Genular: Defining Cellular Identity and Function

Details for: Gja1

Gene ID: 14609

Symbol: Gja1

Ensembl ID: ENSMUSG00000050953

Description: gap junction protein, alpha 1

Associated with

Formation of annular gap junctions
(R-MMU-196025)
Gap junction assembly
(R-MMU-190861)
Gap junction degradation
(R-MMU-190873)
Gap junction trafficking
(R-MMU-190828)
Gap junction trafficking and regulation
(R-MMU-157858)
Membrane trafficking
(R-MMU-199991)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-MMU-190840)
Regulation of gap junction activity
(R-MMU-191650)
Rho gtpase cycle
(R-MMU-9012999)
Rhoq gtpase cycle
(R-MMU-9013406)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Transport of connexons to the plasma membrane
(R-MMU-190872)
Vesicle-mediated transport
(R-MMU-5653656)
Adult heart development
(GO:0007512)
Alpha-tubulin binding
(GO:0043014)
Atp transport
(GO:0015867)
Atrial ventricular junction remodeling
(GO:0003294)
Beta-catenin binding
(GO:0008013)
Beta-tubulin binding
(GO:0048487)
Blood vessel morphogenesis
(GO:0048514)
Bone remodeling
(GO:0046849)
Cell-cell junction organization
(GO:0045216)
Cell-cell signaling
(GO:0007267)
Cell communication
(GO:0007154)
Cell communication by chemical coupling
(GO:0010643)
Cell communication by electrical coupling
(GO:0010644)
Chronic inflammatory response
(GO:0002544)
Columnar/cuboidal epithelial cell maturation
(GO:0002069)
Connexin binding
(GO:0071253)
Disordered domain specific binding
(GO:0097718)
Efflux transmembrane transporter activity
(GO:0015562)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic heart tube development
(GO:0035050)
Epicardial cell to mesenchymal cell transition
(GO:0003347)
Gap junction channel activity
(GO:0005243)
Gap junction channel activity involved in cardiac conduction electrical coupling
(GO:0086075)
Gap junction channel activity involved in cell communication by electrical coupling
(GO:1903763)
Gap junction hemi-channel activity
(GO:0055077)
Glutamate secretion
(GO:0014047)
Glutathione transmembrane transporter activity
(GO:0034634)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
In utero embryonic development
(GO:0001701)
Lens development in camera-type eye
(GO:0002088)
Maintenance of protein localization in endoplasmic reticulum
(GO:0035437)
Male gonad development
(GO:0008584)
Milk ejection reflex
(GO:0060156)
Monoatomic ion transmembrane transporter activity
(GO:0015075)
Negative regulation of cardiac muscle cell proliferation
(GO:0060044)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endothelial cell proliferation
(GO:0001937)
Negative regulation of gene expression
(GO:0010629)
Neuron migration
(GO:0001764)
Neuron projection morphogenesis
(GO:0048812)
Osteoblast differentiation
(GO:0001649)
Pdz domain binding
(GO:0030165)
Positive regulation of cell communication by chemical coupling
(GO:0010652)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glomerular filtration
(GO:0003104)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of meiotic nuclear division
(GO:0045836)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of striated muscle tissue development
(GO:0045844)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of apoptotic process
(GO:0042981)
Regulation of bone mineralization
(GO:0030500)
Regulation of bone remodeling
(GO:0046850)
Regulation of calcium ion transport
(GO:0051924)
Regulation of cell communication by electrical coupling
(GO:0010649)
Regulation of heart contraction
(GO:0008016)
Regulation of ventricular cardiac muscle cell membrane repolarization
(GO:0060307)
Response to ph
(GO:0009268)
Scaffold protein binding
(GO:0097110)
Sh3 domain binding
(GO:0017124)
Signaling receptor binding
(GO:0005102)
Skeletal muscle tissue regeneration
(GO:0043403)
Spermatogenesis
(GO:0007283)
T cell activation
(GO:0042110)
T cell proliferation
(GO:0042098)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)
Tubulin binding
(GO:0015631)
Vascular transport
(GO:0010232)
Vasodilation
(GO:0042311)
Xenobiotic transport
(GO:0042908)

Other Information

Proteins

Gap junction alpha-1 protein
Q8C4N2_MOUSE

Genular Protein ID: 3319547416

Symbol: CXA1_MOUSE

Name: Gap junction alpha-1 protein

UniProtKB Accession Codes:

P23242 Q544I7 Q8CE05

Database IDs:

Citations:

PubMed ID: 1708769

Title: Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages.

PubMed ID: 1708769

DOI: 10.1016/s0021-9258(18)92924-8

PubMed ID: 2060697

Title: Developmental regulation of gap junction gene expression during mouse embryonic development.

PubMed ID: 2060697

DOI: 10.1016/0012-1606(91)90452-9

PubMed ID: 1318884

Title: Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung.

PubMed ID: 1318884

DOI: 10.1083/jcb.117.6.1299

PubMed ID: 8395450

Title: Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43.

PubMed ID: 8395450

DOI: 10.1016/0378-1119(93)90419-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2178193

Title: Changes in the expression of connexin 43, a cardiac gap junctional protein, during mouse heart development.

PubMed ID: 2178193

DOI: 10.1016/0022-2828(90)90061-6

PubMed ID: 11741837

Title: Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness.

PubMed ID: 11741837

DOI: 10.1093/hmg/10.25.2945

PubMed ID: 15181016

Title: Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells.

PubMed ID: 15181016

DOI: 10.1074/jbc.m404073200

PubMed ID: 15213231

Title: CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression.

PubMed ID: 15213231

DOI: 10.1074/jbc.m403952200

PubMed ID: 15709751

Title: Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation.

PubMed ID: 15709751

DOI: 10.1021/bi048306w

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 18079109

Title: A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.

PubMed ID: 18079109

DOI: 10.1074/jbc.m709288200

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19864490

Title: Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins.

PubMed ID: 19864490

DOI: 10.1093/hmg/ddp490

PubMed ID: 20940304

Title: Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75.

PubMed ID: 20940304

DOI: 10.1074/jbc.m110.170753

PubMed ID: 21071693

Title: Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall.

PubMed ID: 21071693

DOI: 10.1161/atvbaha.110.215939

PubMed ID: 22549838

Title: Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm.

PubMed ID: 22549838

DOI: 10.1038/ncomms1812

PubMed ID: 26403541

Title: Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.

PubMed ID: 26403541

DOI: 10.1038/ncomms9391

PubMed ID: 28507509

Title: Loss of Elp3 impairs the acetylation and distribution of connexin-43 in the developing cerebral cortex.

PubMed ID: 28507509

DOI: 10.3389/fncel.2017.00122

Sequence Information:

Length: 382
Mass: 43004
Checksum: 018DCB461FA69490
Sequence:

MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG 
CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG 
VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSVFEVAFL LIQWYIYGFS 
LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV 
KGRSDPYHAT TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN 
YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD SQNAKKVAAG HELQPLAIVD 
QRPSSRASSR ASSRPRPDDL EI

Genular Protein ID: 2864741658

Symbol: Q8C4N2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C4N2

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 108
Mass: 11773
Checksum: 8EFB2B5C03088AC9
Sequence:

TAPLSPMSPP GYKLVTGDRN NSSCRNYNKQ ASEQNWANYS AEQNRMGQAG STISNSHAQP 
FDFPDDSQNA KKVAAGHELQ PLAIVDQRPS SRASSRASSR PRPDDLEI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Gja1

Associated with

Other Information

Evidence that the gap junction protein connexin-43 is the ATP-induced pore of mouse macrophages. PubMed ID: 1708769

Developmental regulation of gap junction gene expression during mouse embryonic development. PubMed ID: 2060697

Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung. PubMed ID: 1318884

Structure, sequence and expression of the mouse Cx43 gene encoding connexin 43. PubMed ID: 8395450

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Changes in the expression of connexin 43, a cardiac gap junctional protein, during mouse heart development. PubMed ID: 2178193

Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness. PubMed ID: 11741837

Connexin43 interacts with NOV: a possible mechanism for negative regulation of cell growth in choriocarcinoma cells. PubMed ID: 15181016

CCN3 (NOV) interacts with connexin43 in C6 glioma cells: possible mechanism of connexin-mediated growth suppression. PubMed ID: 15213231

Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. PubMed ID: 15709751

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43. PubMed ID: 18079109

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. PubMed ID: 19864490

Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75. PubMed ID: 20940304

Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall. PubMed ID: 21071693

Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. PubMed ID: 22549838

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. PubMed ID: 26403541

Loss of Elp3 impairs the acetylation and distribution of connexin-43 in the developing cerebral cortex. PubMed ID: 28507509

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073