CSNK2B | ENSG00000204435 | NCBI 1460

Details for: CSNK2B

Gene ID: 1460

Symbol: CSNK2B

Ensembl ID: ENSG00000204435

Description: casein kinase 2 beta

Associated with

Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Chaperonin-mediated protein folding
(R-HSA-390466)
Condensation of prometaphase chromosomes
(R-HSA-2514853)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glycerophospholipid biosynthesis
(R-HSA-1483206)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Intracellular signaling by second messengers
(R-HSA-9006925)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
L1cam interactions
(R-HSA-373760)
Macroautophagy
(R-HSA-1632852)
Maturation of hrsv a proteins
(R-HSA-9828806)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Mitophagy
(R-HSA-5205647)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Phospholipid metabolism
(R-HSA-1483257)
Pip3 activates akt signaling
(R-HSA-1257604)
Protein folding
(R-HSA-391251)
Pten regulation
(R-HSA-6807070)
Receptor mediated mitophagy
(R-HSA-8934903)
Regulation of pten stability and activity
(R-HSA-8948751)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Respiratory syncytial virus (rsv) genome replication, transcription and translation
(R-HSA-9820965)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-HSA-8939243)
Selective autophagy
(R-HSA-9663891)
Signaling by wnt
(R-HSA-195721)
Signal transduction by l1
(R-HSA-445144)
Synthesis of pc
(R-HSA-1483191)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Viral infection pathways
(R-HSA-9824446)
Wnt mediated activation of dvl
(R-HSA-201688)
Adiponectin-activated signaling pathway
(GO:0033211)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Endothelial tube morphogenesis
(GO:0061154)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Ficolin-1-rich granule lumen
(GO:1904813)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Negative regulation of blood vessel endothelial cell migration
(GO:0043537)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of viral life cycle
(GO:1903901)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Peptidyl-threonine phosphorylation
(GO:0018107)
Plasma membrane
(GO:0005886)
Pml body
(GO:0016605)
Positive regulation of activin receptor signaling pathway
(GO:0032927)
Positive regulation of smad protein signal transduction
(GO:0060391)
Protein-containing complex assembly
(GO:0065003)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase ck2 complex
(GO:0005956)
Protein kinase regulator activity
(GO:0019887)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of dna binding
(GO:0051101)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Secretory granule lumen
(GO:0034774)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Symbiont-mediated disruption of host cell pml body
(GO:0075342)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Casein kinase II subunit beta
A0A1U9X7J2_HUMAN

Genular Protein ID: 2593636872

Symbol: CSK2B_HUMAN

Name: Casein kinase II subunit beta

UniProtKB Accession Codes:

P67870 B0UXA9 P07312 P13862 Q4VX47

Database IDs:

Citations:

PubMed ID: 2666134

Title: Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta.

PubMed ID: 2666134

DOI: 10.1111/j.1432-1033.1989.tb14917.x

PubMed ID: 1694965

Title: Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells.

PubMed ID: 1694965

DOI: 10.1016/0921-8777(90)90036-5

PubMed ID: 2513884

Title: Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II.

PubMed ID: 2513884

DOI: 10.1021/bi00449a014

PubMed ID: 1856204

Title: Structure of the gene encoding human casein kinase II subunit beta.

PubMed ID: 1856204

DOI: 10.1016/s0021-9258(18)92756-0

PubMed ID: 12102635

Title: Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.

PubMed ID: 12102635

DOI: 10.1021/bi025791r

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2300566

Title: Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.

PubMed ID: 2300566

DOI: 10.1073/pnas.87.2.821

PubMed ID: 11298324

Title: Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C.

PubMed ID: 11298324

DOI: 10.1002/1521-4141(200104)31:4<999::aid-immu999>3.0.co;2-r

PubMed ID: 11239457

Title: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.

PubMed ID: 11239457

DOI: 10.1016/s1097-2765(01)00176-9

PubMed ID: 11964394

Title: Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor.

PubMed ID: 11964394

DOI: 10.1074/jbc.m112193200

PubMed ID: 12393879

Title: p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.

PubMed ID: 12393879

DOI: 10.1074/jbc.m209820200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16818610

Title: Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.

PubMed ID: 16818610

DOI: 10.1101/gad.375206

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20719947

Title: Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies.

PubMed ID: 20719947

DOI: 10.1128/jvi.01183-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24216761

Title: Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.

PubMed ID: 24216761

DOI: 10.1128/mcb.00968-13

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28585349

Title: CSNK2B splice site mutations in patients cause intellectual disability with or without myoclonic epilepsy.

PubMed ID: 28585349

DOI: 10.1002/humu.23270

PubMed ID: 31341047

Title: Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation.

PubMed ID: 31341047

DOI: 10.1128/jvi.00989-19

PubMed ID: 31784560

Title: Germline de novo variants in CSNK2B in Chinese patients with epilepsy.

PubMed ID: 31784560

DOI: 10.1038/s41598-019-53484-9

PubMed ID: 10357806

Title: Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization.

PubMed ID: 10357806

DOI: 10.1093/emboj/18.11.2930

PubMed ID: 11574463

Title: Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.

PubMed ID: 11574463

DOI: 10.1093/emboj/20.19.5320

Sequence Information:

Length: 215
Mass: 24942
Checksum: E465B1E699B0E0EC
Sequence:

MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE 
ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML 
PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA 
NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR

Genular Protein ID: 2188601111

Symbol: A0A1U9X7J2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1U9X7J2

Database IDs:

Sequence Information:

Length: 212
Mass: 24685
Checksum: C3831FA07067DCF5
Sequence:

MSSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE 
ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML 
PIDIPGEAMV KLYCPKCMDV YTPKSSRHHH TDGAYFGTGF PHMLFMVHPE YRPKRPANQF 
VPRLYGFKIH PMAYQLQLQA ASNFKSPVKT IR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CSNK2B

Associated with

Other Information

Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta. PubMed ID: 2666134

Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells. PubMed ID: 1694965

Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II. PubMed ID: 2513884

Structure of the gene encoding human casein kinase II subunit beta. PubMed ID: 1856204

Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. PubMed ID: 12102635

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit. PubMed ID: 2300566

Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. PubMed ID: 11298324

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. PubMed ID: 11239457

Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor. PubMed ID: 11964394

p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. PubMed ID: 12393879

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. PubMed ID: 16818610

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Epstein-Barr virus nuclear antigen 1 Hijacks the host kinase CK2 to disrupt PML nuclear bodies. PubMed ID: 20719947

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2. PubMed ID: 24216761

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. PubMed ID: 25755297

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

CSNK2B splice site mutations in patients cause intellectual disability with or without myoclonic epilepsy. PubMed ID: 28585349

Identification of ARKL1 as a Negative Regulator of Epstein-Barr Virus Reactivation. PubMed ID: 31341047

Germline de novo variants in CSNK2B in Chinese patients with epilepsy. PubMed ID: 31784560

Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization. PubMed ID: 10357806

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. PubMed ID: 11574463