 10.1021/acs.biochem.5b00975

Sequence Information:

Length: 572
Mass: 60463
Checksum: EBEB134CF20A4988
Sequence:

MTFRDLLSVS FEGPRPDSSA GGSSAGGGGG SAGGAAPSEG PAVGGVPGGA GGGGGVVGAG 
SGEDNRSSAG EPGSAGAGGD VNGTAAVGGL VVSAQGVGVG VFLAAFILMA VAGNLLVILS 
VACNRHLQTV TNYFIVNLAV ADLLLSATVL PFSATMEVLG FWAFGRAFCD VWAAVDVLCC 
TASILSLCTI SVDRYVGVRH SLKYPAIMTE RKAAAILALL WVVALVVSVG PLLGWKEPVP 
PDERFCGITE EAGYAVFSSV CSFYLPMAVI VVMYCRVYVV ARSTTRSLEA GVKRERGKAS 
EVVLRIHCRG AATGADGAHG MRSAKGHTFR SSLSVRLLKF SREKKAAKTL AIVVGVFVLC 
WFPFFFVLPL GSLFPQLKPS EGVFKVIFWL GYFNSCVNPL IYPCSSREFK RAFLRLLRCQ 
CRRRRRRRPL WRVYGHHWRA STSGLRQDCA PSSGDAPPGA PLALTALPDP DPEPPGTPEM 
QAPVASRRKP PSAFREWRLL GPFRRPTTQL RAKVSSLSHK IRAGGAQRAE AACAQRSEVE 
AVSLGVPHEV AEGATCQAYE LADYSNLRET DI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ADRA1D

Associated with

Cells (max top 100)

Other Information

Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. PubMed ID: 1656955

The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. PubMed ID: 8183249

Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. PubMed ID: 7815325

Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. PubMed ID: 8024574

Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. PubMed ID: 7746284

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation. PubMed ID: 26460884